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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie runxue zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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次声波诱发心脏损伤的作用机制研究进展

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华西医学 2024年第9期39卷 1493-1495页

作者：刘霞方以群施春英周润雪刘琪孙淑维李慈中国人民解放军海军特色医学中心潜水与高气压医学研究室免疫与炎症国家重点实验室上海200433 青岛大学基础医学院人体解剖与组织胚胎学系山东青岛266071

目前,次声波对心脏健康的潜在危害已有研究揭示,但其作用机制尚未见全面综述。因此,该文回顾了次声波对心脏功能的直接和间接影响,并探讨其引发心脏异常的作用机制。与此同时,为后续进一步对次声波开展研究和采取有效的预防措施,该文还... 详细信息

目前,次声波对心脏健康的潜在危害已有研究揭示,但其作用机制尚未见全面综述。因此,该文回顾了次声波对心脏功能的直接和间接影响,并探讨其引发心脏异常的作用机制。与此同时,为后续进一步对次声波开展研究和采取有效的预防措施,该文还综述了次声波暴露对心脏细胞的损伤机制,包括细胞膜改变、电生理特性调节及神经-内分泌途径的生物效应,并突出了次声波暴露对公共健康的影响。

关键词：次声波心脏损伤心率变异促心肌细胞凋亡分子机制

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Selenium,Type-2 Diabetes,and the Possible Protective Role of Vitamin D

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Biomedical and Environmental Sciences 2024年第6期37卷 661-665页

作者： runxue Ma Ce Liu Ling Zhang Jingzhe Guo Erkai zhou Ling Zheng Li He Xiaobing Shan Yunhui Yu Bin Luo Institute of Occupational Health and Environmental Health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

Diabetes is a pervasive and serious global health *** to the International Diabetes Federation report,463 million adults worldwide were living with diabetes in 2019,and this number is projected to reach 700 million in... 详细信息

关键词： Diabetes Selenium Vitamin

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Collagen targeting peptide EBP binding to bFGF protects rats from renal ischemia-reperfusion injury

Collagen targeting peptide EBP binding to bFGF protects rats...

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泛环渤海、华东六省一市生物化学与分子生物学会联盟2023年学术交流会暨研究生教育论坛

作者： LI xiaoge XU qingling CHEN xinhui zhou runxue SHI chunying AO xiang School of Basic Medical Sciences Qingdao Medical College Qingdao University

Acute kidney injury(AKI) is a common human disease, which seriously threatens human health and is one of the important causes of chronic kidney failure. Restoring AKI requires the replacement of damaged cells with new cells that are able to restore the integrity of the tubular epithelium. Basic fibroblast growth factor(bFGF) has been shown to play a role in cell proliferation, migration, and differentiation, thereby regulating angiogenesis and wound healing, among others. It induces the reexpression of morphogenetic proteins in the early stages of injury and accelerates the recovery process after kidney injury, Because BFGF spreads easily in the body, it is especially important to study how to target it for delivery and aggregation to the site of injury. In recent years, targeted peptides have become more widely studied, and it provides new strategies for the continuous delivery of bFGF at the site of injury. In this study, we genetically engineered extracellular matrix binding peptide(EBP) to bFGF with the aim of increasing the concentration of local bFGF at the ischemic site by in situ injection of EBP-bFGF in renal ischemic injury to achieve sustained release of bFGF. Therefore, this study mainly designed and constructed the EBP-bFGF fusion protein through genetic engineering. In the case of renal ischemic injury, the local concentration of bFGF at the ischemic site is increased by EBP-bFGF is EBP-bFGF on ischemic injury by enzyme-linked immunosorbent assay(ELISA), western blotting, immunohistochemistry, pathological staining and renal function tests, and found that EBP-bFGF can promote the increase of cell blood vessel number and vitality through in vitro experiments. In addition, after the injured tubular epithelial cells(HK2) were injected with EBP-bFGF, the protein detection results of Bax and Bcl-2 also significantly inhibited their apoptosis. In order to explore whether the early cause of apoptosis is related to mitochondria, we detected a decrease in mitoc

关键词： Basic fibroblast growth factor Acute kidney injury ischemia-reperfusion apoptosis

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中枢性性早熟遗传学研究进展

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国际内分泌代谢杂志 2020年第6期40卷 416-419页

作者：魏莹周润雪牛婧娅天津医科大学总医院儿科 300052

中枢性性早熟源于下丘脑-垂体-性腺轴过早激活,与正常青春期进展顺序一致。目前引发青春期启动的许多因素仍不明确,遗传学机制可能发挥重要作用。在散发性和家族性病例中已发现kisspeptin系统、MKNR3和DLK1基因激活或失活突变。现对上... 详细信息

中枢性性早熟源于下丘脑-垂体-性腺轴过早激活,与正常青春期进展顺序一致。目前引发青春期启动的许多因素仍不明确,遗传学机制可能发挥重要作用。在散发性和家族性病例中已发现kisspeptin系统、MKNR3和DLK1基因激活或失活突变。现对上述基因及作用机制进行讨论,同时简述与中枢性性早熟相关的15个潜在基因及4个以中枢性性早熟为部分表现的临床综合征。

关键词：中枢性性早熟遗传学全基因组关联研究

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砂化白云岩隧洞围岩分类方法SHF构建及应用

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地球科学 2024年第8期49卷 2813-2825页

作者：董家兴龚欣月米健范开元杨润学赵永川沐红元周伦顺昆明理工大学电力工程学院云南昆明650500 云南省水利水电勘测设计研究院云南昆明650021 云南省滇中引水工程有限公司云南昆明650000

砂化白云岩在我国西南地区分布广泛,在该地层中修建隧洞,常出现掌子面塌方、突水涌砂等地质灾害,因此在滇中引水工程建设中面临的砂化白云岩问题备受关注.砂化等级和地下水条件是控制砂化白云岩隧洞围岩破坏模式与稳定性的关键因素,然而... 详细信息

砂化白云岩在我国西南地区分布广泛,在该地层中修建隧洞,常出现掌子面塌方、突水涌砂等地质灾害,因此在滇中引水工程建设中面临的砂化白云岩问题备受关注.砂化等级和地下水条件是控制砂化白云岩隧洞围岩破坏模式与稳定性的关键因素,然而,在传统围岩分类方法中往往没有全面考虑到这些因素,例如在Q系统中未考虑岩石强度、RMR法未考虑地应力、BQ法对砂化白云岩的结构面状态、粗糙度等,同时,传统方法均未直接考虑砂化等级对于砂化白云岩工程特性的影响.为实现更为快速、客观地进行砂化白云岩隧洞围岩分类,需构建一种适合于砂化白云岩隧洞的围岩分类方法.为解决以上缺陷,以在建的滇中引水工程为依托,首先分析了Q法、RMR法、RMi法、GSI法、BQ法等传统方法在砂化白云岩隧洞中的适用性.其次,结合砂化白云岩工程地质特性及赋存地质环境,构建了以砂化等级、结构面状态、地下水、主要结构面状态、地应力为评价指标的围岩分类体系SHF,并选取依托工程典型洞段对SHF分类方法进行了验证和应用.建立的砂化白云岩隧洞围岩分类方法SHF易于操作,应用该方法所得的围岩分类结果更符合工程实际,研究可为砂化白云岩隧洞支护设计和施工提供理论依据.

关键词：砂化白云岩 SHF围岩分类方法砂化等级地下水滇中引水工程

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浊毒理论指导慢性萎缩性胃炎胃癌前病变治疗近20年研究回顾

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中华中医药杂志 2024年第8期39卷 4416-4418页

作者：王绍坡李佃贵马晓菲叶凤红孙润雪河北省中医院石家庄050011

慢性萎缩性胃炎与胃癌前病变均有胃癌发生风险,在慢性萎缩性胃炎向胃癌前病变甚至胃癌发展的过程中积极干预,逆转或控制胃黏膜病变进展,对于胃癌的防治具有重要意义。目前西医治疗尚无特效药物,而中医药在治疗方面具有独特优势。国医大... 详细信息

慢性萎缩性胃炎与胃癌前病变均有胃癌发生风险,在慢性萎缩性胃炎向胃癌前病变甚至胃癌发展的过程中积极干预,逆转或控制胃黏膜病变进展,对于胃癌的防治具有重要意义。目前西医治疗尚无特效药物,而中医药在治疗方面具有独特优势。国医大师李佃贵首创浊毒理论,指导慢性萎缩性胃炎胃癌前病变的治疗取得了良好的疗效,文章从病因病机、临床研究、实验研究、胃镜病理、其他中医疗法及日常调护几个方面回顾总结,对防治慢性萎缩性胃炎胃癌前病变具有重要意义。

关键词：浊毒理论慢性萎缩性胃炎胃癌前病变回顾研究

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Cobalt catalysts for Fischer–Tropsch synthesis： The effect of support,precipitant and pH value

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Chinese Journal of Chemical Engineering 2018年第4期26卷 747-752页

作者： zhenhua li mengyao si li xin renjie liu runxue liu jing lü Key Lab for Green Chemical Technology of Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

In this report,Co-based catalysts supported on ZnO,Al_2O_3 and ZrO_2 as well as the ZrO_2 derived from different precipitants and different pH values were prepared by co-precipitation *** catalytic Fischer–Tropsch synthesis(FTS)performance was investigated in a fixed-bed *** results revealed that Co catalyst supported on ZrO_2 exhibited better FTS catalytic performance than that supported on ZnO or Al_2O_*** the Co/ZrO_2catalyst,different precipitants showed the following an activity order of NaOH>Na_2CO_3>NH_4OH,and the best pH value is *** catalysts were characterized by N_2adsorption–desorption,XRF,XRD,H_2-TPR,H_2-TPD and *** was found that the main factor affecting the CO conversion of the catalyst was the amounts of low-temperature active adsorption ***,the selectivity of C_5^+hydrocarbons had a positive relationship with the peak temperature of the weak hydrogen adsorption *** higher the peak temperature,the higher the C_5^+selectivity is.

关键词： Fischer–Tropsch synthesis Co-precipitation Carbon monoxide Hydrogenation ZrO2

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高复发进展风险MIBC根治术后辅助化疗和辅助免疫治疗联合化疗的疗效

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中华泌尿外科杂志 2024年第3期45卷 187-194页

作者：李智杨绍博王泽今沈冲张英郎张羽姜润学张哲徐勇胡海龙天津医科大学第二医院泌尿外科天津300211 解放军总医院泌尿外科工作北京 100853

目的探讨高复发进展风险(pT_(2)期伴淋巴结阳性,pT_(3~4a)期伴或不伴淋巴结阳性)肌层浸润性膀胱癌(MIBC)根治术后,辅助化疗和辅助免疫治疗联合化疗的疗效。方法回顾性分析2016年8月至2022年1月天津医科大学第二医院收治的217例高复发进... 详细信息

目的探讨高复发进展风险(pT_(2)期伴淋巴结阳性,pT_(3~4a)期伴或不伴淋巴结阳性)肌层浸润性膀胱癌(MIBC)根治术后,辅助化疗和辅助免疫治疗联合化疗的疗效。方法回顾性分析2016年8月至2022年1月天津医科大学第二医院收治的217例高复发进展风险MIBC患者的临床资料。男183例(84.3%),女34例(15.7%);年龄(67.3±8.6)岁。217例均行根治性膀胱切除术+盆腔淋巴结清扫,根据术后接受辅助治疗情况分为观察组147例(67.7%)和治疗组70例(32.3%)。观察组和治疗组的年龄分别为(67.4±9.0)岁和(66.3±7.6)岁(P=0.14);术后病理分期T_(2)期伴淋巴结阳性分别为8例(5.4%)和6例(8.6%),T_(3~4a)期伴淋巴结阳性分别为34例(23.1%)和18例(25.7%),T_(3~4a)期不伴淋巴结阳性分别为105例(71.5%)和46例(65.7%)(P>0.05);肿瘤直径≥3cm分别为118例(80.3%)和54例(77.1%)(P>0.05),0.05)。治疗组70例中,36例(16.6%)术后应用吉西他滨(1000mg/m^(2),第1、8天)和顺铂(75mg/m^(2),第2~4天)方案化疗(化疗组);34例(15.7%)应用免疫检查点抑制剂(静脉滴注信迪利单抗200mg或替雷利珠单抗200mg或特瑞普利单抗240mg,第1天)和白蛋白紫杉醇(200mg,第2天)方案治疗(免疫联合化疗组)。化疗组和免疫联合化疗组的年龄分别为(66.8±8.4)岁和(65.8±6.8)岁(P>0.05);术后病理分期T_(2)期伴淋巴结阳性分别为3例(8.3%)和3例(8.8%),T_(3~4a)期伴淋巴结阳性分别为6例(16.7%)和12例(35.3%),T_(3~4a)期不伴淋巴结阳性分别为27例(75.0%)和19例(55.9%)(P>0.05);肿瘤直径≥3cm分别为30例(83.3%)和10例(29.4%)(P>0.05),0.05)。采用Kaplan-Meier法和多因素Cox回归分析观察组与治疗组术后1、3年的总生存期(OS),以及化疗组与免疫联合化疗组术后1、3年的无病生存期(DFS)。采用美国卫生及公共服务部发布的常见不良事件评价标准分析化疗组和免疫联合化疗组的并发症。结果本研究中位随访时间18.4(8.2,34.7)个月,观察组和治疗组中位随访时间分别为19.0(8.3,35.2)个月和17.5(7.9,33.2)个月;术后1年总生存率分别为76.2%和90.0%,差异有统计学意义(χ^(2)=6.92,P=0.009);术后3年总生存率分别为57.8%和82.9%,差异有统计学意义(χ^(2)=13.22,P<0.01)。观察组中位OS为35.9个月,治疗组中位OS未达到,差异有统计学意义(HR=2.51,95%CI1.36~4.65,P=0.003)。化疗组和免疫联合化疗组的中位随访时间分别为10.7(7.4,22.1)个月和14.4(6.3,40.7)个月;术后1年无病生存率分别为67.6%和91.2%,差异有统计学意义(χ^(2)=4.60,P=0.032);术后3年无病生存率分别为88.2%和55.6%,差异有统计学意义(χ^(2)=8.37,P=0.004)。化疗组中位DFS为27.7个月,免疫联合化疗组中位DFS未达到,差异有统计学意义(HR=3.39,95%CI1.46~7.89,P=0.016)。治疗组并发症分级1级140例,2级39例,3级8例,4级2例,5级0例。化疗组和免疫联合化疗组均出现5例≥3级不良反应,其中化疗组为2例贫血,2例血小板计数降低,1例中性粒细胞降低;免疫联合化疗组为1例贫血,1例血小板计数降低,2例中性粒细胞降低,1例-谷氨酰胺转移酶增高。化疗组和免疫联合化疗组≥3级不良反应发生率分别为13.9%(5/36)和14.7%(5/34),差异无统计学意义(χ^(2)=0.01,P=0.922)。结论对于高复发进展风险MIBC患者,术后行辅助治疗可明显延长OS。对于铂类化疗不耐受,或拒绝铂类辅助化疗的患者,可采用免疫检查点抑制剂联合白蛋白紫杉醇方案,作为根治性膀胱切除术后的辅助治疗方案,具有较好的疗效和安全性,不良反应可耐受。

关键词：膀胱肿瘤肌层浸润性膀胱癌辅助化疗免疫检查点抑制剂毒性作用

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Features of gut microbiota in patients with anorexia nervosa

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Chinese Medical Journal 2022年第16期135卷 1993-2002页

作者： runxue Yuan Lei Yang Gaiqi Yao Shuxia Geng Qinggang Ge Shining Bo Xueni Li Department of Intensive Care Unit Peking University Third HospitalBeijing 100191China Peking Universty Sixth Hospital Peking University Institute of Mental HealthNational Heath Council Key Laboratory of Mental Health(Peking University)National Clnical Research Center for Mental Disorders(Peking University Sixth Hospital)Bejing 100083China

Background:Anorexia nervosa(AN)is a psychological disorder,which is characterized by the misunderstanding of body image,food restriction,and low body *** increasing number of studies have reported that the pathophysiological mechanism of AN might be associated with the dysbiosis of gut *** purpose of our study was to explore the features of gut microbiota in patients with AN,hoping to provide valuable information on its pathogenesis and ***:In this cross-sectional study,from August 2020 to June 2021,patients with AN who were admitted into Peking University Third Hospital and Peking University Sixth Hospital(n=30)were recruited as the AN group,and healthy controls(HC)were recruited from a middle school and a university in Beijing(n=30).Demographic data,Hamilton Depression Scale(HAMD)scores of the two groups,and length of stay of the AN group were *** diversity analysis of gut microbiota in stool samples from the two groups was analyzed by 16S ribosomal RNA(rRNA)gene ***:The weight(AN ***,[39.31±7.90]kg vs.[56.47±8.88]kg,P<0.001)and body mass index(BMI,AN ***,[14.92±2.54]kg/m^(2)vs.[20.89±2.14]kg/m^(2),P<0.001)of patients with AN were statistically significantly lower than those of HC,and HAMD scores in AN group were statistically significantly higher than those of *** alpha diversity,there were no statistically significant differences between the two groups;for beta diversity,the two groups differed obviously regarding community *** to HC,the proportion of Lachnospiraceae in patients with AN was statistically significantly higher(AN ***,40.50%vs.31.21%,Z=-1.981,P=0.048),while that of Ruminococcaceae was lower(AN ***,12.17%vs.19.15%,Z=-2.728,P=0.007);the proportion of Faecalibacterium(AN ***,3.97%vs.9.40%,Z=-3.638,P<0.001)and Subdoligranulum(AN ***,4.60%vs.7.02%,Z=-2.369,P=0.018)were statistically significantly lower,while that of Eubacterium_halli_group was significantly high

关键词： Gut microbiota Anorexia nervosa Microbial diversity analysis Lachnospiraceae Ruminococcaceae Faecalibacterium Eubacterium_hallii_group Bacteroides

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