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Amphipathicity mediated endocytosis of mesoporous silica nanoparticles with tunable frameworks

Nano Research 2024年第9期17卷 8350-8359页

作者： runfeng lin Tiancong Zhao Liang Chen Minchao Liu Hongyue Yu Ruicong Wang Minjia Yuan Xiaomin Li Dongyuan Zhao Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Shanghai Qiran Biotechnology Co. Ltd.Shanghai 201702China

Due to the amphiphilic nature of phospholipids in the cell membrane,the amphipathicity of the nanomedicine plays a crucial role in the ***,limited biological characterization methods restrict the study of the state of nanoparticles with different amphiphilicities on cell *** understanding of interaction of amphiphilic particle with cell membrane is still ***,by combining the dissipative particle dynamics(DPD)with the framework construction of mesoporous silica nanoparticles(MSNs),we demonstrate the enhanced endocytosis induced by the *** results confirm that the presence of hydrophobic groups on the surface of nanoparticles can disturb the integrity of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)membrane and induce activation of phospholipids to a higher energy level,thereby facilitating the wrapping of *** validate the simulation findings,uniform MSNs with hydrophilic pure silica framework and two types of amphiphilic MSNs with varying hydrophilic organic groups in the framework are rationally synthesized by using different silane *** obtained three kinds of MSNs show similar diameter(~100 nm)and mesopores(~2 nm),but distinct hydrophobicity/hydrophilicity *** phenyl-bridged MSN with a carbon content of 27.1%exhibits enhanced cellular uptake,consistent with the theoretical simulation *** work sheds light on how the surface amphipathicity influences endocytosis through the interaction with cell membrane.

关键词： mesoporous silica nanoparticles mesoporous organosilica endocytosis cell membrane amphipathicity

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Two-dimensional materials-based integrated hardware

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Science China(Information Sciences) 2023年第6期66卷 5-25页

作者： Zhuiri PENG runfeng lin Zheng LI Langlang XU Xiangxiang YU Xinyu HUANG Wenhao SHI Xiao HE Xiaohan MENG Lei TONG Xiangshui MIAO Lei YE School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology Hubei Yangtze Memory Laboratories Department of Electronic Engineering and Materials Science and Technology Research Center The Chinese University of Hong Kong State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences

In recent years, two-dimensional(2D)materials-based fundamental preparing process such as high-quality wafer-level single crystal thin film synthesis technology and high-performance electrode preparing technology has developed rapidly. In addition, the integrated application prospect of 2D materials has been preliminarily verified, owing to the flat and clean interface between 2D materials and substrates. From the perspective of electronics and optoelectronics based on 2D materials, this paper will summarize the recent studies of integrated circuit hardware, integrated optoelectronic hardware, and hetero-integrated hardware,showing their advantages and potential application.

关键词： two-dimensional materials integrated circuit integrated sensor integrated optoelectronics

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Interfacial Assembly Directed Unique Mesoporous Architectures:From Symmetric to Asymmetric

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Accounts of Materials Research 2020年第1期1卷 100-114页

作者： Tiancong Zhao Liang Chen runfeng lin Pengfei Zhang Kun Lan Wei Zhang Xiaomin Li Dongyuan Zhao Department of Chemistry Laboratory of Advanced Materials and Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersCollaborative Innovation Center of Chemistry for Energy Materials(2011-iChEM)Fudan UniversityShanghai 200433P.R.China

CONSPECTUS:Functional mesoporous materials have experienced flourishing developments over the past 30 years,and they are now a big family including large variety of compositions and *** to large surface area,high pore volume,tunable pore size,and unique mesostructures,mesoporous nanomaterials have been widely used in catalysis,energy conversion and storage,drug delivery,*** of the various methods of architecting mesoporous materials,the soft-templating method that allows regulating the architecture by tuning the assembly process,is used mostly for fabricating mesoporous *** soft templating methods,amphiphilic surfactants and precursors assemble into“soft”micelles,and micelles further assemble into mesoporous ***,micelles homogeneously nucleate and assemble into mesoporous *** a homogeneous assembly process naturally leads to“routine”structures such as nanospheres or other symmetric *** of nanoparticles during the micelle assembly process results in conventional core@shell structures,which though combining the mesoporous shell and functional core,is still ***,growing demands in diverse applications urgently require mesoporous nanomaterials with novelty in mesostructures,compositions,surface properties,morphologies,functionalities,***,researchers have been seeking to gain better control of the micelles’assembly process,pursuing the synthesis of mesoporous nanomaterials with unique architectures,especially morphology,mesostructure,surface chemistry,***,the effect of“interface”during micelles’assembly process has aroused great *** introduction of an interface into the reaction system turns the micelles’homogeneous assembly into a heterogeneous one,altering their assembly behavior and thus leading to mesoporous nanomaterials with unique *** manipulation of the interfacial-assembly behavior of micelles,a series of mesoporous nanomaterials wi

关键词： materials. interfacial symmetric

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MOF-Like 3D Graphene-Based Catalytic Membrane Fabricated by One-Step Laser Scribing for Robust Water Purification and Green Energy Production

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Nano-Micro Letters 2022年第11期14卷 48-61页

作者： Xinyu Huang Liheng Li Shuaifei Zhao Lei Tong Zheng Li Zhuiri Peng runfeng lin Li Zhou Chang Peng Kan-Hao Xue Lijuan Chen Gary J.Cheng Zhu Xiong Lei Ye School of Optical and Electronic Information and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hubei Yangtze Memory Laboratories Wuhan 430205People’s Republic of China Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia Key Laboratory of New Processing Technology for Nonferrous Metal and Materials(Ministry of Education) Guangxi Key Laboratory of Optical and Electronic Materials and DevicesCollege of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People’s Republic of China College of Chemistry and Materials Science Hunan Agricultural UniversityHunan 410128People’s Republic of China School of Material Science and Engineering Hunan University of Science and TechnologyXiangtanHunan ProvincePeople’s Republic of China School of Industrial Engineering and Birck Nanotechnology Centre Purdue UniversityWest LafayetteIN 47907USA Institute of Environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongPeople’s Republic of China

Increasing both clean water and green energy demands for survival and development are the grand challenges of our ***,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCM)with active metal nanoparticles(AMNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing *** as-prepared 3D-GCM shows high porosity and uniform distribution with AMNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AMNs in 3D-GCM actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane *** importantly,the 3D-GCM with the welding of laser scribing overcomes the lateral shear force damaging during the long-term ***,the 3D-GCM could emit plentiful of hot electrons from AMNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy ***“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCM microreactor in the tricky wastewater purification and sustainable clean energy production as well.

关键词： 3D graphene Laser scribing Catalytic membrane Water purification Hydrogen production

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Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2443-2461页

作者： Nazi Song Hongjiao Xu Jiahua Liu Qian Zhao Hui Chen Zhibin Yan Runling Yang Zhiteng Luo Qi Liu Jianmei Ouyang Shuohan Wu Suijia Luo Shuyin Ye runfeng lin Xi Sun Junqiu Xie Tian Lan Zhongdao Wu Rui Wang Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Department of Parasitology of Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhou 510006China Provincial Engineering Technology Research Center for Biological Vector Control Sun Yat-sen UniversityGuangzhou 510006China Research Unit of Peptide Science Chinese Academy of Medical SciencesLanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China Guangdong Pharmaceutical University Guangzhou 510006China

Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001.

关键词： GLP-1R GCGR Liver fibrosis Inflammation Apoptosis Candidate peptides

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《共产党宣言》对《共产主义原理》的完善及其意义

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新乡学院学报 2022年第2期39卷 10-13页

作者：林润锋上海师范大学马克思主义学院上海200234

继承《共产主义原理》的核心思想,《共产党宣言》丰富了阶级斗争理论,肯定了资产阶级曾经起过的革命作用。通过完善《共产主义原理》,《共产党宣言》批判了蒲鲁东和空想社会主义者的错误思想,克服了空想社会主义者漠视资产阶级积极作用... 详细信息

继承《共产主义原理》的核心思想,《共产党宣言》丰富了阶级斗争理论,肯定了资产阶级曾经起过的革命作用。通过完善《共产主义原理》,《共产党宣言》批判了蒲鲁东和空想社会主义者的错误思想,克服了空想社会主义者漠视资产阶级积极作用的缺陷,阐明了"两个必然"的重大历史结论。《共产党宣言》对《共产主义原理》的完善,充分彰显了马克思主义与时俱进的理论品质,体现了马克思和恩格斯坚持阶级斗争的革命立场,有力地鼓舞了工人阶级的革命斗志,对新时代实现"四个伟大"具有重要启示作用。

关键词：《共产党宣言》《共产主义原理》科学社会主义

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自拟逐痰祛瘀方对脑血管支架术后再狭窄的预防作用研究

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中西医结合心脑血管病杂志 2017年第16期15卷 2060-2062页

作者：林润锋广东省清远市清城区中医院广东清远511533

目的探讨逐痰祛瘀方对脑血管支架术后再狭窄的预防作用。方法选择2013年1月—2015年2月清远市清城区中医院神经内科收治的脑血管支架术病人50例,随机均分为对照组与观察组,每组25例。对照组采用单纯西药治疗,观察组在对照组基础上给予... 详细信息

目的探讨逐痰祛瘀方对脑血管支架术后再狭窄的预防作用。方法选择2013年1月—2015年2月清远市清城区中医院神经内科收治的脑血管支架术病人50例,随机均分为对照组与观察组,每组25例。对照组采用单纯西药治疗,观察组在对照组基础上给予自拟逐痰祛瘀方治疗,比较两组病人治疗后血液流变学参数及血管再狭窄情况。结果术后6个月,观察组血浆黏度、纤维蛋白浓度、血栓素A_2(TXA_2)/前列环素I2(PGI_2)值均显著低于治疗前,TXA_2、PGI_2浓度则显著升高,差异均有统计学意义(P<0.05);与对照组治疗后比较,观察组治疗后血浆黏度、纤维蛋白、TXA_2、PGI_2浓度及TXA_2/PGI_2值均有显著改善,差异有统计学意义(P<0.05)。观察组支架段直径显著大于对照组(P<0.05),直径减少指数、再狭窄率及再介入率均明显低于对照组,差异均有统计学意义(P<0.05)。结论逐痰祛瘀方可改善脑血管状态,有利于降低支架术后再狭窄的发生率。

关键词：脑血管支架术再狭窄逐痰祛瘀血栓素A2 前列环素I2 纤维蛋白

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卫星光网络中基于DQN的匹配度感知波长路由算法

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光通信技术 2024年第3期48卷 30-37页

作者：艾琪洋何荣希林润峰大连海事大学信息科学技术学院辽宁大连116026

为了进一步降低卫星光网络的业务阻塞率,提出了一种基于深度Q网络(DQN)的匹配度感知波长路由算法。该算法首先设计了路径波长匹配度因子,用以反映当前路径与下一跳节点之间链路的共同空闲波长情况。随后,算法综合考虑了路径波长匹配度... 详细信息

为了进一步降低卫星光网络的业务阻塞率,提出了一种基于深度Q网络(DQN)的匹配度感知波长路由算法。该算法首先设计了路径波长匹配度因子,用以反映当前路径与下一跳节点之间链路的共同空闲波长情况。随后,算法综合考虑了路径波长匹配度、相邻链路时延以及下一跳节点到目的节点的最短跳数等多个因素,以此为基础来构造奖励函数。在分配波长时,为了后续业务请求在相邻链路上有更多的空闲波长,设计了相邻链路波长匹配度指标,用于描述该路径与其相邻链路之间的空闲波长对齐情况。仿真结果表明,该算法可以降低网络阻塞率和时延,提高波长利用率。

关键词：卫星光网络路由波长分配深度强化学习波长匹配度

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Hole-dominated Fowler–Nordheim tunneling in 2D heterojunctions for infrared imaging

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Science Bulletin 2021年第2期66卷 139-146,M0004页

作者： Lei Tong Meng Peng Peisong Wu Xinyu Huang Zheng Li Zhuiri Peng runfeng lin Qiaodong Sun Yaxi Shen Xuefeng Zhu Peng Wang Jianbin Xu Lei Ye School of Optical and Electronic Information and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Physics and Innovation Institute Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Electronic Engineering Materials Science and Technology Research CenterThe Chinese University of Hong KongHong KongChina

Heterostructures based on diverse two-dimensional(2D)materials are effective for tailoring and further promoting device performance and exhibit considerable potential in ***,the problem of high-density thermionic carriers can be hardly overcome in most reported heterostructure devices based on type I and type II band alignment,which leads to an unacceptably small Iphoto/Idark and strong temperature dependence that limit the performance of ***,using the MoTe_(2)/h-BN/MoTe_(2)/h-BN heterostructure,we report the hole-dominated Fowler–Nordheim quantum tunneling transport in both on and off *** state-of-the-art device operating at room temperature shows high detectivity of>10^(8) Jones at a laser power density ofling mechanism,in combination with other unique properties of 2D materials,is significant for novel photodetection.

关键词： MoTe2 Fowler–Nordheim quantum tunneling Response speed Photodetection High detectivity

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石墨烯摩尔超晶格的近场纳米成像(特邀)

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红外与激光工程 2022年第7期51卷 75-77页

作者：孙侨东黄鑫宇林润峰彭追日徐浪浪叶镭华中科技大学光学与电子信息学院湖北武汉430074

具有优异光电响应特性的二维材料,在新型红外探测技术中展现了极高的应用价值与潜力。对于由二维材料制备的红外探测器,通过引入局域场调控的方式能够显著提升其红外探测性能。一种基于光热电效应的局域温度场调控技术被研究人员报道,... 详细信息

具有优异光电响应特性的二维材料,在新型红外探测技术中展现了极高的应用价值与潜力。对于由二维材料制备的红外探测器,通过引入局域场调控的方式能够显著提升其红外探测性能。一种基于光热电效应的局域温度场调控技术被研究人员报道,该技术结合了双层旋角石墨烯形成的摩尔超晶格结构。摩尔超晶格的形成使体系的塞贝克系数产生变化,从而使光照激发的热载流子浓度在空间上形成梯度变化,通过高分辨度的光电流显微镜探针可以探测双层石墨烯内单个摩尔晶胞的光电响应,从而获得体系的高分辨率光电流空间分布。该技术展示了旋角电子学在光电探测领域的前景,为未来的单光子探测器提供了设计思路。

关键词：双层石墨烯超晶格二维材料单光子探测器红外探测器塞贝克系数光电流光电响应

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