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Investigation of surface textures deterioration on pavement skid-resistance using hysteresis friction models and numerical simulation method

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Friction 2024年第4期12卷 745-779页

作者： Haoyuan LUO Siyu CHEN Leyi ZHU Xiyin LIU Yangzezhi ZHENG runming ZHAO Xiaoming HUANG School of Transportation Southeast UniversityNanjing 211189China National Demonstration Center for Experimental Education of Road and Traffic Engineering Southeast UniversityNanjing 211189China

Many rubber friction theories or some method combined theories and field-experiments are employed to evaluate the pavement skid-resistance deterioration due to the evolution of surface ***,these methods are difficult to be implemented in the analysis of situations with multi-factor coupling and some extreme *** study developed a framework to evaluate the skid-resistance deterioration of asphalt *** this framework,the portable laser scanning was used to create the digital worn pavement model,and a hydroplaning finite element(FE)model for these digital worn pavements was constructed to evaluate coupling effects of the texture evolution and factors of slip ratio,slip angle,velocity and water film on braking-cornering characteristics of *** this study,the deterioration of skid-resistance of five typical asphalt pavements due the surface texture wear was systematically investigated by this *** with previous works,this study established the rubber friction models for each digital worn pavement considering the energy hysteresis of rubber and the power spectrum density of surface *** the rubber friction model was used to define the interaction behaviors between the tire and corresponding wore pavements in the FE hydroplaning model,rather than using an empirical friction model or a fixed friction coefficient.

关键词： worn pavement skid-resistance friction coefficient textures evolution water film computer numerical simulation

Establishing cell suitability for high-level production of licorice triterpenoids in yeast

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4134-4148页

作者： Wentao Sun Shengtong Wan Chuyan Liu Ruwen Wang Haocheng Zhang Lei Qin runming Wang Bo Lv Chun Li Department of Chemical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyInstitute of Biochemical EngineeringSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China The University of Chicago ChicagoIL 60637USA Key Lab for Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

Yeast has been an indispensable host for synthesizing complex plant-derived naturalcompounds, yet the yields remained largely constrained. This limitation mainly arises from overlookingthe importance of cell and pathway suitability during the optimization of enzymes and pathways. Herein,beyond conventional enzyme engineering, we dissected metabolic suitability with a framework forsimultaneously augmenting cofactors and carbon flux to enhance the biosynthesis of heterogenoustriterpenoids. We further developed phospholipid microenvironment engineering strategies, dramaticallyimproving yeast’s suitability for the high performance of endoplasmic reticulum (ER)-localized, ratelimitingplant P450s. Combining metabolic and microenvironment suitability by manipulating only threegenes, NHMGR (NADH-dependent HMG-CoA reductase), SIP4 (a DNA-binding transcription factor)andGPP1.(Glycerol-1.phosphate phosphohydrolase 1., we enabled the high-level production of 4.92 g/L rarelicorice triterpenoids derived from consecutive oxidation of b-amyrin by two P450 enzymes afterfermentation optimization. This production holds substantial commercial value, highlighting the criticalrole of establishing cell suitability in enhancing triterpenoid biosynthesis and offering a versatileframework applicable to various plant natural product biosynthetic pathways.

关键词： Cell suitability Phospholipid microenvironment Cytochrome P450 Triterpenoids Saccharomyces cerevisiae

Lithiophilic CoF2@C hollow spheres towards spatial lithium deposition for stable lithium metal batteries

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Journal of Energy Chemistry 2024年第10期97卷 55-67页

作者： Jianxing Wang Shuhao Yao runming Tao Xiaolang Liu Jiazhi Geng Chang Hong Huiying Li Guiyun Yu Haifeng Li Xiao-Guang Sun Jianlin Li Jiyuan Liang School of Optoelectronic Materials & Technology Jianghan University Institute for Advanced Materials and Manufacturing University of Tennessee Applied Materials Division Argonne National Laboratory School of Chemistry & Chemical Engineering Yancheng Institute of Technology Chemical Sciences Division Oak Ridge National Laboratory

Lithium metal（LM） is a promising anode for next-generation batteries due to its high theoretical capacity and low electrode ***,side reactions,volume change,and unwanted lithium dendrite growth seriously limit the practical application of ***,with the aid of a hard template approach,a novel lithiophilic CoF2-carbon hollow sphere（CoF2@C-HS） composite material is successfully prepared via a facile in-situ fluorination and etching *** lithiophilic CoF2acts as nucleation sites to reduce nucleation overpotential as well as induces the spatial Li deposition and the formation of LiFrich solid electrolyte interphase（SEI）,and the hollow carbon matrix can enhance the electrical conductivity and offer free space for LM *** simulations reveal that the synergistic effect of lithiophilic CoF2and hollow carbon matrix homogenizes the electric field distribution and Li+*** from these advantages,the CoF2@C-HS-modified copper substrate electrode delivers an enhanced Coulombic efficiency（CE） of 93.7% for 280 cycles at 1.mA cm-2and 1.mA h *** symmetrical cell using CoF2@C-HS can stably cycle more than 1.00 h with a low voltage hysteresis of 1. mV at a current density of 0.5 MA cm-2and an areal capacity of 0.5 mA h ***,the Li@CoF2@C-HS composite anode enables more than 300 stable cycles at 1.C with a capacity retention of 95% in LiFePO4-based full cell and 1.0 stable cycles at 1.C in LiNi0.8Co0.1.n0.1.2（NCM81.）-based highvoltage full *** work might shed a new light on designing lithiophilic hosts to spatially confine LM deposition,realizing dendrite-free LM anodes and the practical applications of LM batteries.

关键词： Lithiophilic CoF2 Lithium metal anode Nanocomposite Spatial deposition, Stability

Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51.GBGI types categorized under 1. main *** GBGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1.4.2℃),street trees(3.8±3.1.),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–21.0)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines

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Protein & Cell 2010年第4期1卷 342-354页

作者： Shibo Jiang runming Li Lanying Du Shuwen Liu Lindsley F.Kimball Research Institute New York Blood CenterNew YorkNY 10065USA School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Seasonal influenza epidemics and influenza pandemics caused by influenza A virus(IAV)has resulted in millions of deaths in the *** development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza ***(HA)of IAV plays a critical role in viral binding,fusion and entry,and contains the major neutralizing ***,HA is an attractive target for developing anti-IAV drugs and *** we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.

关键词： influenza A virus hemagglutinin viral entry antiviral drugs vaccines

Influence of retinoic acid on TBX1.expression in myocardial cells induced by Shh and Fgf8

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Frontiers of Medicine 2009年第1期3卷 61-66页

作者： Miao LIU Xiaoyan WU Jiawei XU runming JIN Department of Paediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The aim of this study was to explore the regulatory mechanism of retinoic acid(RA)on the TBX1.gene expression in myocardial *** cardio-cytes were isolated from neonatal rats and cultured,and then treated with different concentrations of retinoic *** expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measured by using RT-PCR and Western blot technique,*** was basal expression of Shh and Fgf8 in the control *** treated with 3�1.–7 mol/L RA,we observed that the expression of Shh mRNA and protein in neonatal rat myocardial cells were up-regulated by 1.51.P1.1. times(P1.–7 mol/L RA,they were up-regulated by 2.21.P1.–7 mol/L RA,and they were up-regulated by 3.48(P1.–7 mol/L *** results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardial *** the same time,it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1.expression.

关键词： retinoic acid Tbx1.protein Shh protein Fgf8 protein

国家天然气(页岩气)千亿立方米级产能基地共建共享模式

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天然气技术与经济 2024年第1期18卷 1-6,14页

作者：何润民贺志明辜穗周娟周波李季中国石油西南油气田公司天然气经济研究所四川成都610051 中国石油西南油气田公司四川成都610051

国家天然(页岩气)千亿立方米级产能基地建设是保障国家能源安全、支撑区域社会经济加快发展的重大战略。在借鉴油气共建共享成功经验基础上,构建了国家天然气(页岩气)千亿立方米级产能基地共建共享模式,提出了模式实施路径。研究结果表... 详细信息

国家天然(页岩气)千亿立方米级产能基地建设是保障国家能源安全、支撑区域社会经济加快发展的重大战略。在借鉴油气共建共享成功经验基础上,构建了国家天然气(页岩气)千亿立方米级产能基地共建共享模式,提出了模式实施路径。研究结果表明:①国家天然气(页岩气)千亿立方米级产能基地建设涉及庞大的产业体系与多元主体不同利益诉求,需要以共建共享理念和系统工程思维为指引,立足多元主体与多维度要素协同构建共建共享模式。②模式实施五大路径:强化共建共享顶层战略设计,丰富发展政企共建共享方式,完善企业之间共建共享机制,畅通多元主体沟通协商渠道,健全共建共享应急预警体系。结论认为,该模式以战略视域统筹产能基地建设,能够实现对多元主体利益的有效协同,促进天然气(页岩气)资源开发利用与产业链价值提升,为带动区域社会经济发展并推进共同富裕提供有力支持。

关键词：天然气(页岩气) 千亿立方米级产能基地共建共享模式实施路径

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新质生产力驱动童鞋健康技术的研究与探索

西部皮革 2024年第17期46卷 126-128页

作者：陈鹏飞张倩孙国正赵梓钦邹润茗扬州大学广陵学院

新质生产力概念的提出为童鞋健康设计和儿童足部健康的发展提供了更加多元的可能。文章基于团队调研考察结果，整理归纳出了当前童鞋设计所存在的问题，并根据目前企业设计创新的相关技术成果和高校人才所具备的专业知识融合发展，提出... 详细信息

新质生产力概念的提出为童鞋健康设计和儿童足部健康的发展提供了更加多元的可能。文章基于团队调研考察结果，整理归纳出了当前童鞋设计所存在的问题，并根据目前企业设计创新的相关技术成果和高校人才所具备的专业知识融合发展，提出在推动新质生产力的基础上，完善童鞋设计在儿童足部健康上的缺陷与不足，旨在为儿童足部健康提供保障，推动童鞋行业科学健康地发展。

关键词：新质生产力儿童足部健康技术童鞋设计校企融合

北非地区Ghadames盆地早古生代岩相古地理演化特征

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古地理学报 2024年第1期26卷 45-57页

作者：张忠民李依霖郑乃熙曹喆吕雪雁李宗峰孙润明夏昌盛李磊牛博宿宇驰张浩飞冯志强季汉成鲍志东中国石油化工股份有限公司石油勘探开发研究院油气资源与工程全国重点实验室中国石油大学(北京) 中国石油大学(北京)地球科学学院东北石油大学非常规油气研究院

北非地区Ghadames盆地已成为中国海外油气勘探与项目投资的重点盆地之一,对其早古生代沉积体系及岩相古地理特征的准确认识是进一步勘探的基础,也是建立盆地早期构造与沉积演化过程的关键。以Gha dames盆地早古生界为研究目标,利用岩心... 详细信息

北非地区Ghadames盆地已成为中国海外油气勘探与项目投资的重点盆地之一,对其早古生代沉积体系及岩相古地理特征的准确认识是进一步勘探的基础,也是建立盆地早期构造与沉积演化过程的关键。以Gha dames盆地早古生界为研究目标,利用岩心、地震与测井等资料综合分析,开展古地貌恢复,对沉积体系、岩相古地理演化特征进行探讨。结果表明,Ghadames盆地早古生代共发育4种沉积体系:冲积扇、辫状河、辫状河三角洲和浅海。早中寒武世,阿瓦隆地体向波罗的板块漂移,原特提斯洋初步扩张,形成活动大陆边缘,盆地以陆相沉积为主;奥陶纪,盆地经加里东运动初步形成台内隆坳格局,Ghadames盆地西部和北部大范围剥蚀,冰川大规模出现,发育冰碛岩;早中志留世,古特提斯洋持续扩张,海平面不断上升,盆地北部发生大规模海侵,以浅海沉积环境为主,广泛发育放射性页岩与泥岩,是区域内重要的烃源岩与盖层;泥盆纪,海西运动使区域整体抬升,盆内海域范围减小,以陆相沉积为主。在此基础上,建立Ghadames盆地早古生代特提斯洋演化背景下的海陆过渡沉积模式,可为研究区下一步勘探工作提供参考依据。

关键词：沉积体系岩相古地理沉积模式早古生代 Ghadames盆地北非地区