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Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants

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Science China(Life Sciences) 2024年第2期67卷 391-402页

作者： Awei Zhang Haizhen Zhang Ronghua Wang Hongfu He Baoan song runjiang song National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China

The prevention and control of rice bacterial leaf blight(BLB)disease has not yet been achieved due to the lack of effective agrochemicals and available ***,we develop a series of novel bissulfones and a novel target with a unique mechanism to address this *** developed bissulfones can control Xanthomonas oryzae ***(Xoo),and 2-(bis(methylsulfonyl)methylene)-N-(4-chlorophenyl)hydrazine-1-carboxamide(B_(7))is more effective than the commercial drugs thiodiazole copper(TC)and bismerthiazol(BT).Pyruvate kinase(PYK)in Xoo has been identified for the first time as the target protein of our bissulfone B_(7).PYK modulates bacterial virulence via a CRP-like protein(Clp)/two-component system regulatory protein(reg R)*** elucidation of this pathway facilitates the use of B_(7)to reduce PYK expression at the transcriptional level,block PYK activity at the protein level,and impair the interaction within the PYK-Clp-reg R complex via competitive inhibition,thereby attenuating bacterial biology and *** study offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target *** believe that these valuable discoveries will be used for bacterial disease control in the future.

关键词： 2-bissulfone-N-phenylhydrazine-1-carboxamide derivatives Xoo antibacterial activities pyruvate kinase regulatory mechanism

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肾集合管癌1例报道并文献复习

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河南大学学报（医学版） 2024年第1期43卷 68-71页

作者：武留威郭润江张禹李松张建华侯俊清河南大学淮河医院泌尿外科河南开封475000 中国融通医疗健康集团开封一五五医院泌尿外科河南开封475000

目的:探讨肾集合管癌(CDC)的影像学特点、鉴别诊断、治疗及预后。方法:回顾分析河南大学淮河医院收治的1例CDC并文献复习。结果:给予腹腔镜下左肾切除+左侧输尿管全长切除+膀胱袖状切除术,术后辅以吉西他滨+顺铂化疗,现患者生命体征平... 详细信息

目的:探讨肾集合管癌(CDC)的影像学特点、鉴别诊断、治疗及预后。方法:回顾分析河南大学淮河医院收治的1例CDC并文献复习。结果:给予腹腔镜下左肾切除+左侧输尿管全长切除+膀胱袖状切除术,术后辅以吉西他滨+顺铂化疗,现患者生命体征平稳。结论:肾集合管癌非常少见,早确诊及早手术仍是延长患者生命最有效的方法。

关键词：肾集合管癌影像学鉴别诊断

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