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Endocrine role of bone in the regulation of energy metabolism

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Bone Research 2021年第4期9卷 425-443页

作者： ruoyu zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang Changjun Li Xianghang Luo Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunanChina

Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic ***,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic *** addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte *** findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes *** this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.

关键词： metabolism homeostasis prevention

Treatment of the High Concentration Nonylphenol Ethoxylates (NPEOs) Wastewater by Fenton Oxidation Process

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American Journal of Analytical Chemistry 2017年第1期8卷 72-80页

作者： ruoyu zhou Wenqi Zhang College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai China

The Fenton oxidation process was applied in the treatment of an actual high concentration nonylphenol Ethoxylates (NPEOs) wastewater. The effects of H2O2 dosage, molar ratio of H2O2/Fe2+ (Fe2+ dosage), pH value and reaction time on the degradation of NPEOs were investigated. The orthogonal experiment indicated that the order of degree of influence on the COD removal was molar ratio of H2O2/Fe2+, reaction time, dosage of H2O2, and initial pH. The single-factor tests were carried out to determine the optimal conditions, and the results were H2O2 dosage of 76.32 mmol/L, molar ratio of H2O2/Fe2+ of 3, pH value of 5 and reaction time of 2 h. Under the optimum operation conditions, the COD removal efficiency was 85.6% and the effluent could be mixed with other wastewater into the large-scale biological treatment system.

关键词： Fenton Nonylphenol Ethoxylates Orthogonal Experiment Single-Factor

Reuse of Ferric Sludge by Ferrous Sulfide in the Fenton Process for Nonylphenol Ethoxylates Wastewater Treatment

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Computational Water, Energy, and Environmental Engineering 2017年第1期6卷 89-96页

作者： ruoyu zhou Wenqi Zhang College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai China

In this paper, Fenton process was determined to be an effective technique to treat the refractory Nonylphenol ethoxylates (NPEOs) wastewater. The COD removal efficien-cies above 89% were obtained when the initial COD concentration was 12000mg/L. However, A large number of ferric sludge (SS=8.724g/L) would be produced after the Fenton oxidation of the wastewater and must be disposed appropriately. A novel process for Fenton sludge reused by low-cost ferrous sulfide (FeS) was also investi-gated. Experimental results show that the Fenton sludge could be reduced to produce a certain amount of Fe2+ in the acidic mixed liquor by ferrous sulfide. This mixed liquor from Fenton sludge could be used as the new catalyst in the Fenton process and was also highly effective for the NPEOs wastewater treatment. The residual ferrous sulfide from the mixed liquor could be used for the next batch of the

关键词： Fenton Process Iron-Containing Sludge Ferrous Sulfide Sludge Reused Nonylphenol Ethoxylates

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis

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Cancer Biology & Medicine 2019年第1期16卷 79-88页

作者： Haili Li Yongjin Zhang Juhua Dan ruoyu zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo Faculty of Environmental Science and Engineering Kunming University of Science and Technology Laboratory of Molecular Genetics of Aging &Tumor Kunming University of Science and Technology Division of Nephrology The First People's Hospital of Yunnan Province Department of Cancer Systems Imaging The University of Texas MD Anderson Cancer Center Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston Department of Pathology Kunming General Hospital

Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is ***: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological *** RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease ***: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and ***: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis.

关键词： p53 mutation telomere dysfunction polycystic kidney disease tumorigenesis

AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong Carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang ruoyu zhou Xiaoshu zhou Fengling Wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

纺织品电子商务低碳物流的选址-路径问题探析

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上海纺织科技 2022年第8期50卷 56-59页

作者：周若瑜东华大学旭日工商管理学院上海200051

物流运输作为电子商务供应链的关键因素,是纺织品消费过程中碳排放的重要环节,亟需实现低碳改革与突破。综述了目前物流运输过程中的碳排放现状,介绍了物流运输选址-路径问题的常用模型与算法。在此基础上,将碳排放作为约束条件,总结了... 详细信息

物流运输作为电子商务供应链的关键因素,是纺织品消费过程中碳排放的重要环节,亟需实现低碳改革与突破。综述了目前物流运输过程中的碳排放现状,介绍了物流运输选址-路径问题的常用模型与算法。在此基础上,将碳排放作为约束条件,总结了针对该问题提出的新模型、新算法,并利用碳排放分析与核算方法建立碳足迹评价体系。低碳要求纳入纺织品物流运输选址分配和路径优化决策,具有重要的现实意义。

关键词：纺织品物流电子商务选址分配路径优化

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水轮发电机组转子大立筋安装技术研究

人民长江 2015年第11期46卷 84-87页

作者：周若愚中国水利水电第三工程局有限公司陕西西安710032

转子大立筋安装是水轮发电机组转子安装的一项重要工序,直接关系到整个转子圆度和同心度,对于大容量的大型水轮发电机组而言,其安装工艺要求更高。以金沙江鲁地拉水电站水轮发电机组的转子组装为例,根据其结构特点,对其采用了大立筋及... 详细信息

转子大立筋安装是水轮发电机组转子安装的一项重要工序,直接关系到整个转子圆度和同心度,对于大容量的大型水轮发电机组而言,其安装工艺要求更高。以金沙江鲁地拉水电站水轮发电机组的转子组装为例,根据其结构特点,对其采用了大立筋及热加垫。介绍了鲁地拉水电站水轮发电机组转子大立筋安装工艺及其与常规转子磁轭热打键的区别,阐述了大立筋安装的重点和难点。通过鲁地拉水电站水轮发电机组转子大立筋的安装,总结出了一套适宜于水轮发电机组转子大立筋安装的工艺和方法。

关键词：转子大立筋安装工艺热打键鲁地拉水电站

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大型水轮发电机定子铁损试验技术研究

人民长江 2014年第5期45卷 99-102页

作者：周若愚中国水利水电第三工程局有限公司制造安装分局陕西西安710032

定子铁芯损耗试验是检验新装铁芯的绝缘和实际损耗情况,以及装配质量的重要方法。以鲁地拉电站定子铁损试验为例,介绍了铁损试验的原理、理论数值计算方法,详细阐述了定子铁损试验的现场实施步骤、试验电源选择方案分析、试验接线以及... 详细信息

定子铁芯损耗试验是检验新装铁芯的绝缘和实际损耗情况,以及装配质量的重要方法。以鲁地拉电站定子铁损试验为例,介绍了铁损试验的原理、理论数值计算方法,详细阐述了定子铁损试验的现场实施步骤、试验电源选择方案分析、试验接线以及温升和温差测量方法;对试验计算方法及结果进行了分析,并论证了试验结果的准确性。

关键词：定子铁损试验铁芯叠装大型水轮发电机鲁地拉电站

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Sugar, energy content and added sugar labelling of beverages in Beijing, China: a cross-sectional study

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Sugar, energy content and added sugar labelling of beverages...