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The shadows hang over immunotherapy-neutrophil extracellular traps in cancer

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Science China(Life Sciences) 2023年第5期66卷 1196-1199页

作者： Dan Pu Liyuan Yin Xiaoqian Zhai ruoxiang wang Lin Huang Qiang Wu Lingling Zhu Yuwen Zhou Qinghua Zhou Lu Li Lung Cancer Center West China HospitalSichuan UniversityChengdu 610000China Uro-Oncology Research Department of MedicineCedars-Sinai Medical CenterLos Angeles CA 90048USA Oncology Department West China HospitalSichuan UniversityChengdu 610000China

The development of immune checkpoint inhibitors(ICIs)was a milestone in the advancement of anticancer *** exert their effects by enhancing the function of T cells via inhibition of immune checkpoints,such as programme... 详细信息

关键词： PDL1 death immunotherapy

Multi-Material magnetic field-assisted additive manufacturing system for flexible actuators with programmable magnetic arrangements

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Frontiers of Mechanical Engineering 2024年第2期19卷 109-120页

作者： Yujie HUANG Haonan SUN Chengqian ZHANG ruoxiang GAO Hongyao SHEN Peng ZHAO The State Key Laboratory of Fluid Power and Mechatronic Systems College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China The Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Center for X-Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Manufacturing flexible magnetic-driven actuators with complex structures and magnetic arrangements to achieve diverse functionalities is becoming a popular *** various manufacturing technologies,magnetic-assisted digital light processing(DLP)stands out because it enables precise manufacturing of macro-scale structures and micro-scale distributions with the assistance of an external magnetic *** research on manufacturing magnetic flexible actuators mostly employs single materials,which limits the magnetic driving performance to some *** on these characterizations,we propose a multi-material magnetic field-assisted DLP technology to produce flexible actuators with an accuracy of 200μ*** flexible actuators are printed using two materials with different mechanical and magnetic *** the interface connectivity of multi-material printing,the effect of interfaces on mechanical properties is also *** results indicate good chemical affinity between the two materials we *** overlap or connection length of the interface moderately improves the tensile strength of multi-material *** addition,we investigate the influence of the volume fraction of the magnetic part on *** and experimental results indicate that increasing the volume ratio(20%to 50%)of the magnetic structure can enhance the responsiveness of the actuator(more than 50%).Finally,we successfully manufacture two multi-material flexible actuators with specific magnetic arrangements:a multi-legged crawling robot and a flexible gripper capable of crawling and grasping *** results confirm that this method will pave the way for further research on the precise fabrication of magnetic flexible actuators with diverse functionalities.

关键词： multi-material magnetic field-assisted manufacturing digital light processing flexible actuators magnetic arrangement

Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics

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Asian Journal of Urology 2019年第1期6卷 65-81页

作者： Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung ruoxiang wang Jason Boyang Wu Haiyen E.Zhau Uro-Oncology Research Department of Medicine and Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Bristol-Myer Squibb Company PrincetonNJUSA Department of Urology Emory University School of MedicineAtlantaGAUSA Oncoveda Cancer Research Center Genesis Biotechnology GroupHamiltonNJUSA Texas Tech University Health Sciences Center Department of Cell Biology and BiochemistryLubbockTXUSA Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical SciencesWashington State UniversitySpokaneWAUSA

This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel *** article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma *** article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical *** article referenced the details of the various approaches and discoveries described herein in peer-reviewed *** dedicate this article in our fond memory of *** *** who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine.

关键词： Prostate cancer Castration resistance Metastasis Cancer-stromal interaction Targeted therapy

Cultured circulating tumor cells and their derived xenografts for personalized oncology

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Asian Journal of Urology 2016年第4期3卷 240-253页

作者： ruoxiang wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung Uro-Oncology Research Department of MedicineSamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Uro-Oncology Research Department of SurgerySamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Department of Surgery West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Department of Pathology West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Henry Ford Health System DetroitMIUSA Department of Molecular and Medical Pharmacology University of California Los AngelesLos AngelesCAUSA

Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s *** identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and *** this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested *** of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer *** analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells.

关键词： Cancer metastasis Peripheral blood Circulating tumor cell ex vivo culture

北京市地方标准《卫生应急一次性防护用品使用规范》修订解读

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中国急救复苏与灾害医学杂志 2024年第3期19卷 399-401页

作者：孟璐璐曹若湘王东宁芳北京市疾病预防控制中心科研教学管理办公室北京100013 北京市疾病预防控制中心应急办公室北京100013

目的旨在使卫生应急人员充分理解并掌握《卫生应急一次性防护用品使用规范》(DB11/T 1291—2023)技术要点,最大限度减少职业暴露的发生。方法从适用范围、防护分级、防护用品选择、附录等方面解读修订标准与原标准内容的差异和修订原因... 详细信息

目的旨在使卫生应急人员充分理解并掌握《卫生应急一次性防护用品使用规范》(DB11/T 1291—2023)技术要点,最大限度减少职业暴露的发生。方法从适用范围、防护分级、防护用品选择、附录等方面解读修订标准与原标准内容的差异和修订原因。结果修订标准扩展了其适用范围;增加并细化不同等级防护用品的使用场景;新增一次性隔离衣、防护面罩、动力送风式空气呼吸器的使用要求,去掉长管空气呼吸器及相关要求、参考标准;新增防护用品使用注意事项;调整防护用品的穿脱顺序。结论北京市地方标准《卫生应急一次性防护用品使用规范》的修订为卫生应急人员个体防护及传染病与职业暴露的防控提供参考。

关键词：卫生应急防护用品地方标准标准解读

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完善城乡融合发展体制机制研究

经济地理 2024年第8期44卷 25-30页

作者：侯晓丽徐文静贾若祥窦红涛北京工商大学商学院中国北京100048 国家发展和改革委员会国土开发与地区经济研究所中国北京100038

城市和乡村是互促互进、共生共存的,能否处理好城乡关系,关乎社会主义现代化建设全局;加快推进城乡融合发展、促进城乡共同繁荣既是中国式现代化建设的内在要求,也是把新型城镇化和乡村全面振兴有机结合起来的重大举措。文章在分析当前... 详细信息

城市和乡村是互促互进、共生共存的,能否处理好城乡关系,关乎社会主义现代化建设全局;加快推进城乡融合发展、促进城乡共同繁荣既是中国式现代化建设的内在要求,也是把新型城镇化和乡村全面振兴有机结合起来的重大举措。文章在分析当前我国城乡发展存在不平衡不协调问题的基础上,提出了要健全推进新型城镇化体制机制、巩固和完善农村基本经营制度、完善强农惠农富农支持制度、深化土地制度改革,加快建立城乡融合发展的体制机制,全面提高城乡规划、建设、治理融合水平,促进城乡要素平等交换、双向流动,不断缩小城乡发展差别,加快形成工农互促、城乡互补、全面融合、共同繁荣的新型工农城乡关系,逐步实现城乡居民基本权益平等化、城乡公共服务均等化、城乡居民收入均衡化、城乡要素配置合理化以及城乡产业发展融合化等目标的政策建议。

关键词：城乡融合发展体制机制新型城镇化乡村全面振兴中国式现代化

从园艺疗法到园林康养——以国内主要组织与代表性研究为例

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广东园林 2024年第1期46卷 14-20页

作者：涂若翔宋颂肖毅强华南理工大学建筑学院风景园林系、广州市景观建筑重点实验室广州510000 华南理工大学建筑学院广州510000 华南理工大学亚热带建筑与城市科学全国重点实验室、建筑学院广州510000

园艺疗法是以植物为主题、以园艺活动操作来调节人体身心健康的方法。在中国知网和万方数据库中以园艺疗法、园林康养等为主题词进行中文文献检索,时间截至2024年2月,筛选后得到相关期刊文献162篇。园艺疗法历史理论与设计应用是目前国... 详细信息

园艺疗法是以植物为主题、以园艺活动操作来调节人体身心健康的方法。在中国知网和万方数据库中以园艺疗法、园林康养等为主题词进行中文文献检索,时间截至2024年2月,筛选后得到相关期刊文献162篇。园艺疗法历史理论与设计应用是目前国内研究主流,而多数实证研究由医学研究团队开展。通过VOSviewer软件对关键词进行聚类分析发现,国内园艺疗法研究持续关注心理健康,研究对象扩展至潜在亚健康人群;对作者合作网络进行聚类分析发现,清华大学李树华教授团队是国内该领域最主要的研究团队。选取中文文献中具有代表性的8篇实证研究论文,比较其试验方案与研究结果发现,这些研究为园艺疗法操作流程的优化提供了支持,并为后续实证与循证研究范式的构建提供了参考。对中国园艺疗法主要组织、学术会议发展情况进行梳理亦发现,清华大学团队起到关键作用,并扩展了园艺疗法的内涵与深度。

关键词：园艺疗法园林康养身心健康李树华

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生态产品供需的空间关联与匹配路径研究

生态文明研究 2024年第3期 58-70页

作者：贾若祥胡蕾窦红涛国家发展和改革委员会国土开发与地区经济研究所综合研究室 100038 国家发展和改革委员会国土开发与地区经济研究所城镇发展研究室

生态产品的供给与需求在空间上具有不均质分布特征,供需空间错配是影响生态产品价值实现的关键问题。本文通过文献综述系统总结国内外生态系统服务供需及服务流的研究进展,梳理出生态产品供给、需求、服务流等基本概念内涵、量化方法,... 详细信息

生态产品的供给与需求在空间上具有不均质分布特征,供需空间错配是影响生态产品价值实现的关键问题。本文通过文献综述系统总结国内外生态系统服务供需及服务流的研究进展,梳理出生态产品供给、需求、服务流等基本概念内涵、量化方法,以及促进供需空间匹配和价值实现的策略设计等。为应对国内推进生态产品价值实现面临的现实困境,本文将生态产品空间关联特征纳入社会再生产过程,提出一个生态产品供需空间关联分析框架,在生产和消费环节强调刻画生态产品供需空间分布,识别供给主体和受益主体;在流通环节强调依据生态产品传输特征提高流通和供需对接效率;在分配环节强调优化分配制度设计,促进价值实现和共同富裕目标实现。以内蒙古为例,分析生态产品供需空间关联情况并提出相关政策建议。

关键词：生态产品供需空间关联社会再生产价值实现

Securing Patient-Centric Personal Health Records Sharing System in Cloud Computing

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China Communications 2014年第A1期11卷 121-127页

作者： CHEN Danwei CHEN Linling FAN Xiaowei HE Liwen PAN Su Hu ruoxiang NanjingUniversityofPostsandTelecommunications Nanjing210003JiangsuProvinceER.China InformationSecurityCenter BeijingUniversityofPostsandTelecommunicationsBeijing100876China NationalEngineeringLaboratoryforDisasterBackupandRecovery Beijing100876China

Personal health record （PHR） enables patients to manage their own electronic medical records （EMR） in a centralized way, and it is oRen outsourced to be stored in a third-party server. In this paper we propose a novel secure and scalable system for sharing PHRs. We focus on the multiple data owner scenario, and divide the users in the system into multiple security domains that greatly reduce the key management complexity for owners and users. A high degree of patient privacy is guaranteed by exploiting hierarchical and multi- authority attribute-sets based encryption （HM- ASBE）. Our system not only supports compound attributes due to flexible attribute sets combinations, but also achieves fine-grained access control. Our scheme supports efficient on-demand user/attribute revocation and break-glass access under emergency scenarios.

关键词： personal health records attribute- based encryption data privacy fine-grained access control