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Static recrystallization behaviors and mechanisms of 7Mo super-austenitic stainless steel with undissolved sigma precipitates during double-stage hot deformation

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Journal of Iron and Steel Research International 2024年第2期31卷 475-487页

作者： Shi-guang Xu Jin-shan He run-ze zhang Fu-cheng zhang Xi-tao Wang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina Shandong Provincial Key Laboratory for High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Science)Jinan250353ShandongChina

Static recrystallization(SRX)behaviors and corresponding recrystallization mechanisms of 7Mo super-austenitic stainless steel were studied under different deformation *** order of influence of deformation parameters on static recrystallization behaviors,from high to low,is followed by temperature,first-stage strain and strain ***,the effect of holding time on static recrystallization behaviors is significantly controlled by *** addition,with the increase in temperature from 1000 to 1200°C,the static recrystallization mechanism evolves from discontinuous static recrystallization and continuous static recrystallization(cSRX)to metadynamic recrystallization and cSRX,and finally to *** cSRX exists at all *** is because high stacking fault energy(56 mJ m−2)promotes the movement of dislocations,making the deformation mechanism of this steel is dominated by planar slip of *** undissolved sigma precipitates promote static recrystallization through particle-stimulated ***,small strain-induced precipitates at grain boundaries hinder the nucleation of conventional SRX and the growth of recrystallized grains,while the hindering effect decreases with the increase in temperature.

关键词： 7Mo super-austenitic stainless steel Double-stage hot deformation Conventional static recrystallization Metadynamic recrystallization Strain-induced precipitation

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Syntheses and properties of associative acrylamide copolymers containing short hydrophobic chains used in a friction reducer for slick-water fracturing

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Petroleum Science 2024年第3期21卷 1889-1901页

作者： Ya-Xing Dai Xian-Li zhang Si-Yuan Liu Feng-run-ze zhang Yi-Xi zhang Yu-Tong Sang Jing-Xi Zheng Zhao-Sheng Liu Peng zhang College of Chemistry and Chemical Engineering Chongqing University of Science and TechnologyChongqing401331China College of Ecology and Environment Chongqing Resources and Environmental Protection of UniversityChongqing401331China China China Property Project Department of Dezhou Mining Property Service CenterShengli Oilfield Company of SinopecDezhou253000ShandongChina

Two allyldimethylalkyl quaternary ammonium salt(AQAS)monomers,N,N-dimethylallylphenylpropylammonium bromide(AQAS1)and N,N-dimethylallylnonylammonium bromide(AQAS2),were synthesized and used to prepare modified polyacrylamide *** new drag reducers were synthesized from acrylamide(AM),sodium acrylate(Na AA)and a cationic modified monomer(AQAS1 or AQAS2)via aqueous solution polymerization,and the copolymers were named P(AM/Na AA/AQAS1)and P(AM/Na AA/AQAS2),*** structures of the drag reduction agents were confirmed by IR and1H NMR *** molecular weight(Mw)of P(AM/Na AA/AQAS1)was 1.79×10^(6)g/*** the copolymer concentration was 1000 mg/L and the flow rate was 45 L/min,in fresh water the highest drag reduction rate was 75.8%,in 10,000 mg/L Na Cl solution the drag reduction rate decreased to 72.9%.The molecular weight of P(AM/Na AA/AQAS2)was 3.17×10^(6)g/*** the copolymer concentration was500 mg/L and the flow rate was 45 L/min,the drag reduction rate reached 75.2%,and in 10,000 mg/L Na Cl solution the drag reduction rate was 73.3%,decreased by approximately 1.9%.The drag reduction rate for partially hydrolyzed polyacrylamide(HPAM)was also investigated,and the results showed that the drag reduction rates for 500 and 1000 mg/L HPAM solutions were merely 43.2%and 49.0%in brine,*** with HPAM,both of the above copolymers presented better drag reduction capacities.

关键词： Shale gas Slick water Drag reducer Modified monomer Copolymerization

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DNA methylation markers in the diagnosis and prognosis of common leukemias

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2468-2477页

作者： Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru zhang Jiayi Wang Lianghong Zheng Xiaohong zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte zhang Tina Poon Daniel zhang Ian Ziyar run-ze zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang zhang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China State Key Laboratory of Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Statistics and Institute for Integrative Genome Biology University of California RiversideRiversideCA 92521USA Shanghai Center for Plant Stress Biology Shanghai Institute for Biological SciencesChinese Academy of SciencesShanghai 210602China Faculty of Medicine Macao University of Science and TechnologyTaipaMacaoChina

The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of *** genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal *** established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and *** then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia ***,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection.

关键词： diagnosis prognosis acute

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Interfacial features of TiAl alloy/316L stainless steel joint brazed with Zr−Cu−Ni−Al amorphous filler metal

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Transactions of Nonferrous Metals Society of China 2021年第6期31卷 1680-1688页

作者： Hong-gang DONG run-ze zhang Yue-qing XIA Xiao-hu HAO Peng LI School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China

TiAl alloy and 316L stainless steel were vacuum-brazed with Zr−50.0Cu−7.1Ni−7.1Al(at.%)amorphous filler *** influence of brazing time and temperature on the interfacial microstructure and shear strength of the resultant joints was *** brazed seam consisted of three layers,including two diffusion layers and one residual filler metal *** typical microstructure of brazed TiAl alloy/316L stainless steel joint was TiAl alloy substrate/α2-(Ti3Al)/AlCuTi/residual filler metal/Cu9Zr11+Fe23Zr6/Laves-Fe2Zr/α-(Fe,Cr)/316L stainless steel *** brittle Fe2Zr layer formed near the interface between the residual filler metal layer andα-(Fe,Cr)*** maximum shear strength of brazed joints reached 129 MPa when brazed at 1020℃ for 10 *** diffusion activation energies ofα2-(Ti3Al)andα-(Fe,Cr)phases were−195.769 and−112.420 kJ/mol,respectively,the diffusion constants for these two phases were 3.639×10^(−6) and 7.502×10^(−10)μm^(2)/s,*** initiated at Fe2Zr layer and propagated into the residual filler metal layer during the shear *** Laves-Fe2Zr phase existing on the fracture surface suggested the brittle fracture mode of the brazed joints.

关键词： vacuum brazing dissimilar joining Zr-based amorphous filler metal intermetallic compound growth kinetics

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B细胞成熟抗原的抗肿瘤免疫治疗研究进展

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药物生物技术 2018年第1期25卷 1-6页

作者：张航王阳刘雅利袁敏讷周润泽王旻张娟中国药科大学生命科学与技术学院抗体工程实验室江苏南京210009

B细胞表面成熟抗原(B-cell maturation antigen,BCMA)是一种浆细胞选择性的蛋白,最早发现于成熟的B淋巴细胞表面,在其他组织细胞中几乎不表达。其在恶性增殖的B淋巴细胞(例如骨髓瘤细胞、白血病细胞)中高度表达,同时其介导的下游信号通... 详细信息

B细胞表面成熟抗原(B-cell maturation antigen,BCMA)是一种浆细胞选择性的蛋白,最早发现于成熟的B淋巴细胞表面,在其他组织细胞中几乎不表达。其在恶性增殖的B淋巴细胞(例如骨髓瘤细胞、白血病细胞)中高度表达,同时其介导的下游信号通路,对细胞的存活、增殖、转移和耐药中起着关键性的作用,这些特性使得它成为免疫治疗多发性骨髓瘤的一个靶点。近年来,针对BCMA的新型肿瘤免疫治疗方法日趋成熟,主要包括CAR-T(Chimeric Antigen Receptor T-Cell Immunotherapy)疗法、双特异性抗体(Bispecific antibody,BsAb)和抗体药物偶联物(Antibody-drug coupling,ADC)3大阵营,且目前已有4类药物进入临床Ⅰ期。从已经公开的临床前及临床Ⅰ期试验的结果来看,针对BCMA的靶向药物能够有效的靶向肿瘤细胞,并通过免疫细胞或小分子的细胞毒作用杀伤肿瘤细胞,药效显著,不良反应可控,是一个极具发展潜力的肿瘤靶向治疗新靶点。该文就BCMA的生物学功能、信号通路以及以其为靶点的肿瘤免疫治疗药物进行综述。

关键词： B细胞表面成熟抗原 B细胞激活因子增殖诱导配体肿瘤免疫治疗抗体细胞疗法抗体药物偶联物

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VEP验光技术研究及法医学应用

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国际眼科杂志 2008年第1期8卷 88-89页

作者：张泽润张玲莉饶广勋华中科技大学同济医学院法医学系临床教研室中国湖北省武汉市430030

目的:通过VEP验光结果与电脑验光结果的比较,评价VEP验光技术在眼外伤法医学鉴定中的应用价值。方法:通过对50例86眼不同程度的屈光不正依次行电脑验光和VEP验光,将两种方法所得的结果进行比较分析。结果:VEP验光与电脑验光结果比较无... 详细信息

目的:通过VEP验光结果与电脑验光结果的比较,评价VEP验光技术在眼外伤法医学鉴定中的应用价值。方法:通过对50例86眼不同程度的屈光不正依次行电脑验光和VEP验光,将两种方法所得的结果进行比较分析。结果:VEP验光与电脑验光结果比较无显著性差异。两者差值约有66.1%在0～0.25D之间;约有51.2%的电脑验光结果高于VEP验光结果。结论:在眼损伤的法医学鉴定中,VEP验光技术可以作为一种客观评价受检者屈光不正程度的验光手段。

关键词：电脑验光 VEP验光客观屈光检查法医学应用

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微创接骨板内固定术治疗膝关节内骨折的疗效观察

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中国临床研究 2018年第9期31卷 1236-1239页

作者：刘文祥余润泽张彪安徽省第二人民医院骨科安徽合肥230000

目的观察膝关节内骨折患者行微创接骨板内固定术(MIPO)后骨折愈合情况及功能恢复效果。方法将安徽省第二人民医院2014年2月至2015年12月接诊的51例膝关节内骨折患者分成微创组25例,开放对照组26例。微创组行MIPO,对照组行切开复位接骨... 详细信息

目的观察膝关节内骨折患者行微创接骨板内固定术(MIPO)后骨折愈合情况及功能恢复效果。方法将安徽省第二人民医院2014年2月至2015年12月接诊的51例膝关节内骨折患者分成微创组25例,开放对照组26例。微创组行MIPO,对照组行切开复位接骨板内固定术(ORIF),术后两组均随访6~24个月。观察两组患者术后骨痂形成时间、骨折临床愈合时间、骨性愈合时间及膝关节活动度,评价膝关节功能及临床疗效,观察术后恢复过程中感染、血肿等不良反应发生情况。结果术后,微创组骨痂出现时间、骨折临床愈合时间及骨性愈合时间[(6. 04±0. 38)周、(9. 87±1. 12)周、(10. 08±1. 26)周]均显著短于对照组[(8. 11±0. 49)周、(11. 94±1. 65)周、(12. 61±1. 74)周,P <0. 01];微创组美国特种外科医院膝关节功能评分(HSS)显著高于对照组(87. 52±3. 68 vs83. 45±3. 57,P <0. 01),膝关节活动度显著大于对照组[(127. 68±9. 14)°vs (115. 87±7. 92)°,P <0. 01];术后,微创组膝关节功能优良率显著高于对照组(92. 00%vs 61. 54%,P <0. 05),并发症发生率显著低于对照组(4. 00%vs 30. 77%,P <0. 05)。结论 MIPO治疗膝关节内骨折患者,术后患者在骨折愈合及膝关节功能恢复方面均有显著优势,并能减少并发症发生。

关键词：膝关节内骨折内固定术切开复位微创接骨板骨折愈合膝关节功能恢复

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VEP鉴定伪盲眼的临床法医学研究

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国际眼科杂志 2008年第10期8卷 2059-2061页

作者：胡俊彭新张泽润蒋祁李中伟张玲莉华中科技大学同济医学院法医学系中国湖北省武汉市430030 中国湖南省长沙县刑侦大队 410100 中国湖南省常德市公安局刑侦支队 415000

目的:探讨VEP技术在鉴别伪盲、评价伪盲眼实际视力水平方面的应用价值。方法:选取65例眼外伤后单眼盲或单眼低视力的患者为实验对象,将65只伤眼作为实验组,65只健眼作为对照组,分别行VEP检查。在VEP检查时,受检眼依次接受视角为30′、2... 详细信息

目的:探讨VEP技术在鉴别伪盲、评价伪盲眼实际视力水平方面的应用价值。方法:选取65例眼外伤后单眼盲或单眼低视力的患者为实验对象,将65只伤眼作为实验组,65只健眼作为对照组,分别行VEP检查。在VEP检查时,受检眼依次接受视角为30′、22′、11′、5′、3′的视觉刺激。结果:患眼主观视力与VEP视力不相符者48人,伪盲检出率为73.8%;对照组健眼VEP视力与主观视力符合率可达90.8%。结论:VEP技术能够准确评价受检眼的实际视力水平,并可为鉴别伪盲的法医学应用方面提供可靠依据。

关键词：视觉诱发电位伪盲 VEP视力法医学鉴定

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei zhang Xiao-Mei Song Yu-ze Li Wen-Li Huang Dong-Dong zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Pearprocess:A new phenotypic tool for stone cell trait evaluation in pear fruit

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Journal of Integrative Agriculture 2020年第6期19卷 1625-1634页

作者： XUE Yong-song XU Shao-zhuo XUE Cheng WANG run-ze zhang Ming-yue LI Jia-ming zhang Shao-ling WU Jun Center of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095P.R.China

The content of stone cells is an important factor for pear breeding as a high content indicates severely reduced fruit quality in terms of fruit *** the frozen-HCI method is currently a common method used to evaluate stone cell content in pears,it is limited in incomplete separation of stone cell and pulp and is time consuming and *** research is a promising strategy in modern scientific research for phenotypic data collect!on and is increasingly used in studying *** far,we lack a quantitative tool that can effectively determine stone cell content in pear *** developed a program,Pearprocess,based on an imaging protocol using computer vision and image processing algorithms applied to digital *** photos of hand-cut sections of pear fruit stained with phloroglucin-HCI(Wiesner's reagent),Pearprocess can extract and analyze image-based data to quantify the stone cell-related traits measured in this study:number,size,area and density of stone *** quantified these traits for 395 pear accessions by Pearprocess and revealed large variation in different pear varieties and *** number of stone cells varied greatly from value of 138 to 2866,the density of stone cells ranged from 0.0019 to 0.0632 cm2 cm-2,the distribution of stone cell area ranged from 0.06 to 2.02 cm2,and the stone cell size was between 2e-4 and 1e-3 ***,trait data were correlated with fruit taste *** found that stone cell density is likely the most important factor affecting the taste of pear *** summary,Pearprocess is a new cost-effective web-application for semi-automated quantification of two-dimensional phenotypic traits from digital imagery using an easy imaging *** simpler,feasible and accurate method to evaluate stone cell traits of fruit is a promising new tool for use in evaluating future germplasms for crop breeding programs.

关键词： Pearprocess software quantitative tool stone cell traits

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