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TBBPA rather than its main derivatives enhanced growth of endometrial cancer via p53 ubiquitination

Journal of Environmental Sciences 2024年第3期137卷 82-95页

作者： Hongyan Yu Jingxu Zhang Jing Liu ruonan pan Yu Wang Xiaoting Jin Rifat Zubair Ahmed Yuxin Zheng Department of Occupational Health and Environmental Health School of Public HealthQingdao UniversityQingdao 266071China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Genetics University of KarachiKarachi 75270Pakistan

Tetrabromobisphenol A(TBBPA)and its derivatives widely exist in various environments and biota.Although the available data indicate that TBBPA exposure is highly associated with the increased incidence of endometrial cancer(EC),the effects of TBBPA and its main derivatives on EC proliferation and the involved crucial mechanism remain unclear.The present study aimed to investigate the effects of TBBPA and its derivatives under environmental concentrations on the proliferation of EC,and the crucial mechanism on the progression of EC caused by bromine fame retardants exposure.In this research,TBBPA and two of the most common TBBPA derivatives including TBBPA bis(2-hydroxyethyl ether)(TBBPABHEE)and TBBPA bis(dibromopropyl ether)(TBBPA-BDBPE)were screened for their capacities in induced EC proliferation and explored the related mechanism by in vitro cell culture model and in vivo mice model.Under environmental concentrations,TBBPA promoted the proliferation of EC,the main derivatives of TBBPA(TBBPA-BHEE and TBBPA-BDBPE)did not present the similar facilitation effects.The ubiquitination degradation of p53 was crucial in TBBPA induced EC proliferation,which resulted in the increase of downstream cell cycle and decrease of apoptosis.The further molecular docking result suggested the high affinity between TBBPA and ubiquitinated proteasome.This finding revealed the effects of TBBPA and its derivatives on EC proliferation,thus providing novel insights into the underlying mechanisms of TBBPA-caused EC.

关键词： Tetrabromobisphenol A(TBBPA) Endometrial cancer(EC) Derivatives Ubiquitin proteases p53

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高职采油工程课程思政教学模式实践研究

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天津职业院校联合学报 2024年第1期26卷 19-23页

作者：王若男张远弟孟琦倪攀天津石油职业技术学院天津301607

根据石油工程技术专业的特色和优势,深入挖掘课程思政元素,融入专业课,推进习近平新时代中国特色社会主义思想进课堂、进头脑,强化采油工程课程协同育人导向。主要介绍高职石油类专业课采油工程课程思政教学模式及教学方法的实践研究成... 详细信息

根据石油工程技术专业的特色和优势,深入挖掘课程思政元素,融入专业课,推进习近平新时代中国特色社会主义思想进课堂、进头脑,强化采油工程课程协同育人导向。主要介绍高职石油类专业课采油工程课程思政教学模式及教学方法的实践研究成果,为各高职院校专业课教师进行课程思政教学改革提供参考。

关键词：课程思政石油天然气类专业课堂教学教学方法教学模式

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术前误诊良性肺结节与典型恶性肺结节临床分析

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中华肺部疾病杂志（电子版） 2024年第1期17卷 46-50页

作者：段丽君董鑫潘若楠任梦然卢晓倩曹殿波吉林大学第一医院放射科吉林130021

目的分析术前误诊为恶性的良性孤立性肺结节(solitary pulmonary nodule, SPN)与典型恶性SPN的临床特点和影像学特征,建立模型预测良恶性SPN。方法选择2019年1月至2022年3月我院收治的术前疑似恶性SPN行手术治疗患者621例,术后病理证... 详细信息

目的分析术前误诊为恶性的良性孤立性肺结节(solitary pulmonary nodule, SPN)与典型恶性SPN的临床特点和影像学特征,建立模型预测良恶性SPN。方法选择2019年1月至2022年3月我院收治的术前疑似恶性SPN行手术治疗患者621例,术后病理证实为良性SPN 243例为观察组,恶性SPN 378例为对照组。收集患者临床影像资料,采用多因素Logistic回归分析筛选恶性SPN危险因素,建立模型预测良恶性SPN,验证模型预测价值。结果观察组女129例(53.09%),平均年龄(54.66±10.52)岁,对照组女242例(64.02%),平均年龄(59.68±8.48)岁(P<0.05);观察组实性结节173例(71.19%),肺裂周围结节155例(63.79%),圆形/类圆形结节143例(58.85%),对照组实性结节184例(48.68%),肺裂周围结节77例(20.37%),圆形/类圆形结节161例(42.59%)(P<0.05)。多因素回归分析显示年龄、肿瘤标志物、直径、体积平均CT值、边界是否清楚、与肺裂位置关系、分叶、胸膜凹陷征是恶性SPN危险因素(P<0.05)。验证模型受试者工作特征曲线下面积0.815,大于PKUPH模型(0.785,P=0.776)及梅奥模型(0.502,P=0.012)。结论术前易误诊为恶性的良性SPN女性居多,发病年龄偏小,影像学特征圆形/类圆形、肺裂周围实性成分为主。模型预测SPN性质,具有临床意义。

关键词：孤立性肺结节影像学特征良性/恶性误诊预测模型

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儿童异基因造血干细胞移植100天后闭塞性细支气管炎综合征临床特点及危险因素分析

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临床儿科杂志 2024年第2期42卷 139-145页

作者：孙若楠李泊涵郑德菲赵夏莹林子云胡昳歆高莉高静李捷卢俊肖佩芳潘健凌婧方芳胡绍燕苏州大学附属儿童医院江苏苏州215025

目的分析儿童异基因造血干细胞移植(allo-HSCT)后闭塞性细支气管炎综合征(BOS)的临床特点及危险因素,以进一步优化治疗方案。方法回顾性分析2010年10月至2018年12月在苏州大学附属儿童医院接受alloHSCT患儿的临床资料。结果共纳入351例... 详细信息

目的分析儿童异基因造血干细胞移植(allo-HSCT)后闭塞性细支气管炎综合征(BOS)的临床特点及危险因素,以进一步优化治疗方案。方法回顾性分析2010年10月至2018年12月在苏州大学附属儿童医院接受alloHSCT患儿的临床资料。结果共纳入351例患儿,男213例、女138例。截止至2019年9月1日,共29例(8.3%)患儿发生BOS,男11例、女18例,中位年龄92.0(67.0~132.0)月。移植至发生BOS的中位时间为10.0(8.5~20.0)月。移植后1、2、3年BOS累积发生率分别为(6.0±1.3)%、(10.0±1.8)%、(10.7±2.0)%。29例BOS患儿中,28例BOS发病前合并其他靶器官慢性移植物抗宿主病(cGVHD)。多因素logistic回归分析结果显示年龄较大、女性、移植后100天内有呼吸系统疾病以及合并其他靶器官cGVHD是BOS发生的独立危险因素(P<0.05)。结论BOS是HSCT后的严重并发症。女性、年龄较大、合并其他靶器官cGVHD、移植后100天内有呼吸系统疾病的患儿发生BOS的风险更大。

关键词：造血干细胞移植闭塞性细支气管炎综合征移植物抗宿主病儿童

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Garlic Root Biomass as Novel Biosorbents for Malachite Green Removal： Parameter Optimization, Process Kinetics and Toxicity Test

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Chemical Research in Chinese Universities 2016年第4期32卷 647-654页

作者： REN Hejun ZHANG ruonan WANG Qiaochu pan Hongyu WANG Yan Key Laboratory of Groundwater Resources and Environment Ministry of Education College of Environment and Resources Jilin University Changchun 130021 P. R. China College of Plant Sciences Jilin University Changchun 130062 P. R. China

The potential of the agricultural waste garlic root to remove malachite green（MG） from aqueous solutions was evaluated. The adsorption of this dye onto garlic root was confirmed by means of Fourier transform infrared analysis（FTIR） and scanning electron microscopy（SEM）. The equilibrium data fitted well into the Langmuir model（R2〉0.99）, and the adsorption kinetics followed the pseudo-second-order equation（R2〉0.99）. The maximum ad- sorption capacities of MG onto the adsorbent were 172.41 and 232.56 mg/g with the addition of 1 and 2 g/L garlic root, respectively. The optimal conditions for MG removal were established on the basis of orthogonal experiments（OAl6 matrix）. The concentrations of both MG and garlic root significantly affected the removal efficiency. The acute toxicity test indicated that the treated MG solutions were less toxic than the parent solutions. These results suggest that garlic root is a potential low-cost adsorbent for removing dye from industrial wastewater.

关键词： Garlic root Malachite green Adsorption Toxicity test Wastewater

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From borophosphate to fluoroborophosphate:a rational design of fluorine-induced birefringence enhancement

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Science China Chemistry 2021年第9期64卷 1498-1503页

作者： Wenyao Zhang Zhizhong Zhang Wenqi Jin ruonan Zhang Meng Cheng Zhihua Yang Shilie pan CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryCASXinjiang Key Laboratory of Electronic Information Materials and DevicesUrumqi830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

The introduction of oxofluoride anion into anionic group assists to tune optical properties owing to the change of coordination,electronegativity,and according anionic framework.Here,we proposed a rational design of new compounds by fluorine-driven structure and optical property evolution.A new borophosphate Ba_(2)BP_(3)O_(11)with the monoclinic space group P2_(1/c) has been synthesized in the sealed system.Ba_(2)BP_(3)O_(11)exhibits a rare P-O-P bridge formation,which is the first example in alkaline-earth metal borophosphates.By further substituting[BO_(4)]^(3-)with[BO_(3)F]^(4-),the first alkaline-earth metal/lead fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)with the same space group were designed.Since the scissors effect of fluorine,in M_(2)BP_(2)O_(8)F(M=Ba and Pb),a BO_(3)F tetrahedron corner-sharing with three PO_(4)tetrahedra forms 1D chains along the b-axial direction,which are filled by MO_(n)(M=Ba/Pb,n=5,6,8)distorted polyhedra.The first principles calculation shows that the borophosphate Ba_(2)BP_(3)O_(11)has a birefringence about 0.013@1,064 nm,while the fluoroborophosphates M_(2)BP_(2)O_(8)F(M=Ba and Pb)have the values of 0.035 and 0.043@1,064 nm,respectively.Such an apparent enhancement in birefringence is derived from synergies of the oxyfluoride and cation.The introduction of fluorine-containing heteroanionic groups provides a feasible strategy to design novel promising optical materials.

关键词： borophosphate fluoroborophosphates P-O-P bridges formation birefringence

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Asymmetric Ridge–Furrow and Film Cover Improves Plant Morphological Traits and Light Utilization in Rain-Fed Maize

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Journal of Meteorological Research 2018年第5期32卷 829-838页

作者： Wanlin DONG Hang YU Lizhen ZHANG ruonan WANG Qi WANG Qingwu XUE Zhihua pan Zhigang SUN Xuebiao pan Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Agricultural Meteorological Department College of Resources and Environmental SciencesChina Agricultural University China Meteorological Administration Training Centre Beijing 100081China College of Resources and Environment University of Chinese Academy of SciencesBeijing 1O0190China Wuchuan Scientific and Observing Experimental Station of Agro-Environment Ministry of Agriculture and Rural Affairs Hohhot 011700China Yushu Meteorological Service of Jilin Province Changchun 130061China Texas A&MAgriLife Research and Extension AmarilloTexas 79106-1769USA

Light is one of the most important natural resources for plant growth. Light interception （LI） and use efficiency （LUE） are often affected by the structure of canopy caused by growing pattern and agronomy managements. Agro-nomy practices, such as the ridge-furrow system and plastic film cover, might affect the leaf morphology and then light transmission within the canopy, thus change light extinction coefficient （k）, and LI and LUE. The objective of this study is to quantify LI and LUE in rain-fed maize （Zea Mays L.）, a major cropping system in Northeast China, under different combinations of ridge-furrow and film covering ratios. The tested ridge-furrow system （DRF：＂double ridges and furrows＂） was asymmetric and alternated with wide ridge （0.70 m in width and 0.15 m in height）, narrow furrow （0.10 m）, narrow ridge （0.40 m in width and 0.20 m in height）, and narrow furrow （0.10 m）. Field ex-periments were conducted in 2013 and 2014 in Jilin Province, Northeast China. Four treatments were tested： no ridges and plastic film cover （control, NRF）, ridges without film cover （DRF0）, ridges with 58% film cover （DRF58）, and ridges with 100% film cover （DRFl00）. DRF0 significantly increased LI by 9% compared with NRF, while film cover showed a marginal improvement. Specific leaf area in DRF experiments with film cover was significantly lower than in NRF, and leaf angle was 16% higher than in NRF, resulting in a 4% reduction in k. LUE of maize was not increased by DRF0, but was significantly enhanced by covering film in other DRF experiments, especially by 22% in DRF100. The increase of LUE by film cover was due to a greater biomass production and a lower assimilation portioning to vegetative organs, which caused a higher harvest index. The results could help farmers to optimize maize managements, especially in the region with decreased solar radiation under climate change.

关键词： light interception light use efficiency film mulching plant morphology ridge and furrow cultivation

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Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

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Bioactive Materials 2022年第7期7卷 23-36页

作者： ruonan Zhang Ting pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacao School of Pharmacy and Department of Medical Oncology The Affiliated Hospital of Hangzhou Normal UniversitySchool of MedicineHangzhou Normal UniversityHangzhou311121ZhejiangChina Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines China Engineering Laboratory of Development and Application of Traditional Chinese Medicines China Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou311121ZhejiangChina Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangzhou510006China

Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients.

关键词： Curcumenol Ferroptosis Lung cancer lncRNA H19 miRNA-19b-3p FTH1

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工业机器人如何重塑中国就业结构

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经济学动态 2022年第12期 51-66页

作者：董雪兵潘登池若楠浙江大学区域协调发展研究中心、中国西部发展研究院 310058 浙江大学经济学院 310058 杭州师范大学经济学院 311121

近年来中国制造业就业规模和就业份额连年下降,需引起高度重视。本文结合中国CFPS数据库和IFR数据库,探讨了工业机器人对中国就业结构的影响,结果表明:2013-2017年工业机器人密度的增长解释了同期中国制造业相对服务业就业份额下降原因... 详细信息

近年来中国制造业就业规模和就业份额连年下降,需引起高度重视。本文结合中国CFPS数据库和IFR数据库,探讨了工业机器人对中国就业结构的影响,结果表明:2013-2017年工业机器人密度的增长解释了同期中国制造业相对服务业就业份额下降原因的12.56%。工业机器人一方面提升了服务业相对制造业的劳动力新进入水平,并促进了企业层面由制造业向服务业转型,另一方面促进了劳动力个体层面从其他行业流向服务业。然而,工业机器人对促进制造业劳动力流向服务业影响并不显著,且对增加制造业失业率无显著影响。进一步研究发现,从职业选择看,工业机器人提高了劳动力选择单位负责人、专业技术人员相对制造生产类职业的概率;从替代类型看,工业机器人主要是减少了与其任务内容相重合的职业就业概率,与劳动力的技能水平无关;从行业工资性收入看,工业机器人提高了服务业劳动力的工资性收入,对制造业劳动力工资性收入影响不显著。

关键词：工业机器人就业结构制造业服务业

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The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

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Genes & Diseases 2021年第6期8卷 781-797页

作者： Xingxing Huang Ting pan Lili Yan Ting Jin ruonan Zhang Bi Chen Jiao Feng Ting Duan Yu Xiang Mingming Zhang Xiaying Chen Zuyi Yang Wenzheng Zhang Xia Ding Tian Xie Xinbing Sui Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiang Province310015PR China College of Pharmacy School of MedicineHangzhou Normal UniversityHangzhouZhejiang Province311121PR China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang Province311121PR China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029PR China

Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies,including bladder cancer.This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment.Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of in-flammatory molecules and signals.Recently,it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer,which can be mediated through the stimulation of chronic inflammation.In effect,the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer.In other words,chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer.Here,we provide a detailed and comprehensive account of the link between chronic inflammation,the microbiome and bladder cancer.Finally,we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment.

关键词： Bladder cancer Carcinogenesis Inflammatory microenvironment Pathogenesis Progression Urinary microbiome

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