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Myokines:metabolic regulation in obesity and type 2 diabetes

Life Metabolism 2024年第3期3卷 21-45页

作者： Zhi-Tian chen Zhi-xuan Weng Jiandie D.Lin Zhuo-Xian Meng Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of Disease Proteomics of Zhejiang Province School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute(ZJE) School of MedicineZhejiang UniversityHainingZhejiang 314400China Life Sciences Institute and Department of Cell and Developmental Biology University of MichiganAnn ArborMI 48109United States Department of Geriatrics Affiliated Hangzhou First People’s HospitalHangzhouZhejiang 310006China

Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as *** myokine levels are associated with metabolic diseases,such as type 2 diabetes(T2D).The significance of interorgan crosstalk,particularly through myokines,has emerged as a fundamental aspect of nutrient and energy ***,a comprehensive understanding of myokine biology in the setting of obesity and T2D remains a major chal*** this review,we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades,namely interleukin 6(IL-6),irisin,myostatin(MSTN),growth differentiation factor 11(GDF11),fibroblast growth factor 21(FGF21),apelin,brain-derived neurotrophic factor(BDNF),meteorin-like(Metrnl),secreted protein acidic and rich in cysteine(SPARC),β-aminoisobutyric acid(BAIBA),Musclin,and Dickkopf 3(Dkk3).Related to these,we detail the role of exercise in myokine expression and secretion together with their contributions to metabolic physiology and *** significant advancements in myokine research,many myokines remain challenging to measure accurately and investigate ***,new research techniques and detection methods should be developed and rigorously ***,developing a comprehensive perspective on myokine biology is crucial,as this will likely offer new insights into the pathophysiological mechanisms underlying obesity and T2D and may reveal novel targets for therapeutic interventions.

关键词： myokines skeletal muscle obesity type 2 diabetes metabolism

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Engineering of oxygen vacancy and bismuth cluster assisted ultrathin Bi_(12)O_(17)Cl_(2)nanosheets with efficient and selective photoreduction of CO_(2)to CO

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Carbon Energy 2024年第4期6卷 1-11页

作者： Meili Guan Ni Lu xuan Zhang Qiuwan Wang Jian Bao Guiye chen Hao Yu Huaming Li Jiexiang Xia Xuezhong Gong College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdaoShandongChina Institute for Energy Research Jiangsu UniversityZhenjiangJiangsuChina National Center of International Joint Research for Hybrid Materials Technology Institute of Hybrid MaterialsCollege of Materials Science andEngineeringNational Base of International Science and Technology Cooperation on Hybrid MaterialsQingdao UniversityQingdaoShandongChina

The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global *** work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect *** OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect *** addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance *** study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.

关键词： Bi cluster Bi_(12)O_(17)Cl_(2)nanosheet oxygen vacancy photocatalytic CO_(2)reduction

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An epidermal electrode based triboelectric walking energy harvester for wearable wireless sensing applications

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Science China(Technological Sciences) 2024年第3期67卷 949-957页

作者： CHANG ShiYuan LIU FuHai chen JinKai XIA LianBin ZHOU Hao JIANG JingYang DONG Kang ZHANG chenHao WU Yun chen Jin xuan Weipeng SUN LingLing JIN Hao DONG ShuRong LUO JiKui Ministry of Education Key Laboratory of RF Circuits and Systems Hangzhou Dianzi UniversityHangzhou 310018China Special Equipment College Hangzhou Vocational&Technical CollegeHangzhou 310018China College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 330027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China

Harvesting bio-kinetic energy using a triboelectric nanogenerator(TENG) is one of the promising routes to solve the sustainable energy supply problem for wearable electronics. However, additional materials, complex fabricating processes or specific mechanical structures are needed for existing TENGs to harvest bio-kinetic energy. Besides, they need to be tightly attached to the human body, which may result in detachment and malfunction under tense human motion. Herein, an intrinsic epidermal electrode-based TENG(E-TENG) is proposed to harvest human walking energy. The wearing shoes and ground are used as tribo-materials, and the human epidermis is used as the back electrode of the E-TENG. Compared with the traditional TENGs,the E-TENG does not need any additional tribo-materials and complex mechanical structures. Under optimal conditions, the voltage output of E-TENG can reach 914 V. E-TENG has been used as a self-powered warning sensor and pedometer sensor for demonstration. Furthermore, E-TENG based self-powered wireless sensor system has been developed using a newly designed micro energy electronic switch(MEES). Ambient ultraviolet intensity, temperature and humidity information can be monitored and then transmitted to mobile phone every 3.5 min, demonstrating great potential for widespread wearable applications.

关键词： triboelectric nanogenerator wearable wireless sensing self-powered

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Comparison between ozonesonde measurements and satellite retrievals over Beijing,China

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 14-20页

作者： Jinqiang Zhang Yuejian xuan Jianchun Bian Holger Vomel Yunshu Zeng Zhixuan Bai Dan Li Hongbin chen Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina College of Atmospheric Sciences Lanzhou UniversityLanzhouChina National Center for Atmospheric Research BoulderCOUSA Electronic Engineering College Chengdu University of Information TechnologyChengduChina

从2013年开始,作者团队使用自主研发电化学原理臭氧探空仪在华北平原北京地区进行每周一次观测.本研究首次使用2013-2019年期间北京地区臭氧探空数据评估Aqua卫星搭载大气红外探测仪(AIRS)和Aura卫星搭载微波临边探测器(MLS)反演垂直臭... 详细信息

从2013年开始,作者团队使用自主研发电化学原理臭氧探空仪在华北平原北京地区进行每周一次观测.本研究首次使用2013-2019年期间北京地区臭氧探空数据评估Aqua卫星搭载大气红外探测仪(AIRS)和Aura卫星搭载微波临边探测器(MLS)反演垂直臭氧廓线,并对比臭氧探空,AIRS和Aura卫星搭载臭氧监测仪(OMI)臭氧柱总量结果.尽管臭氧探空与卫星反演垂直臭氧廓线在局部高度处差异较大,但整体来说两者较为接近(相对偏差大多<10%).臭氧探空,AIRS和OMI三种仪器测量臭氧柱总量的年变化特征较为一致,其年均臭氧柱总量分别为351.8±18.4 DU,348.8±19.5 DU和336.9±14.2 DU.后续对国内多站点观测数据分析将有助于进一步理解臭氧探空与卫星反演臭氧资料在不同区域的一致性.

关键词：臭氧探空卫星反演垂直臭氧廓线臭氧柱总量华北平原

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The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-xuan chen Jin-Yue Dai Li-Yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu Ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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Whole petroleum system in Jurassic coal measures of Taibei Sag in Tuha Basin,NW China

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Petroleum Exploration and Development 2024年第3期51卷 519-534页

作者： ZHI Dongming LI Jianzhong YANG Fan chen xuan WU Chao WANG Bo ZHANG Hua HU Jun JIN Jikun PetroChina Tuha Oilfield Company Hami 839009China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China PetroChina Hanzhou Research Institute of Geology Hanzhou 310023China

Based on the latest results of near-source exploration in the Middle and Lower Jurassic of the Tuha Basin,a new understanding of the source rocks,reservoir conditions,and source-reservoir-cap rock combinations of the Jurassic Shuixigou Group in the Taibei Sag is established using the concept of the whole petroleum system,and the coal-measure whole petroleum system is analyzed *** results are obtained in three ***,the coal-measure source rocks of the Badaowan Formation and Xishanyao Formation and the argillaceous source rocks of the Sangonghe Formation in the Shuixigou Group exhibit the characteristics of long-term hydrocarbon generation,multiple hydrocarbon generation peaks,and simultaneous oil and gas generation,providing sufficient oil and gas sources for the whole petroleum system in the Jurassic coal-bearing ***,multi-phase shallow braided river delta–shallow lacustrine deposits contribute multiple types of reservoirs,***,tight sandstone,shale and coal rock,in slope and depression areas,providing effective storage space for the petroleum reservoir formation in coal-measure ***,three phases of hydrocarbon charging and structural evolution,as well as effective configuration of multiple types of reservoirs,result in the sequential accumulation of conventional-unconventional *** high structural positions to depression,there are conventional structural and structural-lithological reservoirs far from the source,low-saturation structural-lithological reservoirs near the source,and tight sandstone gas,coal rock gas and shale oil accumulations within the ***,the tight sandstone gas and coal rock gas are the key options for further exploration,and the shale oil and gas in the depression area is worth of more *** new understanding of the whole petroleum system in the coal measures could further enrich and improve the geological theory of the whole petroleum system,and provide new ideas fo

关键词： Tuha Basin Taibei Sag Middle and Lower Jurassic whole petroleum system coal measure tight oil and gas coal rock gas shale oil

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文学史上的“跨界”现象与文学史的学科边界

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江西师范大学学报(哲学社会科学版) 2024年第3期57卷 110-118页

作者：陈文新蒋璇武汉大学文学院

文学与哲学的“跨界”、文学与史学的“跨界”、文学与艺术的“跨界”,构成了文学史上三种主要的“跨界”现象，哲学史、史学史、艺术史、文学史等因而有不少共同的关注对象。在“跨界”现象的编纂处理中，文学史的学科边界以两种方式... 详细信息

文学与哲学的“跨界”、文学与史学的“跨界”、文学与艺术的“跨界”,构成了文学史上三种主要的“跨界”现象，哲学史、史学史、艺术史、文学史等因而有不少共同的关注对象。在“跨界”现象的编纂处理中，文学史的学科边界以两种方式清晰地呈现出来：首先，中国文学史是否给予一个历史人物较多篇幅，依据的是其文学史地位，而不是哲学史、史学史或艺术史地位。其二，文学史面向历史上的文学活动，而哲学史、史学史、艺术史等面向历史上的哲学活动、史学活动或艺术活动，它们有不同的知识体系、不同的描述重点、不同的评价尺度。

关键词：文学史跨界学科边界

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Assessing the current situation and the influencing factors affecting perceived stigma among older patients after leukemia diagnosis

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World Journal of Psychiatry 2024年第6期14卷 812-821页

作者： xuan Tang Shuang-Qin chen Jiang-Hua Huang Cai-Feng Deng Jie-Qiong Zou Juan Zuo Department of Neurology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Hematology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after ***,there is limited research on the stigma experienced by these patients and the factors that may contribute to *** To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing *** A retrospective analysis was conducted using clinical data obtained from questionnaire surveys,interviews,and the medical records of older patients with leukemia admitted to the Hengyang Medical School from June 2020 to June *** data obtained included participants’basic demographic information,medical history,leukemia type,family history of leukemia,average monthly family income,pension,and tendency to conceal *** Chinese versions of the Social Impact Scale(SIS),Perceived Social Support Scale(PSSS),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess indicators related to stigma,social support,and mental health *** used Pearson’s correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale,and regression analysis to explore the factors related to the stigma of older patients with leukemia after *** Data from 120 patients with leukemia aged 65-80 years were *** total score on the SIS and PSSS was 43.60±4.07 and 37.06±2.87,*** SAS score was 58.35±8.32 and the SDS score was 60.58±*** stigma experienced by older leukemia patients was negatively correlated with social support(r=-0.691,P<0.05)and positively correlated with anxiety and depression(r=0.506,0.382,P<0.05).Age,education level,smoking status,average monthly family income,pension,and tendency to conceal illness were significantly associated with the participants’level of stigma(P<0.05).Age,smoking status,social support,anxiety,and depressi

关键词： Senile leukemia Stigma Social support Anxiety Depression Influencing factors

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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng cheng Lei Zhang Jun-Jun Wang Ying Wang ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li chen Chao Song Xin Zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

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Free radicals trigger the closure of open pores in lignin-derived hard carbons toward improved sodium-storage capacity

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Journal of Energy Chemistry 2024年第7期94卷 551-559页

作者： Wen-Jun Ji Zong-Lin Yi Ming-Xin Song Xiao-Qian Guo Yi-Lin Wang Yi-xuan Mao Fang-Yuan Su Jing-Peng chen Xian-Xian Wei Li-Jing Xie cheng-Meng chen CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030001ShanxiChina

The chemical activation of various precursors is effective for creating additional closed pores in hard carbons for sodium ***,the formation mechanism of closed pores under the influence of pore-forming agents is not well ***,an effective chemical activation followed by a high-temperature self-healing strategy is employed to generate interconnected closed pores in lignin-derived hard carbon(HCs).By systematic experimental design combined with electron paramagnetic res-onance spectroscopy,it can be found that the content of free radicals in the carbon matrix influences the closure of open pores at high *** high activation temperature(>700 C)leads to a low free radical concentration,making it difficult to achieve self-healing of open pores at high *** activation at 700°C,a balance between pore making and self-healing is achieved in the final hard carbon.A large number of free radicals triggers rapid growth and aggregation of carbon microcrys-tals,blocking pre-formed open micropores and creating additional interconnected closed pores in as-obtained hard *** a result,the optimized carbon anode(LK-700-1300)delivers a high reversible capacity of 330.8 mA h g^(-1) at 0.03 A g^(-1),which is an increase of 86 mA h g^(-1) compared to the pristine lignin-derived carbon anode(L-700-1300),and exhibits a good rate performance(202.1 mA h g^(-1) at 1 A g^(-1)).This work provides a universal and effective guidance for tuning closed pores of hard carbons from otherprecursors.

关键词： Hard carbon Chemical activation Free radical Self-healing Closed pores Sodium ion batteries

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