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Chinese Chemical Letters 2007年第5期18卷 505-508页

作者： Chun Xia Tan ruo fei feng Xiao Xia Peng The College of Traditional Medicine of Gansu Lanzhou 730030 China Life Science ＆ Engineering College Northwest University for Nationalities Lanzhou 730030 China

By the condensation of 2,6-bis（4-amino-5-mercapto-[1,2,4]-triazoles-2）pyridine with aromatic acid in the presence of phosphorus oxychloride. Compounds of 2,6-bis（6-aryl-[1,2,4]-triazolo[3,4-b][1,3,4]-thiadiazole-3-yl）pyridines were synthesized. Their structures were confirmed by IR, ^1H NMR spectroscopies and elemental analysis. Their electrochemical behavior and cyclic voltammogram also were be studied. The results showed that they have high ionization potentials and good affinity.

关键词： Synthesis Triazolo-thiadiazoles Electrochemical properties

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基于表面自由能的粒子设计研究进展

中国药学杂志 2017年第14期52卷 1201-1207页

作者：明良山李哲吴飞杜若飞冯怡上海中医药大学中药现代制剂技术教育部工程研究中心上海201203 上海中医药大学中药学院上海201203

随着对表面自由能研究的深入,利用粒子设计过程表面自由能相关参数的变化,探索出许多基于表面自由能性质的粒子设计系统。物料经粒子设计后改变理化属性,表面自由能产生了新的变化。因此,可通过表面自由能性质变化特征指导粒子设计过程... 详细信息

随着对表面自由能研究的深入,利用粒子设计过程表面自由能相关参数的变化,探索出许多基于表面自由能性质的粒子设计系统。物料经粒子设计后改变理化属性,表面自由能产生了新的变化。因此,可通过表面自由能性质变化特征指导粒子设计过程。笔者综述了表面自由能性质在微粉化、粒子改性、混合、包衣、制丸与制粒等粒子设计过程的应用。通过表面自由能相关参数构建了色散力-极性力模型和黏附-凝聚模型,并阐述了色散力-极性力模型和黏附-凝聚模型在粒子设计中的应用。

关键词：表面自由能粒子设计色散力-极性力模型黏附-凝聚模型铺展系数

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong fei Luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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基于FMEA的老年人电子产品交互设计研究

包装工程 2017年第20期38卷 222-227页

作者：许若飞李永锋江苏师范大学徐州221116

目的设计适合老年人使用的电子产品。方法提出基于失效模式与效应分析的方法,成立FMEA专家小组进行讨论;对现有老年人电子产品进行潜在失效模式分析,计算风险优先数值(RPN);针对需要改进的失效模式进行合理的设计改良;针对改良后的产品... 详细信息

目的设计适合老年人使用的电子产品。方法提出基于失效模式与效应分析的方法,成立FMEA专家小组进行讨论;对现有老年人电子产品进行潜在失效模式分析,计算风险优先数值(RPN);针对需要改进的失效模式进行合理的设计改良;针对改良后的产品进行设计评价。结论将失效模式与效应分析的方法应用于老年人电子产品设计,可以发现设计源头问题,尽早采取改进方案,从而使老年人在使用电子产品时,拥有一个良好的交互体验。

关键词：老年人失效模式与效应分析电子产品交互设计

语言模型辅助的英语科技论文摘要语步语料库构建研究

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外语学刊 2025年第1期 29-38页

作者：李洪政王若锦刘芳冯冲北京理工大学外国语学院北京102488 语言工程与认知计算工信部重点实验室北京102488 北京理工大学计算机学院北京100081

语步结构是学术论文中的文本语篇单位,在学术用途英语等方面具有重要价值。尽管关于学术论文的语步研究非常丰富,但语步标注数据资源仍然相对较少。本研究借助自然语言处理领域的语言模型构建了涵盖多个学科领域的英语科技论文摘要语步... 详细信息

语步结构是学术论文中的文本语篇单位,在学术用途英语等方面具有重要价值。尽管关于学术论文的语步研究非常丰富,但语步标注数据资源仍然相对较少。本研究借助自然语言处理领域的语言模型构建了涵盖多个学科领域的英语科技论文摘要语步标注语料库,包括近3.4万个语步结构。语料库构建的第一阶段依靠专家标注形成高质量语料,在第二阶段也是主要阶段,采用基于BERT架构的自动标注模型,在保证标注质量的同时能够快速提升标注速度、扩大标注规模。本研究随后开展了摘要语步自动标注识别实验,对比自动标注模型与大语言模型ChatGPT和Claude3识别不同学科领域的语步结构的效果,验证了模型和语料库的价值。该研究能为科技论文写作智能批改等自然语言处理任务以及学术用途英语等外语教学与研究等提供必要的数据资源,也验证了大语言模型辅助构建语言资源的可能性,体现了语言智能驱动的智慧外语教育的重要性,能有效推动外语教育数字化转型。

关键词：语步结构语料库摘要文本大语言模型

ULTRASONIC INVESTIGATION OF BLOOD

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Chinese Journal of Acoustics 1989年第2期8卷 170-177页

作者： feng, ruo Nanjing Univ Nanjing China

Ultrasonic biophysicists and physicians have continuously exhibited great interest in studying the ultrasonic properties of blood. It is shown that compressibility of red cell appears to be inversely proportional with its hemoglobin content. Among ultrasonic attenuation produced by red cell structure level in blood, absorption of red cell plays predominant role, viscous relative motion loss accounts for less than 15%, and cell scattering contribution is negligible. The coagulation process of blood is accompanied by significant change of sound parameters. The marked advantage has been found in test of blood coagulation process by using ultrasonic technique than the traditional viscous method. Blood coagulation causes sound attenuation, sound backscattering and nonlinearity parameter B/A to increase, but the attenuation frequency dependence hardly changes. All of these findings are of an important realistic significance for developing ultrasonic medicine.

关键词： Mathematical Models Transducers Applications Ultrasonic Waves Velocity Ultrasonics Applications

Image meshing via hierarchical optimization

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Frontiers of Information Technology & Electronic Engineering 2016年第1期17卷 32-40页

作者： Hao XIE ruo-feng TONG Institute of Artificial Intelligence Zhejiang University

Vector graphic, as a kind of geometric representation of raster images, has many advantages, e.g.,definition independence and editing facility. A popular way to convert raster images into vector graphics is image meshing, the aim of which is to find a mesh to represent an image as faithfully as possible. For traditional meshing algorithms, the crux of the problem resides mainly in the high non-linearity and non-smoothness of the ob jective,which makes it difficult to find a desirable optimal solution. To ameliorate this situation, we present a hierarchical optimization algorithm solving the problem from coarser levels to finer ones, providing initialization for each level with its coarser ascent. To further simplify the problem, the original non-convex problem is converted to a linear least squares one, and thus becomes convex, which makes the problem much easier to solve. A dictionary learning framework is used to combine geometry and topology elegantly. Then an alternating scheme is employed to solve both parts. Experiments show that our algorithm runs fast and achieves better results than existing ones for most images.

关键词： Image meshing, Hierarchical optimization, Convexification

Establishment and verification of theoretical model for underwater light-sheet Scheimpflug LiDAR system

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Science China Technological Sciences 2025年第1期 54-61页

作者： fei feng Guojun WU Bo LIU Xu ZHAO Yafeng WU Jinghan XU Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences University of Chinese Academy of Sciences

The Scheimpflug imaging in the air can increase the depth-of-view and has been well studied with an accurate Scheimpflug imaging model. However, there is no corresponding underwater light-sheet Scheimpflug(ULSS) imaging *** a result, imaging accuracy cannot be ensured in the design phase, which mainly relies on the post-calibration. In this paper,the ULSS imaging model is firstly established, which gives the relationship between the pixel number and target distance, as well as that between the target distance and range resolution. A new experimental bracket and an underwater Scheimflug imaging lens were designed and developed. Based on this new device, several experiments were carried out in a pool to study the range resolution of this ULSS LiDAR, by which the correctness of the imaging model was verified. It also shows that the newly designed ULSS LiDAR can achieve a millimeter-level resolution within 8 m.

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药品集采政策与药企研发行为

经济问题 2025年第1期 91-99页

作者：王少飞张勇冯伟忠上海财经大学商学院上海200083 上海财经大学会计与财务研究院上海200083

药品集采政策会加剧医药行业竞争,从而影响医药企业的研发投入。基于药品集采前后三年医药企业的研发专利样本,针对药品集采政策对药企研发行为影响的回归结果表明,集采政策的实施会增加医药企业的研发专利数量,但医药企业所面临的转换... 详细信息

药品集采政策会加剧医药行业竞争,从而影响医药企业的研发投入。基于药品集采前后三年医药企业的研发专利样本,针对药品集采政策对药企研发行为影响的回归结果表明,集采政策的实施会增加医药企业的研发专利数量,但医药企业所面临的转换成本和集采的预期市场收益,会影响医药企业的研发行为,并进一步影响医药企业的创新效率。因此,要降低医药行业的制度成本,加强医药企业之间的分工合作和并购重组,提升医药企业的创新效率,从而加快完善药品集中采购制度和推动健康中国的政策落实。

关键词：药品集采研发专利转换成本预期市场收益

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新生牛血清细菌内毒素的检测

西北民族大学学报（自然科学版） 2003年第4期24卷 59-61页

作者：乔自林李倬冯若飞李明生冯玉萍邓录西北民族大学食品科学与动物科学系甘肃兰州730030

按中国药典2000版二部细菌内毒素检查法及其应用原则,建立了新生牛血清细菌内毒素的检查方法用同一厂家生产的三个批号的鲎试剂与同一厂家生产的三个批号的新生牛血清分别进行干扰试验,在血清最大有效稀释倍数为40时,对鲎试剂无干扰;... 详细信息

按中国药典2000版二部细菌内毒素检查法及其应用原则,建立了新生牛血清细菌内毒素的检查方法用同一厂家生产的三个批号的鲎试剂与同一厂家生产的三个批号的新生牛血清分别进行干扰试验,在血清最大有效稀释倍数为40时,对鲎试剂无干扰;用其中一个批号的鲎试剂法对10批同一厂家生产的新生牛血清进行了细菌内毒素测定,7批新生牛血清细菌内新生牛血清细菌内毒素符合中国药典2000年版的要求,3批不符合

关键词：新生牛血清细菌内毒素检测鲎试剂生物制品