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Integrated Skin Microbiome-Metabolome Analysis Reveals Altered Bacterial Community Composition and Metabolites in Psoriasis

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International Journal of Dermatology and Venereology 2023年第4期6卷 181-188页

作者： Rong Tao Zhe Wan ruo-yu li ruo-Jun Wang Department of Dermatology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Dermatology Peking University First HospitalNational Clinical Research Center for Skin and Immune DiseasesBeijing Key Laboratory of Molecular Diagnosis on DermatosesNMPA Key Laboratory for Quality Control and Evaluation of CosmeticsBeijing 100034China

Objective:Current theories highlight the role of the microbiome in the pathogenesis of ***,abnormal metabolism can alter disease processes in terms of occurrence,progression,and ***,an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for ***:We recruited 22 patients with psoriasis and 22 age-and sex-matched healthy *** swabs were collected from the participants’*** samples underwent amplicon sequencing of the internal transcribed spacer 1 and V3V416S rRNA regions and metabolome *** amplicon data,analysis of the alpha diversities,microbial community structures and principal coordinate analysis were *** metabolites and pathway enrichment were analyzed for metabolome *** test and Wilcoxon rank sum test were used for statistical ***:The psoriatic lesions were characterized by higher bacterial diversity,significantly higher abundances ofCorynebacterium(Plites,nucleotides,and cysteine-and methionine-related metabolites were significantly enriched in patients with psoriasis,and these metabolites were positively correlated with the disease-associated bacteriaStaphylococcus ***:We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.

关键词： skin microbiome skin metabolome psoriasis

White-opaque Switching in Different Mating Type-like Locus Gene Types of Clinical Candida albicans Isolates

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Chinese Medical Journal 2016年第22期129卷 2725-2732页

作者： Hou-Min li yumi Shimizu-Imanishi Reiko Tanaka ruo-yu li Takashi Yaguchi Department of Dermatology Peking University People's Hospital Beijing 100044 China Medical Mycology Research Center Chiba University Chiba 260-8673 Japan Department of Dermatology Peking University First Hospital Beijing 100034 China

Background：Candida albicans （***） can become a pathogen causing superficial as well as life-threatening systemic infections,especially in immunocompromised *** phenotypic attributes contribute to its capacity to colonize human *** our study,93 *** isolates from patients of various candidiasis in a hospital of China were *** aimed to investigate the white-opaque （WO） switching competence,drug sensitivity,and virulence of mating type-like （MTL） a/α ***：Internal transcribed spacer （ITS） gene and the MTL configuration were detected in all the isolates by reverse transcription-polymerase chain ***/opaque phenotype and doubling time of cell growth were *** minimum inhibitory concentrations of antifungal agent were measured using broth microdilution ***：Sixty-four isolates （69.6%） were classified to serotype A,19 （20.6%） to serotype B,and 9 （9.8%） to serotype ***,phylogenetic analysis showed that these isolates were divided into four different subgroups of ITS *** of our clinical isolates were MTLa/α type,while 6.8% remained MTLa or MTLα *** frequency of opaque phenotype was 71.0% （66 isolates）.Following the guidelines of Clinical and Laboratory Standards Institute M27-A3,all isolates were susceptible to caspofungin and a few （0.6-3.2%） of them showed resistance against amphotericin B,flucytosine,fluconazole,itraconazole,and ***：From these analyses,there were comparatively more *** strains classified into serotype B,and the frequency of opaque phase strains was significant in the clinical isolates from ***,phenotypic,or drug susceptibility patterns were not significantly different from previous ***/α isolates could also undergo WO switching which facilitates their survival.

关键词： Candida albicans Drug Susceptibility Genotype Mating Type-like White-opaque

Trichosporon montevideense isolated from the descending colon of a patient with active severe Crohn disease:a case report

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Chinese Medical Journal 2020年第10期133卷 1245-1247页

作者： Sheng-Duo He ruo-yu li Yan Chi Zhe Wan Hua-Hong Wang Department of Gastroenterology Peking University First HospitalBeijing 100034China Department of Dermatology and Venereology Peking University First HospitalBeijing 100034China Research Center for Medical Mycology Peking UniversityBeijing 100034China.

To the Editor:A 13-year-old girl with Crohn disease(CD)from Shandong Province transferred to our inflammatory bowel disease(IBD)center during April *** months previously,the patient presented with hematochezia and fever,but antibiotic treatment was *** admission,a colonoscopy indicated manifestations of segmental lesions,cobble stoning,and stricture[Figure 1 A].Cytomegalovirus,Epstein-Barr virus,Clostridium difficile^and amoebae were excluded as possible *** were also no indications of Behcet disease,systemic vasculitis,or other autoimmune *** initial diagnosis was active severe CD(Vienna typing,A1L3B2).This study was approved by the Ethical Committee of First Hospital of Peking University(No.2019153).An appropriate signed patient consent form was obtained.

关键词： Figure transferred patient

Treatment of portal hypertension from portal vein cavernoma with the meso-Rex bypass

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Chinese Medical Journal 2013年第5期126卷 971-973页

作者： li Jin-liang CHEN Wei-xiu XU Chang-xian WANG ruo-yi CHEN yu-li Division of Pediatric Surgery Department of Surgery SecondHospital and Medical School of Shandong University JinanShandong 250033 China

Extrahepatic or prehepatic portal vein cavernoma and thrombosis is a more common condition in children than that in adult patients with extrahepatic or prehepatic portal vein obstruction （EHPVO）, which involves approximately 30% of children with portal hypertension and can involve all the portal hypertension complications. Cavernomatous transformation of the portal vein is common after portal thrombosis in non-cirrhotic patients. This challenging situation is relatively more frequent after liver transplantation, particularly in pediatric recipients. Acute bleeding from esophageal and gastric varices is temporarily treated by sclerotherapy or variceal banding. Children who experience continued bleeding despite medical management or who experience clinically significant hypersplenism are referred for surgery.

关键词： hypertension portal extrahepatic bypass surgery

Erratum to “Photoenzymatic RAFT Emulsion Polymerization with Oxygen Tolerance”

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Chinese Journal of Polymer Science 2024年第4期42卷 558-558页

作者： ruo-yu li Ze-Sheng An State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun130012China Institute of Nanochemistry and Nanobiology College of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China

The authors regret that the name of the polymers in Table S3 was incorrectly written in the original electronic supplementary information(ESI).The corrected version of Table S3 is provided *** text corrections are not... 详细信息

关键词： correction Oxygen enzymatic

Minimum five-year follow-up of multi-segmental lumbar disc degenerationtreated with discectomy andWallis

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Minimum five-year follow-up of multi-segmental lumbar disc d...

The homology analysis of internal transcribed spacer sequence of ribosomal DNA in common dermatophytes

第二十一届全国中西医结合骨伤科学术研讨会暨骨伤科分会换届大会

作者： yun-qi Jiang Wu Che Hui-ren Wang ruo-yu li Hong lin Jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan University

Study Design Retrospective *** To evaluate the clinical effects and radiological findings of Wallis for the treatment of multi-segmental lumbar disc degeneration after a minimum five-year *** of Background Data Lumbar fusion for lumbar disc degeneration is a common *** surgery,many complicationsmight arise;therefore,differentmethodsfordynamicfixationhavebeen *** has been designed to improve segmental stability while preserving intervertebral mobility after *** could reduce the incidence of adjacent segment *** A total of 26 adult patients with complete data underwent primary discectomy followed by fixation of the segment with Wallis between December 2007 and August *** males and 14femaleswithanagerangeof43to 56years(average47.6)*** visual analogue scale(VAS)for low back and leg pain,Oswestry Disability Index(ODI),foraminal height(FH),anterior disc height(aDH)and posterior disc height(pDH),range of motion(ROM)and Pfarmanngradewereobtainedandcomparedbefore andafter *** The VAS and ODIdecreased postoperatively with statistical significance(p0.05).The postoperative FH and pDH increased with statistical significance compared with the preoperative levels(P0.05).There were no statistically significant changes in the range ofmotion andthe Pfurmann grade atthe instrumented level and the cephalad-adjacent segment(p>0.05).In our study,no patient underwent further surgery because of a re-prolapse or progression of degeneration ofthe index level and adjacent segment *** Wallis was a good alternative for treating multi-segmental lumbar disc degeneration,and it offered significantandlo

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Journal of Microbiology and Immunology 2006年第2期4卷 110-116页

作者： QIANG WANG ZHAO HUI JI HOU MIN li li JUAN ZHANG WEI liU ZHE WAN XIAO HONG WANG DUAN li WANG ruo yu li Department of Dermatology the First Hospital of Peking University Beijing P. R. China Department of Dermatology Shenyang No. 7 People＇s Hospital Shenyang P. R. China Systematic Mycology and lichenology Laboratory Institute of Microbiology Chinese Academy of Sciences Beijing P. R. China

In order to analyze the sequences of the internal transcribed spacer （ITS） including the 5.8 S ribosomal DNA （rDNA） of common dermatophytes, so as to obtain a rapid and accurate method to identify the species of dermatophytes and to establish the phylogenetic tree of these species to understand their relationship, 16 strains of dermatophytes were collected and preliminarily identified by morphological characteristics. General primers for fungi ITS1 and ITS4 were used to amplify the ITS rDNA of each strains with PCR. The PCR products after purification were sequenced directly and were analyzed through internet. In the results, 11 strains were identified by means of morphological features, among which 5 strains were Trichophyton, 5 strains were Microsporum and 1 was Epidermophytoa, which was consistent with the results by molecular biology. In the 5 unidentifiable strains, 1 strain was proved to be Chrysosporium by molecular biology. These strains studied could be divided into 3 different classes as indicated in the analysis of the phylogenetic tree of the sequences in ITS, which were quite different from those of morphological classification. It is evident from the above observations that the molecular method of analysis on the ITS sequences is a rapid, highly sensitive and accurate approach for the detection of dematophyte species, however, it still exhibits some limitations needing the supplementation with morphological identification.

关键词： Dermatophyte Internal transcribed spacer sequence identification Phylogenetic tree

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探寻人类病原真菌——一项漫长的研究之旅

菌物学报 2019年第8期38卷 1211-1212页

作者：席丽艳李若瑜中山大学孙逸仙纪念医院皮肤性病科广东广州510120 北京大学第一医院皮肤性病科北京大学真菌和真菌病研究中心北京100034

随着临床上各种原因导致的免疫受损宿主不断增多,真菌感染尤其是条件致病性真菌所引起的侵袭性真菌感染日益增多,且具有诊断耗时、疗效差、治疗费用高等特点,已成为严重影响人类生活质量、威胁生命健康的全球共同关注的重要健康问题。据... 详细信息

随着临床上各种原因导致的免疫受损宿主不断增多,真菌感染尤其是条件致病性真菌所引起的侵袭性真菌感染日益增多,且具有诊断耗时、疗效差、治疗费用高等特点,已成为严重影响人类生活质量、威胁生命健康的全球共同关注的重要健康问题。据悉,全世界每年由真菌引起的致命性侵袭性真菌感染超过250万例,单在美国,每年有超过160万人死于严重真菌感染,花费超过7亿美金。

关键词：病原真菌人类真菌感染致病性真菌生活质量侵袭性致命性健康

Spontaneous viral clearance after 6-21 years of hepatitis B and C viruses coinfection in high HBV endemic area

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World Journal of Gastroenterology 2003年第9期9卷 2012-2016页

作者： Chun-Lei Fan Lai Wei Dong Jiang Hong-Song Chen Yan Gao ruo-Bing li yu Wang Institute of Hepatology,People’s Hospital,Peking University,Beijing 100044,China Institute of Hepatology People's Hospital Peking University Beijing 100044 China.

AIM: To investigate the clinical and virological course of coinfection by hepatitis B virus (HBV) and hepatitis C virus (HCV) in ***: We enrolled 40 patients with chronic HBV and HCV coinfection (Group BC), 16 patients with chronic HBV infection (Group B) and 31 patients with chronic HCV infection (Group C). They infected HBV and/or HCV during 1982 to *** of all the 87 patients were collected in 1994 and 2002respectively. We detected biochemical and virologic markers and serum HBV DNA and HCV RNA levels of all the patients. Btype ultrasound detection was performed in some ***: In Group BC, 67.5% of the patients cleared HBsAg,and 92.5% of the patients cleared HBeAg. The clearance rate of HBV DNA was 87.5%. There was no significant difference of HBV clearance between Group BC and Group B. In Group BC, 85.7% of males and 47.4% of females cleared HBV, and males were easier to clear HBV (x2=6.686, P=0.010). Such a tendency was also found in Group B. The clearance rate of HCV RNA in Group BC was 87.5%, significantly higher than that in Group C (x2=22.963, P＜0.001). Less than 40% of the patients in all groups had elevated liver enzyme values. The highest value of alanine aminotransferase (ALT) was 218 u/L (normal range for ALT is 0-40 u/L). In most patients the ultrasonogram presentations changed ***: The clinical manifestations of patients with HBV/HCV coinfection are mild and occult. High clearance rate of HBV and easy to clear HBV in male patients are the characteristics of HBV infection in adults in China. HBV can inhibit HCV replication, but no evidence has been found in our data that HCV suppresses HBV replication.

关键词：乙型肝炎病毒丙型肝炎病毒同时感染临床研究病理学中国