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Damage Spreading in Neural Network with Local Connection and Cycle Stored Patterns

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Chinese Physics Letters 1996年第9期13卷 644-647页

作者： JI Dao-yun chen Tian-lun Department of Physics Nankai UniversityTianjin 300071

The simulation results of damage spreading show the happening of dynamical chaotic-frozen phase transition in a one-dimensional system,a neural network with cycle stored patterns and local *** chaotic phase,the averag... 详细信息

关键词： behavior chaotic dynamical

A PpEIL2/3–PpNAC1–PpWRKY14 module regulates fruit ripening by modulating ethylene production in peach

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Journal of Integrative Plant Biology 2024年第11期66卷 2470-2489页

作者： Yudi Liu Wen Xiao Liao Liao Beibei Zheng yunpeng Cao yun Zhao ruo-Xi Zhang Yuepeng Han State Key Laboratory of Plant Diversity and Specialty Crops Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China Hubei Hongshan Laboratory Wuhan 430070China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Hybrid Rice Department of Plant SciencesCollege of Life SciencesWuhan UniversityWuhan 430072China Sino-African Joint Research Center Chinese Academy of SciencesWuhan 430074China

WRKY transcription factors play key roles in plant resistance to various stresses,but their roles in fruit ripening remain largely ***,we report a WRKY gene PpWRKY14 involved in the regulation of fruit ripening in *** expression of PpWRKY14 showed an increasing trend throughout fruit ***14was a target gene of PpNAC1,a master regulator of peach fruit ***14 could directly bind to the promoters of PpACS1 and PpACO1 to induce their expression,and this induction was greatly enhanced when PpWRKY14 formed a dimer with ***,the transcription of PpNAC1 could be directly suppressed by two EIN3/EIL1 genes,PpEIL2 and *** PpEIL2/3 genes were highly expressed at the early stages of fruit development,but their expression was programmed to decrease significantly during the ripening stage,thus derepressing the expression of *** results suggested a PpEIL2/3–PpNAC1–PpWRKY14 module that regulates fruit ripening by modulating ethylene production in *** results provided an insight into the regulatory roles of EIN3/EIL1 and WRKY genes in fruit ripening.

关键词： EIL ethylene NAC1 Prunus persica ripening WRKY

From Parametric Representation to Dynamical System: Shifting Views of the Motor Cortex in Motor Control

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Neuroscience Bulletin 2022年第7期38卷 796-808页

作者： Tianwei Wang yun chen He Cui Center for Excellence in Brain Science and Intlligent Technology Institute of NeuroscienceChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain and Brain-inspired Intelligence Technology Shanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

In contrast to traditional representational perspectives in which the motor cortex is involved in motor control via neuronal preferenceforkinetics andkinematics,a dynamical system perspective emerging in the last decade views the motor cortex as a dynamical machine that generates motor commands by autonomous temporal *** this review,we first look back at the history of the representational and dynamical perspectives and discuss their explanatory power and controversy from both empirical and computational points of ***,we aim to reconcile the above perspectives,and evaluate their theoretical impact,future direction,and potential applications in brain-machine interfaces.

关键词： Dimensionality reduction Neural network Machine learning Population decoding Brain-machine interface

miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism

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World Journal of Gastroenterology 2017年第1期23卷 76-86页

作者： Xi Jin Dong chen ruo-Heng Zheng Hong Zhang Yi-Peng chen Zun Xiang Department of Gastroenterology The First Affiliated HospitalSchool of MedicineZhejiang University Department of Colorectal Surgery The First Affiliated HospitalCollege of MedicineZhejiang University Department of Clinical Medicine Hangzhou Medical College

AIM To investigate the role of the miR-133a-UCP2 pathway in the pathogenesis of inflammatory bowel disease (IBD) and to explore the potential downstream mechanisms with respect to inflammation, oxidative stress and energy metabolism. METHODS C57BL/6 mice were fed dextran sulfate sodium (DSS) liquid for 7 consecutive days, followed by the administration of saline to the DSS group, UCP2 siRNA to the UCP2 group and a miR-133a mimic to the miR-133a group on days 8 and 11. Body weight, stool consistency and rectal bleeding were recorded daily, and these composed the disease activity index (DAI) score for the assessment of disease severity. After cervical dislocation was performed on day 14, the length of the colon in each mouse was measured, and colonic tissue was collected for further study, which included the following: haematoxylin and eosin staining, UCP2 and miR-133a detection by immunohistochemical staining, western blot and quantitative real-time PCR, measurement of apoptosis by TUNEL assay, and the assessment of inflammation (TNF-alpha, IL-1 beta, IL-6 and MCP1), oxidative stress (H2O2 and MDA) and metabolic parameters (ATP) by ELISA and colorimetric methods. RESULTS An animal model of IBD was successfully established, as shown by an increased DAI score, shortened colon length and specific pathologic changes, along with significantly increased UCP2 and decreased miR-133a levels. Compared with the DSS group, the severity of IBD was alleviated in the UCP2 and the miR-133a groups after successful UCP2 knockdown and miR-133a overexpression. The extent of apoptosis, as well as the levels of TNF-alpha, IL-1 beta, MDA and ATP, were significantly increased in both the UCP2 and miR-133a groups compared with the DSS group. CONCLUSION The miR-133a-UCP2 pathway participates in IBD by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.

关键词： miR-133a Mitochondrial uncoupling protein 2 Inflammatory bowel disease Dextran sulfate sodium

Facile and large-scale synthesis of green-emitting carbon nanodots from aspartame and the applications for ferric ions sensing and cell imaging

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Science Bulletin 2017年第18期62卷 1256-1266页

作者： Xin Zhang yun chen Shou-Nian Ding School of Chemistry and Chemical Engineering Southeast University Department of Immunology Nanjing Medical University

A facile, economical and green strategy to prepare green-fluorescent nitrogen-doped carbon nanodots （N- CDs） with a quantum yield （QY） of approximately 31.91% has been built up, while aspartame was employed as the carbon-nitrogen source for the first time. The prepared N-CDs exhibited ultrahigh brightness, favorable strong photostability and negligible cytotoxicity. The outstanding optical properties are mainly derived from the their robost composition and steric distribution of the doped nitrogen atoms, which have been characterized detailedly. The obtained N-CDs showed highly selective and sensitive response toward ferric ions （Fe3＋） through a fluorescence static quenching process in a wide linear range of 0.005-60 μmol/L. The detection limit was as low as 1.43 nmol/L, allowing the analysis of Fe3＋ in a very simple method. The excitation-dependent luminescent behavior of the obtained N-CDs guaranteed the multicolor emissive property when they were used in cell imaging. And the application for intracellular Fe3＋ sensing further verified this novel N-CDs may open more opportunities in biosensor, bioimaging and biological assay.

关键词： Carbon nanodots Green-emitting Aspartame Ferric ions Cell imaging Real sample

Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy

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Fundamental Research 2022年第6期2卷 885-893页

作者： ruo Wu Yafeng Song Shiwen Wu Yongchang chen State Key Laboratory of Primate Biomedical Research&Institute of Primate Translational Medicine Kunming University of Science and TechnologyKunming 650500China yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Institute of Sport and Health Science Beijing Sport UniversityNo.48 Xinxi RoadHaidian DistrictBeijing 100084China Department of Neurology Chinese PLA General Hospital28 Fuxing RoadHaidian DistrictBeijing 100853China

Duchenne muscular dystrophy(DMD)is a serious genetic neuromuscular rare disease that is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes *** is a dystrophin homologous protein on human chromosome *** and utrophin are highly *** can recruit many dystrophin-glycoprotein complex(DGC)-related proteins and co-localize at the sarcolemma in the early stage of human embryonic ***,utrophin is overexpressed naturally at the mature myofiber sarcolemma in DMD ***,utrophin is considered the most promising homologous protein to replace *** review summarizes various modulating drugs and gene therapy approaches for utrophin *** a universal method to treat DMD disease,utrophin has a promising therapeutic prospect and deserves further investigation.

关键词： Utrophin Dystrophin Duchenne muscular dystrophy Sarcolemma Therapy

Distributed H∞ filtering of nonlinear systems with random topology by an event-triggered protocol

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Science China(Information Sciences) 2021年第10期64卷 206-220页

作者： yun chen Mengze ZHU Renquan LU Anke XUE Key Lab for IoT and Information Fusion Technology of Zhejiang Hangzhou Dianzi University School of Automation Guangdong University of Technology

Applying an event-triggered protocol, this paper proposes a distributed Hfilter design for nonlinear perturbed systems under fading measurements with random topology. Nonlinearities in this system obey the one-sided Lipschitz constraint, which embraces the conventional Lipschitz condition as a special *** sensor network allows random variations of the interconnection strengths between adjacent nodes, and the connection coefficient is determined as the product of a constant and a stochastic variable with a known probabilistic feature. To reduce the unnecessary data transmission and efficiently use the limited bandwidth,the transmissions are orchestrated by an event-triggered regulating strategy. A stochastic bounded real lemma is established for the resulting error dynamics. Based on the presented matrix decomposition, which removes the direct coupling between the statistical information of interconnection strengths and the filter gain, the distributed Hfilter gain can be explicitly expressed and easily solved. The usefulness of the theoretical method is demonstrated in a simulation study.

关键词： sensor network distributed H ∞ filtering one-sided Lipschitz condition event-triggered protocol random topology

Recent progress of unconventional and multifunctional integrated supercapacitors

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Chinese Chemical Letters 2018年第4期29卷 564-570页

作者： Mengxue chen yun Yang Dezhi chen Hua Wang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong University Nanchang 330063 China School of Chemistry Beihang University Beijing 100191 China

Integration can diversify the function of a device with the same volume, therefore it facilitates the development of portable, wearable and flexible electronics. In this review, we described several kinds of novel and unconventional multifunctional integrated supercapacitors which can not only be used to storage energy but also be applied to other fields such as photodetecting, electrochromics, monitoring physiological/mechanical activities, gas sensor, and so on. First, a brief introduction of the significance and advantages of multifunctional integrated supercapacitors was presented. Then we outlined the enormous progress which has been made in the area of multifunctional integrated supercapacitors. In the end, the prospects and further developments in this exciting field were also suggested.

关键词： Integration Multifunction Supercapacitor Wearability Electronic

BADF:Bounding Volume Hierarchies Centric Adaptive Distance Field Computation for Deformable Objects on GPUs

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Journal of Computer Science & Technology 2022年第3期37卷 731-740页

作者： Xiao-Rui chen Min Tang cheng Li Dinesh Manocha ruo-Feng Tong Laboratory of Geometry Image and Video Processing Enterprise Intelligent ComputingCollege of Computer Science and TechnologyZhejiang UniversityHangzhou 310007China Geometric Algorithms for Modeling Motionand Animation LaboratoryUniversity of MarylandMaryland 20742U.S.A.

We present a novel algorithm BADF(Bounding Volume Hierarchy Based Adaptive Distance Fields)for accelerating the construction of ADFs(adaptive distance fields)of rigid and deformable models on graphics processing *** approach is based on constructing a bounding volume hierarchy(BVH)and we use that hierarchy to generate an octree-based *** exploit the coherence between successive frames and sort the grid points of the octree to accelerate the *** approach is applicable to rigid and deformable *** GPU-based(graphics processing unit based)algorithm is about 20x--50x faster than current mainstream central processing unit based *** BADF algorithm can construct the distance fields for deformable models with 60k triangles at interactive rates on an NVIDIA GTX GeForce ***,we observe 3x speedup over prior GPU-based ADF algorithms.

关键词： distance field deformable object graphics processing unit(GPU) octree bounding volume hierarchy