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Biomimetic extracellular vesicles for the tumor targeted treatment

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Engineered Regeneration

Engineered Regeneration 2023年第4期4卷 427-437页

作者： ruolin shi An Zhan Xinze Li Bin Kong Gaofeng Liang Medical College and Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment The First Affiliated HospitalSchool of Basic MedicineHenan University of Science and TechnologyLuoyang471023China School of Biomedical Engineering Shenzhen University Medical SchoolShenzhen UniversityShenzhenGuangdong518055China Department of Neurosurgery Health Science CenterThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhenGuangdong518035China Institute of Biomedical Sciences Henan Academy of SciencesZhengzhou 450046China

Extracellular vesicles(EVs)are nanoscale substances produced by most cells,which were not fully understood in the early ***,with the development of advanced techniques,researchers have discovered that EVs play an essential role in information exchange and signal transduction between ***,EVs are being used,modified,and developed as a natural drug carrier in various medical fields because of their high biocompatibility and natural affinity with the source *** studies have shown that multiple sources of EVs have been modified and utilized in cancer therapy to improve patients’treatment windows and effectively prolong patient *** this paper,we review the advances in the treatment of cancer based on *** summarize the types of EVs loading therapy,the modes of drug loading and the latest therapeutic applications of multiple modes combined with EVs in cancer *** conclude with a discussion of the current status,challenges,and prospects of EVs as a tool for tumor therapy.

关键词： Extracellular vesicles Exosomes Nanomedicine Drug delivery systems Cancer treatment

内生沙福芽孢杆菌与生防细菌组合防治桉树青枯病研究

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林业与生态科学 2024年第3期39卷 273-279,296页

作者：师若琳王照玉史晓梦李博雅鲁妍璇冉隆贤河北农业大学林学院河北保定071000 河北省林木种质资源与森林保护重点实验室河北保定071000 中国农业科学院植物保护研究所北京100193

为探究桉树内生沙福芽孢杆菌NP91及生防细菌组合对桉树青枯病的生物防治效果,采用抑菌圈法测定桉树内生沙福芽孢杆菌NP91对青枯病菌的拮抗作用,并用共培养法检测其在桉树体内的定殖转运情况,同时通过蘸根法测定其对桉树青枯病的防治效果... 详细信息

为探究桉树内生沙福芽孢杆菌NP91及生防细菌组合对桉树青枯病的生物防治效果,采用抑菌圈法测定桉树内生沙福芽孢杆菌NP91对青枯病菌的拮抗作用,并用共培养法检测其在桉树体内的定殖转运情况,同时通过蘸根法测定其对桉树青枯病的防治效果,最后通过菌株间的拮抗作用形成3个微生物组合:L-B-4+WCS358r+NP91(组合LWN)、L-B-11+CN181+NP91+WCS358r(组合LCNW)、CN181+WCS417r+NP91+WCS358r(组合CWNW),探究微生物组合对桉树青枯病的防治效果。结果表明,内生沙福芽孢杆菌对青枯病菌具有较强的拮抗活性,且能够在桉苗根部和茎部定殖,接种第15天时,定殖量在根部为6.35 lg CFU/g,在茎部定殖量达到5.23 lg CFU/g。在生防试验中,沙福芽孢杆菌NP91对青枯病的防治效果在第5天和第7天时分别为80.0%和43.8%,但随着时间延长,防治效果逐渐降低。通过多株生防细菌组合后,防治效果最好的组合LCNW对青枯病的防治效果在第7天时达到了100.0%,表明内生沙福芽孢杆菌通过与其他细菌组合可以显著提高对桉树青枯病的防治效果。

关键词：沙福芽孢杆菌内生菌巨尾桉微生物组合青枯病菌

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超声内镜在胰管结石诊断中的价值

中华肝胆外科杂志 2023年第9期29卷 674-678页

作者：石若琳张勇汤善宏杜超西南交通大学医学院成都610031 西部战区总医院消化内科成都610031

目的探讨超声内镜对胰管结石的诊断价值。方法回顾性分析2019年1月至2023年4月在西部战区总医院因腹痛、腹胀、黄疸等疑似诊断胰管结石而行超声内镜检查的204例患者资料。最终入组159例患者,其中男性112例,女性47例,年龄(51.5±13.9)岁... 详细信息

目的探讨超声内镜对胰管结石的诊断价值。方法回顾性分析2019年1月至2023年4月在西部战区总医院因腹痛、腹胀、黄疸等疑似诊断胰管结石而行超声内镜检查的204例患者资料。最终入组159例患者,其中男性112例,女性47例,年龄(51.5±13.9)岁。以手术/ERCP诊断的胰管结石为"金标准"。38例(23.9%)患者同时行腹部超声、143例(89.9%)同时行CT检查、93例(58.5%)同时行MRCP检查,比较四种影像学检查诊断胰管结石的准确率。结果159例患者经手术/ERCP诊断胰管结石61例(38.4%),无胰管结石98例(61.6%)。159例患者中超声内镜诊断胰管结石61例(38.4%),98例(61.6%)无胰管结石,超声内镜诊断胰管结石的灵敏度98.4%、特异度99.0%、阳性预测值98.4%、阴性预测值99.0%、约登指数97.3%、准确率98.7%。超声内镜检查诊断胰管结石准确率优于腹部超声、CT、MRCP,差异均有统计学意义(χ2=7.71、13.76、5.70,P=0.012、P<0.001、P=0.033)。超声内镜与手术/ERCP诊断胰管结石一致性较好(Kappa=0.854,P=0.000)。结论超声内镜对胰管结石有较高的诊断价值,可作为疑似胰管结石的首选影像学检查手段。

关键词：超声检查内窥镜检查诊断胰管结石

Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

No Reference Image Sharpness Assessment Based on Global Color Difference Variation

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Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models

An uncertainty investigation for liner impedance eduction methods

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Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： Weihao shi Xiaodong JING School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

Quantization and Event-Triggered Policy Design for Encrypted Networked Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia shi Ehsan Nekouei the Department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

Families of Schmidt-number witnesses for high dimensional quantum states

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Communications in Theoretical Physics 2024年第8期76卷 44-51页

作者： Xian shi College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Higher dimensional entangled states demonstrate significant advantages in quantum information processing tasks. The Schmidt number is a quantity of the entanglement dimension of a bipartite state. Here we build families of k-positive maps from the symmetric information complete positive operator-valued measurements and mutually unbiased bases, and we also present the Schmidt number witnesses, correspondingly. At last, based on the witnesses obtained from mutually unbiased bases, we show the distance between a bipartite state and the set of states with a Schmidt number less than k.

关键词： Schmidt number entanglement witness mutually unbiased bases

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin YU Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups