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基于第二课堂的小学教育专业师范生自主成长探索与实践

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保定学院学报 2024年第1期37卷 111-115,121页

作者：杨伦马立志王若宁保定学院教师教育学院河北保定071000

地方院校小学教育专业开展丰富的第二课堂活动具有重要意义,通过成立“虚拟小学”,构建“虚拟小学”育师课程、活动、管理体系,提高师范生的教学实践技能和管理能力,引导其形成正确的教师职业认知、职业信念。小学教育专业第二课堂的育... 详细信息

地方院校小学教育专业开展丰富的第二课堂活动具有重要意义,通过成立“虚拟小学”,构建“虚拟小学”育师课程、活动、管理体系,提高师范生的教学实践技能和管理能力,引导其形成正确的教师职业认知、职业信念。小学教育专业第二课堂的育人目标要符合专业培养要求,学习内容要注重推进师范生个性化学习,同时,为提高师范生参与度,要实行第二课堂课程学分制。

关键词：虚拟小学师范生自主成长

Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1100-1125页

作者： Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan wang Liuqing Di ruoning wang College of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery SystemNanjing 210023China

Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the *** improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas *** these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ***-drug delivery systems(NDDS)have been widely used for precise drug *** recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical *** meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese *** reviewed these well-designed NDDS in ***,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS.

关键词： Glioma Blood-brain barrier Non-invasive strategies Nano-drug delivery systems Cascade targeting Responsive delivery and release Biomimetic designs Active ingredients Traditional Chinese medicine

Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo-gene therapy towards glioma

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Bioactive Materials 2022年第7期7卷 286-299页

作者： ruoning wang Xiaohong wang Junsong Li Liuqing Di Jianping Zhou Yang Ding State Key Laboratory of Natural Medicines Department of PharmaceuticsPharmaceutical University24 TongjiaxiangNanjing210009China College of Pharmacy Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System(DDS)Nanjing University of Chinese MedicineNanjing210023China

Glioma is one of the most malignant primary tumors affecting the *** efficacy of therapeutics for glioma is seriously compromised by the restriction of blood-brain barrier(BBB),interstitial tumor pressure of resistance to chemotherapy/radiation,and the inevitable damage to normal brain *** by the natural structure and properties of high-density lipoprotein(HDL),a tumor-penetrating lipoprotein was prepared by the fusion tLyP-1 to apolipoprotein A-I-mimicking peptides(D4F),together with indocyanine green(ICG)incorporation and lipophilic small interfering RNA targeted HIF-1α(siHIF)surface anchor for site-specific photo-gene ***-1 peptide is fused to HDL-surface to facilitate BBB permeability,tumor-homing capacity and-site accumulation of photosensitizer and *** NIR light irradiation,ICG not only served as real-time targeted imaging agent,but also provided toxic reactive oxygen species and local hyperthermia for glioma *** HIF-1αsiRNA in this nanoplatform downregulated the hypoxia-induced HIF-1αlevel in tumor microenvironment and enhanced the photodynamic therapy against *** studies demonstrated that the nanoparticles could not only efficiently across BBB and carry the payloads to orthotopic glioma,but also modulate tumor microenvironment,thereby inhibiting tumor growth with ***,this study develops a new multifunctional drug delivery system for glioma theranostic,providing deeper insights into orthotopic brain tumor imaging and treatment.

关键词： Lipoprotein-biomimetic nanostructure Tumor-targeted penetration Photo-gene therapy HIF-1αinterference after hypoxia exposure Precise glioma therapy

Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders

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Nano Research 2023年第2期16卷 2635-2659页

作者： Jie Wu Lei Ma Danni Sun Xinru Zhang Jiwei Cui Yingjiang Du Yumiao Guo Xue wang Liuqing Di ruoning wang College of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System Nanjing 210023China

Despite noteworthy technological progress and promising preclinical trials,brain disorders are still the leading causes of death *** vesicles(EVs),nano-/micro-sized membrane vesicles carrying bioactive molecules,are involved in cellular *** on their unique properties,including superior biocompatibility,non-immunogenicity,and blood-brain barrier(BBB)penetration,EVs can shield their cargos from immune clearance and transport them to specific site,which have attracted increasing interests as novel nanocarriers for brain ***,considering the limitations of native EVs,such as poor encapsulation efficiency,inadequate targeting capability,uncontrolled drug release,and limited production,researchers bioengineer EVs to fully exploit the clinical ***,this review initially describes the basic properties,biogenesis,and uptake process of EVs from different ***,we highlight the application of EVs derived from different sources for personalized therapy and novel strategies to construct bioengineered EVs for enhanced diagnosis and treatment of brain ***,it also presents a systematic comparison between EVs and other brain-targeted ***,existing challenges and future perspectives of EVs have been discussed,hoping to bolster the research from benchtop to bedside.

关键词： brain disorders extracellular vesicles drug delivery platforms bioengineering strategies responsive materials

Nanotechnologies meeting natural sources:Engineered lipoproteins for precise brain disease theranostics

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 77-98页

作者： ruoning wang Xinru Zhang Kuanhan Feng Wei Zeng Jie Wu Danni Sun Ziyi Lu Hao Feng Liuqing Di School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System Nanjing 210023China

Biological nanotechnologies have provided considerable opportunities in the management of malignancies with delicate design and negligible toxicity,from preventive and diagnostic to therapeutic ***,because of their inherent blood-brain barrier permeability and lesion-homing capability,have been identified as promising strategies for high-performance theranostics of brain ***,the application of natural lipoproteins remains limited owing to insufficient accumulation and complex purification processes,which can be critical for individual therapeutics and clinical *** address these issues,lipoprotein-inspired nano drug-delivery systems(nano-DDSs),which have been learned from nature,have been fabricated to achieve synergistic drug delivery involving site-specific accumulation and tractable preparation with versatile physicochemical *** this review,the barriers in brain disease treatment,advantages of state-of-the-art lipoprotein-inspired nano-DDSs,and bio-interactions of such nano-DDSs are ***,the characteristics and advanced applications of natural lipoproteins and tailor-made lipoprotein-inspired nano-DDSs are ***,the key designs and current applications of lipoprotein-inspired nano-DDSs in the field of brain disease therapy are intensively ***,the current challenges and future perspectives in the field of lipoprotein-inspired nano-DDSs combined with other vehicles,such as exosomes,cell membranes,and bacteria,are discussed.

关键词： Biological modulation Brain diseases Blood-brain barrier Lipoproteins Theranostics

Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis

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Cellular & Molecular Immunology 2018年第6期15卷 618-629页

作者： Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian wang Zhengguo Zhang Yu wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao ruoning wang Guangwei Liu Department of Immunology School of Basic Medical SciencesFudan UniversityShanghai 200032China Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education Institute of Cell BiologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China State Key laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Childhood Cancer and Blood Diseases Hematology/Oncology and BMTThe Research Institute at Nationwide Children's HospitalOhio State UniversityColumbusOhio 43205USA

Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response *** the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains ***,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent *** modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory ***,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of *** studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation.

关键词： glucocorticoid-receptor glycolysis innate immunity liver injuries metabolism myeloid-derived suppressive cells tolerance

The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer

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Cellular & Molecular Immunology 2021年第4期18卷 1074-1076页

作者： Anna Jia Yuexin wang Yufei wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou ruoning wang Yujing Bi Guangwei Liu Key Laboratory of Cell Proliferation and Regulation Biology Ministry of EducationInstitute of Cell BiologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China Center for Childhood Cancer&Blood Diseases The Research Institute at Nationwide Children'sHospitalOhio State UniversityColumbusOH 43205USA State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity.

关键词： inflammation suppressor cancer

The Porous Nanocarbons with Polynuclear Aromatic Cores

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CCS Chemistry 2024年第10期6卷 2427-2438页

作者： Chenxi Zhou ruoning Li Yan Chen Xinyue Liu Haisong Zhao Xue-Qing Yang Zhongjie Ren Dong wang Zhaohui wang Lei Zhang Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Lab of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029 CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190 Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084

Three porous nanocarbons,1–3 that comprise pyrene,corannulene,and coronene cores encircled by cyclo-meta-phenylene(CMP)interconnections,have been synthesized and *** interconnected CMPs caused different curvatures of the cores and imparted high solubility,large bathochromic shift,strong fluorescence,and low reduction potential to the *** solution,these porous nanocarbons existed as a complex mixture of dynamic processes that certainly influenced one another within any single molecule,leading to a set of rather simple proton nuclear magnetic resonance(^(1)H NMR)*** crystal X-ray diffraction and computational minimum energy analysis revealed the boatand saddle-like conformations of 1–3 in the solid state,significantly deviating from their conformations on the Au(111)***,both 1 and 2 could form 2:1 complexes with C_(60),accompanied by adaptive geometry *** addition,1 served as a sky-blue emitter for an organic light-emitting diode(OLED).This work gives access and insights into a model system consisting of porous nanocarbons with intriguing supramolecular and optoelectronic properties.

关键词： porous nanocarbon cyclophenylenes aromatic core structural dynamics crystal packing

基于满意度视角的住院医师规范化培训现状调查分析

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中华医学教育杂志 2024年第2期44卷 131-135页

作者：杨英李烨汪偌宁王翔姜辉北京大学医学部继续教育处北京100191

目的调查北京大学直属附属医院和教学医院住院医师规范化培训(简称住培)现状和满意度,发现住培中存在的问题,提出改进意见。方法本研究采用自行设计的电子问卷,于2023年7月对北京大学直属附属医院和教学医院在培住院医师和专业学位硕士... 详细信息

目的调查北京大学直属附属医院和教学医院住院医师规范化培训(简称住培)现状和满意度,发现住培中存在的问题,提出改进意见。方法本研究采用自行设计的电子问卷,于2023年7月对北京大学直属附属医院和教学医院在培住院医师和专业学位硕士研究生(统称为住培学员)进行调查,以描述性统计、方差分析、logistic回归和线性回归等方法分析培训满意度及其影响因素。结果共回收467份有效问卷。住培学员的整体满意度为74.5%(348/467),对薪资[48.6%(227/467)]、福利[56.3%(263/467)]和培训强度[67.5%(315/467)]的满意度较低。专业学位研究生满意度低于住院医师[(3.50±1.16)分比(4.13±0.81)分,P<0.001]。约三分之二的住培学员每周工作时间超过50小时。培训管理、培训强度、培训指导的满意度和培训内容是否适合临床实际需要是整体满意度的影响因素(β值分别为0.435、0.311、0.157、0.094,均P<0.001)。结论北京大学住培学员整体满意度尚可,临床工作强度和压力较大,应当进一步加强培训管理和培训指导,在薪酬待遇和培训强度等方面进行优化。

关键词：实习医师和住院医师职务住院医师规范化培训满意度培训管理培训强度