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TBBPA rather than its main derivatives enhanced growth of endometrial cancer via p53 ubiquitination

Journal of Environmental Sciences 2024年第3期137卷 82-95页

作者： Hongyan Yu Jingxu zhang Jing Liu ruonan Pan Yu Wang Xiaoting Jin Rifat Zubair Ahmed Yuxin Zheng Department of Occupational Health and Environmental Health School of Public HealthQingdao UniversityQingdao 266071China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Genetics University of KarachiKarachi 75270Pakistan

Tetrabromobisphenol A(TBBPA)and its derivatives widely exist in various environments and *** the available data indicate that TBBPA exposure is highly associated with the increased incidence of endometrial cancer(EC),the effects of TBBPA and its main derivatives on EC proliferation and the involved crucial mechanism remain *** present study aimed to investigate the effects of TBBPA and its derivatives under environmental concentrations on the proliferation of EC,and the crucial mechanism on the progression of EC caused by bromine fame retardants *** this research,TBBPA and two of the most common TBBPA derivatives including TBBPA bis(2-hydroxyethyl ether)(TBBPABHEE)and TBBPA bis(dibromopropyl ether)(TBBPA-BDBPE)were screened for their capacities in induced EC proliferation and explored the related mechanism by in vitro cell culture model and in vivo mice *** environmental concentrations,TBBPA promoted the proliferation of EC,the main derivatives of TBBPA(TBBPA-BHEE and TBBPA-BDBPE)did not present the similar facilitation *** ubiquitination degradation of p53 was crucial in TBBPA induced EC proliferation,which resulted in the increase of downstream cell cycle and decrease of *** further molecular docking result suggested the high affinity between TBBPA and ubiquitinated *** finding revealed the effects of TBBPA and its derivatives on EC proliferation,thus providing novel insights into the underlying mechanisms of TBBPA-caused EC.

关键词： Tetrabromobisphenol A(TBBPA) Endometrial cancer(EC) Derivatives Ubiquitin proteases p53

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Effects of long-term partial substitution of inorganic fertilizer with pig manure and/or straw on nitrogen fractions and microbiological properties in greenhouse vegetable soils

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Journal of Integrative Agriculture 2024年第6期23卷 2083-2098页

作者： Shuo Yuan ruonan Li Yinjie zhang Hao'an Luan Jiwei Tang Liying Wang Hongjie Ji Shaowen Huang State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Agricultural Resources and Environment Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051China College of Resources and Environment Henan Agricultural UniversityZhengzhou 450002China College of Forestry Hebei Agricultural UniversityBaoding 071000China

Partial substitution of inorganic fertilizers with organic amendments is an important agricultural management *** 11-year field experiment(22 cropping periods)was carried out to analyze the impacts of different partial substitution treatments on crop yields and the transformation of nitrogen fractions in greenhouse vegetable *** treatments with equal N,P_(2)O_(5),and K_(2)O inputs were selected,including complete inorganic fertilizer N(CN),50%inorganic fertilizer N plus 50%pig manure N(CPN),50%inorganic fertilizer N plus 25%pig manure N and 25%corn straw N(CPSN),and 50%inorganic fertilizer N plus 50%corn straw N(CSN).Organic substitution treatments tended to increase crop yields since the 6th cropping period compared to the CN *** the 8th to the 22nd cropping periods,the highest yields were observed in the CPSN treatment where yields were 7.5-11.1%greater than in CN *** 11-year fertilization,compared to CN,organic substitution treatments significantly increased the concentrations of NO_(3)^(-)-N,NH_(4)^(+)-N,acid hydrolysis ammonium-N(AHAN),amino acid-N(AAN),amino sugar-N(ASN),and acid hydrolysis unknown-N(AHUN)in soil by 45.0-69.4,32.8-58.1,49.3-66.6,62.0-69.5,34.5-100.3,and 109.2-172.9%,*** analysis indicated that soil C/N and OC concentration significantly affected the distribution of N *** highest concentrations of NO_(3)^(-)-N,AHAN,AAN,AHUN were found in the CPSN *** substitution treatments increased the activities ofβ-glucosidase,β-cellobiosidase,N-acetyl-glucosamidase,L-aminopeptidase,and phosphatase in the *** substitution treatments reduced vector length and increased vector angle,indicating alleviation of constraints of C and N on soil *** substitution treatments increased the total concentrations of phospholipid fatty acids(PLFAs)in the soil by 109.9-205.3%,and increased the relative abundance of G^(+)bacteria and fungi taxa,but decreased the relat

关键词： organic substitution management greenhouse vegetable production N fractions microbial community composition extracellular enzyme activity enzyme stoichiometry coefficients

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Liver fibrosis： mechanisms of immune-mediated liver injury

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Cellular & Molecular Immunology 2012年第4期9卷 296-301页

作者： ruonan Xu Zheng zhang Fu-Sheng Wang Liver Disease Research Center for Biological Therapy Beijing 302 Hospital Beijing China

Liver fibrosis and its end-stage consequence, cirrhosis, represent the final common pathway of virtually all chronic liver diseases. Research into hepatic stellate cell activation, imbalance of the extracellular matrix synthesis and degradation and the contribution of cytokines and chemokines has further elucidated the mechanisms underlying fibrosis. Furthermore, clarification of changes in host adaptive and innate immune systems has accelerated our understanding of the association between liver inflammation and fibrosis. Continued elucidation of the mechanisms of hepatic fibrosis has provided a comprehensive model of fibrosis progression and regression. This review summarizes the current concepts of improvements that have been made in the field of fibrosis.

关键词： cirrhosis hepatic stellate cell liver fibrosis

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From borophosphate to fluoroborophosphate:a rational design of fluorine-induced birefringence enhancement

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Science China Chemistry 2021年第9期64卷 1498-1503页

作者： Wenyao zhang Zhizhong zhang Wenqi Jin ruonan zhang Meng Cheng Zhihua Yang Shilie Pan CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryCASXinjiang Key Laboratory of Electronic Information Materials and DevicesUrumqi830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

The introduction of oxofluoride anion into anionic group assists to tune optical properties owing to the change of coordination,electronegativity,and according anionic ***,we proposed a rational design of new compounds by fluorine-driven structure and optical property evolution.A new borophosphate Ba_(2)BP_(3)O_(11)with the monoclinic space group P2_(1/c) has been synthesized in the sealed ***_(2)BP_(3)O_(11)exhibits a rare P-O-P bridge formation,which is the first example in alkaline-earth metal *** further substituting[BO_(4)]^(3-)with[BO_(3)F]^(4-),the first alkaline-earth metal/lead fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)with the same space group were *** the scissors effect of fluorine,in M_(2)BP_(2)O_(8)F(M=Ba and Pb),a BO_(3)F tetrahedron corner-sharing with three PO_(4)tetrahedra forms 1D chains along the b-axial direction,which are filled by MO_(n)(M=Ba/Pb,n=5,6,8)distorted *** first principles calculation shows that the borophosphate Ba_(2)BP_(3)O_(11)has a birefringence about 0.013@1,064 nm,while the fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)have the values of 0.035 and 0.043@1,064 nm,*** an apparent enhancement in birefringence is derived from synergies of the oxyfluoride and *** introduction of fluorine-containing heteroanionic groups provides a feasible strategy to design novel promising optical materials.

关键词： borophosphate fluoroborophosphates P-O-P bridges formation birefringence

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Finer-scale urban health risk assessment based on the interaction perspective of thermal radiation,human,activity,and space

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Frontiers of Architectural Research 2024年第3期13卷 682-697页

作者： ruonan Guo Fei Guo Jing Dong Zixuan Wang Ruwei Zheng Hongchi zhang School of Architecture and Fine Art Dalian University of TechnologyDalian 116024China Weifang Natural Resources and Planning Bureau High Tech Branch Weifang 261041China

Urban heat stress profoundly affects the health of ***,current research primarily focuses on quantifying the risk of urban heat based on LST,Ta,etc.,overlooking the crucial and intimate influence of continuous intense solar radiation on human thermal comfort and ***,there is a lack of smaller units to support more precise *** study utilized the radiant heat stress intensity(RHSI)metric concentrating on the intensity and duration of thermal radiation,to develop a thermal-radiation induced health risk(TIHR)assessment *** technologies such as the SOLWEIG model,Python,BERT,and GIS enables precise calculations of 12 spatial indices,including RHSI and Weibo *** facilitates a more accurate assessment of health risks at the smallest urban units(blocks)and directly guides *** application of this workflow in the case of Suoyuwan,Dalian,China,confirms its value,as it can be used to determine which blocks should be prioritized for specific aspects of risk prevention and *** results show that some blocks exhibited differences in TIHR even within close proximity,with disaster-causing factors varying according to *** study proposes a novel assessment framework based on the interactive perspective of thermal radiation-human-activity-space.

关键词： Health risk assessment Thermal radiation Finer-scale Block Planning Human-centered

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Garlic Root Biomass as Novel Biosorbents for Malachite Green Removal： Parameter Optimization, Process Kinetics and Toxicity Test

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Chemical Research in Chinese Universities 2016年第4期32卷 647-654页

作者： REN Hejun zhang ruonan WANG Qiaochu PAN Hongyu WANG Yan Key Laboratory of Groundwater Resources and Environment Ministry of Education College of Environment and Resources Jilin University Changchun 130021 P. R. China College of Plant Sciences Jilin University Changchun 130062 P. R. China

The potential of the agricultural waste garlic root to remove malachite green（MG） from aqueous solutions was evaluated. The adsorption of this dye onto garlic root was confirmed by means of Fourier transform infrared analysis（FTIR） and scanning electron microscopy（SEM）. The equilibrium data fitted well into the Langmuir model（R2〉0.99）, and the adsorption kinetics followed the pseudo-second-order equation（R2〉0.99）. The maximum ad- sorption capacities of MG onto the adsorbent were 172.41 and 232.56 mg/g with the addition of 1 and 2 g/L garlic root, respectively. The optimal conditions for MG removal were established on the basis of orthogonal experiments（OAl6 matrix）. The concentrations of both MG and garlic root significantly affected the removal efficiency. The acute toxicity test indicated that the treated MG solutions were less toxic than the parent solutions. These results suggest that garlic root is a potential low-cost adsorbent for removing dye from industrial wastewater.

关键词： Garlic root Malachite green Adsorption Toxicity test Wastewater

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有机层、叙述层、唤起层的观事之道:深度解析欧丁剧团《树》的构作法

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戏剧(中央戏剧学院学报) 2023年第5期211卷 116-128页

作者：张若男 (纽约)菲茨莫里斯声音训练中心

《树》(2016)是尤金尼奥·巴尔巴卸任欧丁剧团行政职务前最后一部集体戏剧作品。导演以其独到视角与跨文化戏剧表现手法,对地缘政治与全球的经济、文化、民族、宗教、种族等元素话题进行不同程度的触及与思考。本文试图从个人见证角度... 详细信息

《树》(2016)是尤金尼奥·巴尔巴卸任欧丁剧团行政职务前最后一部集体戏剧作品。导演以其独到视角与跨文化戏剧表现手法,对地缘政治与全球的经济、文化、民族、宗教、种族等元素话题进行不同程度的触及与思考。本文试图从个人见证角度补充国内对巴尔巴与欧丁剧团演出创作与构作法深度研究的间隙,梳理并呈现作品从灵感构思到最终舞台演出的全过程,解析巴尔巴从获取作品灵感元素材到运用构作法基本层的细节步骤,看他如何将戏剧实践作为探索工具对自我、他人及世界进行思考与审视。

关键词：欧丁剧团尤金尼奥·巴尔巴《树》构作法

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Impact of short-term ambient air pollution exposure on the risk of severe COVID-19

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Journal of Environmental Sciences 2024年第1期135卷 610-618页

作者： Baihuan Feng Jiangshan Lian Fei Yu Dan zhang Weizhen Chen QiWang Yifei Shen Guoliang Xie ruonan Wang Yun Teng Bin Lou Shufa Zheng Yida Yang Yu Chen Department of Laboratory Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province Hangzhou 310000China Institute of Laboratory Medicine Zhejiang UniversityHangzhou 310000China Department of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China

Ecological studies suggested a link between air pollution and severe COVID-19 outcomes,while studies accounting for individual-level characteristics are *** the present study,we aimed to investigate the impact of short-term ambient air pollution exposure on disease severity among a cohort of 569 laboratory confirmed COVID-19 patients admitted to designated hospitals in Zhejiang province,China,from January 17 to March 3,2020,and elucidate the possible biological processes involved using *** with mild cases,severe cases had higher proportion of medical conditions as well as unfavorable results in most of the laboratory tests,and manifested higher air pollution exposure *** exposure to air pollutants was associated with increased risk of severe COVID-19 with odds ratio(OR)of 1.89(95%confidence interval(CI):1.01,3.53),2.35(95%CI:1.20,4.61),2.87(95%CI:1.68,4.91),and 2.01(95%CI:1.10,3.69)for PM_(2.5),PM_(10),NO_(2)and CO,*** for NO_(2)remained significant in two-pollutant models after adjusting for other *** analysis showed 884 differentially expressed genes which mainly were enriched in virus clearance related biological processes between patients with high and low NO_(2)exposure levels,indicating that compromised immune response might be a potential underlying mechanistic *** findings highlight the impact of shortterm air pollution exposure,particularly for NO_(2),on COVID-19 severity,and emphasize the significance in mitigating the COVID-19 burden of commitments to improve air quality.

关键词： Air pollution COVID-19 Severity Transcriptomics Immune response

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政府采购法框架下外文电子期刊数据库采购方式规范化研究

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图书馆理论与实践 2024年第2期 32-37页

作者：张若楠史淑英向佳丽西安交通大学图书馆西安交通大学期刊中心厦门大学图书馆

外文电子期刊数据库是图书馆数字资源建设的重要组成部分,研究外文电子期刊数据库采购方式,有助于促进数字资源采购方式规范化。文章针对现阶段图书馆在外文电子期刊数据库采购过程中采购方式选择的问题,明确了外文电子期刊的特性,指出... 详细信息

外文电子期刊数据库是图书馆数字资源建设的重要组成部分,研究外文电子期刊数据库采购方式,有助于促进数字资源采购方式规范化。文章针对现阶段图书馆在外文电子期刊数据库采购过程中采购方式选择的问题,明确了外文电子期刊的特性,指出选择过程中的几个误区,并针对这些误区提出应该采用“单一来源”方式进行采购、将采购工作内嵌于数据库管理的全生命周期中、精准电子期刊数据库采购“放管服”、引入国家采购等建议与思考。

关键词：外文电子期刊单一来源采购方式政府采购

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Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

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Bioactive Materials 2022年第7期7卷 23-36页

作者： ruonan zhang Ting Pan Yu Xiang Mingming zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacao School of Pharmacy and Department of Medical Oncology The Affiliated Hospital of Hangzhou Normal UniversitySchool of MedicineHangzhou Normal UniversityHangzhou311121ZhejiangChina Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines China Engineering Laboratory of Development and Application of Traditional Chinese Medicines China Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou311121ZhejiangChina Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangzhou510006China

Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer ***,the effect and molecular mechanism of curcumenol in lung cancer are largely ***,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer ***,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first ***,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated *** of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol ***,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of *** conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell ***,our findings will hopefully provide a valuable drug for treating lung cancer patients.

关键词： Curcumenol Ferroptosis Lung cancer lncRNA H19 miRNA-19b-3p FTH1

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