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The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions： A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial

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Chinese Medical Journal 2015年第19期128卷 2557-2564页

作者： Wei Hua run-lin gao Bu-Chang Zhao Jing Wang Xu-Hua Chen Chi Cai Shu Zhang The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Xi'an Cardio-cerebral Vascular Disease HospitalXi'anShaanxi 710000China

Background：Premature ventricular contractions （PVCs） are common in the general population,and frequent PVCs may result in the poor quality of life or even the damage of cardiac *** examined the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs among a relatively large Chinese ***：We performed a randomized,double-blind,placebo-controlled,parallel-group,multicenter trial.A total of 1200 eligible participants were randomly assigned in a ratio of 1：1 to receive Wenxin Keli or the placebo for 4 *** primary and secondary endpoint was the change of PVC numbers and PVC-related symptoms after a 4-week treatment compared with baseline,*** addition,vital signs,laboratory values,and electrocardiographic parameters were assessed in a safety ***：At the initial evaluation,no significant differences in the baseline characteristics were observed between the Wenxin Keli group and the placebo group.A smaller number of PVCs was observed after the 4-week treatment than at baseline,in both the Wenxin Keli group （5686 ± 5940 vs.15,138 ± 7597 beats/d,P ＜ 0.001） and the placebo group （10,592 ± 8009 vs.14,529 ± 5929 beats/d,P ＜ 0.001）;moreover,the Wenxin Keli group demonstrated a significantly greater reduction in the frequency of PVCs than the placebo group （P ＜ 0.001）.In a full analysis set,patients in the Wenxin Keli group exhibited significantly higher total effective responses in the reduction of PVCs compared to those in the placebo group （83.8％ vs.43.5％,P ＜ 0.001）.The per-protocol analysis yielded similar results （83.0％ vs.39.3％,P ＜ 0.001）.Treatment with Wenxin Keli also demonstrated superior performance compared to the placebo with respect to PVC-related *** severe adverse effects attributable to Wenxin Keli were ***：Wenxin Keli treatment effectively reduced the overall number of PVCs and alleviated PVC-related symptoms in patients without structural heart dis

关键词： Wenxin Keli Premature Ventricular Contractions Efficacy Safety Clinical Trial

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Long-term efficacy,safety and biocompatibility of a novel sirolimus eluting iron bioresorbable scaffold in a porcine model

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Bioactive Materials 2024年第9期39卷 135-146页

作者： Ya-Nan gao Hong-Tao Yang Zi-Feng Qiu Feng Qi Qian-Hong Lu Jian-Feng Zheng Zi-Wei Xi Xin Wang Li Li Gui Zhang De-Yuan Zhang Yu-Die Lu Hai-Ping Qi Hong Qiu run-lin gao Yu-Feng Zheng Department of Cardio-Metabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Coronary Artery Disease CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Engineering Medicine Beihang UniversityBeijingChina R&D Center Biotyx Medical(Shenzhen)Co.Ltd.ShenzhenChina Department of Cardiology Fuwai Yunnan HospitalChinese Academy of Medical SciencesAffiliated Cardiovascular Hospital of Kunming Medical UniversityKunmingChina Peking University Health Science Center BeijingChina Department of Cardiology Beijing Tsinghua Changgung HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseasesBeijingChina School of Materials Science and Engineering Peking UniversityBeijingChina

Iron is considered as an attractive alternative material for bioresorbable scaffolds(BRS).The sirolimus eluting iron bioresorbable scaffold(IBS),developed by Biotyx Medical(Shenzhen,China),is the only iron-based BRS with an ultrathin-wall *** study aims to investigate the long-term efficacy,safety,biocompatibility,and lumen changes during the biodegradation process of the IBS in a porcine model.A total of 90 IBSs and 70 cobaltchromium everolimus eluting stents(EES)were randomly implanted into nonatherosclerotic coronary artery of healthy mini *** multimodality assessments including coronary angiography,optical coherence tomography,micro-computed tomography,magnetic resonance imaging,real-time polymerase chain reaction(PCR),and histopathological evaluations,were performed at different time *** was no statistical difference in area stenosis between IBS group and EES group at 6 months,1year,2 years and 5 *** the scaffolded vessels narrowed at 9 months,expansive remodeling with increased mean lumen area was found at 3 and 5 *** IBS struts remained intact at 6 months,and the corrosion was detectable at 9 *** 5 years,the iron struts were completely degraded and absorbed in situ,without in-scaffold restenosis or thrombosis,lumen collapse,aneurysm formation,and chronic *** local or systemic toxicity and abnormal histopathologic manifestation were found in all *** from real-time PCR indicated that no sign of iron overload was reported in scaffolded ***,the IBS shows comparable efficacy,safety,and biocompatibility with EES,and late lumen enlargement is considered as a unique feature in the IBS-implanted vessels.

关键词： Bioresorbable scaffold Sirolimus eluting iron bioresorbable scaffold Preclinical study Completely bioresorbable Late lumen enlargement

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China cardiovascular diseases report 2018: an updated summary

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Journal of Geriatric Cardiology 2020年第1期17卷 1-8页

作者： Li-Yuan MA Wei-Wei CHEN run-lin gao Li-Sheng LIU Man-Lu ZHU Yong-Jun WANG Zhao-Su WU Hui-Jun LI Dong-Feng GU Yue-Jin YANG Zhe ZHENG Sheng-Shou HU National Center for Cardiovascular Diseases BeijingChina Beijing Tiantan Hospital BeijingChina Beijing Anzhen Hospital BeiingChina

1 Introduction Rapid socioeconomic progress has greatly affected the lifestyle in ***,owing to lifestyle changes,urbanization,and accelerated population aging,the risk of cardiovascular diseases(CVD)has *** incidence of CVD has been increasing continuously and this upward trend is projected to continue in the next *** growing burden of CVD has become a major public health issue.

关键词： Cardiovascular diseases Heart failure Risk factors

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IMPLANTATION OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELLS INTO ISCHEMIC MYOCARDIUM ENHANCES CORONARY CAPILLARIES AND SYSTOLIC FUNCTION IN MINISWINE

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Chinese Medical Sciences Journal 2008年第4期23卷 234-238页

作者： Chong-jian Li run-lin gao Yue-jin Yang Feng-huan Hu Wei-xian Yang Shi-jie You Lai-feng Song Ying-mao Ruan Shu-bin Qiao Ji-lin Chen Jian-jun Li Center of Coronary Heart Disease Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 Department of Pathology Fuwai HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037

Objective To investigate the therapeutic effectiveness of intracoronary implantation of autologous bone marrow mononuclear cells (BM-MNC) in miniswine model of reperfused myocardial infarction. Methods Sixteen miniswine myocardial ischemic reperfusion injury models made by ligation of the distal one third segment of left anterior descending artery for 90 minutes were randomized into 2 groups. In BM-MNC group (n = 9), (3.54±0.90)×108 BM-MNC were intracoronary injected, and in the control group (n = 7), phosphate buffered saline was injected by the same way. Echocardiographic and hemodynamic results, vessel density, and myocardial infarction size were evaluated and compared before and 4 weeks after cell transplantation. Results In BM-MNC group, there were no differences between before and 4 weeks after transplantation in aspects of left ventricular ejection fraction (LVEF), interventricular septal thickness, left ventricular lateral and anterior septal wall thickness, cardiac output, or +dp/dtmax. In control group, LVEF, interventricular septal thickness, left ventricular lateral and anterior septal wall thickness, cardiac output, and +dp/dtmax decreased significantly 4 weeks after transplantation (P < 0.05). Left ventricular end-diastolic pressure and –dp/dtmax did not change significantly before and after cell transplantation in both groups. Capillary density in BM-MNC group was greater than that in control group [(13.39 ± 6.96)/high power field vs. (3.50 ± 1.90)/high power field, P < 0.05]. Infarction area assessed by tetrazolium red staining and the infarction percentage decreased in BM-MNC group compared with those in control group (P < 0.05). Conclusions Transplantation of BM-MNC into myocardium with ischemic reperfusion injury increases capillary density and decreases infarction area. It has significantly beneficial effect on cardiac systolic function rather than on diastolic function.

关键词： ischemic myocardium bone marrow mononuclear cells transplantation

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Using machine learning to aid treatment decision and risk assessment for severe three-vessel coronary artery disease

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Journal of Geriatric Cardiology 2022年第5期19卷 367-376页

作者： Liu JIE Xin-Xing FENG Yan-Feng DUAN Jun-Hao LIU Ce ZHANG lin JIANG Lian-Jun XU Jian TIAN Xue-Yan ZHAO Yin ZHANG Kai SUN Bo XU Wei ZHAO Ru-Tai HUI run-lin gao Ji-Zheng WANG Jin-Qing YUAN Xin HUANG Lei SONG State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Endocrinology and Cardiovascular Disease Centre Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesShenzhenChina Nanjing TooBoo Technology Co. Ltd.NanjingChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiomyopathy Ward Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Information Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Solar activity Prediction Center National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina

BACKGROUND Three-vessel disease(TVD)with a SYNergy between PCI with TAXus and cardiac surgery(SYNTAX)score of≥23 is one of the most severe types of coronary artery *** aimed to take advantage of machine learning to help in de-cision-making and prognostic evaluation in such *** We analyzed 3786 patients who had TVD with a SYNTAX score of≥23,had no history of previous revascularization,and underwent either coronary artery bypass grafting(CABG)or percutaneous coronary intervention(PCI)after *** patients were randomly assigned to a training group and testing *** C4.5 decision tree algorithm was applied in the training group,and all-cause death after a median follow-up of 6.6 years was regarded as the class *** The decision tree algorithm selected age and left ventricular end-diastolic diameter(LVEDD)as splitting features and divided the patients into three subgroups:subgroup 1(age of≤67 years and LVEDD of≤53 mm),subgroup 2(age of≤67 years and LVEDD of>53 mm),and subgroup 3(age of>67 years).PCI conferred a patient survival benefit over CABG in sub-group *** was no significant difference in the risk of all-cause death between PCI and CABG in subgroup 1 and subgroup 3 in both the training data and testing *** the total study population,the multivariable analysis revealed significant dif-ferences in the risk of all-cause death among patients in three *** The combination of age and LVEDD identified by machine learning can contribute to decision-making and risk assessment of death in patients with severe *** present results suggest that PCI is a better choice for young patients with severe TVD characterized by left ventricular dilation.

关键词： coronary testing treatment

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Prolonged dual antiplatelet therapy after drug-eluting stent implantation improves long-term prognosis for acute coronary syndrome:five-year results from a large cohort study

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World Journal of Emergency Medicine 2023年第1期14卷 25-30页

作者： Jing-jing Xu Si-da Jia lin Jiang Ying Song Pei Zhu De-shan Yuan Yi Yao Xue-yan Zhao Jian-xin Li Yue-jin Yang Shu-bin Qiao Bo Xu run-lin gao Jin-qing Yuan Department of Cardiology Fuwai Hospital and Cardiovascular InstituteNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

BACKGROUND:To investigate the most appropriate dual antiplatelet therapy(DAPT)duration for patients with acute coronary syndrome(ACS)after drug-eluting stent(DES)implantation in the largest cardiovascular center of ***:We enrolled 5,187 consecutive patients with ACS who received DES from January to December *** were divided into four groups based on DAPT duration:standard DAPT group(11-13 months,n=1,568)and prolonged DAPT groups(13-18 months[n=308],18-24 months[n=2,125],and>24 months[n=1,186]).Baseline characteristics and 5-year clinical outcomes were ***:Baseline characteristics were similar across the four *** the four groups,those with prolonged DAPT(18-24 months)had the lowest incidence of major adverse cardiovascular and cerebrovascular events(MACCEs)(14.1%vs.11.7%vs.9.6%vs.24.2%,P<0.001),all-cause death(4.8%vs.3.9%vs.2.1%vs.2.6%,P<0.001),cardiac death(3.1%vs.2.6%vs.1.4%vs.1.9%,P=0.004),and myocardial infarction(MI)(3.8%vs.4.2%vs.2.5%vs.5.8%,P<0.001).The incidence of bleeding was not different among the four groups(9.9%vs.9.4%vs.11.0%vs.9.4%,P=0.449).Cox multivariable analysis showed that prolonged DAPT(18-24 months)was an independent protective factor for MACCEs(hazard ratio[HR]0.802,95%confidence interval[CI]0.729-0.882,P<0.001),all-cause death(HR 0.660,95%CI 0.547-0.795,P<0.001),cardiac death(HR 0.663,95%CI 0.526-0.835,P<0.001),MI(HR 0.796,95%CI 0.662-0.957,P=0.015),and target vessel revascularization(HR 0.867,95%CI 0.755-0.996,P=0.044).Subgroup analysis for high bleeding risk showed that prolonged DAPT remained an independent protective factor for all-cause death and ***:For patients with ACS after DES,appropriately prolonging the DAPT duration may be associated with a reduced risk of adverse ischemic events without increasing the bleeding risk.

关键词： Dual antiplatelet therapy Acute coronary syndrome Drug-eluting stent implantation

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Impact of Proton-pump Inhibitors on the Pharmacodynamic Effect and Clinical Outcomes in Patients Receiving Dual Antiplatelet Therapy after Percutaneous Coronary Intervention： A Propensity Score Analysis

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Chinese Medical Journal 2017年第24期130卷 2899-2905页

作者： Pei Zhu Zhan gao Xiao-Fang Tang Jing-Jing Xu Yin Zhang Li-Jian gao Jue Chen Shu-Bin Qiao Yue-Jin Yang run-lin gao Bo Xu Jin-Qing Yuan Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background：Prior studies have reported controversial conclusions regarding the risk of adverse cardiovascular events in patients using proton-pump inhibitors （PPIs） combined with clopidogrel therapy,causing much uncertainty in clinical *** sought to evaluate the safety of PPIs use among high-risk cardiovascular patients who underwent percutaneous coronary intervention （PCI） in a long-term follow-up ***：A total of 7868 consecutive patients who had undergone PCI and received dual antiplatelet therapy （DAPT） at a single center from January 2013 to December 2013 were *** diphosphate （ADP）-induced platelet aggregation inhibition was measured by modified thromboelastography （mTEG） in 5042 *** score matching （PSM） was applied to control differing baseline *** proportional hazards regression was used to evaluate the 2-year major adverse cardiovascular and cerebrovascular events （MACCEs）,as well as individual events,including all-cause death,myocardial infarction,unplanned target vessel revascularization,stent thrombosis,and ***：Among the whole cohort,27.2% were prescribed *** ADP-induced platelet aggregation inhibition by mTEG was significantly lower in PPI users than that in non-PPI users （42.0 ± 30.9% vs.46.4 ± 31.4%,t =4.435,P 〈 0.001）.Concomitant PPI use was not associated with increased MACCE through 2-year follow-up （12.7% vs.12.5%,x2 =0.086,P =0.769）.Other endpoints showed no significant differences after multivariate adjustment,regardless of ***：In this large cohort of real-world patients,the combination of PPIs with DAPT was not associated with increased risk of MACCE in patients who underwent PCI at up to 2 years of follow-up.

关键词： Clopidogrel Drug Interactions Percutaneous Coronary Intervention Proton-pump lnhibitors

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Long-term Outcomes of Primary Percutaneous Coronary Intervention with Second-generation Drug-eluting Stents in ST-elevation Myocardial Infarction Patients Caused by Very Late Stent Thrombosis

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Chinese Medical Journal 2017年第8期130卷 929-935页

作者： Chen He Yuan-Liang Ma Chuang-Shi Wang lin Jiang Jia-Hui Zhang Yi Yao Xiao-FangTang Bo Xu run-lin gao Jin-Qing Yuan State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： The ST-segment elevation myocardial inthrction （STEMI） patients due to stent thrombosis （ST） remain a therapeutic challenge for a clinician. Till date, very few researches have been conducted regarding the safety and effectiveness of primary percutaneous coronary intervention （PCI） with second-generation drug-eluting stents （DES） for STEMI caused by very late ST （VLST）. This retrospective study evaluated the safety, efficacy, and outcomes of primary PCI with second-generation DES for STEM1 due to VLST compared with primary PCI for STEM1 due to de novo lesion. Methods： Between January 2007 and December 2013, STEMI patients with primary PCI in Fuwai Hospital had only second-generation DES implanted for de novo lesion （558 patients） and VLST （50 patients） were included in this retrospective study. The primary end points included cardiac death and reinfarction. The secondary end points included cardiac death, reinfarction, and target lesion revascularization. Continuous variables were expressed as mean （standard deviation） or median （interquartile range） and compared by Student＇s t-test or Mann-Whitney U-test as appropriate. Categorical variables were expressed as counts and percentages, and comparison of these variables was performed with Chi-square or Fisher＇s exact test. A two-tailed value of P 〈 0.05 was considered statistically significant for all comparisons. Statistical analyses were performed by SAS software （version 9.4, SAS Institute Inc., Cary, USA） for Windows. Results： In-hospital primary end point and the secondary end point were no significant differences between two groups （P = 1.000 and P = 1.000, respectively）. No significant differences between two groups were observed according to the long-term primary end point and the secondary end point. Kaplan-Meier survival curves showed no significant difference between the two groups in the primary end point and the secondary end point at 2 years （P- 0.340 and P = 0,243, respectively）. According to

关键词： Primary Percutaneous Coronary Intervention Second-generation Drug-eluting Stents ST-elevation Myocardial Infarction Stent Thrombosis

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Comparison of Efficacy and Safety between First and Second Generation Drug-eluting Stents in Patients with Stable Coronary Artery Disease： A Single-center Retrospective Study

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Chinese Medical Journal 2017年第14期130卷 1654-1661页

作者： Ru Liu Fei Xiong Yuan Wen Yuan-Liang Ma Yi Yao Zhan gao Bo Xu Yue-Jin Yang Shu-Bin Qiao run-lin gao Jin-Qing Yuan Department of Cardiology Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Physiology Colleges of Pharmacy and Medicine University of Kentucky Lexington KY 40536 USA

Background：Lots of trials demonstrate that second-generation drug-eluting stents （G2-DES）,with their improved properties,offer significantly superior efficacy and safety profiles compared to first generation DES （Gl-DES） for patients with coronary artery disease （CAD） receiving percutaneous coronary intervention （PCI）.This study aimed to verify the advantage of G2-DES over G1-DES in Chinese patients with stable CAD （SCAD）.Methods：For this retrospective observational analysis,2709 SCAD patients with either G1-DES （n =863） or G2-DES （n =1846） were enrolled consecutively throughout *** score matching （PSM） was applied to control differing baseline ***-year outcomes,including major adverse coronary events as well as individual events,including target vessel-related myocardial infarction,target lesion revascularization （TLR）,target vessel revascularization,and cardiogenic death were ***：The incidence of revascularization between G1-and G2-DES showed a trend of significant difference with a threshold P-value （8.6% vs.6.7%,x2 =2.995,P =0.084）.G2-DES significantly improved TLR-free survival compared to G1-DES （96.6% vs.97.9%,P =0.049） and revascularization-free survival curve showed a trend of improvement of G2-DES （92.0% vs.93.8%,P =0.082）.These difterences diminished after *** Cox proportional hazard regression analysis showed a trend for G 1-associated increase in revascularization （hazard ratio：1.28,95% confidence interval：0.95-1.72,P =0.099） while no significance was found after *** endpoints showed no significant differences after multivariate adjustment regardless of ***：G1-DES showed the same safety as G2-DES in this large Chinese cohort of real-world ***,G2-DES improved TLR-ffee survival of SCAD patients 2 years after *** advantage was influenced by baseline clinical ***-DES was associated with a trend of increase in revascularization risk and was not an independent predictor o

关键词： Drug-etuting Stents Percutaneous Coronary Intervention Stable Coronary Artery Disease

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Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients Thrombotic Risk Score in Chinese Population Undergoing Percutaneous Coronary Intervention:A Prospective Observational Study

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Chinese Medical Journal 2018年第22期131卷 2699-2704页

作者： Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song lin Jiang Jue Chen Lei Song Li-Jian gao Zhan gao Shu-Bin Qiao Yue-Jin Yang run-lin gao Ro Xu Jin-Qing Yuan Coronary Heart Disease Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background: The patterns of nonadherence to antiplatelet regimen in stented patients(PARIS) thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events(CTEs) after percutaneous coronary intervention(PCI) with drug?eluting ***, the prognostic value of this score has not been fully evaluated in non?Euro?American PCI ***: We performed a prospective, observational study of 10,724 patients who underwent PCI in Fuwai hospital, China and evaluated the PARIS thrombotic risk score’s predictive value of CTEs in the PCI population. The area under the receiver operating characteristic curve(AUROC) was used to assess the predictive value of the PARIS score for ***: Among 9782 patients without in?hospital events, a total of 95 CTEs occurred during the 2?year follow?up. The PARIS score was significantly higher in patients with CTEs(3.38 ± 2.04) compared with patients without events(2.53 ± 1.70, P < 0.001).According to the risk stratification of the PARIS thrombotic score, the risk of CTEs in the high?risk group was 3.14 times higher than that in the low?risk group(hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.92–5.13; P < 0.001). However, the risk of CTEs in the intermediate?risk and low?risk groups was not significant(HR, 1.39; 95% CI, [0.86–2.24]; P = 0.184). The PARIS score showed prognostic value in evaluating CTEs in the overall population(AUROC, 0.621; 95% CI, 0.561–0.681), the acute coronary syndrome(ACS) population(AUROC, 0.617; 95% CI, 0.534–0.700; P = 0.003), and the non?ACS population(AUROC, 0.647; 95%CI, 0.558–0.736; P = 0.001).Conclusions: In a real?world Chinese population, the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI. This score also has a predictive value for CTEs in the ACS and non?ACS subgroup populations.

关键词： Coronary Thrombosis Percutaneous Coronary Intervention Prognosis Risk Assessment

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