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A Coupled Thermomechanical Crack Propagation Behavior of Brittle Materials by Peridynamic Differential Operator

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 339-361页

作者： Tianyi Li Xin gu qing Zhang College of Architectural Engineering Jiangsu Open UniversityNanjing210036China Department of Engineering Mechanics Hohai UniversityNanjing211100China

This study proposes a comprehensive,coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator(PDDO),eliminating the need for calibration *** model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics *** simulations conducted on granite and ceramic materials,this model demonstrates its *** successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during *** account for material heterogeneity,the model utilizes the Shuffle algorithm andWeibull distribution,yielding results that align with numerical simulations and experimental *** coupled thermomechanical model shows great promise for analyzing intricate thermomechanical phenomena in brittle materials.

关键词： Peridynamic differential operator thermomechanical coupling heterogeneity numerical simulation

An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 577-591页

作者： qing Zhu Linlin gu Huijie Lin Electricity Technology Branch Nari Technology Co.Ltd.Nanjing211106China NARI-TECH Nanjing Control Systems Co. Ltd.Nanjing211106China

With the rapid development of electric power systems,load estimation plays an important role in system operation and ***,load estimation techniques contain traditional,time series,regression analysis-based,and machine learning-based *** the machine learning-based method can lead to better performance,in this paper,a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is ***,an image fingerprint construction is proposed for training *** the data preprocessing,the training data matrix is constructed by the cyclic shift and cubic spline ***,the linear mapping and the gray-color transformation method are proposed to form the color image ***,a convolutional neural network(CNN)combined with an attentionmechanism is proposed for training performance *** last,an experiment is carried out to evaluate the estimation *** with the support vector machine method,CNN method and long short-term memory method,the proposed algorithm has the best load estimation performance.

关键词： Load estimation deep learning attention mechanism image fingerprint construction

Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1018-1026页

作者： ZHU Miao SHI qing-qing NI Jun WU Wei SUN Xing SUN Mei XU Kai-lin LIU Yan-qing gu Jian gu Hao Department of Hematology Clinical Medical Col ege Yangzhou University Yangzhou Institute of Hematology Department of Hematology The Affiliated Hospital of Xuzhou Medical University Department of Oncology The Affiliated Hospital of Yangzhou University Yangzhou University Department of Neurology The Affiliated Brain Hospital of Nanjing Medical University

Objective:To investigate the inhibitory effect of Celastrus orbiculatus extracts（COE） on the proliferation of lymphoma cells and the immune regulation ability on inflammation and thrombophilia in ***:The 38B9 lymphoma cells were treated with COE（160μg/mL） and CTX（25 μmol/L）.The apoptosis rate and cell cycle of each group were detected by flow *** secretion of inflammatory factors,including interleukin（IL）-6,IL-10,and tumor necrosis factor α（TNF-α）,in cell supernatant was detected by enzyme-linked immunosorbent assay（ELISA）.In vivo,BALB/c mice were subcutaneously injected with 38B9 lymphoma cells to establish lymphoma ***(3 mg·kg-1·d-1) and CTX(40 mg-kg-1·d-1) were administered to the model mice,*** expression of plasma inflammatory factors（IL-6,IL-10 and TNF-α） and thrombus indexes,including D-dimer（D-D）,von Willebrand factor（vWF） and tissue factor（TF）,were detected by ELISA before tumor bearing（1 d）,after tumor formation（14 d） and after intervention（21 d）.PicoGreen dsDNA was used to detect the level of serum neutrophil extracellular traps（NETs）.Flow cytometry was used to detect the expression of platelet activation marker calcium-dependent lectin-like receptor 2（CLEC-2）.The tumor growth and survival of mice were ***:The 38B9 lymphoma cells were apoptotic after the intervention of COE and *** ratio of G2-M phase cells decreased in COE intervented cells compared with the control cells（P<0.05）,and S phase cells decreased in CTX intervented cells（P<0.05）.Also,the secretion level of IL-6 was significantly reduced after COE or CTX intervention（P<0.05）,and IL-10 was significantly increased（P<0.05）.Furthermore,the tumor mass was reduced,and the median survival time was longer in COE and CTX intervented tumor-bearing mice than in nonintervented *** significantly lower levels of TNF-α,IL-6,NETs,TF,DD and CLEC-2,as well as higher IL-10 were observed in COE and CTX treatment mice in comparision with the control mice（P

关键词： Celastrus orbiculatus extract immune regulation lymphoma murine lymphoma cells proliferation inhibition thrombotic state tumor inflammation

Dietary fishmeal replacement by Clostridium autoethanogenum protein meal influences the nutritional and sensory quality of turbot(Scophthalmus maximus)via the TOR/AAR/AMPK pathways

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Animal Nutrition 2024年第3期18卷 84-95页

作者： Zezheng Qi Nan Bai qing Li Shihui Pan Min gu Marine College Shandong UniversityWeihaiShandongChina Key Laboratory of Modern Marine Ranching Technology of Weihai WeihaiShandongChina

Clostridium autoethanogenum protein(CAP)is a promising protein source for aquaculture;however,how CAP influences fish quality is worth extensive *** randomly allocated 630 turbot with initial body weights of about 180 g into 6 groups,with fishmeal-based control diet or diet with CAP replacing 15%(CAP15),30%(CAP30),45%(CAP45),60%(CAP60),or 75%(CAP75)of fishmeal *** a 70-d feeding trial,the fillet yield(P=0.015)and content of protein(P=0.017),collagen(P 0.05).By contrast,the muscle hardness increased linearly with increasing CAP(P=0.004),accompanied by linear reduction of muscle fiber area(P=0.003)and expression of myogenesis-related genes,including cathepsin D(ctsdP<0.001)and muscle ring finger protein 1(murf 1,P<0.001).Phosphorylation of protein kinase B(Akt,P<0.001),target of rapamycin(TOR,P=0.001),eukaryotic initiation factor 4E-binding protein 1(4E-BP1,P<0.001),and ribosomal protein S6(S6,P<0.001)decreased linearly;however,phosphorylation of AMP-activated protein kinase(AMPK,P<0.001),eukaryotic initiation factor 2α(eIF2α,P<0.001),and the abundance of activating transcription factor 4(ATF4,P<0.001)increased with increasing CAP,suggesting that the TOR signaling pathway was inhibited,and the amino acid response(AAR)and AMPK pathways were ***,expression of genes related to protein degradation,including myogenic factor 5(myf 5,P<0.001),myogenic differentiation(myod,P<0.001),paired box 7(pax 7,P<0.001),and ctsd(P<0.001),decreased linearly with increasing *** conclusion,CAP could be used to replace up to 15%of fishmeal without negatively impacting turbot ***,higher levels of CAP decreased fillet yield,muscle protein content,and muscle fiber diameter while increasing muscle hardness,which could be attributed to the inhibition of the TOR pathway and activation of the AAR and AMPK pathways.

关键词： Bacterial meal Clostridium autoethanogenum Turbot Fish quality Muscle growth

Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan Fan Tao Zhang Xin Ding Yushuo gu qing Li Wei Jiang Kelong Fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-qing gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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Simulation of Corrosion-Induced Cracking of Reinforced Concrete Based on Fracture Phase Field Method

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2257-2276页

作者： Xiaozhou Xia Changsheng Qin guangda Lu Xin gu qing Zhang College of Mechanics and Materials Hohai UniversityNanjing210098China State Key Laboratory of Disaster Reduction in Civil Engineering&College of Civil Engineering Tongji UniversityShanghai200092China

Accurate simulation of the cracking process caused by rust expansion of reinforced concrete(RC)structures plays an intuitive role in revealing the corrosion-induced failure *** the quasi-brittle fracture of concrete,the fracture phase field driven by the compressive-shear term is constructed and added to the traditional brittle fracture phase field *** rationality of the proposed model is verified by a mixed fracture example under a shear displacement ***,the extended fracture phase model is applied to simulate the corrosion-induced cracking process of *** cracking patterns caused by non-uniform corrosion expansion are discussed for RC specimens with homogeneous macroscopically or heterogeneous with different polygonal aggregate distributions at the mesoscopic ***,the effects of the protective layer on the crack propagation trajectory and cracking resistance are investigated,illustrating that the cracking angle and cracking resistance increase with the increase of the protective layer thickness,consistent with the experimental ***,the corrosion-induced cracking process of concrete specimens with large and small spacing rebars is simulated,and the interaction of multiple corrosion cracking is easily influenced by the reinforcement spacing,which increases with the decrease of the steel bar *** conclusions play an important role in the design of engineering anti-corrosion *** fracture phase field model can provide strong support for the life assessment of RC structures.

关键词： Fracture phase field corrosion-induced cracking non-uniform corrosion expansion protective layer thickness reinforcement concrete

Potential effects of aerosol generation and transmission during bedside endoscope cleaning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 628-632页

作者： Tingting SHENG Xin WU Li CEN Ye LU Chenying ZHOU qing gu Nursing Department the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China

Airborne transmission is among the most frequent types of nosocomial *** years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East respiratory syndrome(MERS)in 2012,and coronavirus disease 2019(COVID-19),with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore(Gralton et al.,2011;Wang et al.,2021).An increasing number of studies have shown that certain highly transmissible pathogens can maintain long-term stability and efficiently spread through aerosols(Leung,2021;Lv et al.,2021).As reported previously,influenza viruses that can spread efficiently through aerosols remain stable for a longer period compared to those that *** World Health Organization(WHO)has stated that aerosol-generating procedures(AGPs)play an important role in aerosol transmission in hospitals(Calderwood et al.,2021).AGPs,referring to medical procedures that produce aerosols,including dental procedures,endotracheal intubation,sputum aspiration,and laparoscopic surgeries,have been reported to be significantly associated with an increased risk of nosocomial infection among medical personnel(Hamilton,2021).

关键词： Endoscopy Endoscopic surgery Aerosol transmission Bedside endoscope precleaning

Improvement for creep strength of a second-generation single crystal superalloy by design of heat treatments

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Rare Metals 2024年第1期43卷 342-350页

作者： Wan-Shun Xia Xin-Bao Zhao Jia-Chen Xu Quan-Zhao Yue qing-qing Ding Huan-Chang Duan Yue-Feng gu Hong-Bin Bei Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon and Advanced Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Design of heat treatments is related to the key technology for development of nickel-based single crystal superalloys(Ni-SXs). Based on the full understanding of the solidification characteristics, this work applies optimization design of heat treatments for a second-generation Ni-SX. Microstructure evolution and creep properties are compared in the material under conventional/standard(Std.) and optimized(Opt.) treatments. For the Std. sample,strong dendritic segregations determine inconsistent microstructure evolution in the dendritic(D) and interdendritic region(ID), while the latter serves as weak area to have the prior microcrack initiation, damaging overall performance of the alloy. The Opt. treatment applies higher homogenization temperature, leading to overall reduced segregations, while not inducing incipient melting. A lower temperature of first-step ageing is used to lower the size ofγ'particles. These help to form the more uniform microstructure in dendritic and interdendritic region and relieve the inconsistent microstructure evolution. The balanced local strength makes ID no longer as the weak area,thus restricting microcrack initiation. Great improvement of high temperature and low stress property is obtained by this progress, leading to the pronounced increase of creep rupture life under 1100 °C/140 MPa.

关键词： Single crystal superalloy Heat treatment Segregation Solidification Creep property

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