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Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen Li Jiali Huang Chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu Li Yi Ma Jinlei bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such *** address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation *** optimized prodrug,DON-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell *** the parent drug DON,DON-TK-BM3 exhibited no toxicity toward normal ***,DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in *** study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

Comparison between ozonesonde measurements and satellite retrievals over Beijing,China

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 14-20页

作者： Jinqiang Zhang Yuejian Xuan Jianchun bian Holger Vomel Yunshu Zeng Zhixuan Bai Dan Li Hongbin Chen Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina College of Atmospheric Sciences Lanzhou UniversityLanzhouChina National Center for Atmospheric Research BoulderCOUSA Electronic Engineering College Chengdu University of Information TechnologyChengduChina

从2013年开始,作者团队使用自主研发电化学原理臭氧探空仪在华北平原北京地区进行每周一次观测.本研究首次使用2013-2019年期间北京地区臭氧探空数据评估Aqua卫星搭载大气红外探测仪(AIRS)和Aura卫星搭载微波临边探测器(MLS)反演垂直臭... 详细信息

从2013年开始,作者团队使用自主研发电化学原理臭氧探空仪在华北平原北京地区进行每周一次观测.本研究首次使用2013-2019年期间北京地区臭氧探空数据评估Aqua卫星搭载大气红外探测仪(AIRS)和Aura卫星搭载微波临边探测器(MLS)反演垂直臭氧廓线,并对比臭氧探空,AIRS和Aura卫星搭载臭氧监测仪(OMI)臭氧柱总量结果.尽管臭氧探空与卫星反演垂直臭氧廓线在局部高度处差异较大,但整体来说两者较为接近(相对偏差大多<10%).臭氧探空,AIRS和OMI三种仪器测量臭氧柱总量的年变化特征较为一致,其年均臭氧柱总量分别为351.8±18.4 DU,348.8±19.5 DU和336.9±14.2 DU.后续对国内多站点观测数据分析将有助于进一步理解臭氧探空与卫星反演臭氧资料在不同区域的一致性.

关键词：臭氧探空卫星反演垂直臭氧廓线臭氧柱总量华北平原

The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma

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Genes & Diseases 2024年第1期11卷 80-83页

作者： Zhouliang bian Benhong Gu Guohai Shi Jiahui Guo Dong Li Hanlin Zengg Bin Jiang Daliu Min Hengchuan Su Yanjie Zhang Department of Oncology Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 201900China Shanghai Institute of Precision Medicine Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Urology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China Department of Urology Fudan University Shanghai Cancer CenterShanghai200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Diffuse large B cell lymphoma(DLBCL)is one of the most prevalent lymphoid *** current standard of care can cure about two-thirds of DLBCL patients.1 Primary testicular diffuse large B-cell lymphoma(PT-DLBCL)is a rare but highly aggressive form of mature B-cell lymphoma that accounts for approximately 1%-9%of testicular *** from nodal DLBCL,PT-DLBCL has a markedly worse prognosis because of inferior response to the current treatment regimens and significant extranodal tropism.2 Three main questions remained unresolved in the field of PT-DLBCL research.

关键词： lymphoma markedly prognosis

A Deep-Learning and Transfer-Learning Hybrid Aerosol Retrieval Algorithm for FY4-AGRI:Development and Verification over Asia

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Engineering 2024年第7期38卷 164-174页

作者： Disong Fu Hongrong Shi Christian AGueymard Dazhi Yang Yu Zheng Huizheng Che Xuehua Fan Xinlei Han Lin Gao Jianchun bian Minzheng Duan Xiangao Xia Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 10029China Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Solar Consulting Services ColebrookNH 03576USA School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150006China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry Institute of Atmospheric Composition and Environmental MeteorologyChinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China h National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

The Advanced Geosynchronous Radiation Imager(AGRI)is a mission-critical instrument for the Fengyun series of *** acquires full-disk images every 15 min and views East Asia every 5 min through 14 spectral bands,enabling the detection of highly variable aerosol optical depth(AOD).Quantitative retrieval of AOD has hitherto been challenging,especially over *** this study,an AOD retrieval algorithm is proposed that combines deep learning and transfer *** algorithm uses core concepts from both the Dark Target(DT)and Deep Blue(DB)algorithms to select features for the machinelearning(ML)algorithm,allowing for AOD retrieval at 550 nm over both dark and bright *** algorithm consists of two steps:①A baseline deep neural network(DNN)with skip connections is developed using 10 min Advanced Himawari Imager(AHI)AODs as the target variable,and②sunphotometer AODs from 89 ground-based stations are used to fine-tune the DNN ***-of-station validation shows that the retrieved AOD attains high accuracy,characterized by a coefficient of determination(R2)of 0.70,a mean bias error(MBE)of 0.03,and a percentage of data within the expected error(EE)of 70.7%.A sensitivity study reveals that the top-of-atmosphere reflectance at 650 and 470 nm,as well as the surface reflectance at 650 nm,are the two largest sources of uncertainty impacting the *** a case study of monitoring an extreme aerosol event,the AGRI AOD is found to be able to capture the detailed temporal evolution of the *** work demonstrates the superiority of the transfer-learning technique in satellite AOD retrievals and the applicability of the retrieved AGRI AOD in monitoring extreme pollution events.

关键词： Aerosol optical depth Retrieval algorithm Deep learning Transfer learning Advanced Geosynchronous Radiation Imager

Propane dehydro-aromatization reaction over PtFe@S-1 coupling with Zn/ZSM-5 tandem catalysts: the role of Zn species

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FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 2024年第8期18卷 87-0页

作者： bian, Kai Liu, Sirui Fan, Huahua Zhang, Guanghui Zhang, Xinwei Ocran, Gideon Abaidoo Wang, Mingrui Liu, Quanjie Nie, Xiaowa Hou, Shuandi Guo, Xinwen Sinopec Dalian Res Inst Petr & Petrochem Dalian 116045 Peoples R China Dalian Univ Technol Frontier Sci Ctr Smart Mat DUT Joint Ctr Energy Res Sch Chem Engn Dalian 116024 Peoples R China

Unraveling the structure-activity relationship and improving the catalytic performance is paramount in propane dehydro-aromatization reactions. Herein, a tandem catalyst with high propane dehydro-aromatization reaction performance was prepared via coupling the PtFe@S-1 with Zn/ZSM-5 zeolites (PtFe@S-1&1.0Zn/ZSM-5), which exhibits high dehydrogenation activity, aromatics selectivity (similar to 60% at similar to 78% propane conversion), and stability. The addition of zinc inhibits the cleavage of C6= intermediates on ZSM-5 and promotes the aromatization pathway by weakening zeolite acid strength, significantly improving the selectivity to aromatics. This understanding of the structure-activity relationship in propane dehydro-aromatization reaction helps develop future high-performance catalysts.

关键词： propane dehydro-aromatization reaction tandem catalysts the structure-activity relationship of zinc species ZEOLITE DEHYDROGENATION HZSM-5 AROMATICS ALKANES ZSM-5 PERFORMANCE SELECTIVITY ACTIVATION ETHANE

A potential threat from biodegradable microplastics: mechanism of cadmium adsorption and desorption in the simulated gastrointestinal environment

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 63-75页

作者： Timing Jiang Xiang Wu Shushan Yuan Changfei Lai Shijie bian Wenbo Yu Sha Liang Jingping Hu Liang Huang Huabo Duan Yafei Shi Jiakuan Yang School of Environmental Science&Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Resources and Environmental Science Hubei UniversityWuhan 430062China Hubei Provincial Engineering Laboratory for Solid Waste Treatment Disposal and Recycling Wuhan 430074China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

It has been demonstrated that microplastics (MPs) can accumulate heavy metals from the environment and transfer them into organisms via the food chain. However, adsorption and desorption capacities for biodegradable MPs relative to those for conventional MPs remain poorly understood. In this study, cadmium (Cd(II)) adsorption and desorption characteristics of polylactic acid (PLA), a typical biodegradable MP, were investigated. Two conventional MPs, i.e., polypropylene (PP) and polyamide (PA) were used for comparison. The maximum Cd(II) adsorption capacities of the MPs studied in the adsorption experiments decreased in the order PA (0.96 ± 0.07 mg/g) > PLA (0.64 ± 0.04 mg/g) > PP (0.22 ± 0.03 mg/g). The Pseudo-second-order kinetic model and Freundlich isothermal model described the Cd(II) adsorption behaviors of PLA MPs well. X-ray photoelectron spectroscopy and two-dimensional Fourier transform infrared correlation spectroscopy analysis indicated that oxygen functional groups were the major and preferential binding sites of PLA MPs, which contributed to their high Cd(II) adsorption capacities. Simulated gastric and intestinal fluids both significantly enhanced the desorption capacities of the examined MPs. Notably, degradation of the PLA MPs during in vitro human digestion made the Cd(II) on the PLA MPs more bioaccessible (19% in the gastric phase and 62% in the intestinal phase) than Cd(II) on the PP and PA MPs. These results indicate the remarkable capacities of biodegradable MPs to accumulate Cd(II) and transfer it to the digestive system and show that biodegradable MPs might pose more severe threats to human health than conventional nonbiodegradable MPs.

关键词： Biodegradable microplastics Cadmium Adsorption and desorption Gastrointestinal environment Two-dimensional correlation spectroscopy Bioaccessibility

Research and Analysis on the Application of Strategic Performance Management in Enterprises

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Proceedings of Business and Economic Studies 2024年第3期7卷 86-91页

作者： Weiyi Li Jiang bian Beijing Yousong Education Technology Co. Ltd.Beijing 100193China Baidu Online Network Technology(Beijing)Co. Ltd.Beijing 100193China

In today’s competitive business environment,strategic performance management(SPM)is crucial for continuous growth and ***,it is important to realize the advantages of SPM in enterprise *** paper analyzes the theoretical basis,implementation framework,and application effects of SPM in enterprises by examining actual cases from different *** reveals the core elements of an effective performance management system,including clear goal setting,reasonable performance indicators,and periodic performance ***,the paper examines the impact of China’s specific economic policy environment on the implementation of SPM and proposes strategies to optimize performance management practices,ultimately promoting the achievement of strategic *** paper provides specific and personalized practical guidance for enterprises.

关键词： Strategic performance management Enterprise Application measures

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1560-1591页

作者： Yu Fu Jia Li Wenyun Cai Yulan Huang Xinlong Liu Zhongyi Ma Zhongjie Tang Xufei bian Ji Zheng Jiayun Jiang Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Institute of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Urology Urologic Surgery CenterXinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China

Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful infuence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in *** accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional ***,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying ***,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,infammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed *** hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

关键词： Tumor microbe microenvironment Microbiota metabolites Immunomodulation Chemoresistance Multidisciplinary approach Genetically engineered microbiota Autophagy Outer membrane vesicles

Solar-assisted selective separation and recovery of precious group metals from deactivated air puriﬁcation catalysts

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Science Bulletin 2024年第15期69卷 2379-2386页

作者： Meijun Wu Yao Chen Zhenpeng Guo Xinru Wang Hanyun Zhang Ting Zhang Shuhui Guan Zhenfeng bian Ministry of Education Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Normal UniversityShanghai 200234China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China Shanghai YK Pao School Shanghai 201620China

The mitigation of environmental and energy crises could be advanced by reclaiming platinum group precious metals(PGMs) from decommissioned air purification catalysts. However, the complexity of catalyst composition and the high chemical inertness of PGMs significantly impede this process. Consequently,recovering PGMs from used industrial catalysts is crucial and challenging. This study delves into an environmentally friendly approach to selectively recover PGMs from commercial air purifiers using photocatalytic redox technology. Our investigation focuses on devising a comprehensive strategy for treating three-way catalysts employed in automotive exhaust treatment. By meticulously pretreating and modifying reaction conditions, we achieved noteworthy results, completely dissolving and separating rhodium(Rh), palladium(Pd), and platinum(Pt) within a 12-h time frame. Importantly, the solubility selectivity persists despite the remarkably similar physicochemical properties of Rh, Pd, and Pt. To bolster the environmental sustainability of our method, we harness sunlight as the energy source to activate the photocatalysts, facilitating the complete dissolution of precious metals under natural light irradiation. This ecofriendly recovery approach demonstrated on commercial air purifiers, exhibits promise for broader application to a diverse range of deactivated air purification catalysts, potentially enabling implementation on a large scale.

关键词： Photocatalysis Air purification catalysts Platinum group precious metals Selective recovery