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Variation in Bombyx mori immune response against fungal pathogen Beauveria bassiana with variability in cell wallβ-1,3-glucan

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Insect Science 2024年第1期31卷 211-224页

作者： Yulong Wang Zhen Liu Xuebing Yin Shihong Liu Kai Wang Rongjie Wan Haoran chen Xinyang Li Bo Huang Anhui Provincial Key Laboratory of Microbial Pest Control Anhui Agricultural UniversityHefeiChina

Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of ***,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain *** Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx *** molecular mechanisms underlying the immune response in *** were investigated using RNA sequencing,which revealed differences in the immune response to different *** strains at 12 h *** assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence ***βGRP4 silencing in *** with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of *** was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by Bmβ***,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between *** *** results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of ***.

关键词： ombyx mori BmβGRP4 innate immunity insect fungal pathogen virulence

HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata

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Journal of Analysis and Testing 2024年第1期8卷 83-94页

作者： Renguo Zhang Xinjian Liu Tong Wang Jie Yu Mengyuan Wang Jianmin Sun Xueling Yu Na Niu Ligang chen College of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic *** this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant ***,network pharmacology was used to predict Q-markers and core *** results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug *** further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was *** results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/*** Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling *** study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.

关键词： Saposhnikovia divaricata Q-markers Fingerprint Chemometrics Network pharmacology Molecular docking

Greening the Belt and Road Initiative: Evidence from emergy evaluation of China’s provincial trade with ASEAN countries

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Fundamental Research 2024年第2期4卷 379-393页

作者： Xu Tian Joseph Sarkis Wei chen Yong Geng Haozhi Pan Zuoxi Liu Sergio Ulgiati SJTU-UNIDO Joint Institute of Inclusive and Sustainable Industrial Development School of International and Public AffairsShanghai Jiao Tong UniversityShanghai 200030China Worcester Polytechnic Institute Worcester MA 01609-2280USA School of Geography and Environment Shandong Normal UniversityJinan 250358China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of Clean Energy of Liaoning School of Energy and EnvironmentShenyang Aerospace UniversityShenyang 110136China Department of Science and Technology Parthenope University of NapoliNaples 80143Italy School of Environment Beijing Normal UniversityBeijing 100875China

The Belt and Road Initiative(BRI)is a central policy within China’s regional development and foreign trade *** trade has typically depended on economic valuation of resources,while the embedded environmental value is rarely *** situation exists in most BRI trade *** address BRI environmental sustainability issues,we consider the role of pivotal Chinese provinces and their key trade partners(ASEAN countries)as an illustration for the environmental value of resource *** accounting is used as the valuation tool for a sample period of seventeen *** results include:(1)Emergy valuations show sustainability of sample provinces decreased over time;(2)ASEAN countries such as Indonesia,Malaysia,Singapore,Thailand,and Vietnam play significant resource roles for provincial economic systems;(3)Diverse trends in trade between pivotal provinces and ASEAN countries resulted in an unbalanced trade structure from *** implications are proposed to promote a more globally sustainable and fair trade using BRI as an established trade policy.

关键词： International trade Emergy Belt and road initiative Environmental sustainability Province

Self-Adaptive and Electric Field-Driven Protective Layer with Anchored Lithium Deposition Enable Stable Lithium Metal Anode

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Energy & Environmental Materials 2024年第3期7卷 32-40页

作者： Ting chen Luchao Yue Guoqiang Shu Qing Yang Dong Wang ruoyang Wang Xianyan Qiao Yan Sun Benhe Zhong Zhenguo Wu Xiaodong Guo Department of Chemical Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Lithium metal battery has great development potential because of its lowest electrochemical potential and highest theoretical ***,the uneven deposition of Li^(+)flux in the process of deposition and stripping induces the vigorous growth of lithium dendrites,which results in severely battery performance degradation and serious safety ***,the tetragonal BaTiO3 polarized by high voltage corona was used to build an artificial protective layer with uniform positive polarization direction,which enables uniform Li^(+)*** contrast to traditional strategies of using protective layer,which can guide the uniform deposition of lithium *** ferroelectric protective layer can accurately anchor the Li^(+)and achieve bottom deposition of lithium due to the automatic adjustment of the electric ***,the huge volume changes caused by Li^(+)migration change of the lithium metal anode during charging and discharging is functioned to excite the piezoelectric effect of the protective layer,and achieve seamless dynamic tuning of lithium deposition/*** dynamic effect can accurately anchor and capture Li^(+).Finally,the layer-modified Li anode enables reversible Li plating/stripping over 1500 h at 1 mA cm^(-2)and 50℃in symmetric *** addition,the assembled Li-S full cell exhibits over 300 cycles with N/P≈*** work provides a new perspective on the uniform Li^(+)flux at the Li-anode interface of the artificial protective layer.

关键词： dense plating/stripping process electric field ferroelectric materials lithium metal batteries solid electrolyte interphase

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表面纹理对水泥吸波路面微波除冰性能的影响

科学技术与工程 2024年第14期24卷 6003-6011页

作者：刘浩翔王选仓赵静陈律任俊儒长安大学公路学院西安710064 陆军勤务学院重庆401331

为了增强水泥混凝土路面除冰效率,制备了吸波及疏水涂层,并在此基础上,构建了8种不同表面纹理,用于探究表面纹理、吸波材料对微波升温性能的影响。首先,以石墨为微波吸收剂,掺加纳米SiO_(2)制备了兼具疏水和吸波性能的水泥基涂层;通过... 详细信息

为了增强水泥混凝土路面除冰效率,制备了吸波及疏水涂层,并在此基础上,构建了8种不同表面纹理,用于探究表面纹理、吸波材料对微波升温性能的影响。首先,以石墨为微波吸收剂,掺加纳米SiO_(2)制备了兼具疏水和吸波性能的水泥基涂层;通过机器学习改进铺砂法获得不同纹理的平均构造深度(mean texture depth,MTD);为了评估MTD对微波升温效率、均匀性的影响,采用课题组自行研发的微波除冰车进行微波升温试验;同时,测试了普通及涂层混凝土表面的接触角,进行了冰-混凝土冰黏附性剪切试验,用于评价本文所制备涂层的除冰效果。最后,为了保证本文设计涂层的抗滑性能,还进行了表面抗滑摆值测试。结果表明:不同程度纹理和吸波涂层两者耦合作用增强水泥路面的吸波升温效率,但纹理对升温均匀性有负面影响;当MTD从0.41 mm(未处理表面)提高至2.11mm时,吸波涂层试件的吸波升温效率提高1.42倍。同时,涂层也显著增强了试件表面的接触角,接触角从25.5°提升至104°,进而冰黏附强度降低。当设计厚度为1.5 mm时,在满足抗滑性的同时涂层仍具有较好的吸波性能。

关键词：微波除冰水泥路面纹理吸波涂层纳米材料

Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022

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Journal of Environmental Sciences 2024年第2期136卷 172-188页

作者： Yaping Jiang Shaocai Yu Xue chen Yibo Zhang Mengying Li Zhen Li Zhe Song Pengfei Li Xiaoye Zhang Eric Lichtfouse Daniel Rosenfeld Key Laboratory of Environmental Remediation and Ecological Health Ministry of EducationResearch Center for Air Pollution and HealthCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Science and Technology Hebei Agricultural UniversityBaoding 071000China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Aix-Marseille Univ CNRSColl FranceCNRSIRDINRAEEuropole Mediterraneen de l’ArboisAvenue Louis Philibert13100 Aix en ProvenceFrance Xi’an Jiaotong University State Key Laboratory of Multiphase Flow in Power EngineeringXi’an 710049China Institute of Earth Sciences The Hebrew University of JerusalemJerusalemIsrael

To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control *** provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special ***,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological *** show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,*** emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in *** the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission *** the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,*** results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission ***,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost *** implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted.

关键词： PM_(2.5) WRF-CMAQ Meteorological conditions Emission reductions Winter Olympic games

Supporting factors model for the sustainable step development of supply chain:An empirical study from China with grounded theory

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Frontiers of Engineering Management 2024年第2期11卷 311-325页

作者： Xiaohong chen Chunfang LU Weihua LIU Siyu WANG Shangsong LONG Jingcheng QIU Yujie WANG Hunan University of Commerce Changsha 410205China Chinese Academy of Engineering Beijing 100088China College of Management and Economics Tianjin UniversityTianjin 300072China

The ongoing stability of supply chains faces significant challenges from trade protectionism,anti-globalization trends,and the COVID-19 *** remain resilient in this dynamic market environment,supply chains must evolve through iterative upgrades and transition to a higher level of sustainability,a process termed“step development.”The current literature,however,offers limited insights into achieving such step development in supply chain sustainability and its critical supporting *** study,grounded in theory,involved interviews with representatives from eight diverse Chinese *** introduce a model delineating supporting factors and a roadmap for Sustainable Step Development of Supply Chains(SSDSC).Our findings highlight three pivotal categories of support for SSDSC:institutional,technological,and social ***,we observed that external influences in these categories positively modulate their internal *** study identifies industrial technology,digital intelligence technology,corporate responsibility,and stakeholder needs as key elements in this *** conclude by offering theoretical and practical recommendations to foster SSDSC.

关键词： supply chain sustainable development supporting factors grounded theory

Adenine nucleotide translocase 2(Ant2)is required for individualization of spermatogenesis of Drosophila melanogaster

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Insect Science 2024年第4期31卷 1055-1072页

作者： Zhen He Yang Fang Fengchao Zhang Yang Liu Xinkai cheng Jiajia Wang Dechen Li Dengsong chen Fan Wu Industrial Crops Institute Hubei Academy of Agriculture SciencesWuhanChina Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdaoShandong ProvinceChina

Successful completion of spermatogenesis is crucial for the perpetuation of the *** Drosophila,spermatid individualization,a process involving changes in mitochondrial structure and function is critical to produce functional mature ***2,encoding a mitochondrial adenine nucleotide translocase,is highly expressed in male testes and plays a role in energy metabolism in the ***,its molecular function remains ***,we identified an important role of Ant2 in spermatid *** Ant2 knockdown testes,spermatid individualization complexes composed of F-actin cones exhibited a diffuse distribution,and mature sperms were absent in the seminal vesicle,thus leading to male *** most striking effects in Ant2-knockdown spermatids were decrease in tubulin polyglycylation and disruption of proper mitochondria derivatives *** apoptotic cells were also observed in Ant2-knockdown *** further investigate the phenotype of Ant2 knockdown in testes at the molecular level,complementary transcriptome and proteome analyses were *** the mRNA level,868 differentially expressed genes were identified,of which 229 genes were upregulated and 639 were downregulated induced via Ant2 ***-labeling proteome analysis revealed 350 differentially expressed proteins,of which 117 proteins were upregulated and 233 were *** expression of glutathione transferase(GstD5,GstE5,GstE8,and GstD3),proteins involved in reproduction were significantly regulated at both the mRNA and protein *** results indicate that Ant2 is crucial for spermatid maturation by affecting mitochondrial morphogenesis.

关键词： adenine nucleotide translocase Drosophila melanogaster individualization complexes mitochondria spermatogenesis tubulin polyglycylation

Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

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Military Medical Research 2024年第4期11卷 616-619页

作者： Zhi-Wen Luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui chen Ren-Wen Wan Shi-Yi chen Jie Mei Wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)