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Self-confocal NIR-II fluorescence microscopy for multifunctional in vivo imaging

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 105-119页

作者： jing Zhou Tianxiang Wu runze Chen Liang Zhu Hequn Zhang Yifei Li Liying Chen Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058P.R.China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058P.R.China College of Biomedical Engineering and Instrument Science Interdisciplinary Institute of Neuroscience and Technology(ZIINT)Zhejiang UniversityHangzhou 310027P.R.China

Fluorescence imaging in the second near-infrared window(NIR-II,900–1880 nm)with less scattering background in biological tissues has been combined with the confocal microscopic system for achieving deep in vivo imaging with high spatial ***,the traditional NIR-IIfluorescence confocal microscope with separate excitation focus and detection pinhole makes it possess low confocal e±ciency,as well as di±cultly to *** types of upgraded NIR-IIfluorescence confocal microscopes,sharing the same pinhole by excitation and emission focus,leading to higher confocal e±ciency,are built in this *** type is-ber-pinhole-based confocal microscope applicable to CW laser *** is constructed forfluorescence intensity imaging with large depth,high stabilization and low cost,which could replace multiphotonfluorescence microscopy in some applications(e.g.,cerebrovascular and hepatocellular imaging).The other type is air-pinhole-based confocal microscope applicable to femtosecond(fs)laser *** can be employed not only for NIR-IIfluorescence intensity imaging,but also for multi-channelfluorescence lifetime imaging to recognize different structures with similarfluorescence ***,it can be facilely combined with multiphotonfluorescence microscopy.A single fs pulsed laser is utilized to achieve up-conversion(visible multiphotonfluorescence)and down-conversion(NIR-II one-photonfluorescence)excitation simultaneously,extending imaging spectral channels,and thus facilitates multi-structure and multi-functional observation.

关键词： Self-confocal fiber-pinhole air-pinhole multi-channe fluorescence lifetime imaging multi-color imaging

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City,China,2010-2022

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Biomedical and Environmental Sciences 2024年第9期37卷 1015-1029页

作者： Ying Li runze Lu Liyan Dong Litao Sun Zongyi Zhang Yating Zhao Qing Duan Lijie Zhang Fachun Jiang jing Jia Huilai Ma Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijing 100050China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Qingdao Municipal Center for Disease Control and Prevention Qingdao 266024ShandongChina Jiaozhou Center for Disease Control and Prevention Qingdao 266399ShandongChina Institute for Infectious Disease Control and Prevention Shandong Center for Disease Control and PreventionJinan 250013ShandongChina Office of Epidemiology(Technical Guidance Office for Patriotic Health Work) Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,*** Information was collected on HFRS cases in Qingdao City from 2010 to *** epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were *** A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”*** HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring *** HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and *** spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter *** The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering *** typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.

关键词： Hemorrhagic fever with renal syndrome Epidemic characteristics Spatio-temporal distribution

Impact of industrial virtual power plant on renewable energy integration

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Global Energy Interconnection 2020年第6期3卷 545-552页

作者： runze Liu Yu Liu Zhaoxia jing School of Electric Power South China University of TechnologyGuangzhou 510641P.R.China

An industrial park is one of the typical en ergy con sumption schemes in power systems owing to the heavy in dustrial loads and their abilities to resp ond to electricity price cha ***,en ergy in tegrati on in the industrial sector is ***,the concept of industrial virtual power plant(IVPP)has been proposed to deal with such *** study demonstrates an IVPP model to man age resources in an eco-i ndustrial park,including en ergy storage systems,dema nd resp onse(DR)resources,and distributed *** addition,fuzzy theory is used to cha nge the deterministic system constraints to fuzzy parameters,considering the uncertainty of renewable energy,and fuzzy chance constraints are then set based on the credibility *** maximizi ng the daily ben efits of the IVPP owners in day-ahead markets,DR and energy storage systems can be scheduled ***,the energy between the grid and IVPP can flow in both directions:the surplus renewable electricity of IVPP can be sold in the market;when the electricity gen erated in side IVPP is not enough for its use,IVPP can also purchase power through the *** studies based on three win d-level scenarios dem on strate the efficie nt syn ergies betwee n IVPP *** validatio n results indicate that IVPP can optimize the supply and demand resources in in dustrial parks,thereby decarbonizing the power systems.

关键词： IVPP Virtual power plants Industrial loads Renewable energy integration Fuzzy chanee constraint Credibility theory

原发性胶质母细胞瘤瘤内细菌特征基因及其功能研究

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中华神经外科杂志 2024年第9期40卷 945-951页

作者：于润泽魏成王博李泽生靖博元韩磊天津医科大学总医院天津市神经病学研究所教育部"中枢神经损伤与再生"重点实验室天津市"神经损伤变异与再生"重点实验室天津300052

目的分析原发性胶质母细胞瘤(GBM)患者肿瘤组织中细菌相关特征基因,并研究肿瘤内细菌相关特征基因在GBM中的功能及作用机制。方法采用基于癌症基因组图谱(TCGA)数据分析得到的原发性GBM瘤内细菌相关特征基因的公开数据,共152例。根据GB... 详细信息

目的分析原发性胶质母细胞瘤(GBM)患者肿瘤组织中细菌相关特征基因,并研究肿瘤内细菌相关特征基因在GBM中的功能及作用机制。方法采用基于癌症基因组图谱(TCGA)数据分析得到的原发性GBM瘤内细菌相关特征基因的公开数据,共152例。根据GBM患者总生存时间的中位数,将其分为低生存组(78例)和高生存组(74例)。使用秩和检验评估组间α多样性的差异;采用非度量多维尺度(NMDS)分析和主坐标分析(PCoA)评估组间β多样性的差异;采用线性判别分析(LDA)比较两组GBM样本中丰富度存在显著差异的细菌种类。分别根据各差异细菌相关特征基因的相对丰富度将152例患者分为高丰富度组和低丰富度组,采用Kaplan-Meier法分析高丰富度组与低丰富度组患者生存率的差异。对与良好预后相关的高丰富度细菌相关特征基因GBM样本中显著上调的基因进行基因本体论(GO)生物过程功能注释和京都基因和基因组百科全书(KEGG)通路富集分析;通过TCGA转录组测序数据集分析肿瘤免疫微环境景观,应用曼特尔检验分析免疫细胞浸润含量与预后相关细菌特征基因的相关性。所有数据分析均采用R软件,以P<0.05为差异有统计学意义。结果152例GBM组织中共鉴定出252种细菌相关特征基因,其中234种特征基因在低生存组与高生存组均存在,8种仅存在于低生存组,10种仅存在于高生存组。NMDS和PCoA结果显示,两组的β多样性的差异有统计学意义(P<0.05)。LDA显示,高生存组与低生存组的肿瘤组织中细菌相关特征基因的丰富度存在差异(P<0.05),其中脆弱拟杆菌相关特征基因在高生存组的丰富度较高(P<0.05),并与患者的总生存期呈正相关(χ^(2)=4.13,P<0.05)。功能富集分析显示,肿瘤内脆弱拟杆菌相关特征基因丰富度较高的患者肿瘤组织中高表达与免疫途径相关的基因(P<0.05)。曼特尔检验分析结果显示,原发性GBM肿瘤组织中脆弱拟杆菌相关特征基因的丰富度与M1巨噬细胞浸润呈正相关(P<0.05)。结论脆弱拟杆菌相关特征基因在高生存原发性GBM患者肿瘤组织中的丰富度较高,并影响肿瘤的免疫微环境。

关键词：胶质母细胞瘤细菌相关特征基因肿瘤内细菌转录组

An inverse design method for supercritical airfoil based on conditional generative models

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Chinese Journal of Aeronautics 2022年第3期35卷 62-74页

作者： jing WANG runze LI Cheng HE Haixin CHEN Ran CHENG Chen ZHAI Miao ZHANG Shanghai Aircraft Design and Research Institute Shanghai 200436China School of Aerospace Engineering Tsinghua UniversityBeijing 100084China Guangdong Provincial Key Laboratory of Brain-Inspired Intelligent Computation Department of Computer Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Inverse design has long been an efficient and powerful design tool in the aircraft *** this paper,a novel inverse design method for supercritical airfoils is proposed based on generative models in deep learning.A Conditional Variational Auto Encoder(CVAE)and an integrated generative network CVAE-GAN that combines the CVAE with the Wasserstein Generative Adversarial Networks(WGAN),are conducted as generative *** are used to generate target wall Mach distributions for the inverse design that matches specified features,such as locations of suction peak,shock and aft *** and quantitative results show that both adopted generative models can generate diverse and realistic wall Mach number distributions satisfying the given *** CVAE-GAN model outperforms the CVAE model and achieves better reconstruction accuracies for all the samples in the ***,a deep neural network for nonlinear mapping is adopted to obtain the airfoil shape corresponding to the target wall Mach number *** performances of the designed deep neural network are fully demonstrated and a smoothness measurement is proposed to quantify small oscillations in the airfoil surface,proving the authenticity and accuracy of the generated airfoil shapes.

关键词： Conditional Variational AutoEncoder(CVAE) Deep learning Generative Adversarial Networks(GAN) Generative models Inverse design Supercritical airfoil

冻融循环作用下二灰盐渍土无侧限抗压强度研究

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黑龙江大学工程学报(中英俄文) 2024年第3期15卷 78-87页

作者：王润泽孙静季雨航刘宇轩黑龙江大学建筑工程学院

我国盐渍土分布较广，盐渍土在冻结状态下的工程性能随冻融循环的发展逐渐恶化，影响盐渍土地区工程的安全运营及其耐久性。以黑龙江省大庆市盐渍土为研究对象，通过无侧限抗压试验，研究不同冻融循环次数下石灰、稻壳灰掺量对盐渍土无... 详细信息

我国盐渍土分布较广，盐渍土在冻结状态下的工程性能随冻融循环的发展逐渐恶化，影响盐渍土地区工程的安全运营及其耐久性。以黑龙江省大庆市盐渍土为研究对象，通过无侧限抗压试验，研究不同冻融循环次数下石灰、稻壳灰掺量对盐渍土无侧限抗压强度的影响。结果表明：冻融循环使应力-应变曲线的轴向应力峰值对应的应变变大，为应变软化型，弹性模量变小，0次和1次冻融循环弹性阶段突出，3次冻融循环后压密阶段明显。随着冻融循环次数的增加，原状土和二灰土的无侧限抗压强度均先小幅提升后大幅降低，1次冻融循环时强度最大，1～5次冻融循环处于快速劣化阶段，5次冻融循环后达到稳定阶段，建议将5次冻融循环的无侧限抗压强度作为强度稳定值。石灰6%和稻壳灰8%时无侧限抗压强度提升效果最大，在0、1、3、5、7和9次冻融循环下的无侧限抗压强度加强系数分别为4.32、3.50、4.83、3.63、3.39和3.31,二灰的提升效果优于单灰，单稻壳灰优于单石灰。

关键词：冻融循环二灰盐渍土无侧限抗压强度应力-应变曲线

北京黑猪GREB1L和MIB1基因多态性与肋骨数及胴体性状的关联分析

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畜牧兽医学报 2024年第1期55卷 79-86页

作者：牛乃琪赵润泽宗文成刘先策刘海石国华井西涛张龙超中国农业科学院北京畜牧兽医研究所北京100193 北京黑六牧业科技有限公司北京102211

旨在开展GREB 1L和MIB 1基因多态性与肋骨数和胴体性状(胴体长、胴体直长、胴体斜长及胴体重)关联分析,筛选关键功能位点。本研究选取屠宰日龄为215天的317头健康北京黑猪,并提取耳组织DNA,对GREB 1L和MIB 1基因进行引物设计、并利用聚... 详细信息

旨在开展GREB 1L和MIB 1基因多态性与肋骨数和胴体性状(胴体长、胴体直长、胴体斜长及胴体重)关联分析,筛选关键功能位点。本研究选取屠宰日龄为215天的317头健康北京黑猪,并提取耳组织DNA,对GREB 1L和MIB 1基因进行引物设计、并利用聚合酶链式反应(PCR)技术和Sanger测序技术等对SNPs进行基因分型,计算变异位点基因型频率以及等位基因频率分布,并与肋骨数和胴体性状进行关联分析。试验共筛选到6个SNPs,包括GREB 1L基因的3个同义突变、MIB 1基因的2个同义突变和1个内含子区的可变剪切突变。将6个SNPs分别对肋骨数和胴体性状使用Duncan’s多重检验统计分析发现,GREB 1L基因上的3个同义突变6:106574972 G>A、6:106648540 C>T、6:106648558 A>G与性状关联均不显著(P>0.05);MIB 1基因上的1个同义突变6:106936590 C>T与胴体长显著相关(PG可变剪切突变与肋骨数显著相关(PA与肋骨数和胴体性状均无显著差异(P>0.05)。结果显示,显著的2个位点可作为北京黑猪肋骨数及胴体长变异的候选基因功能位点。

关键词：北京黑猪 GREB 1L MIB 1 肋骨数胴体性状

蚌埠市结直肠癌社会性筛查结肠镜检查顺应性及影响因素分析

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实用预防医学 2024年第3期31卷 330-333页

作者：王井曹大龙施恒远朱润泽王燕芈静张皎平蚌埠市第一人民医院安徽蚌埠233000 蚌埠医学院公共卫生学院安徽蚌埠233000

目的了解蚌埠市结直肠癌早诊早治项目高危人群结肠镜检查顺应性及影响因素分析。方法选取2021年10—12月在蚌埠市定点筛查医院进行筛查的4805名40~74岁的常住居民。采用χ^(2)检验比较不同特征人群的结肠镜检查顺应性;采用多因素logisti... 详细信息

目的了解蚌埠市结直肠癌早诊早治项目高危人群结肠镜检查顺应性及影响因素分析。方法选取2021年10—12月在蚌埠市定点筛查医院进行筛查的4805名40~74岁的常住居民。采用χ^(2)检验比较不同特征人群的结肠镜检查顺应性;采用多因素logistic回归分析评估影响结肠镜检查的危险因素。结果4805名调查对象中结直肠癌高危人群共计1327人,结直肠癌高危人群中接受结肠镜检查共计376人,结肠镜检查顺应性为28.33%(376/1327)。logistic回归结果显示:男性(OR=1.374,95%CI:1.095~1.724)、50~59岁(OR=2.286,95%CI:1.656~3.154)和60~74岁(OR=1.667,95%CI:1.180~2.357)、中专/中学(OR=2.960,95%CI:2.127~4.118)和大学/大专及以上文化(OR=3.640,95%CI:2.483~5.337)、有慢性便秘史人群(OR=2.530,95%CI:1.989~3.219)、有结直肠癌家族史人群(OR=3.712,95%CI:2.945~4.679)、有溃疡性结肠炎人群(OR=2.562,95%CI:1.543~4.254)更易接受结肠镜检查。结论蚌埠市结直肠癌早诊早治项目高危人群结肠镜检查的顺应性不高,需加大落实结直肠癌筛查力度并精准施策。

关键词：结直肠癌结肠镜筛查顺应性

The Variation of Stone Cell Content in 236 Germplasms of Sand Pear(Pyrus pyrifolia)and Identification of Related Candidate Genes

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Horticultural Plant Journal 2021年第2期7卷 108-116页

作者： Jiaying Zhang Jiaming Li Cheng Xue runze Wang Mingyue Zhang Kaijie Qi jing Fan Hongju Hu Shaoling Zhang Jun Wu Center of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095China Institute of Fruit and Tea Hubei Academy of Agriculture SciencesWuhan 430064China

Stone cells have been described to substantially influence pear fruit quality,as lignin and cellulose are the main components of stone ***,there are limited studies on the relationship between the variation and molecular basis of stone cells,lignin and cellulose content among different pear ***,to reveal the variation of stone cell content within different cultivated species,we collected 236 germplasms of sand pear(Pyrus pyrifolia)at 50 days after flower blooming(DAFB),the key stage of stone cell *** our results,we measured the content of stone cells,lignin and cellulose and found that these contents ranged from2.82%to 29.00%,8.84%to 55.30%and 11.52%to 30.55%,*** analysis showed that the variation coefficient of stone cell,lignin and cellulose content was 39.10%,28.03%and 16.71%,***,a significant correlation between stone cell,lignin and cellulose content were detected,and the correlation coefficient between the contents of stone cell and lignin(0.912)was higher than between the contents of stone cell and cellulose(0.796).Moreover,the average lignin content(29.73%)was higher than the average cellulose content(18.03%)in stone cells in pear fruits,indicating that lignin is the main component of stone cell in ***,on the basic of the transcriptome data,we identified 10 transcription factors belonging to bHLH,ERF,MYB,and NAC transcript families,which might be involved in lignin formation in stone ***-PCR experiments verified coincident trends between expression of candidate genes and stone cell *** research laid foundation for future studies on genetic variation of stone cells in pear fruits and provided important gene resources for stone cell regulation.

关键词： pear stone cell lignin cellulose transcription factor