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Optical coherence tomography angiography metrics in different stages of diabetic macular edema

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Eye and Vision 2024年第3期10卷 13-20页

作者： Ruyi Han ruowen Gong Wei Liu Gezhi Xu Eye Institute and Department of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai200031People’s Republic of China Key Laboratory of Visual Impairment and Restoration Fudan UniversityShanghaiPeople’s Republic of China Key Laboratory of Myopia(Fudan University) Chinese Academy of Medical SciencesNational Health CommissionShanghaiPeople’s Republic of China

Background To investigate the optical coherence tomography angiography(OCTA)characteristics of diabetic macular edema(DME)at different *** This study was a cross-sectional *** diagnosed with DME were *** was classified into early,advanced,and severe *** vessel density(VD)in the superficial vascular plexus(SVP),deep vascular plexus(DVP)and foveal avascular zone(FAZ)parameters,including FAZ area,FAZ perimeter,acircularity index and foveal VD in a 300-μm-wide region around the FAZ(FD-300),were calculated by the AngioVue software.A multivariate generalized estimating equation was used to evaluate the associations between visual acuity and OCTA *** Ninety-two eyes from 74 patients with DME were included in this *** to early(P=0.006)and advanced DME(P=0.003),the acircularity index was higher in severe *** whole and parafoveal VD in the DVP decreased in eyes with severe DME compared to early DME(P=0.018,P=0.005,respectively)and advanced DME(P=0.035,P=0.012,respectively).In the multivariate generalized estimating equation,DME severity,FAZ area and foveal thickness were positively associated with worse visual acuity(P=0.001,P=0.007 and P=0.001,respectively).Conclusion Compared to early and advanced DME,severe DME showed increased irregularity in the FAZ and more extensive vessel damage in the *** severity level of DME,larger FAZ area,and increased foveal thickness could be risk factors for poor visual *** registration The protocol was published in the Chinese Clinical Trial Registry(ChiCTR2000033082).

关键词： Optical coherence tomography angiography Diabetic macular edema Vessel density Acircularity index

The source of Double ITCZ induced by the SST bias over the tropical western Pacific as reflected in CAS-ESM2 Model

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Science China Earth Sciences 2024年第5期67卷 1604-1615页

作者： Jinning TONG Fei ZHENG Jiangbo JIN ruowen YANG Jiang ZHU Qingcun ZENG Department of Atmospheric Sciences Yunnan UniversityKunming 650091China International Center for Climate and Environment Science Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

“Double ITCZ”is a common precipitation bias over the tropical Pacific in current climate models and Earth system models,but the reasons for its formation are still worth exploring and *** this study,we adopted the second version of Chinese Academy of Sciences Earth System Model(CAS-ESM2),by comparing a set of sea surface temperature(SST)bias correction experiments over the tropical Pacific,to explore the possible mechanism of SST bias on inducing the“Double ITCZ”from the perspective of the climatic annual mean bias in the coupled *** revealed that the simulated climatic annual mean SST bias over the tropical Pacific can affect the bias of latent heat flux through the saturation specific humidity,and the bias of latent heat flux can further affect that of vertical velocity of humid air by the condensation release mechanism,and finally modulate the simulated bias in ***,through the inter-comparison between different experiments,it is found that the source of Double ITCZ might mainly come from the annual mean SST bias over the tropical western Pacific through the proposed air-sea coupled process of“SST-saturated specific humidity-latent heat flux-vertical velocity-precipitation”,indicating a possible way on reducing the couple biases in models over the tropical Pacific to improve the accuracy of CAS-ESM2 for climate simulation.

关键词： SST bias Double ITCZ Nudging SST CAS-ESM2

Enhancing CO2 cycloaddition through ligand functionalization:A case study of UiO-66 metal-organic frameworks

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The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

结构化学 2024年第2期43卷 9-12页

作者： ruowen Liang Chao Zhang Guiyang Yan Fujian Province Key Laboratory of Featured Biochemical and Chemical Materials Ningde Normal UniversityNingde352100PR China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University Fuzhou350002PR China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University Fuzhou350002PR China

The synthesis of cyclic carbonates from CO2 and epoxides offers a remarkable 100％atomic *** literature describes the CO2 cycloaddition mechanism predominantly as an"epoxide activation"pathway[1].This process can be effectively facilitated by heterogeneous catalysts possessing Lewis acidity,potentially optimising the capture and activation of the epoxide via metal-oxygen ***-organic frameworks(MOFs)have recently garnered attention as new catalysts,credited to their structural adaptability and multifunctional ***,MOFs with exposed metal sites function as Lewis acid sites,thus enhancing the cycloaddition *** numerous researchers emphasize the pivotal role of epoxide activation in the CO2 cycloaddition process,the challenge of activating inherently stable CO2 molecules often remains *** CO2 activation can potentially reduce the energy barriers of the reaction,thereby enhancing the overall *** prior studies on MOFs'catalytic activities for CO2 cycloaddition primarily emphasise their Lewis acidity sites[2,3],with scant attention to the syn-ergistic effects between the Lewis acid and base sites.

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao Dali Wei Qinglai Yang Cai Yang ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang Huang Jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

油品扬沸火灾形成与强度主要影响因素试验研究

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应用基础与工程科学学报 2011年第2期19卷 288-296页

作者：谭家磊汪彤宗若雯谢昱姝北京市劳动保护科学研究所北京100054 中国科学技术大学火灾科学国家重点实验室安徽合肥230027

针对扬沸火灾复杂的形成原因,通过对胜利原油和轻质柴油的热重分析及试验测量的热波传播速度与油品线性燃烧速率的比值,分析得到油品中重质组分越多,热波传播速率与线性燃烧速率的比值越大,越容易形成扬沸;试验分析了油品含水率及乳化... 详细信息

针对扬沸火灾复杂的形成原因,通过对胜利原油和轻质柴油的热重分析及试验测量的热波传播速度与油品线性燃烧速率的比值,分析得到油品中重质组分越多,热波传播速率与线性燃烧速率的比值越大,越容易形成扬沸;试验分析了油品含水率及乳化水水滴直径与热波传播速率的关系,得到含水率在1.3%—2%时,热波传播速度存在最大值;在试验条件下,当乳化水水滴直径小于80μm时,不会形成扬沸;对6种不同沸点(沸程)和粘度的油品进行了扬沸试验,发现随着油品沸点(沸程)的升高,扬沸强度和扬沸时过热水层厚度一般都增大;一般随着油品粘度的增大扬沸强度和过热水层温度都增大.试验结果可用于探索扬沸的致灾机理和抑制扬沸的形成及降低扬沸的危害程度.

关键词：扬沸重质组分含水率粘度沸点

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人员密集场所火灾毒气扩散后果动态评价

中国安全科学学报 2021年第12期31卷 167-175页

作者：王继贇宗若雯陆守香中国科学技术大学火灾科学国家重点实验室安徽合肥230027 中国科学技术大学苏州高等研究院苏州市城市公共安全重点实验室江苏苏州215123

为定量评价人员密集场所火灾毒气扩散后果,选取宿舍建筑作为典型的人员密集场所火灾场景,采用PyroSim软件获取火灾过程中毒气浓度的时空分布,采用Pathfinder软件获取疏散过程中人员位置的时空分布;基于2个软件的输出结果,采用Matlab软... 详细信息

为定量评价人员密集场所火灾毒气扩散后果,选取宿舍建筑作为典型的人员密集场所火灾场景,采用PyroSim软件获取火灾过程中毒气浓度的时空分布,采用Pathfinder软件获取疏散过程中人员位置的时空分布;基于2个软件的输出结果,采用Matlab软件编写数据查询算法,获取人员疏散过程中的暴露浓度,并计算平均吸入剂量,将其作为毒气扩散后果评价指标,用以评价不同的火灾场景。研究结果表明:火源位于第1层时,毒气扩散后果最严重;开启2个疏散出口,会极大地降低火灾毒气扩散后果;随着探测时间的减小,平均吸入剂量基本呈现线性递减;当火源靠近楼梯间时,探测时间的下降对降低毒气扩散后果有着更明显的作用。

关键词：人员密集场所火灾毒气扩散 PyroSim软件 Pathfinder软件动态评价

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不同石化燃料燃烧烟尘的来源辨识

化工学报 2011年第12期62卷 3595-3600页

作者：支有冉宗若雯曾文茹任小男谭家磊中国科学技术大学火灾科学国家重点实验室安徽合肥230026 中国科学技术大学苏州研究院苏州市城市公共安全重点实验室江苏苏州215123 北京市劳动保护科学研究所北京100054

利用固相微萃取-气质联用(SPME-GC-MS)技术,对汽油、柴油、聚苯乙烯、ABS 4种石化燃料进行燃烧烟尘的特征组分分析,对其特征组分谱图中的保留时间进行归纳总结。对获得的20×35的数学矩阵,进行了主成分分析,得到了3个主成分,其累计率达... 详细信息

利用固相微萃取-气质联用(SPME-GC-MS)技术,对汽油、柴油、聚苯乙烯、ABS 4种石化燃料进行燃烧烟尘的特征组分分析,对其特征组分谱图中的保留时间进行归纳总结。对获得的20×35的数学矩阵,进行了主成分分析,得到了3个主成分,其累计率达到了92%,表明主成分所组成的二维数学坐标以及三维坐标系能较好地将不同比例的烟尘进行分类。最后在主成分分析的基础上,应用高级模式识别方法系统聚类方法,以100%的精确度将四类不同来源的燃料烟尘归类分开。

关键词：石化燃料聚苯乙烯模式识别燃烧烟尘

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矩形喷口射流火火焰轴向温度研究

火灾科学 2017年第2期26卷 87-92页

作者：沈燕陶常法宗若雯支有冉中国科学技术大学火灾科学国家重点实验室合肥230026 合肥工业大学动力机械及工程系合肥230009 中国科学技术大学苏州城市公共安全重点实验室苏州215123 南京工程学院机械工程学院南京211167

随着我国能源结构低碳化的发展,天然气产业在我国得到进一步升级。在利用高压管道进行输运的过程中,因泄漏而引发的天然气火灾爆炸事故时有发生。实验以甲烷为燃料,研究不同开口特征下(长宽比n=1,2.25,4,9,16)矩形火源火焰中心轴线的温... 详细信息

随着我国能源结构低碳化的发展,天然气产业在我国得到进一步升级。在利用高压管道进行输运的过程中,因泄漏而引发的天然气火灾爆炸事故时有发生。实验以甲烷为燃料,研究不同开口特征下(长宽比n=1,2.25,4,9,16)矩形火源火焰中心轴线的温度分布。研究表明,火焰温度随热电偶相对位置的变化呈现出三段分布的规律。通过引入虚点源Z_0对经典羽流模型进行修正,发现不同长宽比下无量纲虚点源与火焰佛罗德数Fr_f呈现一定的函数关系,且无量纲温度在高度方向上仍呈现三段式分布。

关键词：矩形喷口射流火轴向温度虚点源

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丙烯腈-丁二烯-苯乙烯燃烧毒性尺度规律

燃烧科学与技术 2020年第6期26卷 544-550页

作者：王继贇陈海燕任小男宗若雯中国科学技术大学火灾科学国家重点实验室合肥230027 中国科学技术大学苏州研究院苏州城市公共安全重点实验室苏州215123

聚合物燃烧释放的毒气是火灾中主要的致死因素,选取了丙烯腈-丁二烯-苯乙烯(ABS)作为样品研究聚合物燃烧毒性尺度规律.在小尺寸条件下,利用稳态管式炉测定不同通风状态下ABS材料燃烧释放毒气体积分数,并采用FDS软件进行数值模拟.模拟结... 详细信息

聚合物燃烧释放的毒气是火灾中主要的致死因素,选取了丙烯腈-丁二烯-苯乙烯(ABS)作为样品研究聚合物燃烧毒性尺度规律.在小尺寸条件下,利用稳态管式炉测定不同通风状态下ABS材料燃烧释放毒气体积分数,并采用FDS软件进行数值模拟.模拟结果显示与实验结果吻合较好,保证了CFD模型的有效性.在此基础上,保持Froude数不变,建立多种尺度的CFD模型.结果表明:随着实验尺度的增加,燃料周围的CO体积分数也在增加;当通风状态由良好变为不良时,CO体积分数的增长率随着实验尺度的增加而增加,且二者基本满足一次函数关系;FED值的变化趋势与CO体积分数的变化趋势呈现一致性.

关键词：丙烯腈-丁二烯-苯乙烯稳态管式炉燃烧毒性数值模拟尺度规律