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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

Ammonium persulphate promoted synthesis of polyethylene glycol entrapped potassium tribromide and its application in acylation and bromination of some selective organic compounds

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Chinese Chemical Letters 2013年第10期24卷 866-868页

作者： rupa Rani Dey Siddhartha Sankar Dhar Department of Chemistry National Institute of Technology

In this study, a new method of synthesis of polyethylene glycol supported potassium tribromide （PEG KBr3） and its application in acylation and bromination reactions are reported. Ammonium persulphate oxidizes I（Br to the corresponding tribromide which is entrapped by polyethylene glycol leading to stable PEG KBr3. The reagent is proved to be highly efficient for the acylation of variety of alcohols and bromination of activated aromatic substrates. The method is a mild, one pot reaction and involves no use of toxic reagents.

关键词： Potassium bromide Polyethylene glycol (PEG) Ammonium per sulphate Acylation Bromination

Diabetes and COVID-19:Role of insulin resistance as a risk factor for COVID-19 severity

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World Journal of Diabetes 2021年第9期12卷 1550-1562页

作者： Charitha Gangadharan rupa Ahluwalia Alben Sigamani Department of Clinical Research Narayana Hrudayalaya LimitedBangalore 560099KarnatakaIndia Consultant in Diabetes and Endocrinology Norfolk and Norwich University Hospitals NHS Foundation TrustNorwich NR47UYUnited Kingdom Chief Scientific Officer Numen HealthBangalore 560095KarnatakaIndia

Patients with diabetes are more susceptible to coronavirus disease 2019(COVID-19),and as a consequence,develop more severe form of *** is partly due to a systemic inflammatory state and pro thrombotic milieu seen in metabolic *** this review,we attempt to explore the pathogenetic links between insulin resistance and COVID-19 disease *** resistance is an underlying condition for metabolic syndromes,including type 2 diabetes,which impairs insulin signaling pathways affecting metabolic and cardiovascular homeostasis.A high concentration of circulating insulin shifts the balance to mitogen activated protein kinase(MAPK)-dependent signaling and causes endothelial cell *** phosphatidylinositol 3 kinase and MAPK dependent signaling pathways maintain a balance between nitric oxide-dependent vasodilator and endothelin-1 dependent vasoconstriction actions of *** smooth muscle cell dysfunction is responsible for inflammation and blood coagulation leading to microvascular and macrovascular complications in *** in renin-angiotensin system is implicated in development of islet oxidative stress and subsequentβ-cell dysfunction,as it alters the islet blood *** deleterious effects of insulin resistance involving altered blood pressure,vascular dysfunction,and inflammation could be associated with increased severity in COVID-19 *** conclude that clinical and/or biochemical markers of insulin resistance should be included as prognostic markers in assessment of acute COVID-19 disease.

关键词： Insulin resistance Renin-angiotensin system Blood flow measurements Inflammation Thrombosis Severity of COVID-19

Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India

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Eye and Vision 2021年第1期8卷 192-202页

作者： Sriee Viswarubhiny rupa Anjanamurthy Ayyasamy Vanniarajan Devarajan Bharanidharan Vijayalakshmi Perumalsamy Periasamy Sundaresan Department of Molecular Genetics Aravind Medical Research FoundationAravind Eye HospitalMaduraiTamil Nadu 625020India Department of Molecular Biology Aravind Medical Research Foundation-Affiliated to Alagappa UniversityKaraikudiTamil NaduIndia Department of Paediatric and Adult strabismus Aravind Eye HospitalMaduraiTamil NaduIndia Department of Bioinformatics Aravind Medical Research FoundationAravind Eye HospitalMaduraiTamil NaduIndia

Background:Leber congenital amaurosis(LCA),primarily characterized by retinal degeneration is the most severe form of inherited retinal dystrophy(IRD)responsible for congenital *** presence of phenotypic heterogeneity makes the diagnosis of LCA challenging,especially in the absence of pronounced disease pathognomonic,yet it can be well comprehended by employing molecular ***,the present study aimed to reveal the causative mutations in ten LCA patients with variable phenotypes using clinical exome sequencing(CES).Methods:CES was performed in ten unrelated LCA *** information and family history of all patients were obtained to make a meaningful *** clinical exome data was analyzed and prioritized using a bioinformatics pipeline to identify mutations,which was further validated by Sanger *** analysis was also performed on available family ***:CES led to the identification of causative mutations in nine LCA *** patients harbored a mutation in six LCA candidate genes,including RPE65,LCA5(n=2),CRX,PRPH2,CEP290,and ALMS1,while two patients possess a mutation in IFT80 and RP1,known to cause other *** novel mutations in LCA5(c.1823del),CRX(c.848del)and CEP290(c.2483G>T)were *** current study reports for the first time,a mutation in PRPH2,CEP290,and ALMS1 from the Indian ***,we observed a novel association of LCA phenotype with IFT80 known to cause Jeune *** on the genetic finding,the patient AS09,who harbored a mutation in the RP1 gene,was re-diagnosed with early-onset retinitis ***:In conclusion,the results underline the importance of CES in clinically diagnosed LCA patients with variable *** correlation between mutations in candidate genes and clinical phenotypes,helps to refine the clinical ***,molecular evaluation with a larger cohort of LCA patients is needed for better understa

关键词： Leber congenital amaurosis Clinical exome sequencing Southern India Molecular diagnosis Genotype-phenotype correlation

Two arms-three instruments robot-assisted laparoscopic hysterectomy:A reproducible technique

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第2期4卷 44-47页

作者： Rooma Sinha Bana rupa Girija Shankar Mohanty Department of Gynaecology Apollo Health CityHyderabad500033India

Although laparoscopic hysterectomy has been used for more than 3 decades,it is not universally adopted due to steep learning *** robotic platform can bridge this gap and reduce the need for open hysterectomy with enhanced dexterity and accurate depth perception by 3D vision and wristed intuitive *** technical note introduces a two arms-three instruments“Sinha-Apollo technique”for da Vinci Si system for performing robotic-assisted laparoscopic hysterectomy in simplified and reproducible steps.

关键词： Robotic Hysterectomy Technique Reproducible

Surface Pressure and Summer Monsoon Rainfall over India

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Advances in Atmospheric Sciences 1992年第3期9卷 359-366页

作者： B.Parthasarathy K.rupa Kumar A.A.Munot Indian Institute of Tropical Meteorology Pune-411008 IndiaIndian Institute of Tropical Meteorology Pune-411008 IndiaIndian Institute of Tropical Meteorology Pune-411008 India

The relationship between the all-India summer monsoon rainfall and surface pressure over the Indian region has been examined to obtain a useful predictor for the monsoon rainfall. The data series of all-India monsoon rainfall and the mean pressures of three seasons before and after the monsoon season as well as the winter-to-spring pressure tendency (MAM-DJF) at 100 stations for the period 1951-1980 have been used in the *** all-India monsoon rainfall is negatively correlated with the pressure of the spring (MAM) season preceding the monsoon and winter-to-spring seasonal difference as pressure tendency (MAM-DJF), at almost all the stations in India, and significantly with the pressures over central and northwestern regions. The average mean sea level pressure of six stations (Jodhpur, Ahmedabed, Bombay, Indore, Sagar and Akola) in the Western Central Indian (WCI) region showed highly significant (at 1% level) and consistent CCs of-0.63 for MAM and -0.56 for MAM-DJF for the period 1951 - 1980. Thus, the pre-monsoon seasonal pressure anomalies over WCI could provide a useful parameter for the long-range forecasting scheme of the Indian monsoon rainfall.

关键词： over In Surface Pressure and Summer Monsoon Rainfall over India MAM

Artificial neural network model of non-Darcy MHD Sutterby hybrid nanofluid flow over a curved permeable surface:Solar energy applications

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Propulsion and Power Research 2023年第3期12卷 410-427页

作者： Shaik Jakeer Maduru Lakshmi rupa Seethi Reddy Reddisekhar Reddy A.M.Rashad Centre for Computational Modeling Chennai Institute of TechnologyChennai 600069India Department of Mathematics S.A.S.Vellore Institute of TechnologyVellore 632014India Department of Mathematics Koneru Lakshmaiah Education FoundationBowrampetHyderabad 500043TelanganaIndia Department of Mathematics Aswan UniversityFaculty of ScienceAswan 81528Egypt

The conversion of solar radiation to thermal energy has recently much interest as the requirement for renewable heat and power *** to their enhanced ability to promote heat transmission,nanofluids can significantly improve solar-thermal systems’*** section aims to study the heat transfer behavior of the Sutterby hybrid nanofluid flow of magnetohydrodynamics in the presence of a non-uniform heat source/sink and linear thermal radiation over a non-Darcy curved permeable surface.A novel implementation of an intelligent numerical computing solver based on multi-layer perceptron(MLP)feed-forward back-propagation artificial neural network(ANN)with the Levenberg-Marquard algorithm is provided in the current *** were gathered for the ANN model’s testing,certification,and *** mathematical equations are nonlinear,which are resolved for velocity,the temperature in addition to the skin friction coefficient,and the rate of heat transfer by using the bvp4c with MATLAB *** ANN model selects data,constructs and trains a network,then evaluates its efficacy via mean square *** illustrate the impact of a wide range of physical factors on variables,including pressure,velocity,and *** the entire study,the thermal energy improved by the SiO2(silicon dioxide)-Au(gold)hybrid nanofluid than the SiO2-TiO2(titanium dioxide)hybrid *** higher internal heat generation/absorption parameter values increase the temperature.

关键词： ANN model Sutterby hybrid nanofluid Magnetic field Non-DarcyForchheimer Curved surface Radiation

The epigenetics of CHARGE syndrome

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Frontiers in Biology 2016年第2期11卷 85-95页

作者： Nina K. Latcheva rupa Ghosh Daniel R. Marenda Department of Biology Drexel University Philadelphia PA 19104 USA Program in Molecular and Cellular Biology and Genetics Drexel University College of Medicine Philadelphia PA 19129 USA Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia PA 19129 USA

In biology, we continue to appreciate the fact that the DNA sequence alone falls short when attempting to explain the intricate inheritance patterns for complex traits. This is particularly true for human disorders that appear to have simple genetic causes. The study of epigenetics, and the increased access to the epigenetic profiles of different tissues has begun to shed light on the genetic complexity of many basic biological processes, both physiological and pathological. Epigenetics refers to heritable changes in gene expression that are not due to alterations in the DNA sequence. Various mechanisms of epigenetic regulation exist, including DNA methylation and histone modification. The identification, and increased understanding of key players and mechanisms of epigenetic regulation have begun to provide significant insight into the underlying origins of various human genetic disorders. One such disorder is CHARGE syndrome （OMIM #214800）, which is a leading cause of deaf-blindness worldwide. A majority of CHARGE syndrome cases are caused by haploinsufficiency for the CHD7 gene, which encodes an ATP-dependent chromatin remodeling protein involved in the epigenetic regulation of gene expression. The CHD7 protein has been highly conserved throughout evolution, and research into the function of CHD7 homologs in multiple model systems has increased our understanding of this family of proteins, and epigenetic mechanisms in general. Here we provide a review of CHARGE syndrome, and discuss the epigenetic functions of CHD7 in humans and CHD7 homologs in model organisms.

关键词： Drosophila Kismet CHD7 CHARGE syndrome chromatin remodeling

The Stretch, Limit and Path Forward for Particle Reinforced Metal Matrix Composites of 7075 Al-Alloys

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Engineering（科研） 2010年第4期2卷 237-256页

作者： rupa dasgupta 不详

Al-based metal matrix composites [MMCs] have been the research interest of a wide spectrum of material scientists throughout the world for some over two decades now. The present paper has chosen one alloy system namely the 7xxx series and from an extensive literature review concluded that since the beginning of the new millennium nothing note worthy has been added to the knowledge already gained in the last quarter of the last century except confirm the earlier findings that MMCs if properly fabricated by choosing the processing route and with appropriate size and volume fraction of dispersoids can improve most of the mechanical, corrosion and wear resistant properties of the base alloy. The author’s own research activities using this alloy system for making MMCs that include attempts to improve upon the properties by making composites, ageing and also secondary processing have been included. An attempt has been made to establish the stretch to which improvement is possible in the alloy system by making composites and trying all other routes known for meaningful improvement in properties. Further, the way forward for such particulate composites has been drawn to realise the material scientists’ dream of seeing such MMCs as engineering components. For this, the areas which now need research include mass production of composites, focus on its machining, joining, processing as also reduction in the size of dispersoids are some of the areas that have been identified and discussed in the paper.

关键词： Al-based MMCs 7xxx Series 7075 Alloy Tempering Ageing Retrogression And Reageing Hardness Mechanical Properties Wear Properties Extrusion Corrosion Machining Joining Mass Production