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World Journal of Gastroenterology 2000年第3期6卷 415-416页

作者： Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang run huang Yun He Min jie Wang Guo Shu Xu Department of Pathology Kunming Medical CollegeKunming 650031China Department of Image Analyses Scientific Experiment Center Yunnan UniversityKunming 650091

INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and *** order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantit... 详细信息

关键词： liver neoplasms carcinoma hepatocellular alpha fetoprotein morphometry

PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

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Genes & Diseases 2021年第6期8卷 838-848页

作者： Chao Li Shang-Ze Li Xi-Cheng huang jie Chen Wenbin Liu Xiao-Dong Zhang Xue-Min Song run-Lei Du Research Centre of Anesthesiology and Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei Province430071PR China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei Province430072PR China College of Health Sciences and Nursing Wuhan Polytechnic UniversityWuhanHubei Province430023PR China

Protein tyrosine phosphatase non-receptor type 18(PTPN18)is often highly expressed in colorectal cancer(CRC),but its role in this disease remains *** demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results in ***,a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis in ***18 activated the MYC signaling pathway and enhanced CDK4 expression,which is tightly associated with the cell cycle and proliferation in cancer ***,we found that MYC interacted with PTPN18 and increased the protein level of *** conclusion,our results suggest that PTPN18 promotes CRC development by stabilizing the MYC protein level,which in turn activates the MYC-CDK4 ***,PTPN18 could be a novel therapeutic target in the future.

关键词： CDK4 Colorectal cancer MYC Proliferation PTPN18

Gut health:The results of microbial and mucosal immune interactions in pigs

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Animal Nutrition 2021年第2期7卷 282-294页

作者： jie Peng Yimei Tang Yanhua huang Innovative Institute of Animal Healthy Breeding Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China College of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China Guangzhou Fishtech Biotechnology Co. Ltd.Guangdong510640China

There are a large number of microorganisms in the porcine intestinal *** microorganisms and their metabolites contribute to intestinal mucosal immunity,which is of great importance to the health of the *** host immune system can regulate the distribution and composition of intestinal mi-croorganisms and regulate the homeostasis of intestinal flora by secreting a variety of immune effector factors,such as mucin,secretory immunoglobulin A(sIgA),regenerating islet-derivedⅢ(RegⅢ)γ,and ***,intestinal microorganisms can also promote the differentiation of immune cells including regulatory T cells(Treg)and Th17 cells through their specific components or *** have shown that imbalances in the intestinal flora can lead to bacterial translocation and compromised intestinal barrier function,affecting the health of the *** review focuses on the composition of the pig intestinal flora and the characteristics of intestinal mucosal immunity,discusses the interaction mechanism between the flora and intestinal mucosal immunity,as well as the regulation through fecal microbiota transplantation(FMT),dietary nutritional composition,probiotics and pre-biotics of pig intestinal ***,this review provides insights into the relationship between intestinal microorganisms and the mucosal immune system.

关键词： Gut microbe Pig Intestine Mucosal immunity

Micro shape of coal particle and crushing energy

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International Journal of Mining Science and Technology 2018年第6期28卷 1009-1014页

作者： Jiayuan Luo Gun huang Long Zhang Fei huang jie Zheng State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China College of Resource and Environmental Science Chongqing UniversityChongqing 400030China Liu Panshui Administration of Work Safety of Gui Zhou Province Liu Panshui 553001China

A large amount of energy is consumed in a coal and gas outburst since a mass of coal is pulverized and ejected, accompanying a great quantity of gas emitted, resulting in a major mining hazard in underground coal mining around the world. Understanding how potential energy stored in gassy coal seams dissipates in the process of outbursting may possibly be a key to clarify the mechanisms responsible for coal and gas outburst. The present study was aimed to evaluate energy for crushing coal to various size fractions in coal and gas outbursts through theoretical and experimental investigation into the shape of fine coal particles and their equivalent diameter. Theoretical analysis indicates that the shape of a particle has a significant impact both on its equivalent diameter and hence on its outer surface *** observations demonstrate the particle fraction with diameters less than 0.075 mm, produced from crushing coal samples, mostly takes on a spherical or ellipsoidal shape, and experimental data also show this part of particles consists of 30%–50% surface area newly generated from crushing operation,though these fine coal accounts for only less than ten percentages by weight. Further, analysis of experimental data indicates that the total surface area of this particle size fraction varies exponentially with input crushing energy, and the specific area energy is not a constant but probably in association with physical properties and textures of material.

关键词： Coal and gas outburst Coal breakage New surface area Shape of a fine particle Crushing energy

Weyl Spectrum of Upper Triangular Operator Matrices

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Acta Mathematica Sinica,English Series 2020年第7期36卷 783-796页

作者： Xiu Feng WU Jun jie huang School of Mathematical Sciences Inner Mongolia Normal UniversityHohhot 010022P.R.China School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021P.R.China

This paper is concerned with general n×n upper-triangular operator matrices with given diagonal *** characterizations of perturbations of their left(***)Weyl spectrum and Weyl spectrum are given,based on the space decomposition ***,some sufficient and necessary conditions are given under which the left(***)Weyl spectrum and the Weyl spectrum of such operator matrix,respectively,coincide with the union of the left(***)Weyl spectrum and the Weyl spectrum of its diagonal entries.

关键词： technique. diagonal spectrum

Static Recrystallization Behavior of Hot Deformed Austenite for Micro-Alloyed Steel

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Journal of Materials Science & Technology 2003年第z1期19卷 117-118页

作者： jie huang Zhou XU Xin XING Key Laboratory for High Temperature Materials and Tests of Ministry of Education Shanghai Jiaotong UniversityShanghai 200030 China Key Laboratory for High Temperature Materials and Tests of Ministry of Education Shanghai Jiaotong UniversityShanghai 200030 China Key Laboratory for High Temperature Materials and Tests of Ministry of Education Shanghai Jiaotong UniversityShanghai 200030 China

Static recrystallization behavior of austenite for micro-alloyed steel during hot rolling was studied and the influence (τ-ε diagram) of holding time and deformation at different deformations and isothermal temperatures on microstructuralstate of austenite were discussed. Corresponding to parameter Z in the dynamic recrystallization diagram, parameterY was then introduced to simplify static recrystallization diagrams.

关键词： Micro-alloyed steel, Hot deformation of austenite, Static recrystallization

Local Weak Hydrogen Bonds Significantly Enhance CO_(2)Electroreduction Performances of a Metal-Organic Framework

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CCS Chemistry 2023年第1期5卷 145-151页

作者： Yu Wang Ning-Yu huang Hao-Yu Wang Xue-Wen Zhang Jia-run huang Pei-Qin Liao Xiao-Ming Chen jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou 510275

Technological application of the electrochemical reduction of CO_(2)relies on efficient *** demonstrate that the introduction of amino groups alongside the porphyrin cobalt centers in a metal-organic framework(MOF)can dramatically accelerate the electrochemical CO_(2)reduction performance.A classic cobalt porphyrin-based MOF showing moderate CO_(2)-to-CO electroreduction performance(turnover frequency[TOF]=0.20 s^(−1),Faradic efficiency[FE]=47.4%)is *** molecular design of the porphyrin-based ligand,amino groups are introduced alongside the cobalt center,giving remarkably enhanced CO_(2)-to-CO electroreduction performance as high as FE 99.4%,current density 7.2 mA cm^(−2),and TOF 21.17 s^(−1),in a nearneutral aqueous solution at a low overpotential of 525 *** functional theory calculations showed that the prepositioned amino groups,although located not sufficiently close to the active center,serve as hydrogen-bonding donors to stabilize the intermediate Co-CO_(2)adduct and impede the formation of Co-H_(2)O adduct,which not only promotes the CO_(2)reduction reaction but also restrains the hydrogen evolution reaction.

关键词： CO_(2)electroreduction metal-organic frameworks hydrogen bond porphyrin amino groups

An overview on the distributed internal model approach and its applications

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Control Theory and Technology 2024年第3期22卷 345-359页

作者： Youfeng Su He Cai jie huang College of Computer and Data Science Fuzhou UniversityFuzhou 350116China School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinHong KongChina

The cooperative output regulation problem has been studied by two approaches:the distributed observer(DO)approach and the distributed internal model(DIM)approach,*** of these two approaches has its own merits and ***,we presented an overview on the cooperative output regulation problem by the DO *** paper further surveys the cooperative output regulation problem by the DIM *** first summarize the constructions and the roles of two different versions of the internal models:the distributed p-copy internal model and the distributed canonical internal ***,we describe an integrated framework that combines the DO approach and the DIM *** and variants of the DIM and their applications will also be highlighted.

关键词： Cooperative output regulation Distributed p-copy internal model Distributed canonical internal model Integrated approach

Structure and evolution of the submarine cable network of Chinese mainland

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Journal of Geographical Sciences 2022年第5期32卷 932-956页

作者： XIE Yongshun WANG Chengjin huang jie Institute of Geographic Sciences and Natural Resources Research CASBeijing100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China

Submarine cable network is one of the most important connectivity infrastructures in the digital *** the past 20 years,the submarine cable network of Chinese mainland has formed a complex connectivity *** paper focuses on exploring the structure and evolution of the submarine cable network of Chinese *** results show that the evolution can be divided into four stages:an initial stage(1993-1998),a developmental stage(1999-2002),a stagnation stage(2003-2015)and an accelerated stage(2016-2018).The connectivity structure can be analyzed at micro,meso and macro ***,the connectivity increased significantly overall,but showed significant differences in *** the microscale,the landing cities were characterized by“extensive but low,exclusive and high”;for the mesoscale,the connectivity of countries or regions was characterized by“distance attenuation”as a whole,but,in part,by a“regional identity”;for the macroscale,intercontinental connectivity differences have been *** hierarchy has been upgraded from a“3 system”to a“2+3 system”.Finally,this paper discusses the interaction between submarine cable network construction and international relations,and puts forward policy suggestions for China’s submarine cable construction.

关键词： submarine cable network structure connectivity evolution Chinese mainland

Multi-agent system motion planning under temporal logic specifications and control barrier function

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Control Theory and Technology 2020年第3期18卷 269-278页

作者： Xinyuan huang Li LI jie CHEN College of Electronics and Information Engineering Tongji UniversityShanghai 201804China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China

In this paper,w e provide a novel scheme to solve the motion planning problem of multi-agent systems under high-level task ***,linear temporal logic is applied to express the global task *** an efficient and decentralized algorithm is proposed to decom pose it into local tasks.M oreover,w e use control barrier function to synthesize the local controller for each agent under the linear temporal logic motion plan with safety ***,simulation results show the effectiveness and efficiency of our proposed scheme.

关键词： Temporal logic multi-agent system formal methods control barrier function