检索结果-南通市图书馆

鞋类工艺与设计 2023年第12期3卷 75-77页

作者：钱若男吉林艺术学院吉林长春130012

本文从科学的角度探寻光与色之间的关联,研究色彩体系的建立,分析色彩理论对印象派绘画的作用。科学地探索色彩的产生、应用和规律,用色彩表达思想感情和审美,用色彩理论作为依据参与艺术实践。从大师作品中学习配色方法,从自然和生活... 详细信息

本文从科学的角度探寻光与色之间的关联,研究色彩体系的建立,分析色彩理论对印象派绘画的作用。科学地探索色彩的产生、应用和规律,用色彩表达思想感情和审美,用色彩理论作为依据参与艺术实践。从大师作品中学习配色方法,从自然和生活中捕捉光与色的美。

关键词：五色观色彩学印象派

在线全文

学校读者我要写书评

暂无评论

计算机电子信息工程技术的应用与安全

现代工业经济和信息化 2021年第7期11卷 116-117,148页

作者：钱若楠山东省社会信用中心山东济南250011

计算机为人类的生活带来便捷的同时,也存在着极大的安全问题。文章分析计算机电子工程技术在各个领域的应用,针对计算机电子信息工程技术的安全问题,提出应对策略。

关键词：计算机电子信息工程技术应用安全

Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2023年第10期50卷 807-812页

作者： Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong ruonan qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu Key Laboratory of Developmental Genes and Human Diseases School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Institute of Translational Medicine Yangzhou University Medical CollegeYangzhouJiangsu 225009China Department of Radiology&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China The First Affiliated Hospital of Soochow University SuzhouJiangsu 215006China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 210029China Author links open overlay panelYexi Huang Guangdong Provincial People's Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200001China Department of Laboratory Medicine The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210031China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery HospitalShanghai 201800China The Fifth People's Hospital Soochow UniversitySuzhouJiangsu 215007China Department of Gastroenterology Jiangsu University Affiliated Kunshan HospitalKunshanJiangsu 215300China Department of Gastroenterology Yixing People's HospitalYixinJiangsu 214200China Department of Gastroenterology Yancheng First People's HospitalYanchengJiangsu 224005China Department of Gastroenterology Taicang First People's HospitalSoochow UniversityTaicangJiangsu 215400China Department of Hepatology Jingjiang Second People's HospitalJingjiangJiangsu 214500China Department of Hepatology The Third People's Hospital of ChangzhouChangzhouJiangsu 213001China Department of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Laboratory Medicine Jiangyin People's HospitalSoutheast UniversityJiangyinJiangsu 214400China Department of Labora

Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi... 详细信息

关键词： cholangitis biliary

sea-derived fungus Acremonium ***16-126

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2021年第2期6卷 127-133页

作者： ruonan Sun Hengyi Xu Yanyan Feng Xuewen Hou Tianjiao Zhu qian Che Blaine Pfeifer Guojian Zhang Dehai Li School of Medicine and Pharmacy Ocean University of ChinaQingdao266003People’s Republic of China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao266237People’s Republic of China Department of Chemical and Biological Engineering The State University of New York at BuffaloBuffaloNY14260United States

Acremonium species are prolific producers of therapeutic molecules which include the widely used beta-lactam antibiotic,*** light of their significant medical value,an efficient gene disruption method is required for the physiological and biochemical studies on this genus of ***,the number of selection markers that can be used for gene targeting is limited,which constrain the genetic analysis of multiple functional *** this study,we established a uridine auxotrophy based marker recycling system which achieves scarless gene deletion,and allows the use of the same selection marker in successive transformations in a deep seaderived fungus Acremonium *** identified one homologue of Acremonium chrysogenum pyrG(also as a homologous gene of the yeast URA3)from HDN16-126,designated as pyrG-A1,which can be used as a selection marker on uridine free *** then removed pyrG-A1 from HDN16-126 genome via homologous recombination(HR)on MM medium with 5-fluoroortic acid(5-FOA),a chemical that can be converted into a toxin of 5-flurouracil by pyrG-A1 activity,thus generating the HDN16-126-△pyrG mutant strain which showed auxotrophy for uridine but insensitivity to 5-FOA and enabled the use of exogenous pyrG gene as both positive and negative selection marker to achieve the scarless deletion of target DNA *** further applied this marker recycling system to successfully disrupt two target genes pepL(encodes a putative 2OG-Fe(Ⅱ)dioxygenase)and pepM(encodes a putative aldolase)identified from HDN16-126 genome,which are proposed to be functional genes related to 2-aminoisobutyric acid metabolism in *** work is the first application of uridine auxotrophy based scarless gene deletion method in Acremonium species and shows promising potential in assisting sequential genetic analysis of filamentous fungi.

关键词： Acremonium sp. Deep sea-derived Homologous recombinant Marker recycling system Markerless deletion

The green-emitting fluorescence of nano Y_2O_3:Er^(3+) under different excitations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2012年第7期55卷 1152-1157页

作者： JI ruonan YE YanXi HU XiaoYun FAN Jun LIU EnZhou ZHANG qian ZHAO ChaoShuai YE SiWen Physics Department of Northwest University Xi'an 710069China School of Chemical Engineering Northwest University Xi'an 710069China Fuzhou Software Technology Vocational College Fuzhou 350003China

The green-emitting fluorescent powders of nano Y2O3：Er^3＋ were fabricated by the coprecipitation method. The X-ray diffrac- tion pattern shows that as-prepared Y2O3：Er^3＋ is the cubic phase crystal with a grain size of about 30 nm. The UV-Vis spec- trum indicates Y^O3：Er^3＋ exhibits five ultraviolet visible absorption peaks at 365, 377, 489, 521 and 652 nm respectively. Meanwhile, the fluorescence spectra of Y2O3：Er^3＋ display four emission peaks at 522, 537, 550 and 562 nm at the excitation of 365,377 and 521 nm, respectively. The green-emitting fluorescent mechanism of Y2O3：Er^3＋ is proposed as well. Additionally, the temperature dependence of fluorescence properties and metal Ag fluorescence enhancement effect are investigated. Results show that increasing the annealing temperature and metal Ag doping both can enhance the fluorescence intensity. The maxi- mum enhancement is 87.5% after Ag is doped.

关键词： nano Y2O3:Er^3+ coprecipitation method luminous properties localized surface plasmon resonance fluorescence enhancement

Peptaibols:Diversity, bioactivity, and biosynthesis

在线全文

学校读者我要写书评

暂无评论

Engineering Microbiology 2022年第3期2卷 1-12页

作者： Xuewen Hou ruonan Sun Yanyan Feng Runfang Zhang Tianjiao Zhu qian Che Guojian Zhang Dehai Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Marine Biomedical Research Institute of Qingdao Qingdao 266101China

Peptaibols are a large family of linear,amphipathic polypeptides consisting of 5-20 amino acid residues gener-ated from the fungal nonribosomal peptide synthetase(NRPS)*** a relatively high content of non-proteinogenic amino acids such as𝛼-aminoisobutyrate(Aib)and isovaline(Iva)in the skeleton,peptaibols exhibit a wide range of biological activities,including anti-microbial,cytotoxic,and neuroleptic *** five peptai-bols brought to market for use as biocontrol agents,this class of peptides has received increasing attention from both biochemists and *** this review,we summarized the progress made in structural character-ization,elucidation of biosynthetic pathways,and investigation of biosynthesis elucidation and bioactivities,to promote further efforts to develop peptaibols as pharmaceuticals.

关键词： Peptaibols Structural diversity Bioactivity,anti-infection Biosynthesis

高盐废水处理的耐盐菌株及其高效除磷特性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北京大学学报（自然科学版） 2013年第5期49卷 880-884页

作者：邓若男陈倩倪晋仁北京大学环境工程系水沙科学教育部重点实验室北京100871

筛选出一株能够高效除磷的耐盐菌株HG-1。通过个体形态、菌落特征的观察和16S rRNA基因的序列分析,初步鉴定为盐弧菌属（Salinivibrio sp.）。对菌株HG-1的耐盐性能及其在不同盐度下对磷酸盐的去除效果进行考察,结果表明菌株对盐度的耐... 详细信息

筛选出一株能够高效除磷的耐盐菌株HG-1。通过个体形态、菌落特征的观察和16S rRNA基因的序列分析,初步鉴定为盐弧菌属（Salinivibrio sp.）。对菌株HG-1的耐盐性能及其在不同盐度下对磷酸盐的去除效果进行考察,结果表明菌株对盐度的耐受范围为1%~13%,最适盐度为3%。进一步的单因素和正交实验表明,4个环境因素对菌株HG-1磷酸盐去除率影响的强弱为：pH〉碳氮比〉温度〉接种量,最优的除磷条件为pH6.5~7.0,温度30℃,接种量10%,碳氮比9,在该条件下菌株在24小时内对磷酸盐的去除率可达100%。将该菌株应用于高盐废水的处理,可实现磷酸盐的有效去除,具有良好的实际应用价值,为高盐条件下生物除磷难题的解决提供了一条新的途径。

关键词：除磷高盐废水耐盐菌

在线全文

学校读者我要写书评

暂无评论

硫磺熏蒸对亳白术药材质量影响的初步研究

辽宁中医药大学学报 2025年第1期27卷 63-69页

作者：徐倩胡云飞王振华张博涛谢若男安徽中医药大学第二附属医院安徽合肥230061 亳州学院中药学院安徽亳州236800 天津中医药大学中药制药工程学院天津300193 安徽世茂中药股份有限公司安徽亳州236800

目的对硫磺熏蒸前后亳白术药材的质量评价进行初步研究,并建立硫磺熏蒸前后质量评价方法。方法根据市场调研情况,制备不同程度硫磺熏蒸亳白术样品,采用表里综合比较理念,对硫磺熏蒸前后亳白术药材的色度、二氧化硫残留量、亚硫酸盐残留... 详细信息

目的对硫磺熏蒸前后亳白术药材的质量评价进行初步研究,并建立硫磺熏蒸前后质量评价方法。方法根据市场调研情况,制备不同程度硫磺熏蒸亳白术样品,采用表里综合比较理念,对硫磺熏蒸前后亳白术药材的色度、二氧化硫残留量、亚硫酸盐残留量进行测定,采用液相特征图谱表征硫磺熏蒸前后亳白术药材的物质基础变化,并采用ATR-FTIR光谱结合模式识别技术比较中红外光谱吸收差异。结果该实验制备了无硫熏及低、中、高浓度硫熏的亳白术药材,实验结果表明,随着硫熏程度升高,亮度增加,总色值增加,二氧化硫残留量、亚硫酸盐残留量升高,醇溶性浸出物及主要成分含量降低,ATR-FTIR光谱出现明显的亚硫酸根的伸缩振动吸收峰,同时-OH吸收峰逐步下降,结合PCA及OPLS-DA分析能够实现硫熏及非硫熏样品有效区分。结论硫磺熏蒸严重影响了亳白术药材的品质。本研究全面和客观评价了硫磺熏蒸对亳白术的品质影响,可为亳白术药材的产地加工、质量评价等提供参考。

关键词：硫磺熏蒸白术质量评价亚硫酸盐指纹图谱

底泥就地稳定化中零价铁(Fe^0)对有机污染物的作用及其对上覆水体水质的影响

在线全文

学校读者我要写书评

暂无评论

湖泊科学 2018年第5期30卷 1218-1224页

作者：章萍相明雪马若男刘强葛刚钱光人南昌大学资源环境与化学工程学院鄱阳湖环境与资源利用教育部重点实验室南昌330031 上海大学环境与化学工程学院上海200444

在实验室模拟静态湖泊体系条件下,通过向实际底泥中投加零价铁(Fe^0),考察反应前后底泥中有机物数量、种类、总有机质含量以及上覆水体溶解氧(DO)浓度、氧化还原电位(Eh)、pH和化学需氧量(CODCr)浓度等指标的变化,探讨Fe^0对底泥有机物... 详细信息

在实验室模拟静态湖泊体系条件下,通过向实际底泥中投加零价铁(Fe^0),考察反应前后底泥中有机物数量、种类、总有机质含量以及上覆水体溶解氧(DO)浓度、氧化还原电位(Eh)、pH和化学需氧量(CODCr)浓度等指标的变化,探讨Fe^0对底泥有机物的降解效果以及对上覆水体水质的影响.结果表明,投加Fe^0处理80 d后,(1)经GC-MS检测出底泥中易被降解的小分子有机物(分子量小于200)数量明显增多,底泥总有机去除率为44%.(2)上覆水体的DO浓度、Eh和pH都有不同程度的变化.DO浓度从6.6 mg/L迅速下降至0.2 mg/L,Eh从150 mV左右下降至74 mV,pH升高至8.4,此体系易形成厌氧环境;且上覆水体中CODCr低于纯底泥-水体系,上覆水中DO浓度、Eh及pH与CODCr浓度具有一定相关性.综上,底泥中投加Fe^0可有效降解有机物,且不会对上覆水体产生持久、较大的影响.

关键词：就地稳定零价铁(Fe0) 底泥有机污染物上覆水

磺丁基醚-β-环糊精在药物制剂中的应用及安全性研究进展

在线全文

学校读者我要写书评

暂无评论

中国医药工业杂志 2019年第9期50卷 949-957页

作者：王若男钱仪敏李华马璟中国医药工业研究总院国家上海新药安全评价研究中心上海益诺思生物技术股份有限公司

磺丁基醚-β-环糊精(SBECD)是由1,4-丁烷磺内酯在碱性条件下与β-环糊精的2-、3-、6-位碳上的羟基发生取代反应而得到的阴离子型高水溶性环糊精衍生物。与β-环糊精相比,SBECD 的水溶性增强,并具有更高的体内安全性,广泛应用于注射剂、... 详细信息

磺丁基醚-β-环糊精(SBECD)是由1,4-丁烷磺内酯在碱性条件下与β-环糊精的2-、3-、6-位碳上的羟基发生取代反应而得到的阴离子型高水溶性环糊精衍生物。与β-环糊精相比,SBECD 的水溶性增强,并具有更高的体内安全性,广泛应用于注射剂、口服制剂、鼻腔给药制剂、滴眼剂等制剂工艺中。本文综述了SBECD 的特点及在制剂工艺中的应用,并重点阐述了其在健康人及肾功能损伤患者体内安全性的研究进展。

关键词：磺丁基醚-β-环糊精环糊精衍生物安全性肾功能损伤