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学科交叉视角下的特种铸造技术及其融合发展

特种铸造及有色合金 2022年第1期42卷 7-13页

作者：邢书明邢若宇北京交通大学机械与电子控制工程学院北京100044 北京科技大学分析检验中心

近年来,各种特种铸造技术互相交叉融合,均取得了巨大发展。重力铸造技术不断引入非重力因素,向加压铸造方向发展;压铸技术在保持其生产薄壁复杂件方面优势的同时,向低速和可热处理方向发展;低压和差压铸造技术向更高压方向发展;半固态... 详细信息

近年来,各种特种铸造技术互相交叉融合,均取得了巨大发展。重力铸造技术不断引入非重力因素,向加压铸造方向发展;压铸技术在保持其生产薄壁复杂件方面优势的同时,向低速和可热处理方向发展;低压和差压铸造技术向更高压方向发展;半固态铸造技术则开始淡化其"半固态"特征,向液态成形和固态成形方向融合发展。这种交叉与融合发展的物理本质是流变充型、流变凝固和流变补缩。

关键词：学科交叉低压铸造半固态铸造挤压铸造

Label-free colorimetric nanosensor with improved sensitivity for Pb^2+ in water by using a truncated 8-17 DNAzyme

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Frontiers of Environmental Science & Engineering 2019年第1期13卷 129-134页

作者： Abdul Ghaffar Memon Xiaohong Zhou Yunpeng xing ruoyu Wang Lanhua Liu Mohsin Khan Miao He Center for Sensor Tech no logy of Environment and Health State Key Joint Laboratory of ESPC School of Environment Tsinghua University Beijing 100084 China Department of Environmental Engineering NED University of Engineering and Technology Karachi 75270. Pakistan

Water pollution accidents, such as the Flint water crisis in the United States, caused by lead contamination have raised concern on the safety of drinking water distribution systems. Thus, the routine monitoring of lead in water is highly required and demands efficient, sensitive, cost-effective, and reliable lead detection methods. This study reports a label-free colorimetric nanosensor that uses unmodified gold nanoparticles (AuNPs) as indicators to enable rapid and ultra-sensitive detection of lead in environmental water. The 8-17 DNAzyme was truncated in this study to facilitate the detachment of single-stranded DNA fragments after substrate cleavage in the presence of Pb「. The detached fragments were adsorbed over AuNPs and protected against salt concentration-induced aggregation. Accordingly, high Pb^2+ would result in rapid color change from blue to pink. The established sensing principle achieved a sensitive limit of detection of 0.2×10^-9mol/L Pb^2+. with a linear working range of two orders of magnitude from 0.5×10^-9mol/L to 5×10^-9mol/L. The selectivity of the nanosensor was demonstrated by evaluating the interfering metal ions. The developed nanosensor can serve as a substitute for the rapid analysis and monitoring of trace lead levels under the drinking water distribution system and even other environmental water samples.

关键词： Colorimetric nanosensor Truncated 8-17 DNAzyme Pb^2+ detection Unmodified AuNPs

Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation

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Science China(Life Sciences) 2023年第8期66卷 1858-1868页

作者： Shijia xing Xiaolu Zheng Huifang Yan Yanquan Mo ruoyu Duan Zhixing Chen Kunhao Wang Kai Gao Tongsheng Chen Shiqun Zhao Jingmin Wang Liangyi Chen National Biomedical Imaging Center State Key Laboratory of Membrane BiologyBeijing Key Laboratory of Cardiometabolic Molecular MedicineInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijing 100871China Department of Pediatrics Peking University First HospitalBeijing 100034China PKU-IDG/McGovern Institute for Brain Research Beijing 100871China National Biomedical Imaging Center Institute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijing 100871China Key Laboratory of Laser Life Science Ministry of EducationCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China National Center for Children’s Health Department of NeurologyBeijing Children’s HospitalCapital Medical UniversityBeijing 100045China

Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin *** identified as a lysosomal protein,the TMEM106B D252N mutant has recently been associated with ***,how lysosomal TMEM106B facilitates myelination and how the D252N mutation disrupts that process are poorly *** used superresolution Hessian structured illumination microscopy(Hessian-SIM)and spinning discconfocal structured illumination microscopy(SD-SIM)to find that the wild-type TMEM106B protein is targeted to the plasma membrane,filopodia,and lysosomes in human *** D252N mutation reduces the size of lysosomes in oligodendrocytes and compromises lysosome changes upon starvation *** importantly,we detected reductions in the length and number of filopodia in cells expressing the D252N ***1 is the most abundant myelin protein that almost entirely colocalizes with TMEM106B,and coexpressing PLP1 with the D252N mutant readily rescues the lysosome and filopodia phenotypes of ***,interactions between TMEM106B and PLP1 on the plasma membrane are essential for filopodia formation and myelination in oligodendrocytes,which may be sustained by the delivery of these proteins from lysosomes via exocytosis.

关键词： superresolution imaging oligodendrocyte TMEM106B lysosome filopodia

AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong Carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang ruoyu Zhou Xiaoshu Zhou Fengling Wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

数字普惠金融、劳动力流动与产业结构优化——基于新经济地理视角的实证分析

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经济问题探索 2023年第4期 142-156页

作者：邢赵婷钟若愚山西财经大学经济学院太原030006 深圳大学经济学院广东深圳518055

在新一轮科技革命背景下,数字普惠金融的发展为我国产业结构带来新的机遇和挑战。数字普惠金融能降低多种经济成本,提高资源配置效率,促进劳动力的流动,加速生产要素在行业间的分配影响着产业结构的演变,进而影响着经济增长。基于此,以... 详细信息

在新一轮科技革命背景下,数字普惠金融的发展为我国产业结构带来新的机遇和挑战。数字普惠金融能降低多种经济成本,提高资源配置效率,促进劳动力的流动,加速生产要素在行业间的分配影响着产业结构的演变,进而影响着经济增长。基于此,以新经济地理学理论为基础,研究数字普惠金融、劳动力流动与产业结构优化的作用机理,检验了数字普惠金融是否会影响产业结构优化,以及是否存在中介效应及空间溢出效应。实证研究发现:(1)信息服务成本高于冰山交易成本时,就形成了相对完善的地区分工,当全地区数字普惠金融产品消费占比充足时,数字普惠金融部门逐步向外围地区部分分散,形成新的产业结构;(2)劳动力流动是数字普惠金融发挥作用的有效中介渠道。数字普惠金融不仅对产业结构优化产生直接影响,还通过劳动力流动产生间接影响,从而提高产业结构优化效率;(3)数字普惠金融能够影响区域产业结构优化,能够对本地产生促进作用,但短期内对周边地区作用不甚显著。研究结果为新兴工业化国家促进信息化和工业化的融合,为转型和升级制造业提供了新的见解。

关键词：数字普惠金融劳动力流动产业结构优化新经济地理学空间计量

Live-cell superresolution pathology reveals different molecular mechanisms of pelizaeus-merzbacher disease

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Science Bulletin 2020年第24期65卷 2061-2064,M0004页

作者： Xiaolu Zheng ruoyu Duan Liuju Li Shijia xing Haoran Ji Huifang Yan Kai Gao Jianyong Wang Jingmin Wang Liangyi Chen State Key Laboratory of Membrane Biology Beijing Key Laboratory of Cardiometabolic Molecular MedicineInstitute of Molecular MedicinePeking UniversityBeijing 100871China Department of Pediatrics Peking University First HospitalBeijing 100034China School of Software and Microelectronics Peking UniversityBeijing 100871China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100034China Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases Peking University First HospitalPeking University First HospitalBeijing 100083China PKU-IDG/McCovem Institute for Brain Research Beijing 100871China

Modern cellular pathology relies on conventional microscopes to study the etiology and pathogenesis of diseases,which suffer from limited spatial resolution,little dynamic information due to sample fixation,and the lack of molecular *** example,Pelizaeus-Merzbacher disease(PMD)is a genetic disorder of the central nervous system caused by different duplications or mutations of the proteolipid protein 1 gene(PLP1)in oligodendrocytes,which leads to hypomyelination and leukodystrophy in patients classified into either classical,transitional,or connatal phenotype[1].However,the correlations between genotypes and phenotypes at cellular level remain elusive.

关键词：精准治疗超分辨率病理学通用工具药物筛选细胞病理临床分型光漂白

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锚点位置对大跨度斜拉桥成桥线形的影响

铁道建筑 2024年第11期64卷 63-67页

作者：邢龙飞苑仁安韩若愚中铁大桥勘测设计院集团有限公司武汉430056 桥梁智能与绿色建造全国重点实验室武汉430056

为研究大跨度斜拉桥由名义锚点转化为实际锚点位置时的线形变化,首先从力的三要素出发,分析斜拉索设计过程中由于锚点位置转变导致桥梁线形偏差的原因,然后结合工程算例对不同试验工况下锚点位置转变引起的线形偏差进行计算分析。结果表... 详细信息

为研究大跨度斜拉桥由名义锚点转化为实际锚点位置时的线形变化,首先从力的三要素出发,分析斜拉索设计过程中由于锚点位置转变导致桥梁线形偏差的原因,然后结合工程算例对不同试验工况下锚点位置转变引起的线形偏差进行计算分析。结果表明:在斜拉索设计时须充分考虑梁端锚点预偏与锚垫板厚度对斜拉索实际锚点和下料长度的影响,否则斜拉索可能会出现设计不合理的问题,导致实际锚点位置的成桥线形发生较大偏差。

关键词：斜拉桥锚点位置数值模拟斜拉索设计成桥线形施工控制

相机稳像系统中陀螺信号的实时采集与数据优化

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传感技术学报 2009年第10期22卷 1422-1425页

作者：谢洪波胡兴罗青马若玉天津大学精密仪器与光电子工程学院光电信息技术科学教育部重点实验室天津300072

陀螺信号的采集与处理对于整个图像稳定系统的性能具有决定性作用。本文设计了一种应用于相机光学图像稳定系统中的陀螺信号实时采集处理器的系统方案;采用低成本的压电陀螺,运用高精度模/数转换模块和高性能数字信号处理器(DSP)对传感... 详细信息

陀螺信号的采集与处理对于整个图像稳定系统的性能具有决定性作用。本文设计了一种应用于相机光学图像稳定系统中的陀螺信号实时采集处理器的系统方案;采用低成本的压电陀螺,运用高精度模/数转换模块和高性能数字信号处理器(DSP)对传感器数据进行了采集;运用基于离散小波变换的实时滤波算法对姿态测量数据进行了优化处理,为后续姿态测量精度的提高提供了基础。

关键词：光学稳像惯性测量小波滤波陀螺信号处理

不同光强处理对长茎葡萄蕨藻叶绿素荧光特性的影响

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中国水产科学 2017年第4期24卷 783-790页

作者：苏醒邹潇潇朱军黄惠琴刘若愚鲍时翔海南大学热带农林学院中国热带农业科学院热带生物技术研究所

通过调制叶绿素荧光仪(MINI-PAM),对长茎葡萄蕨藻(Caulerpa lentillifera)在10μmol/(m~2·s)、120μmol/(m~2·s)、360μmol/(m~2·s)光强下的叶绿素荧光特性进行了研究。结果表明:随着光照强度从10μmol/(m~2·s)上升到360μmol/(m~2·s),长茎葡萄蕨藻最大光量子产量(F/F)、实际光量子产量、相对电子传递速率(rETR)、快速光曲线初始斜率均呈下降趋势;用120μmol/(m~2·s)和360μmol/(m~2·s)光强处理的样品光化学猝灭(qP)较高,而非光化学猝灭(NPQ)较低;不同光强处理4 h和8 h时,与10μmol/(m~2·s)处理组相比,120μmol/(m~2·s)处理组最大相对电子传递速率(rETR)、半饱和光强(I)均显著上升,360μmol/(m~2·s)处理组I显著上升,rETR明显降低;在360μmol/(m~2·s)光强下处理12 h与处理8 h相比,样品rETR、I均显著降低。上述结果说明长茎葡萄蕨藻偏向适应10μmol/(m~2·s)的低光条件,在120μmol/(m~2·s)和360μmol/(m~2·s)的高光条件下能通过不同的方式提高对光强的耐受能力,但是在360μmol/(m~2·s)光强下处理12 h会引起光氧化对光合结构造成破坏。

关键词：长茎葡萄蕨藻光强光胁迫光合作用叶绿素荧光