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Behavioral Intervention Reduces Unhealthy Eating Behaviors in Preschool Children via a Behavior Card Approach

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 895-903页

作者： ming LIN Li-ping PAN Juan HAN Li LI jing-xiong JIANG run-ming jin Department of Pediatrics Union Hospital Tonal Medical College Huazhong University of Science and Technology Wuhan 430022 China National Center for Women and Children＇s Health Chinese Center for Disease Control and Prevention Beijing 102206 China

Many eating behaviors form in childhood,and some unhealthy behaviors may persist into adulthood and have potential impacts on people＇s *** study evaluated the effectiveness of behavioral intervention in reducing consumption of Western fast food,sweetened beverages,fried food in preschool children,and changing parents＇ rewarding behaviors that encourage the consumption of the unhealthy *** research was a cluster randomized trial of seven kindergartens,involving 1138 children aged 3–6 years and their parents in Beijing,*** and children allocated to the intervention group received two lectures and printed resources,including behavior cards,educational ***＇s behavior cards,applied with behavior-changing techniques,were used to intervene,and monitor behavior changes over *** in the control group just followed their usual health education curriculum in *** effects on food consumption behaviors were assessed by examining pre-and *** the 1138 children screened at baseline,880（77.3%） were measured at the end of the intervention *** intervention lasted from March to June in *** results showed that consumption of Western fast food,sweetened beverages,and fried food was decreased among the intervention group（P〈0.001）.Proportions of parents using Western fast food as rewards for their children were decreased（P=0.002）.From March to June 2010,the frequency of each target behavior in children tended to decrease over the intervention period（P〈0.001）.Most parents favored regularly-delivered behavior cards or materials for behavioral *** conclusion,the behavioral intervention encourages the healthier eating behaviors of children and reduces the parents＇ practice of using unhealthy foods as reward.

关键词： behavioral intervention eating behaviors preschool children

Dose-individualization Efficiently Maintains Sufficient Exposure to Methotrexate without Additional Toxicity in High-dose Methotrexate Regimens for Pediatric Acute Lymphoblastic Leukemia

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Current Medical Science 2022年第4期42卷 769-777页

作者： Ya-qing SHEN Zhu-jun WANG Xiao-yan WU Kun LI Zhong-jian WANG Wen-fu XU Fen ZHOU run-ming jin Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:Methotrexate(MTX)can be safely administered to most patients but may cause severe toxicity in *** study aimed to summarize the characteristics of high-dose methotrexate(HD-MTX)chemotherapy and to evaluate whether the modified dose-adjustment program was able to improve the maintenance of sufficient MTX exposure levels while minimizing ***:We evaluated 1172 cycles of high-dose MTX chemotherapy from 294 patients who were treated according to the CCCG-ALL-2015 protocol(clinical trial number:ChiCTR-IPR-14005706)and analyzed the data of actual MTX dosage,MTX concentration,toxicity,and *** compared data between the dose-adjustment Program 1(fixed 20%reduction in dose)and the dose-adjustment Program 2(dose-individualization based on reassessment of the creatine clearance rate and the MTX concentration-monitoring point at 16 h),which were applied if the MTX clearance was delayed in the previous ***:The patients who used Program 2 had higher actual MTX infusion doses and infusion rates and were able to better maintain the MTX concentration at 44 h at the established target value than those on Program 1(P<0.001).No significant differences in toxicities were found between these two programs except that abnormal serum potassium levels and prolonged myelosuppression in intermediate-risk/high-risk patients were more frequently observed in patients using Program 2(P<0.001).No significant correlations were observed between the MTX dose,dose-adjustment programs,or MTX concentrations and relapse-free ***:Adjusting the MTX dose using Program 2 is more efficient for maintaining sufficient MTX exposure without significantly increasing the toxicity.

关键词： methotrexate high-dose methotrexate individualizing methotrexate dose toxicity acute lymphoblastic leukemia prognosis

A New Immunosuppressive Therapy for Very Severe Aplastic Anemia in Children with Autoantibodies

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Current Medical Science 2022年第2期42卷 379-386页

作者： Zhong-jian WANG Hong-bo CHEN Fen ZHOU Hui YU Xiao-yan WU Ya-qing SHEN Yi-ning QIU run-ming jin Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective At present,a number of very severe aplastic anemia(VSAA)patients cannot receive hematopoietic stem cell transplantation(HSCT)or standard immunosuppressive therapy(IST)due to the high cost of therapy,shortage of sibling donors,and lack of resources to support the *** addition,some VSAA patients with autoantibodies have no life-threatening infections or bleeding at the time of initial *** the disease condition,economics and other factors,the present study designed a new and relatively mild treatment strategy:cyclosporine A plus pulsed high-dose prednisone(CsA+HDP).Methods The present study retrospectively analyzed 11 VSAA patients,who were treated with CsA+HDP in our hospital from August 2017 to August *** The median follow-up time for these patients was 24.9 *** overall response rate was 54.5%(6/11)at six months after the initiation of IST and 81.8%(9/11)at *** patients achieved complete remission and four patients met the criteria for partial response at the last *** median time to response for responders was 110 *** patients underwent HSCT due to the poor effect of CsA+HDP or to find a suitable transplant *** and clonal evolution were not found in any of these *** estimated 3-year overall survival rate and 3-year failure-free survival rate were 100.0%and 72.7%,*** addition,the results revealed that the cyclosporine-prednisone-associated toxicity was mild and well-tolerated by most *** The novel CsA+HDP regimen has good therapeutic effect and safety for VSAA patients with autoantibodies,who have no serious life-threatening infections or bleeding at the time of initial diagnosis.

关键词： aplastic anemia cyclosporine A prednisone immunosuppressive therapy children

Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph+ Leukemia Cells

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Current Medical Science 2020年第2期40卷 354-362页

作者： Wen-fu XU Zhu-jun WANG Kun LI Ya-qing SHEN Ke LU Xuc-yan LV Yu-xi WEN run-ming jin Deparment of Pediatrics Union HospitalTongji Medical CollegeHuzhong University of Science and TechnologyWuhan 430022China

Imatinib mesylate(IM)is the first-line treatment for Philadelphia(Ph)chromosomal positive leukemia by inhibiting phosphorylation of substrates via binding to the ABL kinase *** of the drug resistance,side effects and the high cost of IM,it is necessary to find anti-cancer drugs with relatively low toxicity and cost,and enhanced efficacy,such as traditional Chinese medicines(TCMs).As one of TCMs,Huai Qi Huang(HQH)was chosen to treat BV173 and K562 *** concentrations of HQH were added to cells for 24-72 ***-treatment of HQH and trametinib,an MEK inhibitor,was used to verify the synergistic effects on cell viability and *** and overexpression of mitogen-activated protein kinase kinase 4(MEK4)were implemented to demonstrate the role of MEK in cell *** viability and apoptosis were measured by cell counting kit-8 assay(CCK8)and flow cytometry,*** blotting and real-time quantitative PCR(RT-qPCR)were used to assess protein and mRNA expression levels,*** results showed that HQH inhibited survival and promoted apoptosis of BV173 and K562 cells in a dose-dependent manner,accompanied with down-regulation of PRKCH mRNA as well as CRAF,MEK4,phospho-ERK(pERK)and BCL2 proteins,and up-regulation of cleaved caspase3 ***-treatment of HQH and trametinib had.a synergistic effect on inhibiting survival and promoting ***4 knockdown increased apoptosis,and had a synergistic effeet with *** contrast,MEK4 overexpression ***,and had the opposite efect with ***,the results of this study may identify a therapeutic mechanism of HQH on promoting apoptosis,and provide a potential option for treatment of Pht leukemia.

关键词： Huai Qi Huang leukemia apoptosis BCR-ABL RAF/MEK/ERK

Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China

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Current Medical Science 2020年第2期40卷 275-280页

作者： Fang ZHENG Chun LIAO Qi-hong FAN Hong-bo CHEN Xue-gong ZHAO Zhong-guo XIE Xi-lin LI Chun-xi CHEN Xiao-xia LU Zhi-sheng LIU Wei LU Chun-bao CHEN Rong JIAO Ai-ming ZHANG jin-tang WANG Xi-wei DING Yao-guang ZENG Li-ping CHENG Qing-feng HUANG Jiang WU Xi-chang LUO Zhu-jun WANG Yan-yan ZHONG Yan BAI Xiao-yan WU run-ming jin Deparment of Pediatrics Union HospitalTongji Medical CollegeHuazhong University 0f Science and TechnologyWuhan 430022China Deparment of Pediatrics Yichang No.3 People's HospitalYichang 443000China Department of Pediarics Jingzhou First People's HospitalJingzhou 434000China Xishui People's Hospital Huanggang 438000China Wuhan Children's Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Pediatrics Yichang Central HospialYichang 443000China Deparment of Pediatrics Xiangyang First People's HospitalXiangyang 441000China Deparment of Pediatrics Shiyan People's HospitalShiyan 442000China Department of Pediatrics Huanggang Central HospitalHuanggang 438000China Department of Pediatrics Jiangling People's HospitalJingzhou 434101China Huangshi Maternity and Child Health Care Hospital Huangshi 435000China Department of Pediatrics Huazhong University of Science and Technology HospitalWuhan 430074China

Since December 2019,COVID-19 has occurred unexpectedly and emerged as a health problem worldw *** the rapidly increasing number of cases in subsequent weeks,the clinical characteristics of pediatric cases are rarely described.A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province.A total of 25 confirmed pediatric cases of COVID-19 were *** demographic data,epidemiological history,underlying discascs,clinical mani festations,laboratory and radiological data,treatments,and outcomes were *** 25 hospitalized patients with COVID-19,the boy to girl ratio was 1.27:*** median age was 3 ***-19 cases in children aged<3 years,3-6 years,and≥6-years patients were 10(40%),6(24%),and 9(36%),*** most common symptoms at onset of ilness were fever(13[52%]),and dry cough(11[44%]).Chest CT images showed essential normal in 8 cases(33.3%),unilateral involvement of lungs in 5 cases(20.8%),and bilateral involvement in 11 cases(45.8%).Clinical diagnoses included upper respiratory tract infection(n=8),mild pneumonia(n=15),and critical cases(n=2).Two critical cases(8%)were given invasive mechanical ventilation,corticosteroids,and *** symptoms in 24(96%)of 25 patients were alleviated and one patient had been *** was concluded that children were susceptible to COVID-19 like adults,while the clinical presentations and outcomes were more favorable in ***,children less than 3 years old accounted for majority cases and critical cases lied in this age group,which demanded extra attentions during home caring and hospitalization treatment.

关键词： SARS-CoV-2 COVID-19 coronavirus children

Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

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World Journal of Pediatrics 2020年第3期16卷 232-239页

作者： Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu run-ming jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang Global Pediatric Pulmonology Alliance China National Clinical Research Center for Respiratory Diseases Department of Respiratory MedicineBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Institute of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijingChina Center of Hematologic Oncology National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatrics Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhanChina Department of Respiratory Medicine Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Pediatrics Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Respiratory Medicine Shenzhen Children's HospitalShenzhenChina China National Clinical Research Center for Respiratory Diseases Beijing Institute of PediatricsBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthResearch Unit of Critical Infection in ChildrenChinese Academy of Medical SciencesBeijing 2019RU016China Department of Neurology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanChina Institute of Hospital Management Wuhan UniversityZhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Medicine Children's Hospital of ShanghaiShanghaiChina Department of Respiratory Medicine Guangzhou Women and Children's Medical CenterGuangzhouChina Department of Infectious Diseases Shenzhen Children's HospitalShenzhenChina Office of Infection Management Wuhan Children's Ho

In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this *** accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition *** current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in *** the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is *** early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical *** version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide.

关键词： Children COVID-19 Infection SARS-CoV-2 Treatment

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

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World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang Yue-Jie Zheng Lei Zhou Lu-Zhao Feng Lin Ma Bao-Ping Xu Hong-Mei Xu Wei Liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun Luo Zhi-Sheng Liu Sai-Nan Shu Jian-She Wang Yi Jiang Yun-Xiao Shang Miao Liu Li-Wei Gao Zhuang Wei Guang-Hua Liu Gang Liu Wei Xiang Yu-Xia Cui Gen Lu Min Lu Xiao-Xia Lu run-ming jin Yan Bai Le-Ping Ye Dong-Chi Zhao A-Dong Shen Xiang Ma Qing-Hua Lu Feng-Xia Xue Jian-Bo Shao Tian-You Wang Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by National Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease

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World Journal of Gastroenterology 2025年第3期31卷 1-10页

作者： ming-Hua Zheng Amedeo Lonardo Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Internal Medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical *** paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related *** from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood *** is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is *** second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for *** disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related ***,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic *** sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.

关键词： Cirrhosis Liver fibrosis Natural course Prognostication Stratification