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A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

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Chinese Chemical Letters 2024年第10期35卷 364-369页

作者： Chuan-Zhi ni ruo-Ming Li Fang-Qi Zhang Qu-Ao-Wei Li Yuan-Yuan Zhu Jie Zeng Shuang-Xi Gu School of Chemistry and Environmental Engineering School of Chemical Engineering&PharmacyPharmaceutical Research InstituteHubei Key Laboratory of Novel Reactor and Green Chemical TechnologyWuhan Institute of TechnologyWuhan 430205China Nanjing Pusheng Biomedical Co. Ltd.Nanjing 210033China

A novel and readily available binaphthyl-based fluorescent probe(S)-1 was designed and synthesized.(S)-1 can be used to not only chemoselectively discriminate 3 basic amino acids out of common amino acids,but also enantioselectively recognize ***,enantioselective imaging of histidine in cells was achieved for the first time by the probe(S)-*** performances endowed it potential application in the chiral analysis of basic amino acids in asymmetric synthesis and cell imaging for diagnosis of diseases caused by racemization of *** magnetic resonance(NMR)and mass spectrometry investigations suggested that different reaction extent of(S)-1 with L/D-histidine and different product structures generated the observed enantioselective fluorescent *** molecular structures and thermodynamic stability of the complexes,formed from(S)-1+Zn2+and enantiomers of histidine,were calculated by Gaussian 16 based on density functional theory(DFT)to validate the above action mechanism.

关键词： Fluorescent probe Chiral recognition Enantioselectivity Chemoselectivity Basic amino acids Cell imaging

Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells

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Current Medical Science 2022年第5期42卷 958-965页

作者： Yan-ni SUN Yan-ni MA Xiao-qing JIA Qi yao Jie-ping CHEN Hui LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Objective Acute myeloid leukemia(AML)is a highly heterogeneous and recurrent hematological *** the emergence of novel chemotherapy drugs,AML patients’complete remission(CR)remains ***,it is imperative to discover new therapeutic targets or medications to treat *** epigenetic changes like DNA methylation and histone modification play vital roles in *** deminase(PAD)is a protein family of histone demethylases,among which the PAD2 and PAD4 expression have been demonstrated to be elevated in AML patients,thus suggesting a potential role of PADs in the development or maintenance of AML and the potential for the identification of novel therapeutic *** AML cells were treated in vitro with the pan-PAD inhibitor BB-Cl-Amidine(BB-Cl-A).The AML cell lines were effectively induced into apoptosis by ***,the PAD4-specific inhibitor GSK484 did *** PAD2 played a significant role in ***,we found that BB-Cl-A could activate the endoplasmic reticulum(ER)stress response,as evidenced by an increase in phosphorylated PERK(p-PERK)and eIF2α(p-eIF2α).As a result of the ER stress activation,the BB-Cl-A effectively induced apoptosis in the AML *** Our findings indicated that PAD2 plays a role in ER homeostasis maintenance and apoptosis ***,targeting PAD2 with BB-Cl-A could represent a novel therapeutic strategy for treating AML.

关键词： acute myeloid leukemia BB-Cl-Amidine peptidylarginine deminase endoplasmic reticulum stress apoptosis

A PSO Based Multi-Domain Virtual Network Embedding Approach

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China Communications 2019年第4期16卷 105-119页

作者： Yongjing ni Guoyan Huang Sheng Wu Chenxi Li Peiying Zhang Haipeng yao College of Information Science and Engineering Yanshan University College of Information Science and Engineering Hebei University of Science and Technology The Key Laboratory for Computer Virtual Technology and System Integration of Hebei Province Yanshan University School of Information and Communication Engineering Beijing University of Posts and Telecommunications College of Computer & Communication Engineering China University of Petroleum (East China)

This paper proposed a multi-domain virtual network embedding algorithm based on multi-controller SDN architecture. The local controller first selects candidate substrate nodes for each virtual node in the domain. Then the global controller abstracts substrate network topology based on the candidate nodes and boundary nodes of each domain, and applies Particle Swarm Optimization Algorithm on it to divide virtual network requests. Each local controller then embeds the virtual nodes of the divided single-domain virtual network requests in the domain, and cooperates with other local controllers to embed the inter-domain virtual links. Simulation experimental results show that the proposed algorithm has good performance in reducing embedding cost with good stability and scalability.

关键词： multi-domain virtual network embedding candidate node particle swarm optimization algorithm virtual network request division

Spin-glass behavior in the competing CoCrGaO_(4)cubic spinel system

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Nano Research 2025年第1期18卷 501-507页

作者： Jiyu Hu Jiangli ni Zhenfa Zi Chaocheng Liu School of Physics and Materials Engineering Hefei Normal UniversityHefei 230009China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

Spin glasses(SGs),generally defined as disordered systems with randomized competing interactions,are widely investigated complex *** the ground states of spin glasses is crucial for understanding the nature of disordered magnets and many other physical manifestations,while also helping to solve some hard combinatorial optimization problems across multiple ***,the intrinsic cause of SG has always been elusive,especially in spinel oxide ***,we report the SG behavior observed in the cubic spinel oxides CoCrGaO_(4),and provide a comprehensive understanding of its intrinsic *** results indicate a frustrated state under multi-magnetic competition,and the features of SG are confirmed by susceptibility *** fitting parameters ofτ0,T0,and zv of isothermal remanent magnetization further reveal the relaxation behavior and strong spin ***,the varying exchange coupling under different temperatures and magnetic fields is unveiled,which should be responsible for the disordered *** studies unravel the underlying mechanism responsible for doping-induced magnetic frustration and introduce CoCrGaO_(4)as a potential platform for investigating spin glass behavior,thereby advancing fundamental research on frustrated magnetism within the spinel system.

关键词： spin glass(SG) magnetic frustration magnetic competition spinel ferrites

La1-xCexMnO3/attapulgite nanocomposites as catalysts for NO reduction with NH3 at low temperature

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Particuology 2016年第3期14卷 66-72页

作者： Xiazhang Li YU Yin Chao yao Shixiang Zuo Xiaowang Lu Shiping Luo Chaoying ni fiangsu Key Laboratory of Advanced Catalytic Materials and Technology School of Petrochemical Engineering Changzhou University Changzhou 213164 China R&D Center of Xuyi Attapulgite Applied Technology Chinese Academy of Sciences Xuyi 211700 China W. M. Keck CenterforAdvanced Microscopy and Microanalysis University of Delaware Newark DE 19716 USA

A series of attapulgite （ATP） supported perovskite-type La1-xCexMnO3 ix=0-0.2） nanocomposites were prepared by a sol-gel method. The samples were characterized by X-ray diffraction, transmission elec- tron microscopy, Fourier-transform infrared spectroscopy, H2 temperature-programmed reduction, and temperature-programmed desorption of NH3. Their selective catalytic reduction of NO with NH3 was evaluated in the low-temperature range. The impact of the doping fraction of Ce4＋ on the NO conversion was investigated. The results indicated that the La1-xCexMnO3 nanoparticles with a size of ca. 15 nm were uniformly immobilized on the surface of ATP with a loading amount of 20wt%. The highest conversion rate of NO reached 98.6% when the doping fraction x was O.1, while the ATP support supplied a high surface areas facilitating the nanoparticles dispersion as well as the gas adsorption. Incorporation of an appropriate amount of Ce4＋ in the La3＋ site resulted in a high degree of reduction by the active perovskite species with enhanced catalytic activity.

关键词： Attapulgite Rare earth perovskite Nanocomposite Selective catalytic reduction NO conversion

Status and progress of metal-supported solid oxide fuel cell: Towards large-scale manufactory and practical applications

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Energy Reviews 2024年第1期3卷 1-23页

作者： Haoran Xu Yu Han Jing Zhu Meng ni Zhen yao State Key Laboratory of Clean Energy Utilization Zhejiang University38 Zheda RoadHangzhou310027China Department of Building and Real Estate Research Institute for Sustainable Urban Development(RISUD)&Research Institute for Smart Energy(RISE)Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Fakultät für Physik Universität BielefeldUniversitätsstr.2533615BielefeldGermany

Metal-supported solid oxide fuel cells(MS-SOFCs)own advantages of high performance,fast start-up,thermal cycle stability,easy sealing,and reduced material *** recent years,significant progress has been made in the development of MS-SOFCs,particularly with respect to improved electrochemical performance,long-term stability,and industrial *** studies have mainly focused on stainless steel-based MS-SOFCs,with an emphasis on the development of low-temperature preparation processes,antioxidant coatings,stable electrodes,and the direct utilization of hydrocarbon ***,Ceres Power and GE have successfully commercialized MS-SOFCs and have constant cooperated with several institutions and companies,such as Jülich Research Center,Weichai and Cummins,to promote the performance and expand the market of *** ahead,this review paper provides an outlook on future research directions in this rapidly evolving field.

关键词： Metal support Solid oxide fuel cell High performance Long-term stability

Insight on Viscoelasticiy of Ti16.7Zr16.7Hf16.7Cu16.7ni16.7Be16.7 High Entropy Bulk Metallic Glass

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Journal of Iron and Steel Research International 2016年第1期23卷 19-23页

作者： Ji-chao QIAO Jean-marc PELLETIER ning LI yao yao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina Universite de Lyon MATEISUMR CNRS5510Bat.B.PascalINSA-LyonF-69621 Villeurbanne cedexFrance Department of Materials Science and Engineering State Key Laboratory for Materials Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074HuheiChina

High entropy bulk metallic glasses show promising mechanical and physical *** mechanical properties of Ti_（16.7）Zr_（16.7）Hf_（16.7）Cu_（16.7）ni_（16.7）Be_（16.7）high entropy bulk metallic glass were investigated by mechanical spectroscopy（or called dynamic mechanical analysis）.The main（α）relaxation was observed in the framework of the loss modulus G″,which is related to the dynamic glass transition behaviour for the glassy *** physical model point of view,dynamic mechanical properties of the Ti_（16.7）Zr_（16.7）Hf_（16.7）Cu_（16.7）ni_（16.7）Be_（16.7）high entropy bulk metallic glass show good agreement compared with the quasi-point defects theory.

关键词： high entropy bulk metallic glass viscoelasticity mechanical spectroscopy quasi-point defect theory

Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018

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World Journal of Pediatrics 2019年第4期15卷 405-411页

作者： Zhen-Ran Xu Miao-Ying Zhang Jin-Wen ni ruo-Qian Cheng Zhang-Qian Zheng Li Xi Fei-Hong Luo Department of Pediatric Endocrinology and Inherited Metabolic Diseases Children's Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background The limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult *** date,data on the clinical features,metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D *** A total of 56 children with T2D,31 with prediabetes and 159 with obesity were *** characteristics,metabolic profiles,beta-cell function and insulin resistance were *** The mean onset age of T2D was 12.35 ± 1.99 (7.9-17.8) years,and 7% of children were younger than 10 years;55% of them were male,57% had a family history of diabetes and 64% had classic symptoms,and 25% had a low or high birth weight.89% of T2D patients were obese or overweight.A total of 58% of the patients with prediabetes were *** fast serum C-peptide level was highest in the obesity group (P nificant difference between the T2D and prediabetes *** mean homeostatic model of assessment of beta-cell function was the highest in the obesity group and was lowest in the T2D group (P ning and intervention program for T2D is recommended in high-risk or obese Chinese pediatric populations starting at 7 years.

关键词： Diabetes mellitus,type 2 Obesity Prediabetic state

A New Method to Determine Central Wavelength and Optimal Bandwidth for Predicting Plant nitrogen Uptake in Winter Wheat

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Journal of Integrative Agriculture 2013年第5期12卷 788-802页

作者： yao Xin-feng yao Xia TIAN Yong-chao ni Jun LIU Xiao-jun CAO Wei-xing ZHU Yan National Engineering and Technology Center for Information Agriculture Ministry of Industry and Information Technology/Jiangsu Key Laboratory for Information AgricultureScience and Technology Department of Jiangsu Province/College of AgricultureNanjing Agricultural University

Plant nitrogen （N） uptake is a good indicator of crop N status. In this study, a new method was designed to determine the central wavelength, optimal bandwidth and vegetation indices for predicting plant N uptake （g N m-2） in winter wheat （Triticum aestivum L.）. The data were collected from the ground-based hyperspectral reflectance measurements in eight field experiments on winter wheat of different years, eco-sites, varieties, N rates, sowing dates, and densities. The plant N uptake index （PNUI） based on NDVI of 807 nm combined with 736 nm was selected as the optimal vegetation index, and a linear model was developed with R2 of 0.870 and RMSE of 1.546 g N m-2 for calibration, and R2 of 0.834, RMSE of 1.316 g N m-2, slope of 0.934, and intercept of 0.001 for validation. Then, the effect of the bandwidth of central wavelengths on model performance was determined based on the interaction between central wavelength and bandwidth expansion. The results indicated that the optimal bandwidth varies with the changes of the central wavelength and with the interaction between the two bands in one vegetation index. These findings are important for prediction and diagnosis of plant N uptake more precise and accurate in crop management.

关键词： central wavelength optimal bandwidth plant nitrogen uptake winter wheat