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World Journal of Clinical Cases 2022年第9期10卷 2916-2922页

作者： Yi-Ting Zhou ruo-yu Wang Yao Zhang Dong-Yi Li Jian yu Hyperthermia Center The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China Department of Medical Oncology The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China Department of Bone and Soft Tissue Oncology The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a type of soft tissue sarcoma,the histologic origin and differentiation direction of which are still *** are few treatment options for UPS other than *** we describe a patient who had multiple recurrences of UPS postoperatively,but R0 resection was achieved by local hyperthermia combined with chemotherapy,thus providing a new treatment approach for similar *** SUMMARY A 65-year-old man sought evaluation from a physician for a mass on his right *** surgery,the pathologic diagnosis was *** the follow-up evaluations until 2021,the patient had four relapses of varying *** pathology confirmed the recurrence of UPS on the right *** March 2021,he underwent local hyperthermia combined with two cycles of chemotherapy for recurring *** magnetic resonance imaging reexamination and preoperative examination,the patient chose surgery *** the operation,the tumors were easy to excise,the amount of bleeding decreased significantly,and the pathologic evaluation confirmed that one of the specimens was an R0 *** Local hyperthermia combined with chemotherapy enables R0 resection to be achieved in patients with advanced UPS recurrence.

关键词： Undifferentiated pleomorphic sarcoma Local hyperthermia Chemotherapy R0 resection Case report

输尿管软镜下钬激光碎石术治疗输尿管上段结石患者的效果观察

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中国医疗器械信息 2024年第10期30卷 82-84页

作者：林若飞厦门市中医院泌尿外科福建厦门361000

目的:分析输尿管软镜下钬激光碎石术治疗输尿管上段结石患者的效果。方法:选取2021年2月~2022年3月本院诊治的64例输尿管上段结石患者,随机分为2组,对照组采用输尿管硬镜下钬激光碎石术治疗,研究组采用输尿管软镜钬激光碎石术治疗,对比... 详细信息

目的:分析输尿管软镜下钬激光碎石术治疗输尿管上段结石患者的效果。方法:选取2021年2月~2022年3月本院诊治的64例输尿管上段结石患者,随机分为2组,对照组采用输尿管硬镜下钬激光碎石术治疗,研究组采用输尿管软镜钬激光碎石术治疗,对比分析两组输尿管结石患者的治疗效果。结果:两组患者的手术时间接近(P>0.05);研究组患者住院时间短于对照组,出血量少于对照组(P<0.05);研究组一次清除成功率高于对照组,不良反应发生率低于对照组(P<0.05)。结论:输尿管软镜下钬激光碎石术治疗输尿管上段结石患者具有良好的效果,相较于输尿管硬镜下钬激光碎石术治疗,可提高一次清除成功率,减少术中出血量及术后并发症,建议在输尿管上段结石治疗中优先选用。

关键词：输尿管上段结石输尿管软镜钬激光碎石术成功率

Surgical treatment of liver cancer and pancreatic cancer under the China Healthcare Security Diagnosis Related Groups payment system

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World Journal of Clinical Cases 2024年第21期12卷 4673-4679页

作者： yun-He Hu Fan yu yu-Zhuo Zhou Ai-Dong Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Data from the World Health Organization’s International Agency for Research on Cancer reported that China had the highest prevalence of cancer and cancer deaths in *** and pancreatic cancers accounted for the highest number of new ***-world data(RWD)is now widely preferred to traditional clinical trials in various fields of medicine and healthcare,as the traditional research approach often involves highly selected populations and interventions and controls that are strictly ***,research results from the RWD match global reality better than those from traditional clinical *** To analyze the cost disparity between surgical treatments for liver and pancreatic cancer under various *** This study analyzed RWD 1137 cases within the HB1 group(patients who underwent pancreatectomy,hepatectomy,and/or shunt surgery)in *** distinguished different expenditure categories,including medical,nursing,technical,management,drug,and consumable ***,it assessed the contribution of each expenditure category to total hospital costs and performed cross-group comparisons using the non-parametric Kruskal–Wallis *** study used the Steel–Dwass test for post-hoc multiple comparisons and the Spearman correlation coefficient to examine the relationships between *** The study found that in HB11 and HB13,the total hospitalization costs were significantly higher for pancreaticoduodenectomy than for pancreatectomy and *** no significant difference was observed in the length of hospital stay between patients who underwent pancreaticoduodenectomy and pancreatectomy,both were significantly longer than those who underwent liver *** HB15,no significant difference was observed in the total cost of hospitalization between pancreaticoduodenectomy and pancreatectomy;however,both were significantly higher than those in ***,the length of hospital stay was significan

关键词： China health care security diagnosis-related groups Real-world study Liver cancer surgical treatment Pancreatic cancer surgical treatment Hospitalization costs Cost structure Average length of stay

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侦查监督数字化的现实检视及优化路径

河北公安警察职业学院学报 2024年第3期24卷 41-45页

作者：王若冰中国人民公安大学法学院北京100038

侦查监督数字化在一定程度上改善了传统侦查监督模式下存在的问题,但同时也面临着侦查监督职能边界不清、技术与传统司法之间存在冲突、数字化能力有限等现实困境。为真正实现侦查监督的数字化转型,需要在理念层面形成数字化思维,坚守... 详细信息

侦查监督数字化在一定程度上改善了传统侦查监督模式下存在的问题,但同时也面临着侦查监督职能边界不清、技术与传统司法之间存在冲突、数字化能力有限等现实困境。为真正实现侦查监督的数字化转型,需要在理念层面形成数字化思维,坚守保障人权的监督观念;在技术层面积累法律专业领域的知识图谱,自上而下搭建数字共享平台,为大数据模型运作提供前提性保障;在制度层面对侦查监督进行去行政化改造,通过明确侦查监督的执行主体,推进侦查监督与协作配合办公室的实质化运行,从而将侦查监督拉回司法轨道,实现侦查监督数字化合法性与有效性的平衡。

关键词：侦查监督数字检察司法大数据去行政化

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基于轻量卷积神经网络的钢筋交点识别算法

价值工程 2024年第13期43卷 107-109页

作者：凤若成中铁九局集团有限公司沈阳110005

随着建筑行业逐步向智能化的发展,钢筋绑扎机器人代替人工完成绑扎作业已成为全行业关注和亟待解决的问题。结合平面钢筋绑扎机器人的研发,本文对其钢筋交叉点识别问题进行研究,提出了运行在低算力平台上的钢筋交点识别算法,使用轻量卷... 详细信息

随着建筑行业逐步向智能化的发展,钢筋绑扎机器人代替人工完成绑扎作业已成为全行业关注和亟待解决的问题。结合平面钢筋绑扎机器人的研发,本文对其钢筋交叉点识别问题进行研究,提出了运行在低算力平台上的钢筋交点识别算法,使用轻量卷积Ghost模块替换YOLOv5主干中特征提取网络中的常规卷积,并测试改进后算法的准确性。实验结果表明,改进后的GhostYOLOv5满足使用要求,适用于小型移动式钢筋绑扎机器人的钢筋交点识别。

关键词：智能建造机器视觉深度学习

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食源性抗氧化剂缓解内分泌干扰物生殖毒性的研究进展

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环境与职业医学 2024年第1期41卷 110-117页

作者：陈佳娴苗茂华王子亮复旦大学公共卫生学院上海200032 上海市生物医药技术研究院公共卫生与政策研究所/国家卫生健康委员会计划生育药具重点实验室/上海市疾病与健康基因组学重点实验室上海200237

内分泌干扰物(EDCs)是一类广泛存在于日常生活环境中的化学物质,可通过多种途径进入人体,危害生殖发育和健康。氧化应激(OS)是EDCs产生生殖毒性的重要基础机制之一。大量研究发现,EDCs暴露通过增加人体生殖系统的活性氧(ROS)水平,同时... 详细信息

内分泌干扰物(EDCs)是一类广泛存在于日常生活环境中的化学物质,可通过多种途径进入人体,危害生殖发育和健康。氧化应激(OS)是EDCs产生生殖毒性的重要基础机制之一。大量研究发现,EDCs暴露通过增加人体生殖系统的活性氧(ROS)水平,同时降低酶促抗氧化剂的活性和数量,进而导致氧化应激,从DNA和细胞等各个层面诱导生殖系统的损伤。许多研究结果表明,补充食源性非酶促抗氧化剂能够清除人体内的ROS,并增加酶促抗氧化剂的活性,从而降低OS水平,并进一步修复EDCs诱导的生殖损害。另外,许多食源性抗氧化剂本身也是参与生殖生理活动的重要元素,对生殖健康具有保护作用。本文归纳了EDCs的生殖毒性,包括损伤生殖细胞、干扰性激素作用和影响生殖相关基因的表观遗传调控,阐述了OS在EDCs诱导生殖毒性中的作用,进一步总结了多种维生素、微量元素以及植物中的多酚和色素等食源性抗氧化剂缓解EDCs生殖毒性的作用及相关机制,为防治EDCs的生殖毒性提供理论基础和科学依据。

关键词：内分泌干扰物食源性抗氧化剂生殖毒性氧化应激表观遗传调控

Accurate estimation of Li/Ni mixing degree of lithium nickel oxide cathode materials

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Chinese Physics B 2024年第5期33卷 631-635页

作者：陈鹏浩徐磊禹习谦李泓 Institute of Physics Chinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Frontier Research Center on Clean Energy Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijing 101400China

Li/Ni mixing negatively influences the discharge capacity of lithium nickel oxide and high-nickel ternary cathode ***,accurately measuring the Li/Ni mixing degree is difficult due to the preferred orientation of labbased XRD measurements using Bragg–Brentano ***,we find that employing spherical harmonics in Rietveld refinement to eliminate the preferred orientation can significantly decrease the measurement error of the Li/Ni mixing *** Li/Ni mixing ratio obtained from Rietveld refinement with spherical harmonics shows a strong correlation with discharge capacity,which means the electrochemical capacity of lithium nickel oxide and high-nickel ternary cathode can be estimated by the Li/Ni mixing *** findings provide a simple and accurate method to estimate the Li/Ni mixing degree,which is valuable to the structural analysis and screening of the synthesis conditions of lithium nickel oxide and high-nickel ternary cathode materials.

关键词： lithium nickel oxide high-nickel ternary cathode Li/Ni mixing spherical harmonics function discharge capacity

Causal relationship between hypertension and epilepsy:a mendelian randomization study

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Acta Epileptologica 2024年第1期7卷 53-59页

作者： Zhen Sun Tong Jiang Mengwen Zhang yulong Li Jing Zhang Yanping Sun Xiaofeng yu Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdao266000China Department of Endocrinology and Metabolism The Affiliated Hospital of Qingdao UniversityQingdao266000China Department of Neurology Qingdao Eighth People’s HospitalQingdao266000China

Background Recent studies suggest that hypertension may increase the risk of epilepsy onset,revealing intricate interactions between cardiovascular health and neurological disorders,thus emphasizing the significance of conducting further investigations into their *** study aimed to investigate the potential causality between hypertension,either in systolic or diastolic blood pressure,and epilepsy,using a Mendelian randomization *** A two-sample Mendelian randomization design was used in this *** extracted data from the UK Biobank,FinnGen,and the International Consortium of Blood Pressure,utilizing blood pressure-related single nucleotide polymorphisms as instrumental variables to evaluate the influence of hypertension on the risk of *** variance weighted,weighted median,and MR-Egger approaches were used for *** There was a potential association between hypertension,primarily in systolic blood pressure,and an elevated epilepsy risk,while the relationship between hypertension in diastolic blood pressure and epilepsy risk remained *** analyses suggest an absence of substantial heterogeneity and confounding effects,suggesting the reliability of our *** Our study lays the groundwork for further investigations into the mechanisms of this causal relationship,which may potentially involve vascular change,neuroinflammatory pathways,and alterations in cerebral blood flow,which are crucial for understanding the complex hypertension-epilepsy nexus.

关键词： Mendelian randomization Epilepsy Hypertension Systolic blood pressure

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中国降水特征及拟合参数时空分布研究

人民珠江 2024年第3期45卷 48-58页

作者：周雨张育嘉苗昌盛浙江大学建筑工程学院浙江杭州310058 上海华锦建设有限公司上海200063

为总结全国降水特征,并探究降水历时的分布,对中国698个气象站56年连续日降水数据,从降水的季节分布、极端特征、持续时间3个方面分析降水特征的空间分布和年际变化,并利用伽马分布对降水历时曲线进行拟合和参数估计,分析影响拟合参数... 详细信息

为总结全国降水特征,并探究降水历时的分布,对中国698个气象站56年连续日降水数据,从降水的季节分布、极端特征、持续时间3个方面分析降水特征的空间分布和年际变化,并利用伽马分布对降水历时曲线进行拟合和参数估计,分析影响拟合参数的潜在物理因素。结果显示:(1)降水趋势总体呈现东南地区增加,中部下降,东部、西北、东北冬季降水量增加且分布范围较广,从中国东南地区到西北地区,降水百分位的变化趋势呈先升再减再升,99百分位降水阈值的分布更不均匀,临河站的降水百分位变化趋势下降最大,尤其是湿日降水百分位,湿期在西南和中部地区处于下降趋势,沿海和西北地区处于上升趋势,且流域旱涝持续时间分布特征在大部分地区表现出相反状态,湿期的年际变化相较于干期小;(2)伽马分布对降水量有较好的拟合效果,尺度参数β与降水量和降水百分位的相关性较高,且对强降水事件的极端降水阈值有更好的表现,这一发现能够为后续基于物理影响因素的降水过程研究提供理论支持。

关键词：伽马分布降水历时曲线(PDC) 降水的空间分布及年际变化估计参数物理控制

妊娠期重金属混合暴露与新生儿出生体重关联的研究

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中华预防医学杂志 2024年第7期58卷 1055-1061页

作者：赵建章白文琳袁苗董美祺房瑞玲余红梅山西医科大学医学科学院太原030001 山西医科大学公共卫生学院太原030001 煤炭环境致病与防治教育部重点实验室太原030001 重大疾病风险评估山西省重点实验室太原030001

妊娠期重金属混合暴露对新生儿出生体重的影响一直备受关注。本研究选取美国新罕布什尔州出生队列研究(NHBCS)中258对母婴作为研究对象,采集了胎盘中铝(Al)、钴(Co)、铬(Cr)、镍(Ni)、铅(Pb)、硒(Se)、砷(As)等七种重金属的浓度,同时收... 详细信息

妊娠期重金属混合暴露对新生儿出生体重的影响一直备受关注。本研究选取美国新罕布什尔州出生队列研究(NHBCS)中258对母婴作为研究对象,采集了胎盘中铝(Al)、钴(Co)、铬(Cr)、镍(Ni)、铅(Pb)、硒(Se)、砷(As)等七种重金属的浓度,同时收集新生儿出生体重及母亲和新生儿的相关协变量信息。采用加权分位数和回归(WQS)、分位数g计算(QGC)和贝叶斯核机器回归(BKMR)三种方法进行分析。调整了母亲孕龄、孕前BMI、吸烟状况、受教育程度、产次、胎龄及新生儿性别后,综合三种方法表明七种重金属混合暴露对出生体重的总效应呈负向关系。具体来看,WQS结果显示,Se对出生体重的效应最大,其次为Al;QGC结果显示,与女婴出生体重降低相关的重金属主要是Se,与男婴出生体重降低相关的主要是Al;BKMR结果显示,胎盘7种重金属混合暴露对男婴和女婴的出生体重都有负联合效应,按性别分层后,女婴中后验包含概率(PIP)最高的是Se(0.45),男婴中PIP最高是Al(0.64)。综上表明,妊娠期重金属混合暴露与新生儿出生体重降低相关,且存在性别差异,Se和Al分别与女婴和男婴的出生体重降低相关联。这一发现为预防不良妊娠结局和制定改善新生儿健康状况的卫生政策提供了理论依据。

关键词：重金属混合暴露新生儿出生体重加权分位数和回归贝叶斯核机器回归分位数g计算