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Improving lipid production by Rhodotorula glutinis for renewable fuel production based on machine learning

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 23-35页

作者： Lihe zhang Changwei zhang xi Zhao Changliu He Xu zhang National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Bioprocess Beijing University of Chemical TechnologyBeijing 10029China

Microbial lipid fermentation encompasses intricate complex cell growth processes and heavily relies on expert experience for optimal *** modeling of the fermentation process assists researchers in making intelligent decisions,employing logical reasoning and strategic planning to optimize lipid *** this study,the effects of medium components and concen-trations on lipid fermentation were investigated,*** then,leveraging the collated data,a variety of machine learning algorithms were used to model and optimize the lipid fermentation *** models,based on artificial neural networks and support vector machines,achieved R?values all higher than 0.93,ensuring accurate predictions of the fermentation *** linear regression was used to evaluate the respective target parameter,which were affected by the medium components of lipid ***,single and multi-objective optimiza-tion were conducted for lipid fermentation using the genetic *** results demonstrated the maximum biomass of 50.3 g·L^(-1) and maximum lipid concentration of 14.1 g:L^(-1) with the error between the experimental and predicted values less than 5%.The results of the multi-objective optimization reveal the synergistic and competitive relationship between biomass,lipid concentration,and conversion rate,which lay a basis for in-depth optimization and amplification.

关键词： microbial lipid machine learning artificial neural network support vector machine genetic algorithm

Modified Projective Synchronization of Fractional-order Chaotic Systems with Different Dimensions

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 527-538页

作者： xi zhang Ran-chao WU School of Mathematics Anhui UniversityHefei 230601China Nanchang No.1 Secondary Vocational School Nanchang330013China

In this paper,the modified projective synchronization between two fractional-order chaotic systems with different dimensions is *** added-order scheme and the reduced-order scheme are proposed,*** on the Laplace transformation and feedback control theory,controllers are designed such that two chaotic systems with different dimensions could be synchronized asymptotically under the presented *** numerical simulations are given to show the effectiveness of the proposed schemes.

关键词： Modified projective synchronization Fractional-order chaotic systems Laplace transformation

On the∂∂-Lemma and Bott-Chern cohomology with local coefficients

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Communications in Mathematics and Statistics 2024年第1期12卷 79-90页

作者： Lihao Huang Chuanjing zhang xi zhang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026People’s Republic of China

AFrölicher-type inequality forBott-Chern cohomology and its relationwith∂∂-lemma were introduced in[1].In this paper,we generalize these results to the cohomology groups with coefficients in flat complex vector bundles.

关键词： Bott-Chern cohomology·∂∂-lemma·Non-Kähler

The non-abelian Hodge correspondence on some non-K?hler manifolds

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Science China Mathematics 2023年第11期66卷 2545-2588页

作者： Changpeng Pan Chuanjing zhang xi zhang School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

The non-abelian Hodge correspondence was established by Corlette(1988),Donaldson(1987),Hit chin(1987)and Simpson(1988,1992).It states that on a compact Kahler manifold(X,ω),there is a one-to-one correspondence between the moduli space of semi-simple flat complex vector bundles and the moduli space of poly-stable Higgs bundles with vanishing Chern *** this paper,we extend this correspondence to the projectively flat bundles over some non-Kahler manifold ***,we prove an existence theorem of Poisson metrics on simple projectively flat bundles over compact Hermitian *** its application,we obtain a vanishing theorem of characteristic classes of projectively flat ***,on compact Hermitian manifolds which satisfy Gauduchon and astheno-K?hler conditions,we combine the continuity method and the heat flow method to prove that every semi-stable Higgs bundle withΔ(E,?E)·[ωn-2]=0 must be an extension of stable Higgs *** the above results,over some compact non-Kahler manifolds(M,ω),we establish an equivalence of categories between the category of semi-stable(poly-stable)Higgs bundles(E,?E,φ)withΔ(E,?E)·[ωn-2]=0 and the category of(semi-simple)projectively flat bundles(E,D)with(-1)(1/2)FD=α■IdE for some real(1,1)-formα.

关键词： projectively flat bundle Higgs bundle non-Kahler the Hermitian-Yang-Mills flow e-regularity theorem

单一及多组分混合物绿松石仿制品的光谱学特征研究

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光谱学与光谱分析 2025年第1期45卷 183-190页

作者：杨池玉汪田田张维肖汤维茜同济大学浙江学院浙江嘉兴314051

对市场新出现的一类仿制品进行了拉曼光谱、红外光谱、化学成分、紫外-可见-近红外吸收光谱分析,对其主要谱学特征进行了归纳总结。结果表明这类仿制品主要由重晶石、三水铝石、方解石粉末单一组分或多组分混合压制再经环氧树脂类或丙... 详细信息

对市场新出现的一类仿制品进行了拉曼光谱、红外光谱、化学成分、紫外-可见-近红外吸收光谱分析,对其主要谱学特征进行了归纳总结。结果表明这类仿制品主要由重晶石、三水铝石、方解石粉末单一组分或多组分混合压制再经环氧树脂类或丙烯酸酯类有机物胶结,并经人工染剂染色而成。红外光谱显示:单一矿物组分仿制品和绿松石差异明显,重晶石仿制品显示[SO_(4)]^(2-)的1078 cm^(-1)吸收峰等,方解石仿制品显示[CO_(3)]^(2-)的1476±cm^(-1)吸收峰等;多组分仿制品可见综合了多种矿物特征的吸收光谱,谱学特征复杂。根据缺失水峰,或仅显示三水铝石结构水OH-导致的3623、3528、3472和3388 cm^(-1)吸收峰,指纹区显示[SO_(4)]^(2-)、[CO_(3)]^(2-)相关吸收峰,可初步区分于绿松石。显微拉曼光谱测试结果表明多组分仿制品的不同测试位置矿物组成不同,可分别测试到三水铝石(3360、3432、3522、3614 cm^(-1))、重晶石(989 cm^(-1))、方解石(1088 cm^(-1))的特征峰,结合显微拉曼光谱及化学分析结果可进一步确认仿制品的具体矿物组成。紫外-可见-近红外吸收光谱表明样品均经人工染剂染色,显示633±、713±nm吸收宽峰或610±、675±nm吸收宽峰。

关键词：三水铝石重晶石方解石振动光谱微区分析

Compressional behavior of MgCr_2O_4 spinel from first-principles simulation

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Science China Earth Sciences 2016年第5期59卷 989-996页

作者： zhang YanYao LIU xi xiONG ZhiHua zhang ZhiGang Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education of China School of Earth and Space Sciences Peking University Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences

The compressional behavior of the MgCr_2O_4 spinel has been investigated with the CASTEP code using density functional theory and planewave pseudopotential technique. We treated the exchange-correlation interaction by both the local density approximation（LDA） and generalized gradient approximation（GGA） with the Perdew-Burker-Ernzerhof functional. Our simulation was conducted for the pressure range of 0–19 GPa. We obtained the isothermal bulk modulus（K_T） of the MgCr_2O_4 spinel as 181.46（48） GPa（GGA; low boundary） or 216.1（11） GPa（LDA; high boundary）, with its first derivative（K＇_T） as 4.41（6） or 4.5（1）, respectively. The oxygen parameter u is not constant but negatively correlated with P, and decreases by about 0.5–0.6% for the investigated P range. The component polyhedra have different compressibilities, increasing in the order of（O_4）_1

关键词： MgCr_2O_4 spinel Compressional behavior GGA LDA Polyhedral compressibility

Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer

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Journal of Integrative Medicine 2021年第5期19卷 408-417页

作者： Hao Gou ruo-chen Huang Fu-lei zhang Yong-hua Su Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Internal Medicine Tianjin Binhai New Area Hospital of TCMFourth Teaching Hospital of Tianjin University of TCMTianjin 300451China International Joint Cancer Institute Naval Medical UniversityShanghai 200433China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China

Objective: Bufalin is an effective drug for the treatment of liver cancer. But its high toxicity, poor watersolubility, fast metabolism and short elimination half-life limit its use in tumor treatment. How to make the drug accumulate in the tumor and reduce side effects while maintaining its efficacy are urgent problems to be solved. The goal of this study is to solve these ***: A copolymer with tunable poly-N-isopropylacrylamide and polylactic acid was designed and synthesized. The corresponding dual targeting immunomicelles(DTIs) loaded with bufalin(DTIs–BF)were synthesized by copolymer self-assembly in an aqueous solution. The size and structure of DTIs–BF were determined by ZetaSizer Nano-ZS and transmission electron microscopy. Then, its temperature sensitivity, serum stability, critical micelle concentration(CMC), entrapment efficiency(EE), drug release and non-cytotoxicity of blank block copolymer micelles(BCMs) were evaluated. Next, the effects of DTIs–BF on cellular uptake, cytotoxicity, and tumor cell inhibition were evaluated. Finally, the accumulation of DTIs–fluorescein isothiocyanate(FITC) and the in vivo anti-tumor effect were observed using an interactive video information ***: DTIs–BF had a small size, spherical shape, good temperature sensitivity, high serum stability, low CMC, high EE, and slow drug release. The blank BCMs had very low cytotoxicity. Compared with free bufalin, the in vitro cellular internalization and cytotoxicity of DTIs–BF against SMMC-7721 cells were significantly enhanced, and the effects were obviously better at 40 ℃ than 37 ℃. In addition, the therapeutic effect on SMMC-7721 cells was further enhanced by the programmed cell death specifically caused by bufalin. When DTIs–FITC were injected intravenously in BALB/c nude mice bearing liver cancer,the accumulation of FITC was significantly increased in ***: DTIs–BF is a potentially effective nano-formulation and has broad prospects in the cl

关键词： Bufalin Liver cancer Epidermal growth factor receptor Immunomicelles

Numerical simulation and transonic wind-tunnel test for elastic thin-shell structure considering fluid–structure interaction

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Chinese Journal of Aeronautics 2015年第1期28卷 141-151页

作者： Yan Yunju xi Zhuyou zhang Shanzhi School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University College of Science Liaoning University of Technology

Aerodynamic force can lead to the strong structural vibration of flying aircraft at a high speed. This harmful vibration can bring damage or failure to the electronic equipment fixed in aircraft. It is necessary to predict the structural dynamic response in the design course. This paper presents a new numerical algorithm and scheme to solve the structural dynamics responses when considering fluid–structure interaction（FSI）. Numerical simulation for a free-flying structural model in transonic speed is completed. Results show that the small elastic deformation of the structure can greatly affect the FSI. The FSI vibration tests are carried out in a transonic speed windtunnel for checking numerical theory and algorithms, and the wind-tunnel test results well accord with that of the numerical simulation. This indicates that the presented numerical method can be applied to predicting the structural dynamics responses when containing the FSI.

关键词： considering tunnel checking aircraft meshes flying completed rigid acceleration harmful

SIMULATION OF HYDRAULIC TRANSIENTS IN HYDROPOWER SYSTEMS USING THE 1-D-3-D COUPLING APPROACH

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Journal of Hydrodynamics 2012年第4期24卷 595-604页

作者： zhang xiao-xi CHENG Yong-guang State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China

Although the hydraulic transients in pipe systems are usually simulated by using a one-dimensional （l-D） approach, local three-dimensional （3-D） simulations are necessary because of obvious 3-D flow features in some local regions of the hydropower systems. This paper combines the 1-D method with a 3-D fluid flow model to simulate the Multi-Dimensional （MD） hydraulic transients in hydropower systems and proposes two methods for modeling the compressible water with the correct wave speed, and two strategies for efficiently coupling the 1-D and 3-D computational domains. The methods are validated by simulating the water hammer waves and the oscillations of the water level in a surge tank, and comparing the results ~with the 1-D solution data. An MD study is conducted for the transient flows in a realistic water conveying system that consists of a draft tube, a tailrace surge tank and a tailrace tunnel. It is shown that the 1-D-3-D coupling approach is an efficient and promising way to simulate the hydraulic transients in the hydropower systems in which the interactions between 1-D hydraulic fluctuations of the pipeline systems and the local 3-D flow patterns should be considered.

关键词： hydropower station hydraulic transients compressible water model coupling of 1-D and 3-D methods