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Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1882-1892页

作者： Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang ruonan zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui Holistic Integrative Pharmacy Institutes and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Institute of Chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province Hangzhou Normal UniversityHangzhouZhejiangChina State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacaoP.R.China Zhejiang Chinese Medicinal University HangzhouChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina Department of Medical Oncology Zhejiang UniversityHangzhouChina Department of Hematology and Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Radiation Detection Research Center Northwest Institute of Nuclear TechnologyXi’anChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingChina

Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including *** ferroptosis in cancer cells may be a potential strategy for cancer ***,ferroptosis-inducing drugs are attracting more attention for cancer ***,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer ***,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH *** ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell ***,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing *** together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment.

关键词： peroxidation lung drugs

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

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Signal Transduction and Targeted Therapy 2019年第1期4卷 176-185页

作者： Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang ruonan zhang Bi Chen Mingming zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin zhang Ting Pan Lili Yan Ting Jin Wenzheng zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui Holistic Integrative Pharmacy Institutes and Comprehensive Cancer Diagnosis and Treatment Center the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province Hangzhou Normal UniversityHangzhouZhejiangChina Department of Hepatobiliary Pancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Colorectal Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Ultrasound Medicine The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingChina

5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical *** previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in ***,the relationship between PCDH17 and 5-FU resistance in CRC remains ***,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 ***,this expression profile contributed to superior prognosis and increased survival in CRC *** PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell ***,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor ***17 inhibition by siRNA decreased the autophagy response and 5-FU ***,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced *** compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC *** together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell ***17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients.

关键词： death treatment apoptosis

无线组播网络中应用网络编码的动态组合重传算法

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西安交通大学学报 2016年第12期50卷 38-44页

作者：李彬李泉张若南蒋毅杨荣西北工业大学电子信息学院西安710072 西安交通大学工程坊西安710049

针对无线组播网络中降低数据包重传次数及对抗信道衰落、建立稳定无线连接的需求,提出了一种基于网络编码的动态组合重传算法。该算法采用动态线性组合编码算法(DLCCA),以提高无线组播网络带宽利用效率。首先,利用发送端向用户发送原始... 详细信息

针对无线组播网络中降低数据包重传次数及对抗信道衰落、建立稳定无线连接的需求,提出了一种基于网络编码的动态组合重传算法。该算法采用动态线性组合编码算法(DLCCA),以提高无线组播网络带宽利用效率。首先,利用发送端向用户发送原始数据包;其次,通过组播网络的控制信道,发送端获取了网络用户的接收状态,对未正确解码的数据包进行编码,并在传输过程中根据网络状态采用动态组合策略来形成网络编码包,从而有效提高了网络的整体吞吐量。与此同时,还进一步提出了低复杂度编码算法,并分析了所提编码算法的性能,获得了相应的理论分析结果。仿真实验表明,与传统的无编码算法和XOR网络编码算法相比,动态组合重传算法可以显著减少30%的数据重传次数,提高了网络吞吐量。

关键词：组播网络网络编码动态线性组合

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基于改进序列凸优化的固体火箭入轨制导方法

中国惯性技术学报 2021年第1期29卷 119-125页

作者：王洪波张若男梁卓吕瑞中国运载火箭技术研究院北京100076

针对推力大小与关机时间不可调节的耗尽关机固体火箭入轨制导问题,提出一种改进序列凸优化算法。首先利用Legendre-Gauss-Radau伪谱法对模型离散,将滑行时间增广为控制变量,解决点火时间不确定问题,保证求解最优性。其次对非凸推力矢量... 详细信息

针对推力大小与关机时间不可调节的耗尽关机固体火箭入轨制导问题,提出一种改进序列凸优化算法。首先利用Legendre-Gauss-Radau伪谱法对模型离散,将滑行时间增广为控制变量,解决点火时间不确定问题,保证求解最优性。其次对非凸推力矢量约束进行松弛凸化,并证明松弛手段的无损性;然后,对非凸运动方程与终端状态约束进行线性化,构建凸优化模型。最后设计初值生成器,为快速迭代构建良好的初始轨迹。仿真结果表明,该制导算法能够满足高精度入轨要求,且问题求解时间仅为伪谱法的6.72%,验证了改进序列凸优化算法有效性。为耗尽关机固体火箭入轨在线高精度快速制导提供重要参考。

关键词：序列凸优化固体火箭耗尽关机入轨制导

原子力显微镜加工轨迹测压电剪切叠堆二维高频运动位移

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强激光与粒子束 2024年第8期36卷 158-164页

作者：尹若楠薛勃张津铭吴哲东北林业大学机电工程学院哈尔滨150040

针对两轴压电剪切叠堆在高频电压驱动下的二维高频运动的位移测量问题,提出使用(AFM)探针在敲击模式下的加工痕迹测量压电剪切叠堆运动位移的方法,首先制备热塑性聚合物聚甲基丙烯酸甲酯(PMMA)薄膜,随后进行AFM探针敲击加工实验,扫描AM... 详细信息

针对两轴压电剪切叠堆在高频电压驱动下的二维高频运动的位移测量问题,提出使用(AFM)探针在敲击模式下的加工痕迹测量压电剪切叠堆运动位移的方法,首先制备热塑性聚合物聚甲基丙烯酸甲酯(PMMA)薄膜,随后进行AFM探针敲击加工实验,扫描AMF探针加工轨迹并对其进行后处理,成功得到压电剪切叠堆的二维高频运动位移,实现了以半接触的方式对压电剪切叠堆二维高频复杂运动的准确检测,并依据实验数据对压电剪切叠堆二维运动位移随电压幅值及频率的变化情况进行分析。实验结果表明,在10 Hz~5 kHz的激励信号频率范围内,所提出的方法能准确测量压电剪切叠堆的运动位移。

关键词：原子力显微镜敲击加工压电剪切叠堆二维高频运动

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Prediction skill and Predictability of Eurasian Snow Cover Fraction in the NCEP Climate Forecast Version 2 Reforecasts

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中国冬季积雪特征及欧亚大陆积雪对中国气候影响

第32届中国气象学会年会

作者： Qiong He Zhiyan Zuo Renhe zhang Song Yang Wanqiu Wang ruonan zhang Emily E.Riddle Chinese Academy of Meteorological Sciences Department of Atmospheric Sciences Sun Yat-sen University Climate Prediction Center NCEP/NWS/NOAACollege Park Department of Geosciences University of Massachusetts

Eurasian snow cover fraction（SCF） prediction is analyzed using the recently developed NCEP Climate Forecast System,version 2（CFSv2） monthly retrospective forecasts for ***,the CFSv2 is capable of reproducing the observed Eurasian SCF seasonal cycle and climatology except some systematic *** study focuses on the prediction skill and predictability of Eurasian SCF in snowmelt and snowfall seasons since the most robust variability occurs in these *** CFSv2 reasonably predicts the interannual variations,long-term trend and leading EOF pattern in snowmelt season several months *** with the prediction skill in snowmelt season,although the CFSv2 shows a slightly better prediction skill in climatological values,it underestimates the observed interannual variability in snowfall ***,The CFSv2 predicts a downward trend whereas theobservations exhibit an upward trend in snowfall *** systematic biases,the larger climatology and smaller interannual variations in both snowmelt and snowfall seasons,might be the result that the CFSv2 predicts the cooler atmosphere in the low to middle troposphere and more precipitation and weaker variability in them compared with the *** is interesting that the prediction skill is higher and more stable after late-1990 s than before in the two *** is possibly caused by the changesbothin the initial conditionin the CFSv2 and the observed SCF in late-1990 s.

关键词： Eurasian SCF NCEP CFSv2 Prediction Predictability Tropospheric temperature

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应用气象学报 2016年第5期27卷 513-526页

作者：张人禾张若楠左志燕中国气象科学研究院北京100081 国家气候中心北京100081

该文首先回顾了有关中国冬季积雪的研究进展,包括中国冬季积雪的空间分布气候特征以及季节、年际和年代际变化,中国冬季降雪特征,气象因子对中国冬季积雪水量平衡的影响,外强迫和大气环流系统在积雪形成中的作用等。冬春季欧亚大陆积雪... 详细信息

该文首先回顾了有关中国冬季积雪的研究进展,包括中国冬季积雪的空间分布气候特征以及季节、年际和年代际变化,中国冬季降雪特征,气象因子对中国冬季积雪水量平衡的影响,外强迫和大气环流系统在积雪形成中的作用等。冬春季欧亚大陆积雪对同期和后期中国气候影响的相关研究说明与欧亚大陆积雪异常相关联的中国气候异常以及积雪通过改变土壤湿度、表面温度和辐射分布,引起大气环流异常,进而对中国气候产生影响的物理过程。应用美国环境预测中心(NCEP)第2版气候预测系统(CFSv2)的回报试验结果,对CFSv2在欧亚大陆积雪变化及其与中国气候关系的可预报性方面的分析表明,CFSv2能够较好地回报出春季欧亚积雪的年际和年代际变异及其与中国夏季降水之间的联系。文章最后提出了在积雪及其气候效应研究方面一些有待解决的问题。

关键词：中国积雪气候变异欧亚大陆

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中国冬季多种积雪参数的时空特征及差异性

气候与环境研究 2014年第5期19卷 572-586页

作者：张若楠张人禾左志燕中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 中国科学院大学北京100049 中国气象科学研究院北京100081

利用1979～2006年冬季中国站点最大雪深和站点雪日、卫星遥感雪深、积雪覆盖率和雪水当量5种积雪资料，从多角度深入细致地分析了我国冬季积雪的时空变化特征。结果表明：5种积雪资料的经验正交分解第一模态都表现为中国南、北方反位相... 详细信息

利用1979～2006年冬季中国站点最大雪深和站点雪日、卫星遥感雪深、积雪覆盖率和雪水当量5种积雪资料，从多角度深入细致地分析了我国冬季积雪的时空变化特征。结果表明：5种积雪资料的经验正交分解第一模态都表现为中国南、北方反位相的特征，即当新疆和东北三省-内蒙古地区积雪偏多（少）时，青藏高原和南方地区积雪偏少（多）。新疆和东北三省-内蒙古地区的雪深、积雪覆盖率和雪日随时间有逐渐增多的趋势，而其中边缘山区的雪水当量表现出减少的趋势，青藏高原地区的积雪表现出与其完全相反的特征。南方地区站点最大雪深和雪日表现出随时间减少的趋势，卫星遥感难以监测到该区积雪。相比较而言，卫星遥感资料比较适合高原和山区缺少气象站的地区及北半球更大区域积雪的研究，而站点资料更适用于中国中东部和平原地区积雪的区域研究。雪深、雪日、积雪覆盖率和雪水当量这些多样性积雪参数存在一定的差异性，因此5种积雪资料结合使用才能得到更准确的结论。

关键词：中国冬季最大雪深积雪覆盖率雪日雪水当量

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中国冬季积雪变异及其与北极涛动的联系

大气科学 2015年第3期39卷 634-642页

本文利用1979～2010年NCEP/NCAR再分析资料、中国台站观测雪深、气温和降雪资料,分析了中国冬季积雪时空分布特征,结果表明：雪深经验正交分解第一模态有显著的南、北反位相特征,当新疆北部、东北地区积雪偏多（少）时,对应黄河以南和... 详细信息

本文利用1979～2010年NCEP/NCAR再分析资料、中国台站观测雪深、气温和降雪资料,分析了中国冬季积雪时空分布特征,结果表明：雪深经验正交分解第一模态有显著的南、北反位相特征,当新疆北部、东北地区积雪偏多（少）时,对应黄河以南和青藏高原地区积雪偏少（多）.近30年来中国冬季积雪变异与北极涛动（AO）有非常紧密的联系,雪深的南、北反位相分布型与北极涛动有明显的反相关关系.AO负位相时,500hPa等压面上40＆#176;N以北存在着中心在贝加尔湖附近的气旋环流,而在其南存在着中心在中国西南的反气旋性环流,中国北方和南方地区分别受气旋和反气旋的控制.在我国北方地区,与AO相联系的气旋环流异常导致降雪增多、地表温度偏低,使得积雪增加;而在南方地区,与AO相联系的反气旋性环流异常导致的降雪减少和气温偏高,导致了积雪减少.本文的研究说明了北极涛动通过影响中国降雪和气温,进而对中国冬季积雪产生可能的影响.

关键词：雪深降雪气温北极涛动