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Investigation of Anxiety, Depression, Stress and Related Factors in the Primary Caregivers of Inpatients with Cancer

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Journal of Nutritional Oncology 2020年第4期5卷 176-181页

作者： Hong Hong Xu ruo tong xue Yi Cheng Yu Jie Zhang Jie Rao Mei Liu Shi Ying Yu Ling Xiang Liu Yi Qian Liu Yong Qian Shu Liu Qing Yang Han Ping Shi Medical Psychology Department Peking University Health Science CenterBeijing 100191China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Gastrointestinal Surgery Department of Clinical NutritionBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objectives To explore the anxiety,depression,stress and related factors in the primary caregivers of inpatients with *** A total of 235 selected caregivers of inpatients with cancer were included as the research subjects,and the Depression-Anxiety-Stress Self-Rating Scale 21(DASS-21)was used to evaluate their depression,anxiety and *** data were statistically analyzed using SPSS 25.0 *** The study showed that the caregivers of cancer patients had different levels of depression,anxiety and stress,but all rates were above the normal range,with 51.7%,56.0%and 34.9%of subjects respectively reporting these *** addition,the above indicators were correlated with the caregivers’gender,age,relationship with the cancer patients,the family’s economic status,religious belief and duration of caregiving:being female(T-Statistic=-2.061,P=0.040)and having a low income(F=2.627,P=0.035)were positively correlated with the caregivers’stress *** a low income(F=2.804,P=0.027)was also positively correlated with the depression *** the caregivers were the patient's parents,they had higher levels of anxiety(F=2.429,P=0.036)than caregivers in other *** results of a linear correlation analysis showed that the depression of caregivers was negatively correlated with the family’s economic status(r value=-0.244,P<0.01)and positively correlated with the duration of caregiving(r=0.138,P<0.05).The anxiety score was positively correlated with the caregivers’age(r=0.141,P<0.05)and duration of caregiving(R=0.132,P<0.05),but negatively correlated with the family’s economic status(r=-0.187,P<0.01).The stress level was positively correlated with the caregivers’gender(r=0.137,P<0.05),age(r=0.210,P<0.01),duration of caregiving(r=0.171,P<0.01)and current job status(r=0.165,P<0.05),but negatively correlated with the family’s economic status(r=-0.202,P<0.01).The results of a multiple stepwise regression showed that age and religious belief

关键词： Caregiver Anxiety Depression Stress

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Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-tong Cui Hua-Ru xue Dian-Fang Wei Xiao-Yu Feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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Image meshing via hierarchical optimization

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Frontiers of Information Technology & Electronic Engineering 2016年第1期17卷 32-40页

作者： Hao XIE ruo-feng tong Institute of Artificial Intelligence Zhejiang University

Vector graphic, as a kind of geometric representation of raster images, has many advantages, e.g.,definition independence and editing facility. A popular way to convert raster images into vector graphics is image meshing, the aim of which is to find a mesh to represent an image as faithfully as possible. For traditional meshing algorithms, the crux of the problem resides mainly in the high non-linearity and non-smoothness of the ob jective,which makes it difficult to find a desirable optimal solution. To ameliorate this situation, we present a hierarchical optimization algorithm solving the problem from coarser levels to finer ones, providing initialization for each level with its coarser ascent. To further simplify the problem, the original non-convex problem is converted to a linear least squares one, and thus becomes convex, which makes the problem much easier to solve. A dictionary learning framework is used to combine geometry and topology elegantly. Then an alternating scheme is employed to solve both parts. Experiments show that our algorithm runs fast and achieves better results than existing ones for most images.

关键词： Image meshing, Hierarchical optimization, Convexification

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Experimental Study on Inducement and Development of Flow Instabilities in a Centrifugal Compressor with Different Diffuser Types

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Journal of Thermal Science 2020年第2期29卷 435-444页

作者： xue Xiang WANG tong Gas Turbine Research Institute Shanghai Jiao Tong UniversityShanghai 200240China

A centrifugal compressor is a typical compressed air energy storage device. In order to ensure the safety of the compressed energy storage process in the compressor, the internal unsteady flow phenomena need to be closely monitored, especially some serious ones like stall and surge. It is necessary to explore the mechanism of flow instabilities under different conditions. A centrifugal air compressor was tested with a vaneless diffuser and a variable vaned diffuser with five different vane setting angles, respectively. Various diffuser types resulted in various modes of flow instabilities prior to surge. The vaneless region between the impeller and the diffuser was focused on. Multiple high-speed sensors were arranged along the circumferential direction. The pressure signals at all these positions were being measured and collected in real time as the compressor was slowly throttled into surge. This paper emphasizes on the influence of matching between the impeller and the diffuser on the flow instability. The experimental results showed that the diffuser vane setting angle affected the stall characteristics. Due to the asymmetry of the volute, the circumferential pressure distribution was always severely distorted prior to surge. A high-pressure region appeared near the volute tongue, and a low-pressure region was formed away from the volute tongue. In the case of the vaned diffuser with non-design installation angle and the vaneless diffuser, the rotating stall signal was originated in the low-pressure region and propagated circumferentially. However, in the case of the vaned diffuser with the design installation angle, the circumferential high-pressure region became the most sensitive region for the generation of stall, and another form of instability occurred there. Both the inducement and development of these flow instabilities have been studied. The dynamic experimental research on the compressor matching different types of diffusers could be a good case supple

关键词： compressed air energy storage centrifugal compressor flow instability stall

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Experimental and Computational Analysis of the Unstable Flow Structure in a Centrifugal Compressor with a Vaneless Diffuse

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Chinese Journal of Mechanical Engineering 2019年第4期32卷 127-139页

作者： Xiang xue tong Wang Gas Turbine Research Institute Shanghai Jiao Tong University

The unstable flow phenomena in compressors, such as stall and surge, are closely related to the e ciency and the operating region. It is indispensable to capture the unstable flow structure in compressors and understand the mechanism of flow instability at low flow rates. Cooperated with the manufacturer, an industrial centrifugal compressor with a vaneless di user is tested by its performance test rig and our multi-phase dynamic measurement system. Many dynamic pressure transducers are circumferentially mounted on the casing surface at seven radial locations, spanning the impeller region and the di user inlet region. The pressure fields from the design condition to surge are measured in details. Based on the multi-phase dynamic signals, the original location of stall occurring can be determined. Meanwhile, the information of the unstable flow structure is obtained, such as the circumferential mode and the propagating speed of stall cells. To get more details of the vortex structure, an unsteady simulation of this tested compressor is carried out. The computational result is well matched with the experimental result and further illustrates how the unstable flow structure in the impeller region gradually a ects the stability of the total machine at low flow rates. The dynamic mode decomposition(DMD) method is applied to get the specific flow pattern corresponding to the stall frequency. Both experimental and computational analysis show that the flow structure at a particular radial location in the impeller region has a great impact on the stall and surge. Some di erences between the computational and experimental result are also discussed. Through these two main analytical methods, an insight into the unstable flow structure in an industrial compressor is gained. The result also plays a crucial role in the guidance of the compressor stabilization techniques.

关键词： Unstable flow Vortex structure Centrifugal compressor Vaneless di user

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From aqueous Zn-ion battery to Zn-MnO_(2) flow battery:A brief story

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Journal of Energy Chemistry 2021年第3期30卷 194-201页

作者： tong xue Hong Jin Fan School of Materials Science and Engineering North Minzu UniversityYinchuan 750021NingxiaChina School of Physical and Mathematical Sciences and Innovative Centre for Flexible DevicesNanyang Technological UniversitySingapore 637371Singapore

Aqueous Zn-ion battery(AZIB)has become an attractive technology because of its unique features of low cost,high safety and the ***_(2) is the model cathode material for AZIB since the first report on reversible Zn-MnO_(2) battery,but recent studies have unveiled different charge storage *** to revamping of the electrochemistry and redesigning of the electrolyte and interface,there is tremendous performance enhancement in *** mini Review will first give a brief introduction of ZIB,including fundamentals of materials and components,and the progress in recent ***,a general classification of working mechanisms related to MnO_(2) in neutral and mildly acidic electrolyte is *** focus is put on the recent blossoming Zn-MnO_(2) electrolytic mechanism,which has given birth to the Zn-MnO_(2) redox flow batteries that are highly promising for large-scale static energy storage.

关键词： Aqueous zinc-ion battery Deposition/dissolution Electrolytic battery Zn-MnO2 flow battery

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不同荷载作用下五边形石墨烯的变形破坏机理研究

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原子与分子物理学报 2025年第6期42卷 51-57页

作者：赵泽若韩同伟李仁葛峻铭王嘉越江苏大学土木工程与力学学院镇江212013

五边形石墨烯是一种完全由碳五元环组成的准二维的亚稳态碳结构,在不同载荷作用下其变形破坏机理仍需进一步研究.本文基于ReaxFF反应力场采用分子动力学方法模拟研究了五边形石墨烯的拉伸、剪切和纳米压痕破坏过程,得到了五边形石墨烯... 详细信息

五边形石墨烯是一种完全由碳五元环组成的准二维的亚稳态碳结构,在不同载荷作用下其变形破坏机理仍需进一步研究.本文基于ReaxFF反应力场采用分子动力学方法模拟研究了五边形石墨烯的拉伸、剪切和纳米压痕破坏过程,得到了五边形石墨烯的拉伸和剪切应力-应变曲线以及压入载荷-位移曲线,系统分析了五边形石墨烯的变形破坏机理,并验证了五边形石墨烯在不同载荷作用下是否表现出塑性变形特征的一致性问题.研究结果表明,通过拉伸或纳米压入等不同加载方式均可准确测出五边形石墨烯的本征力学性能参数,其杨氏模量265.4~285.1 N/m,与第一性原理计算结果一致.研究还发现,五边形石墨烯在拉伸、剪切和纳米压痕过程中均会出现不可逆的塑性变形特征,而引起塑性变形的原因是由于不可逆的碳五元环向碳多元环结构的转变.以上研究结果可为基于五边形石墨烯的微/纳米机电系统的实际应用提供重要指导.

关键词：五边形石墨烯变形破坏机理分子动力学

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K-DSA for the multiple traveling salesman problem

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Journal of Systems Engineering and Electronics 2023年第6期34卷 1614-1625页

作者： tong Sheng QU Hong xue Junjie Air Traffic Control and Navigation College Air Force Engineering UniversityXi’an 710051China

Aimed at a multiple traveling salesman problem(MTSP)with multiple depots and closed paths,this paper proposes a k-means clustering donkey and a smuggler algorithm(KDSA).The algorithm first uses the k-means clustering method to divide all cities into several categories based on the center of various samples;the large-scale MTSP is divided into multiple separate traveling salesman problems(TSPs),and the TSP is solved through the *** proposed algorithm adopts a solution strategy of clustering first and then carrying out,which can not only greatly reduce the search space of the algorithm but also make the search space more fully explored so that the optimal solution of the problem can be more quickly *** experimental results from solving several test cases in the TSPLIB database show that compared with other related intelligent algorithms,the K-DSA has good solving performance and computational efficiency in MTSPs of different scales,especially with large-scale MTSP and when the convergence speed is faster;thus,the advantages of this algorithm are more obvious compared to other algorithms.

关键词： k-means clustering donkey and smuggler algorithm(DSA) multiple traveling salesman problem(MTSP) multiple depots and closed paths.

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Gravitational Instability in Neutrino Dominated Accretion Disks

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Chinese Physics Letters 2011年第12期28卷 309-311页

作者： LIU tong xue Li Department of Physics and Institute of Theoretical Physics and Astrophysics Xiamen UniversityXiamen 361005

We revisit the vertical structure of neutrino-dominated accretion flows(NDAFs)in spherical coordinates under a boundary condition based on a mechanical *** solutions show that the NDAF is significantly geometrically *** Toomre parameter is determined by the mass accretion rate and the viscosity parameter,which is defined as Q=cSΩ/πGΣ,where cS,ΩandΣare the sound speed,angular velocity and surface density,*** to the distribution of the Toomre parameter,the possible fragments of the disk may appear near the disk surface in the outer *** possible outflows originating from the gravitational instability of the disk may account for the late-time flares in gamma-ray bursts.

关键词： parameter viscosity coordinates

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