检索结果-南通市图书馆

SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 978-992页

作者： Ming-Yan Shi Yarong wang Ying Shi ruofei Tian Xiaohong chen Hai Zhang Ke wang Zhinan chen ruo chen National Translational Science Center for Molecular Medicine & Department of Cell Biology Fourth Military Medical UniversityXi'anShaanxi 710032China

Protein post-translational modifications(PTMs)are at the heart status of cellular signaling events and broadly involved in tumor ***147 is a tumor biomarker with various PTMs,promoting tumor metastasis and metabolism ***,the relationship between the PTMs of CD147 and apoptosis has not been *** our study,we produced a specific anti-CD147-K71 di-methylation(CD147-K71me2)antibody by immunizing with a di-methylated peptide and observed that the level of CD147-K71me2 in non-small cell lung cancer(NSCLC)tissues were lower than that in NSCLC adjacent ***1 was identified as the methyltransferase catalyzing CD147 to generate ***-seq showed that FOSB was the most significant differentially expressed gene(DEG)between wild-type CD147(CD147-WT)and K71-mutant CD147(CD147-K71R)***,we found that CD147-K71me2 promoted the expression of FOSB by enhancing the phosphorylation of p38,leading to tumor cell *** vivo experiments showed that CD147-K71me2 significantly inhibited tumor progression by promoting cell *** together,our findings indicate the inhibitory role of CD147-K71me2 in tumor progression from the perspective of post-translational modification,which is distinct from the pro-cancer function of CD147 itself,broadening our perspective on tumor-associated antigen CD147.

关键词： CD147 di-methylation Cell apoptosis FOSB Non-small cell lung cancer SETDB1

Hypertonic and isotonic potassium solutions have different effects on vessel contractility resulting in differences in optimal resting tension in rat aorta

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第5期28卷 643-650页

作者： Yun-feng GUAN ruo-hua chen Pei wang Ye QIN Ding-feng SU Chao-yu MIAO Department of Pharmacology,Second Military Medical University,Shanghai 200433,China Department of Pharmacology Second Military Medical University Shanghai China

Aim:To compare high K~+-induced contraction and optimal resting tension mea-sured by two commonly used techniques of hypertonic and isotonic K~+ in aortaswith and without adventitial fat from various age ***:Three age groupsof rats (15,25,and 62 weeks) were used to prepare thoracic aortic rings in whichadventitial fat was either removed or left *** K~+ (30 mmol/L)-inducedcontractions were observed under increasing resting tensions of 1.0,1.5,2.0,2.5,3.0,and 3.5 *** resting tension was the resting tension at which the aortashowed a maximal ***:The contractions induced by 2 kinds ofhigh K~+ were significantly *** and isotonic K~+ induced a differ-ent style of contraction,and the pattern varied with different *** the age of15 weeks,isotonic K~+-induced contractions were greater than hypertonic K~+-in-duced ***,at the age of 62 weeks,isotonic K~+-induced con-tractions were smaller than hypertonic K~+-induced *** restingtensions measured by 2 kinds of high K~+ were *** restingtensions in different kinds of aortic preparations from various age rats were almosta constant of 2 g,determined by isotonic K~+,but a variable,determined by hyper-tonic K~+.The adventitial fat could delay the development of high K~+-inducedcontractions at different resting tensions,but had little effect on the ***:Hypertonic and isotonic K~+ may produce differentcontractions resulting in differences in optimal resting tension in rat aorta.

关键词： potassium osmolarity contraction aorta fat

Challenges and countermeasures for developing countries in addressing loss and damage caused by climate change

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第2期15卷 353-363页

作者： Shuo LIU Yu-E LI Bin wang An-Dong CAI Chao FENG Hua LAN ruo-chen ZHAO Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Agricultural Environment Ministry of Agriculture and Rural AffairsBeijing 100081China China Clean Development Mechanism Fund Management Center Beijing 100045China School of International Law China University of Political Science and LawBeijing 100088China

Loss and damage caused by extreme climate events have attracted increasing *** 28th Conference of the Parties to the United Nations Framework Convention on Climate Change(hereinafter referred to as the Convention)has agreed to adopt Loss and Damage Fund agreement,which identified the source of funding and the funds to be entrusted to the World ***,there is still ambiguous that how to allocate the funds could accelerate the effectiveness of meeting the needs for developing ***-disaster prevention and preparedness is one of the most effective measures to deal with loss and damage,which closely related to *** studies rarely analyzed quantitatively the financial needs of pre-disaster prevention and preparedness relating to adaptation to reduce loss and *** on the official reports submitted by countries under the Convention,this study analyzes the annual change in the total financial support provided by developed countries to developing countries,the proportion of pre-disaster prevention and preparedness in the adaptation needs of developing countries,and the progress in raising the current annual funding target of 100 billion USD for developed countries,to reveal the financial and technical challenges facing by developing countries on addressing loss and *** results show that by 2030,the total adaptation financial needs of developing countries are estimated to be about 3.8 trillion USD,of which pre-disaster prevention matters account for about 9%.Therefore,by 2030,developing countries will need about 342 billion USD in pre-disaster prevention and preparedness finance to withstand loss and *** addition,developing countries face a lack of technical methods to quantify information about their *** on the above analysis,this study puts forward countermeasures and suggestions,including strengthening the allocation amount of loss and damage fund on pre-disaster warning,prevention and control actions,and

关键词： Loss and damage Funding mechanism Pre-disaster warning and preparedness Convention negotiations Countermeasures

Identification of Two Mutations in PCDHGA4 and SLFN14 Genes in an Atrial Septal Defect Family

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2018年第6期38卷 989-996页

作者： Wei SU ruo-chen wang Mahesh Kumar Lohano Li wang Peng ZHU Yue LUO Li-juan GUO Qing LV Hong JIANG Jun-han wang Li MEI Jun WENG Li SU Nian-guo DONG Department of Cardiovascular Surgery Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologWuhan 430074 China Department of Internal Medicine Affiliated Hospital of Huazhong University of Science and TechnologyWuhan 430074 China Department of Ultrasonography Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Atrial septal defect (ASD)is a common acyanotic congenital cardiac disorder associated with genetic *** objective of this study was to identify the genetic factors in a Chinese family with ASD patients by a whole exome sequencing *** ASD gene mutations were examined in 16 members from a three-generation family,among which 6 individuals were diagnosed as having *** hundred and eighty-three unrelated healthy Chinese were recruited as a normal control *** venous blood was collected from every subject for genetic *** sequencing was performed in the ASD *** causal mutations were detected in non-ASD family members and normal controls by polymerase chain reaction and sequencing *** results showed that all affected family members carried two novel compound mutations,c.1187delT of PCDHGA4 and c.2557insC of SLFN14,and these two mutations were considered to have synergetic function on *** conclusion,the mutations of c.1187delT of PCDHGA4 and c.2557insC of SLFN14 may be pathogenic factors contributing to the development of ASD.

关键词： congenital heart disease atrial septal defect mutation PCDHGA4 SLFN14

Identifying Three New AGNs among Fermi Unidentified Gigaelectronvolt Sources

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第7期24卷 257-267页

作者： Shun-Hao Ji Zhong-Xiang wang Qiang-Meng Huang ruo-Heng Yang Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We report our identification of three gigaelectronvoltγ-ray sources,4FGL J0502.6+0036,4FGL J1055.9+6507,and 4FGL J1708.2+5519,as Active Galactic Nuclei(AGNs).They are listed in the latest Fermi-Large Area Telescope source catalog as unidentified *** find that the sources all showedγ-ray flux variations in recent *** different survey catalogs,we are able to find a radio source within the error circle of each source's *** analysis of optical sources in the fields allows us to determine the optical counterparts,which showed similar variation patterns to those seen inγ-*** optical counterparts have reported redshifts of 0.6,1.5,and 2.3,respectively,estimated from photometric *** addition,we also obtain an X-ray spectrum of 4FGL J0502.6+0036 and a flux upper limit on the X-ray emission of 4FGL J1055.9+6507 by analyzing the archival *** broadband spectral energy distributions of the three sources from radio toγ-rays are *** mainly theγ-ray properties of the three sources with those of different sub-classes of AGNs,we tentatively identify them as *** optical spectroscopy is highly warranted for obtaining their spectral features and thus verifying the identification.

关键词： gamma-rays galaxies-(galaxies)BL Lacertae objects general-(galaxies)quasars general

A proposal for detecting weak electromagnetic waves around 2.6μm wavelength with Sr optical clock

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第4期33卷 452-457页

作者：韩弱水王伟汪涛 Department of Physics and Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China Center of Modern Physics Institute for Smart City of Chongqing University in LiyangLiyang 213300China State Key Laboratory of Quantum Optics and Quantum Optics Devices Shanxi UniversityTaiyuan 030006China

Infrared signal detection is widely used in many *** to the detection principle,however,the accuracy and range of detection are *** to the ultra stability of the^(87)Sr optical lattice clock,external infrared electromagnetic wave disturbances can be responded *** the ac Stark shift of the clock transition,we propose a new method to detect infrared *** to our calculations,the theoretical detection accuracy in the vicinity of its resonance band of 2.6μm can reach the order of 10-14W,while the minimum detectable signal of common detectors is on the order of 10^(-10)W.

关键词： infrared signal detection ^(87)Sr optical lattice clock ac Stark shift ultra stability

Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 233-241页

作者： Peng Li Ting Zhang ruo Wu Jun-Yu Zhang Yan Zhuo Shan-Gang Li Jiao-Jian wang Wen-Ting Guo Zheng-Bo wang Yong-Chang chen State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube *** folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often attributable to genetic factors,remain *** SHROOM3 gene has been implicated in NTD cases that are unresponsive to folate supplementation;at present,however,the underlying mechanism remains *** tube morphogenesis is a complex process involving the folding of the planar epithelium of the neural *** determine the role of SHROOM3 in early developmental morphogenesis,we established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate *** of SHROOM3 resulted in shorter neuroepithelial cells and smaller *** morphological changes were attributed to the insufficient recruitment of cytoskeletal proteins,namely fibrous actin(F-actin),myosin II,and phospho-myosin light chain(PMLC),to the apical side of the neuroepithelial ***,these defects were not rescued by folate *** sequencing revealed that differentially expressed genes were enriched in biological processes associated with cellular and organ *** summary,we established an authentic in vitro system to study NTDs and identified a novel mechanism for NTDs that are unresponsive to folate supplementation.

关键词： Neural tube defects SHROOM3 Neuroepithelial Organoids Cynomolgus monkey

Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao chen Xin-Yu wang Biao Yu Chuan-Lin Feng Guo-Feng cheng Lei Zhang Jun-Jun wang Ying wang ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li chen Chao Song Xin Zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第6期30卷 607-609页

作者： Bai-Wei Zhao Ying-Jia chen ruo-Peng Zhang Yong-Ming chen Bo-Wen Huang Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina Health Science Center Peking UniversityBeijing 100191China

The present letter to the editor is related to the study titled‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.

关键词： Angiotensin-converting enzyme 2 Hepatic stellate cells Liver fibrosis Angiotensin II Angiotensin 1-7 Renin-angiotensin system