检索结果-南通市图书馆

The mRNA Binding Proteome of Proliferating and differentiated muscle Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2020年第4期18卷 384-396页

作者： monika Hiller miriam Geissler George Janssen Peter van Veelen Annemieke Aartsma-rus Pietro Spitali Department of Human Genetics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands Center for Proteomics and metabolomics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands

muscle formation is a coordinated process driven by extensive gene expression changes where single cells fuse together to form multinucleated muscle fibers. Newly synthesized m RNAs are then regulated by RNA binding proteins(RBPs), affecting post-transcriptional transcript metabolism. Here, we determined how large-scale gene expression changes affect the catalog of RBPs by studying proliferating and differentiated muscle cells in healthy and dystrophic conditions. Transcriptomic analysis showed that the expression of more than 7000 genes was affected during myogenesis. We identified 769 RBPs, of which 294 were muscle-specific and 49 were uniquely shared with cardiomyocytes. A subset of 32 RBPs(half of which were muscle-specific) was found to be preferentially associated with target mRNAs in either myoblasts(mBs) or myotubes(mTs). A large proportion of catalytic proteins were bound to mRNAs even though they lack classical RNA binding domains. Finally, we showed how the identification of cell-specific RBPs enabled the identification of biomarkers that can separate healthy individuals from dystrophic patients. Our data show how interactome data can shed light on new basic RNA biology as well as provide cell-specific data that can be used for diagnostic purposes.

关键词： RNA binding protein Interactome Duchenne muscular dystrophy Proteomics Skeletal muscle

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2020年第4期12卷 149-159页

作者： lars lind lars Johansson Hakan Ahlstrom Jan W Eriksson Anders larsson Ulf Risérus Joel Kullberg Jan Oscarsson Department of medical Sciences UppsalaUniversityUppsala 75185Sweden Antaros medical AB BioVenture HubMolndal 43153Sweden Department of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Department of Public Health and Caring Sciences Clinical Nutrition and metabolism Uppsala UniversityUppsala 75122Sweden Global medicines Development AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFlD)is a common disorder,with an estimated prevalence ranging from 20%to 35%in the general *** scores based on easily measurable biochemical and clinical parameters,including the fatty liver index(FlI),hepatic steatosis index(HSI),lipid accumulation product(lAP),and NAFlD liver fat score(lFS),have been developed for the detection of ***,comparative information regarding the efficacy of these scores for predicting NAFlD in population-based samples comprising normal and high-risk individuals is *** To evaluate four NAFlD detection scores in two samples with different NAFlD *** NAFlD screening was performed in a population-based sample of 50-year-old individuals in Uppsala,Sweden[n=310;Prospective investigation of obesity,energy and metabolism(POEm)study]and a high-risk population comprising patients with a body mass index>25 kg/m2 and either high plasma triglycerides(≥1.7 mmol/l)or type 2 diabetes(n=310;EFFECT studies).NAFlD was defined as liver fat>5.5%using magnetic resonance imaging-proton density fat ***,HSI,lAP,and NAFlD lFS were assessed.A logistic regression model was used to evaluate the effectiveness of the different *** The prevalence of NAFlD was 23%in *** showed the highest receiver operating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the lAP score(P=0.005 vs lAP,P=0.08 vs lFS,P=0.12 vs HSI)for detection of *** other three indices performed equally in POEm(0.77-0.78).The prevalence of NAFlD was 74%in EFFECT;lFS performed best(ROC AUC 0.80)in this *** ROC AUC for lFS(0.80)was significantly higher than that for FlI(P=0.0019)and lAP(P=0.0022),but not HSI(P=0.11).We performed a sensitivity analysis with stratification for the two high-risk subgroups(patients with diabetes or hypertriglyceridemia)from the EFFECT *** performed best in patients with *** major differences

关键词： Comparison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

Percutaneous nephrostomy versus ureteral stent in hydronephrosis secondary to obstructive urolithiasis:A systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第2期11卷 261-270页

作者： Andreia Cardoso Aparício Coutinho Gonçalo Neto Sara Anacleto Catarina laranjo Tinoco Nuno morais mário Cerqueira-Alves Estevão lima Paulo mota Department of Urology Hospital de BragaBragaPortugal School of medicine University of MinhoBragaPortugal Association(2CA-Braga).School of medicine University of MinhoBragaPortugal

Objective: To assess if there is a preferable intervention between retrograde ureteral stent (rus) and percutaneous nephrostomy (PCN) tube, in cases of upper urinary tract stone obstruction with complications requiring urgent drainage, by evaluating outcomes regarding urinary symptoms, quality of life (Qol), spontaneous stone passage, and length of hospital stays, since there is no literature stating the superiority of one modality over the ***: We searched mEDlINE and other sources for relevant articles in June 2019 without any date restrictions or filters applied. The selection was done first by the title and abstract screening and then by full-text assessment for eligibility. Only randomized controlled trials or cohort studies in patients with hydronephrosis secondary to obstructive urolithiasis that presented comparative data between PCN and rus placement concerning at least one of the defined outcome measures were included. lastly, mEDlINE database and Pubmed platform were screened again using the same terms, from June 2019 until November ***: Of 556 initial articles, seven were included in this review. most works were considered of moderate-to-high quality. Three studies regarding Qol showed a tendency against stenting, even though only one demonstrated statistically significant negative impact on overall health state. Two works reported significantly more post-intervention urinary symptoms in stenting patients. One article found that PCN is a significant predictor of spontaneous stone passage, when adjusted for stone size and location. Findings on length of hospital stays were not consistent among ***: PCN appears to be the intervention better tolerated, with less impact on the patient’s perceived Qol and less post-operative urinary symptoms, in comparison with rus. Nevertheless, further studies with larger samples and a randomized controlled design are suggested.

关键词： Ureteral stent Percutaneous nephrostomy Obstructive urolithiasis Urinary symptoms Quality of life

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水泵水轮机导水机构优化

国外大电机 1996年第5期 44-49页

作者： Tom,rus 田正中

本文介绍了２５０ｍ水头段水泵水轮机导水机构优化试验研究及其对效率的影响，讨论了机组在四象限运行时导水机构内的能量特性、压力脉动以及导叶的正压力和扭振，在相对于固定导叶枢轴三个圆周位置上，对三组不同导叶进行了试验研究。

关键词：水泵水轮机导水机构

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

来访者中心

建筑实践 2017年第14期 8-15页

作者： Arkis Birgir Teitsson Arnar Tór Jónsson lárus Guemundsson 华通设计顾问工程有限公司

斯纳菲尔斯都法来访者中心与周围自然物高度相融并紧密联系。它以其独特的面貌吸引来访者,建筑可以分为三个部分,可以根据时节的不同以不同的方式利用。建筑地点选择在可以确保防风、光线充足和有山脉景色的地方。建筑形式的灵

关键词：来访者

Plasma electrolytic oxidation of AZ31 and AZ91 magnesium alloys:Comparison of coatings formation mechanism

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of magnesium and Alloys 2020年第3期8卷 587-600页

作者： A.G.Rakoch E.P.monakhova Z.V.Khabibullina m.Serdechnova C.Blawert m.l.Zheludkevich A.A.Gladkova aDepartment of metal Protection and Surface Treatment National University of Science and Technology‘MISiS’Leninskiy prospekt 4119049 MoscowRussia Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research GmbHMax-Plank Str.l21502 GeesthachtGermany Faculty of Engineering Kiel UniversityKaiserstrasse 224143 KielGermany

The growth kinetics of PEO coatings on AZ31 and AZ91 magnesium alloys were studied and correlated with their structure,compositions(phase and elemental)and corrosion *** was established that the coatings have a two-(outer and anodic)or three-layer structure(outer,inner and anodic)depending on the treatment ***,at short treatment time only an anodic layer and outer layer *** of the outer PEO layer takes place due to the micro discharges,which occur in vertical pores and voids with spherical *** the time is increasing,and electrolyte inside of the pores is heating-up,etching of the mg substrate and oxide film becomes more dominant and horizontal pores in the interface between coating and metal are *** the pores new anodic layer will form and at this time the formation of the third inner layer *** growth of the inner layer happens via the anodic film as a result of micro discharge ignition in the horizontal pores,accompanied by formation of plasma in numerous micro-voids of this *** coatings formed on AZ91 alloy are denser,than those on AZ31,which is related to the difference in the rates of inner layer growth and dissolving of oxides which are located at the bottom of the horizontal *** of the lower Al content,the AZ31 substrate itself and the also the oxide films are less stable and tend to dissolve at a higher rate compared to ***,it was demonstrated that a good corrosion resistance of the coatings was only obtained on AZ91 and if the average thickness of the coating is around 50μm,correlating with the formation of a sufficiently dense inner laye-Knowing this mechanism,a new two-step treatment was suggested,combining the standard PEO treatment with a subsequent PEO process in an electrolyte supporting the inner film *** concept was successfully applied and a further improved corrosion resistance was obtained compared to the single stage PEO *** improvement of corrosion re

关键词： Plasma electrolytic oxidation magnesium alloys Coating formation Coating growth Corrosion resistance.

在线全文

学校读者我要写书评

暂无评论

俄罗斯现代化与文化

学术交流 2020年第4期 5-13页

作者： [俄]B.m.梅茹耶夫(В.М.Межуев) 丁海丽(译) 俄罗斯科学院哲学所哈尔滨工程大学马克思主义学院哈尔滨150001

俄罗斯现代化的主要障碍是占主导地位的、建基于崇拜(神化)最高政权和缺乏成熟法律意识基础之上的政治文化类型。这同样也是向现代(理性)行为方式与意识转型不彻底性的原因,因为现代行为与意识对历史传承下来的价值体系秉持强烈的批判... 详细信息

俄罗斯现代化的主要障碍是占主导地位的、建基于崇拜(神化)最高政权和缺乏成熟法律意识基础之上的政治文化类型。这同样也是向现代(理性)行为方式与意识转型不彻底性的原因,因为现代行为与意识对历史传承下来的价值体系秉持强烈的批判反思立场。

关键词：现代化文化法律意识传统纯理性主义保守主义

Cardiovascular prevention in elderly patients

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon Pablo Díez-Villanueva Carmen rus mansilla Héctor García-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de Pablo-Zarzoso manuel martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé Servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INClIVA ValenciaSpain Servicio Cardiología Hospital Universitario de Jaén Spain Servicio Cardiología Hospital de Donosti Spain Servicio de Cardiología Hospital Universitario La Princesa de MadridSpain Servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiología Hospital Rio Hortega de ValladolidSpain Servicio Cardiología Hospital Clínico San Cecilio de Granada Spain Servicio de Cardiología Hospital Universitario Central de AsturiasSpain Servicio de Cardiologia Hospital de LugoSpain Servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiología Hospital Universitario de la Paz de madrid Spain Servicio de Cardiología Hospital Ramón y Cajal de MadridSpain Department of Cardiology.Hospital Universitario Gregorio marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiología del Hospital General de Alicante Spain Servicio de Cardiología Hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing *** this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular ***,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation ***,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

P3: An installation for high-energy density plasma physics and ultra-high intensity laserematter interaction at ElI-Beamlines

在线全文

学校读者我要写书评

暂无评论

matter and Radiation at Extremes 2017年第4期2卷 149-176页

作者： S.Weber S.Bechet S.Borneis l.Brabec m.Bucka E.Chacon-Golcher m.Ciappina m.Demarco A.Fajstavr K.Falk E.-R.Garcia J.Grosz Y.-J.Gu J.-C.Hernandez m.Holec P.Janecka m.Jantac m.Jirka H.Kadlecova D.Khikhlukha O.Klimo G.Korn D.Kramer D.Kumar T.lastovicka P.lutoslawski l.morejon V.Olsovcova m.Rajdl O.Renner B.rus S.Singh m.Smid m.Sokol R.Versaci R.Vrana m.Vranic J.Vyskocil A.Wolf Q.Yu ElI-Beamlines Institute of PhysicsAcademy of Sciences of the Czech Republic18221 PragueCzech Republic

ElI-Beamlines(ElI-Bl),one of the three pillars of the Extreme light Infrastructure endeavour,will be in a unique position to perform research in high-energy-density-physics(HEDP),plasma physics and ultra-high intensity(UHI)ð>10^(22) W=cm^(2)) lasereplasma *** the need for HED laboratory physics was identified and the P3(plasma physics platform)installation under construction in ElI-Bl will be an *** ElI-Bl 10 PW laser makes possible fundamental research topics from high-field physics to new extreme states of matter such as radiation-dominated ones,high-pressure quantum ones,warm dense matter(WDm)and ultra-relativistic *** is of fundamental importance for research in the field of laboratory astrophysics and inertial confinement fusion(ICF).Reaching such extreme states of matter now and in the future will depend on the use of plasma optics for amplifying and focusing laser *** article will present the relevant technological infrastructure being built in ElI-Bl for HEDP and UHI,and gives a brief overview of some research under way in the field of UHI,laboratory astrophysics,ICF,WDm,and plasma optics.

关键词： High-energy-density-physics Ultra-high-intensity Warm dense matter laboratory astrophysics High repetition rate lasers Plasma optics Inertial confinement fusion lasereplasma interaction Relativistic plasmas