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A multicenter randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of rhubarb in treating acute exacerbation of chronic obstructive pulmonary disease of the syndrome type phlegm-heat obstructing the lungs

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Journal of Traditional Chinese Medical Sciences 2016年第2期3卷 71-80页

作者： Fengjie Zheng Yan Sun Xianggen Zhong Yueqi Wang ruohan wu Miao Liu Yuchao Liu Kuo Gao Yuhang Li School of Preclinical Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective:To observe the clinical efficacy and safety of oral administration of the traditional Chinese herb rhubarb to treat acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:This was a multicenter randomized double-blinded placebo controlled study that took place in 7 provinces of China that enrolled 244 patients(aged 18e80 years)who had acute exacerbation of COPD with the traditional Chinese syndrome pattern of phlegm-heat obstructing lung.Participants were divided into experimental and control groups.The experimental group received 4.5 g of rhubarb granules twice daily and the control group received placebo granules.Both groups also received conventional Western therapy consisting of oxygen therapy,an antibiotic,expectorant,and a bronchodilator.Treatment lasted 10 days.Symptom scores for cough,sputum volume and color,wheezing and chest tightness before treatment and on days 3,5,7,and 10 during the treatment were recorded.Lung function,arterial blood gas and levels of serum inflammatory factors,interleukin-4(IL-4),interleukin-8(IL-8),and interleukin-10(IL-10)and tumor necrosis factor-alpha(TNF-a),before and after treatment were measured.Results:The sample size of the full analysis set(FAS)was 244 participants,and the sample size of per protocol set(PPS)was 235.Following 10 days’treatment,symptom scores of the experimental group were markedly lower than those of the placebo group(FAS:mean difference1.67,95%CI:e2.66 to0.69,P Z 0.001;PPS:mean difference1.55,95%CI:2.56 to0.54,P Z 0.003).Lung function in the experimental group was significantly higher than in the placebo group(FEV1,FAS:mean difference 0.12,95%CI:0.06 to 0.18;P<0.001;PPS:mean difference 0.12,95%CI 0.05 to 0.18;P<0.001.FVC:FAS:mean difference 0.16,95%CI:0.06 to 0.26;P Z 0.002;PPS:mean difference 0.16,95%CI 0.05 to 0.26;P Z 0.003.FEV1%,FAS:mean difference 5.95,95%CI:3.36 to 8.53;P<0.001;PPS:mean difference 5.92,95%CI 3.28 to 8.56;P<0.001.).PaO2,PaCO2,as well as serum inflammatory factors were also improved when compared t

关键词： Traditional Chinese medicine COPD Phlegm-heat obstructing the lung syndrome Rhubarb Randomized controlled trial

Tunable Ru-Ru2P heterostructures with charge redistribution for efficient pH-universal hydrogen evolution

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InfoMat 2022年第5期4卷 164-173页

作者： Ding Chen ruohan Yu Ruihu Lu Zonghua Pu Pengyan Wang Jiawei Zhu Pengxia Ji Dulan wu Jinsong wu Yan Zhao Zongkui Kou Jun Yu Shichun Mu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshanChina Nanostructure Research Centre(NRC) Wuhan University of TechnologyWuhanChina State Key Laboratory of Silicate Materials for Architectures International School of Materials Science and EngineeringWuhan University of TechnologyWuhanChina

Designing synergistic heterogeneous catalytic interfaces is the key to developing highly compatible pH-universal electrocatalysts for complex chemical environments.Our theoretical calculation results demonstrate that the Ru-Ru2P heterointerface can not only promote the redistribution of charges,but also reduce the d-band center,and then enhances the adsorption capacity of the key intermediate.However,in situ and facile synthesis of Ru-Ru2P heterostructures is severely limited by thermodynamic obstacles.Herein,we propose a molten salt-assisted catalytic synthesis scheme,and successfully build a series of homologous metallic Ru-Ru2P heterostructure catalysts with different molar ratios of Ru to P under atmospheric pressure and low-temperature(400C).The resultant Ru-Ru2P with rich heterostructures show the Pt-like HER performance in different pH media.Particularly,it is prominent under alkaline conditions(18 mV@10 mA cm^(2)),which outperforms the Pt catalyst(37 mV@10 mA cm^(2)).Furthermore,Ru-Ru2P heterostructures also show certain potential in the electrolysis of seawater to produce hydrogen.This work represents a significant supplement of high-efficiency pH-universal HER catalysts,and provides a new light on interface engineering in energy technology fields and beyond.

关键词： DFT calculation heterostructure molten salt-assisted synthesis pH-universal hydrogen evolution ruthenium phosphide

一种移动平台红外搜索跟踪系统的稳定控制方法

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红外技术 2024年第6期46卷 634-645页

作者：熊辉李锐华刘海阎歆婕舒骏逸郑婕冯建伟冯若涵林宇吴佳俊林丹丹宋治杭张晋昆明物理研究所云南昆明650223 云南省红外探测技术应用重点实验室云南昆明650223

基于移动平台的红外搜索跟踪系统已成为新一代光电搜索跟踪系统的主流趋势,小型化和轻量化是其高机动性的保证。载体运动姿态变化耦合的角速度扰动和系统内部力矩干扰将对其搭载的光电载荷视轴稳定控制带来严峻挑战,基于多轴多框架和高... 详细信息

基于移动平台的红外搜索跟踪系统已成为新一代光电搜索跟踪系统的主流趋势,小型化和轻量化是其高机动性的保证。载体运动姿态变化耦合的角速度扰动和系统内部力矩干扰将对其搭载的光电载荷视轴稳定控制带来严峻挑战,基于多轴多框架和高精度陀螺反馈控制相结合的传统视轴稳定方法已无法适用。本文针对两轴两框架移动平台红外搜索跟踪系统的光电载荷视轴稳定控制,提出了基于平方PI和Luenberger扰动观测前馈的双速度闭环同阶串级控制方法。仿真和实验表明,相对于传统的单陀螺闭环和双速度闭环稳定控制方法,该稳定控制方法有效提升了载体运动低频扰动下的视轴稳定精度。1°/1 Hz扰动下,仿真稳定精度达到2.7817μrad,实验稳定精度达到35.85μrad。1°/2 Hz扰动下,仿真稳定精度达到38.199μrad,实验稳定精度达到119.1μrad。最终,利用本文提出的稳定控制方法,两轴两框架移动平台红外搜索跟踪系统有效克服了行进间载体运动姿态变化耦合的低频角速度扰动,实现了高平稳高动态的光电载荷视轴指向控制性能。

关键词：移动平台红外搜索跟踪系统视轴稳定同阶串级平方PI 扰动观测前馈

Research on neck dissection for oral squamous-cell carcinoma:a bibliometric analysis

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International Journal of Oral Science 2021年第2期13卷 156-162页

作者： Zhou Jiang Chenzhou wu Shoushan Hu Nailin Liao Yingzhao Huang Haoran Ding ruohan Li Yi Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Head and Neck Oncology West China Hospital of StomatologySichuan UniversityChengduChina

Neck dissection for oral squamous-cell carcinoma(OSCC)is a clinically controversial issue and has therefore been the subject of abundant research.However,no one has performed a bibliometric study on this topic to date.The aim of this study was to assess the development of research on neck dissection for OSCC in terms of the historical evolution,current hotspots and future directions,particularly including research trends and frontiers from 2010 to 2019.Literature records related to research on neck dissection for OSCC were retrieved from the Web of Science Core Collection(WoSCC).CiteSpace was used as a tool to perform a bibliometric analysis of this topic.The survey included 2096 papers.“Otorhinolaryngology”was the most popular research area.The most active institutions and countries were Memorial Sloan Kettering Cancer Center and the USA,respectively.Shah J.P.was the most cited author.Among the six identified“core journals”,Head&Neck ranked first.The top three trending keywords were‘invasion’,‘upper aerodigestive’and‘negative neck’.‘D’Cruz AK(2015)’was the most cited and the strongest burst reference in the last decade.The study evaluated the effect on survival of elective versus therapeutic neck dissection in patients with lateralized early-stage OSCC.The depth of invasion and the management of N0 OSCC were research frontiers in this field.The present study provides a comprehensive bibliometric analysis of research on neck dissection for OSCC,which will assist investigators in exploring potential research directions.

关键词： dissection invasion squamous

Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease:a four-center,randomized,double-blind,placebo-controlled study

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Journal of Traditional Chinese Medicine 2016年第4期36卷 418-426页

作者： Liu Miao Zheng Fengjie Ni Lei Sun Yan wu ruohan Zhang Tianyu Zhang Jinchao Zhong Xianggen Li Yuhang School of Preclinical Medicine Beijing University of Chinese Medicine

OBJECTIVE:To evaluate the efficacy and safety of sugarcane bagasse dietary fiber as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a multicenter,randomized,double-blind,placebo-controlled trial.A total of196 participants were randomized into a trial group(treated with 6 g/day sugarcane bagasse plus conventional treatment,n = 98) and a control group(treated with placebo plus conventional treatment,n = 98).All efficacy analyses were performed according to the intention-to-treat(ITT) principle.A per-protocol analysis set(PPS) was used to analyze the cases that completed the clinical trial with good compliance.The trial period was 30 days,with a 6-month follow-up.Pre-and post-treatmentpulmonary symptom scores(cough,sputum,wheezing,and dyspnea) were recorded for both groups.The St.George's Respiratory Questionnaire(SGRQ) and the modified Medical Research Council(m MRC) dyspnea scale were assessed before treatment and at the end of the 6-month follow-up.RESULTS:The ITT population was 178 and the PPS population was 166.Post-treatment pulmonary clinical symptoms and severity of dyspnea(m MRC and SGRQ evaluation) were significantly improved in both the trial group and the control group(ITT and PPS:P < 0.05).However,there was no statistical difference between the two groups in post-treatment pulmonary symptoms and m MRC.There was a greater reduction in the SGRQ subscales of activity,effect and total score in the trial group compared with the control group(ITT and PPS:P < 0.01).There was no statistical difference in pre-and post-treatment safety variables in either group.CONCLUSION:Sugarcane bagasse combined with conventional treatment improved quality of life in patients with stable COPD.Sugarcane bagasse appears to be a safe herbal medicine with potential for treating patients with stable COPD when taken orally as an adjuvant therapy.

关键词： Saccharum Pulmonary disease chronic obstructive Randomized clinical trial Medicine Chinese Traditional

ZIF-Mediated Anchoring of Co species on N-doped Carbon Nanorods as an Efficient Cathode Catalyst for Zn-Air Batteries

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Energy & Environmental Materials 2023年第3期6卷 257-263页

作者： Qiang Yu Jianshuai Lv Jiantao Li ruohan Yu Jinsong wu Shibo Xi Xinyuan Li Nuo Xu Liang Zhou Liqiang Ma State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China Nanostructure Research Centre Wuhan University of TechnologyyWuhan 430070China Institute of Chemical and Engineering Sciences A*STAR(Agency for ScienceTechnology and Research)Singapore 627833Singapore School of Science Wuhan University of TechnologyWuhan 430070China

Developing efficient oxygen reduction reaction(ORR)catalyst is essential for the practical application of Zn-air batteries(ZABs).In this contribution,we develop a novel zeolitic imidazolate framework(ZIF)-mediated strategy to anchor Co species on N-doped carbon nanorods for efficient ORR.Featuring ultrahigh N-doping(10.29 at.%),monodisperse Co nanocrystal decoration,and well-dispersed Co-N_(x)functionalization,the obtained Co-decorated N-doped carbon nanorods(Co@NCNR)exhibit a decent ORR performance comparable to commercial Pt/C in alkaline media.Aqueous ZABs have been assembled using Co@NCNR as the cathode catalyst.The assembled ZABs manifest high initial open-circuit voltage as well as high energy density.In addition,the Co@NCNR also demonstrates ideal ORR performance in quasi-solid-state ZABs.

关键词： Co nanocrystals Co-N_(x) N-doped carbon oxygen reduction reaction Zn-air battery

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带吸收剂存储的火电机组碳捕集系统预测控制

动力工程学报 2022年第11期42卷 1123-1130页

作者：邱若菡席涵吴啸东南大学大型发电装备安全运行与智能测控国家工程研究中心南京210096

结合系统特性和运行目标,为带吸收剂存储的火电机组碳捕集系统设计有效控制系统是实现灵活性支撑功能的关键。在深入分析带溶剂存储的碳捕集系统动态特性的基础上,提出基于吸收-解吸过程独立设计和基于系统整体设计的2种控制方法,利用... 详细信息

结合系统特性和运行目标,为带吸收剂存储的火电机组碳捕集系统设计有效控制系统是实现灵活性支撑功能的关键。在深入分析带溶剂存储的碳捕集系统动态特性的基础上,提出基于吸收-解吸过程独立设计和基于系统整体设计的2种控制方法,利用贫液质量流量和富液质量流量分别控制碳捕集率和再沸器温度,考虑到预测模型中烟气和抽汽对系统性能的影响,引入前馈作用,实现对扰动的及时补偿。结果表明:所提2种控制方法可以实现碳捕集率的快速调节并有效抑制烟气与抽汽的扰动影响,控制性能优于常规控制方法。

关键词：火电机组化学吸收碳捕集吸收剂存储预测控制灵活运行

Reservoir Characteristics and Controlling Factors of Silurian Lower Kepingtage Formation in Tahe Area, Tarim Basin, NW China

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Journal of Earth Science 2017年第6期28卷 1135-1144页

作者： ruohan Liu Zaixing Jiang Ming Wang Weili Yang Jingxiang Guo Minghao wu Yi Gao Shanyazi Wei Zhihong Nie Hong He School of Energy Resources China University of Geosciences Beijing 100083 China Institute of Earth Sciences China University of Geosciences Beijing 100083 China Exploration and Production Research Institute SINOPEC Beijing 100083 China Geophysical-China Oilfield Services Limited Tianjin 300451 China PetroChina Coalbed Methane Company Limited Beijing 100028 China

With the breakthrough of exploration in Well TP16-1, the lower Kepingtage Formation becomes a key target for petroleum exploration of deep clastic reservoir in Tahe area. In this paper we focused on the research of the reservoir characteristics and its controlling factors in two sub-member formations（S1k11 and S1k13）. Based on X-ray diffraction, conventional physical properties data（porosity and permeability） and reservoir storage space data（casting thin section and scanning electron microscope）, we determined that the S1k1 Formation belongs to extra-low porosity and permeability reservoir, although the upper S1k13 Formation shows relative better physical characteristic than the lower S1k11 Formation. The development of storage space in the study area is controlled by sedimentary microfacies, diagenesis process. Reservoirs in S1k1 Formation are mainly located in channel（S1k11 sandstones） and sand flat（S1k13 sandstones）. The sand flat sediments with a more coarse grain size compared with the channel. In diagenesis, compaction is the major controlling factor for reducing the porosity, followed by cementation. Dissolution of diagenesis is the major controlling factor in enhancing the reservoir porosities. Compared with channel（S1k11） sandstones, sand flat sandstones（S1k13） have better reservoir quality for its weaker compaction, cementation and stronger dissolution. On the basis of sedimentary characteristics（grain size and subfacies）, physical property（porosity and permeability） and reservoir storage space, we divide the S1k1 reservoir into three categories（I, II and III）. Type I reservoir is high quality reservoir. It is mainly distributed in the south area of S1k11 and S1k13 reservoir. Type II is moderate reservoir. It is located in the middle of S1k11 reservoir and in the north of S1k13 reservoir. Type III is the poor reservoir. It is only located in the north of S1k11 reservoir.

关键词： reservoir characteristics controlling factors reservoir assessment lower Kepingtage Formation Tahe area Tarim Basin

自然时效对Al-2.95Cu-1.55Li-0.57Mg-0.18Zr合金160℃人工时效的影响

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金属学报 2023年第11期59卷 1428-1438页

作者：巩向鹏伍翠兰罗世芳沈若涵鄢俊湖南大学材料科学与工程学院高分辨电镜中心长沙410012

针对Al-Cu-Li-Mg合金中自然时效对后续人工时效析出行为的影响机制问题,借助TEM、三维原子探针(3DAP)、三维重构(3DET)及力学性能测试等实验方法,系统研究了自然时效对Al-2.95Cu-1.55Li-0.57Mg-0.18Zr合金在160℃人工时效时微观组织及... 详细信息

针对Al-Cu-Li-Mg合金中自然时效对后续人工时效析出行为的影响机制问题,借助TEM、三维原子探针(3DAP)、三维重构(3DET)及力学性能测试等实验方法,系统研究了自然时效对Al-2.95Cu-1.55Li-0.57Mg-0.18Zr合金在160℃人工时效时微观组织及力学性能的影响。结果表明,自然时效形成的富Mg或Cu-Mg原子团簇及δ'相在人工时效早期溶解,导致硬度下降;随后大量的GPB区弥散均匀析出,硬度回升,随时效时间延长T1相析出,硬度进一步增加,在96 h出现第一个强化峰;随后,GPB区溶解,合金硬度降低;继续延长时效时间,T1相体积分数及板条状S相的数量增加,合金硬度再次升高,在192 h出现第二个强化峰。研究表明自然时效原子团簇可明显改变合金的人工时效析出行为及力学性能演变规律。

关键词： Al-Cu-Li-Mg合金自然时效时效析出行为原子团簇