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Comprehensive silk gland multi-omics comparison illuminates two alternative mechanisms in silkworm heterosis

Zoological Research 2022年第4期43卷 585-596页

作者： han Xu Lei Chen Xiao-Ling Tong Hai Hu Li-Yuan Liu Gui-Chun Liu Ya-Nan Zhu ruo-Ping Zhao Wen Wang Fang-yin Dai Xin Li Hui Xiang School of Medicine Shenzhen Campus of Sun Yat-Sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China School of Ecology and Environment Northwestern Polytechnical UniversityXi’anShaanxi 710072China State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest UniversityChongqing 400715China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Heterosis is a common phenomenon in plants and animals with diverse underlying ***,we applied two widely used silkworm hybrid systems and performed multi-omics analysis to identify possible intrinsic associations between different hybrid strategies and epigenetic mechanisms with silkworm *** found significant differences in the silk gland transcriptomic landscape between the two systems,including differentially expressed genes and expression patterns in the hybrid offspring compared to their *** the quaternary hybrid system,hybrid vigor was primarily due to upregulated genes and the parent-dominant upregulated expression pattern,involving multiple transport processes,cellular nitrogen compound catabolism,glucose metabolism,and tricarboxylic acid *** the binary system,hybrid vigor was mainly due to the down-regulated genes and transgressively down-regulated expression pattern,mainly involving basic nitrogen synthesis metabolism and body *** also demonstrated that DNA methylation may affect hybrid vigor by regulating the expression of several heterosis-related ***,this study revealed two alternative mechanisms that may contribute to silkworm heterosis,both of which facilitate the efficient utilization of energy and nitrogen for silk production.

关键词： Heterosis Silkworm Hybrid systems Multi-omics Silk production

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Combined hamartoma of the retina and retinal pigment epithelium:A case report

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World Journal of Clinical Cases 2023年第8期11卷 1788-1793页

作者： Qing Ren Ning han Rui Zhang ruo-Fan Chen Peng Yu Department of Ophthalmology The Second Hospital of Jilin UniversityChangchun 130022Jilin ProvinceChina

BACKGROUND Combined hamartoma of the retina and retinal pigment epithelium(CHRRPE)is a rare congenital benign tumor which is commonly *** CHRRPE comprises slightly raised lesions at the posterior pole,with proliferation membrane often leading to vascular *** severe cases,macular edema,macular hole,retinal detachment or vitreous hemorrhage may *** with atypical clinical manifestations are prone to misdiagnosis by inexperienced *** SUMMARY A 33-year-old man reported onset of right eye blurred vision for one week *** segment and intraocular pressure were normal in both *** eye fundus photography was *** eye ophthalmoscopy showed vitreous hemorrhage and off-white raised retinal lesions below the optic *** membranes on the lesion surfaces resulted in superficial retinal detachment and tortuosity and occlusion of peripheral blood vessels.A horseshoe-like tear in the temporal periphery was surrounded by retinal *** coherence tomography revealed retinal thickening at the focal site with structural disturbance indicated by high *** eye ultrasound showed retinal thickening at the lesion,stretching and uplifting of the proliferative membrane,with moderately patchy echo at the optic disc *** and antibodies were detected in vitreous fluids during the operation to rule out other *** fluorescein angiography(FFA)at postoperative follow-up led to final diagnosis of *** FFA is helpful in diagnosing retinal and retinal pigment epithelial combined *** addition,other cytokine and etiological tests facilitate further differential diagnosis to rule out other suspected diseases.

关键词： Combined hamartoma of the retina and retinal pigment epithelium Ocular toxoplasmosis Fundus fluorescein angiography Vitreous hemorrhage Retinal tears Case report

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饲用酶制剂在鸡肠道健康中的调控作用研究进展

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饲料研究 2024年第10期47卷 144-149页

作者：赵净颖李丰耘赵若含柴倩兰玉龄贾俊静豆腾飞云南农业大学动物科学技术学院云南昆明650201 云南省西双版纳州勐腊县畜牧兽医站云南西双版纳666300

家禽胃肠道是将摄入的饲料转化为机体维持生长和繁殖所需营养物质的重要系统。鸡的胃肠道中定植着种类丰富且数量繁多的微生物群,这些微生物群在宿主机体的健康和功能方面起着重要作用。饲用酶制剂是一类具有生物催化能力的蛋白质,具有... 详细信息

家禽胃肠道是将摄入的饲料转化为机体维持生长和繁殖所需营养物质的重要系统。鸡的胃肠道中定植着种类丰富且数量繁多的微生物群,这些微生物群在宿主机体的健康和功能方面起着重要作用。饲用酶制剂是一类具有生物催化能力的蛋白质,具有高效、安全、无毒、无残留、绿色等优点,可调节饲料的理化性质,影响肠道组织结构,调节肠道内源酶活性和肠道菌群,从而改善家禽肠道健康以及生产性能。文章对鸡胃肠道组成和功能、肠道微生物分布以及酶制剂对鸡肠道健康的调控作用进行综述,以期为酶制剂对肠道健康调控的进一步研究提供参考。

关键词：鸡肠道健康肠道微生物酶制剂

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Hole fertilization in the root zone facilitates maize yield and nitrogen utilization by mitigating potential N loss and improving mineral N accumulation

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Journal of Integrative Agriculture 2023年第4期22卷 1184-1198页

作者： SHI Wen-xuan ZhanG Qian LI Lan-tao TAN Jin-fang XIE ruo-han WANG Yi-lun College of Resources and Environment Henan Agricultural UniversityZhengzhou 450002P.R.China School of Agriculture Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107P.R.China

Reducing environmental impacts and improving N utilization are critical to ensuring food security in *** root-zone fertilization has been considered an effective strategy to improve nitrogen use efficiency (NUE),the effect of controlled-release urea (CRU) applied in conjunction with normal urea in this mode is ***,a 3-year field experiment was conducted using a no-N-added as a control and two fertilization modes (FF,furrow fertilization by manual trenching,i.e.,farmer fertilizer practice;HF:root-zone hole fertilization by point broadcast manually) at 210 kg N ha^(–1) (controlled-release:normal fertilizer=5:5),along with a 1-year in-situ microplot *** yield,NUE and N loss were investigated under different fertilization *** results showed that compared with FF,HF improved the average yield and N recovery efficiency by 8.5 and 22.3%over three years,*** had a greater potential for application than FF treatment,which led to increases in dry matter accumulation,total N uptake,SPAD value and *** addition,HF remarkably enhanced the accumulation of ^(15)N derived from fertilizer by 17.2%compared with FF,which in turn reduced the potential loss of^(15)N by 43.8%.HF increased the accumulation of N in the tillage layer of soils at harvest for potential use in the subsequent season relative to ***,HF could match the N requirement of summer maize,sustain yield,improve NUE and reduce environmental N loss ***,root-zone hole fertilization with blended CRU and normal urea can represent an effective and promising practice to achieve environmental integrity and food security on the North China Plain,which deserves further application and investigation.

关键词： maize yield hole fertilization NUE ^(15)N-labeled blended urea ^(15)N loss

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基于生命体征时序数据的创伤致死性大出血伤情动态预测模型开发及验证

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解放军医学杂志 2024年第6期49卷 629-635页

作者：郭程娱龚明慧沈翘楚韩辉王若琳张红亮王俊康李春平黎檀实南开大学医学院天津300071 解放军总医院第一医学中心急诊科北京100853 清华大学软件学院北京100083

目的基于生命体征时序数据和机器学习算法建立创伤致死性大出血伤情动态预测模型。方法回顾性分析重症监护医疗信息(MIMIC-Ⅳ)数据库2008-2019年7522例创伤伤员的生命体征时序数据,并按照创伤后是否发生致死性大出血事件分为致死性大出... 详细信息

目的基于生命体征时序数据和机器学习算法建立创伤致死性大出血伤情动态预测模型。方法回顾性分析重症监护医疗信息(MIMIC-Ⅳ)数据库2008-2019年7522例创伤伤员的生命体征时序数据,并按照创伤后是否发生致死性大出血事件分为致死性大出血组(n=283)与非致死性大出血组(n=7239)。采用逻辑回归(LR)、支持向量机(SVM)、随机森林(RF)、自适应提升(AdaBoost)、门控循环单元(GRU)、门控循环单元-D(GRU-D)共6种机器学习算法开发创伤致死性大出血伤情动态预测模型,对创伤伤员未来T小时(T=1、2、3)发生致死性大出血伤情的风险进行动态预测。通过准确率、敏感度、特异度、阳性预测值、阴性预测值、约登指数以及受试者工作特征(ROC)曲线下面积(AUC)评估模型性能。基于解放军总医院创伤数据库对模型进行外部验证。结果MIMIC-Ⅳ数据集中,基于GRU-D算法开发的一组动态预测模型效果最优,预测未来1、2和3 h发生致死性大出血的AUC分别为0.946±0.029、0.940±0.032和0.943±0.034,且差异无统计学意义(P=0.905)。创伤数据集中,GRU-D模型取得了最佳外部验证效果,预测未来1、2和3 h发生致死性大出血的AUC分别为0.779±0.013、0.780±0.008和0.778±0.009,且差异无统计学意义(P=0.181)。该组模型已部署在公开的网页计算器和医院急诊科信息系统中,便于公众和医护人员使用和验证。结论成功开发并验证了一组动态预测模型,可对创伤致死性大出血伤情进行早期诊断和动态预测。

关键词：创伤大出血机器学习辅助诊断

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Non-spherical symmetry development of underwater shock waves created by laser-induced breakdown

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Journal of Hydrodynamics 2023年第1期35卷 76-82页

作者： ying-xue Wang Di-xi han Jian-hua Liu Qiang Zhong Zhi-feng Yao ruo-fu Xiao Fu-jun Wang College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China China Ship Scientific Research Centre Wuxi214082China Taihu Laboratory of Deepsea Technological Science Wuxi214082China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing100083China

As a controllable alternative to cavitation collapse-induced shock waves,numerous cavitation studies on laser-induced breakdown have been carried out in *** the laser focusing region is not spherical,the shock waves caused by laser breakdown also exhibit non-spherical symmetry ***,some researchers have proposed the linear superposition theory based on the far field measurement data to explain this asymmetry,assuming that it is essentially the linear superposition of multiple wave fronts caused by multiple points of laser-induced breakdown that leads to the asymmetric propagation of shock *** this study,measurements of shock wave propagation processes with different breakdown energies are carried out based on a nanosecond resolution photogrammetry system,and the propagation velocities of shock waves in different directions are directly measured using a double exposure technique on a single *** the experiment,the velocity of the shock wave at the beginning of the breakdown was measured up to nearly 4000 m/*** early shock wave front was ellipsoidal,and the propagation velocity in the laser incident direction was generally slower than that in the perpendicular direction,decaying to the speed of sound in water within 1000 ns after the breakdown,and the wave front gradually approached to a *** variability of the shock wave front pressure ratio in the laser propagation direction and the vertical direction implies that the linear superposition theory applicable to the far field is not applicable to the near *** may be more complex mechanism for the near-field shock wave propagation process.

关键词： Underwater shock wave non-spherical symmetry velocity decay linear superposition laser breakdown

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Reasonable suppression of polysulfides/polyselenides shuttle based on MXene in Na-SeS_(2)batteries

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Rare Metals 2023年第5期42卷 1594-1602页

作者： Qiu-Ju Yang Jing Zhao Wei Gao Wei Zhong Yu-ruo Qi Jin han Shu-Juan Bao Mao-Wen Xu School of Materials and Energy Southwest UniversityChongqing400715China Helmholtz Institute Ulm Ulm89081Germany Karlsruhe Institute of Technology Karlsruhe76021Germany

Metal-sulfur/selenium batteries have become the focus of new-generation energy storage systems due to the advantages of low-cost and high energy ***,it still suffers from the notorious shuttle of polysulfides/polyselenides,poor electronic conductivity and tremendous volume ***,a dual defense system for polysulfides/polyselenides was proposed and constructed based on *** nitrogen-doped porous carbon(NPC)decorated by Ti_(3)C_(2)T_(x)MXene(M@NPC)was employed as the SeS_(2)host(SeS_(2)@M@NPC).Particularly,Ti_(3)C_(2)T_(x)sheets wrapped on NPC guarantee the rapid ion diffusion and serve as the first barrier for SeS_(2)and dissolved sodium polysulfides/***,the few-layered Ti_(3)C_(2)T_(x)sheets coated on glass fiber separators act as the second barrier for alleviating the shuttle of polysulfides/polyselenides through physical interception and chemical *** this elaborate design,the integrated Na-SeS_(2)battery achieves a high specific capacity of 1243 mAh·g^(-1)at 1.0C,revealing a distinct superiority over its counterparts(SeS_(2)@M@NPC,1083mAh·g^(-1)at 0.5C;and SeS_(2)@NPC,823 mAh·g^(-1)at 0.5C).The findings gained in this work provide a creative idea for the construction of durable room-temperature Na-SeS_(2)batteries based on MXenes and their derivative materials.

关键词： MXene Integrated strategy Shuttle effect Room temperature(RT)Na-SeS_(2)batteries

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A fiber-reinforced solid polymer electrolyte by in situ polymerization for stable lithium metal batteries

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Nano Research 2023年第7期16卷 9259-9266页

作者： Yifan Xu ruo Zhao Lei Gao Tingsong Gao Wenjuan Wang Juncao Bian Songbai han Jinlong Zhu Qiang Xu Yusheng Zhao Institute for Advanced Study Shenzhen UniversityShenzhen 518055China Guangdong Provincial Key Laboratory of Energy Materials for Electric Power Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and DevicesAcademy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Micro/Nano-Porous Functional Materials Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Materials Science and Engineering Peking UniversityBeijing 100871China

Solid polymer electrolytes(SPEs)by in situ polymerization are attractive due to their good interfacial contact with *** reported in situ polymerized SPEs,however,suffer from the low polymerization degree that causes poor mechanical strength,Li dendrite penetration,and performance decay in Li-metal *** highly polymerized SPEs are more stable than lowly polymerized ones,they are restricted by their sluggish long-chain mobility and poor ionic *** this work,a three-dimensional fibrous membrane with ion selectivity was prepared and used as a functional filler for the in situ formed *** obtained SPE has high stability due to its high polymerization degree after the long-term heating *** fibrous membrane plays a vital role in improving the SPE’s *** rich anion-adsorption sites on the fibrous membrane can alleviate the polarization effect and benefit a uniform current distribution at the *** fibrous nanostructure can efficiently interact with the polymeric matrix,providing rich hopping sites for fast Li+***,the obtained SPE enables a uniform Li deposition and long-term cycling performance in Li-metal *** work reported an in situ formed SPE with both high polymerization degree and ionic conductivity,paving the way for designing high-performance SPEs with good comprehensive properties.

关键词： solid polymer electrolytes fibrous solid filler metal-organic frameworks in situ polymerization ion selectivity

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面向配电网终端设备的数字孪生映射方法研究

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计算机仿真 2024年第2期41卷 141-145页

作者：韩璟琳冯喜春侯若松刘洋国网河北省电力有限公司经济技术研究院河北石家庄050000 国网河北省电力有限公司河北石家庄050000

提出了一种面向配电网终端设备的数字孪生映射方法,推动电网企业数字化转型和电力系统自动化,降低成本与安全风险。方法利用虚拟数字孪生空间映射电网物理设备,实现对区域配电网多类型设备故障的实时诊断。首先,对配电网终端设备数据进... 详细信息

提出了一种面向配电网终端设备的数字孪生映射方法,推动电网企业数字化转型和电力系统自动化,降低成本与安全风险。方法利用虚拟数字孪生空间映射电网物理设备,实现对区域配电网多类型设备故障的实时诊断。首先,对配电网终端设备数据进行压缩转换和级联映射,提取感知终端监测信息与物理拓扑连接关系。其次,采用改进的轻量级Yolov4网络模型进行设备类型识别与分割,结合物理拓扑图进行数字孪生映射,形成设备孪生模型。最后,设计基于卷积注意力机制的状态评估模型,充分考虑区域设备关联与故障特征,实现对设备孪生模型的故障评估及物理空间设备的状态反馈。上述创新方法有望为电力行业带来更高效、安全的运行模式,推进电网智能化发展。

关键词：数字孪生轻量化网络状态感知智能电网深度可分离卷积

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Brain pathways of pain empathy activated by pained facial expressions: a meta-analysis of fMRI using the activation likelihood estimation method

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Neural Regeneration Research 2019年第1期14卷 172-178页

作者： ruo-Chu Xiong Xin Fu Li-Zhen Wu Cheng-han Zhang Hong-Xiang Wu Yu Shi Wen Wu Clinical Medicine First Clinical Medicine School Southern Medical University Department of Rehabilitation Medicine Zhujiang Hospital Southern Medical University

OBJECTIVE: The objective of this study is to summarize and analyze the brain signal patterns of empathy for pain caused by facial expressions of pain utilizing activation likelihood estimation, a meta-analysis method. DATA SOURCES: Studies concerning the brain mechanism were searched from the Science Citation Index, Science Direct, PubMed, DeepDyve, Cochrane Library, SinoMed, Wanfang, VIP, China National Knowledge Infrastructure, and other databases, such as SpringerLink, AMA, Science Online, Wiley Online, were collected. A time limitation of up to 13 December 2016 was applied to this study. DATA SELECTION: Studies presenting with all of the following criteria were considered for study inclusion: Use of functional magnetic resonance imaging, neutral and pained facial expression stimuli, involvement of adult healthy human participants over 18 years of age, whose empathy ability showed no difference from the healthy adult, a painless basic state, results presented in Talairach or Montreal Neurological Institute coordinates, multiple studies by the same team as long as they used different raw data. OUTCOME MEASURES: Activation likelihood estimation was used to calculate the combined main activated brain regions under the stimulation of pained facial expression. RESULTS: Eight studies were included, containing 178 subjects. Meta-analysis results suggested that the anterior cingulate cortex(BA32), anterior central gyrus(BA44), fusiform gyrus, and insula(BA13) were activated positively as major brain areas under the stimulation of pained facial expression. CONCLUSION: Our study shows that pained facial expression alone, without viewing of painful stimuli, activated brain regions related to pain empathy, further contributing to revealing the brain's mechanisms of pain empathy.

关键词： nerve regeneration facial expression pain empathy functional magnetic resonance imaging GringleALE activation likelihood estimation brain function imaging anterior cingulate cortex anterior central gyrus fusiform gyrus insula neural regeneration

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