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Three-dimensional visualization technology for guiding one-step percutaneous transhepatic cholangioscopic lithotripsy for the treatment of complex hepatolithiasis

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World Journal of Gastroenterology 2024年第28期30卷 3393-3402页

作者： Yong-Qing ye Ya-Wen Cao Rong-Qi Li En-ze Li Lei Yan Zhao-Wei Ding Jin-Ming Fan Ping Wang Yi-Xiang Wu Department of Hepatobiliary Surgery The Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization *** with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)*** This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for *** patients were divided into two groups:The 3D-PTOBF group and the PTOBF *** clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were *** Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)*** immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF *** complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF *** Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary *** perioperative and long-term outcomes are satisfactory for patients with complicated primary *** minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.

关键词： Hepatolithiasis One-step percutaneous transhepatic cholangioscopic lithotripsy Biliary disease Three-dimensional visualization Clinical efficacy

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Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng ye ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

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Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4194-4208页

作者： Ming He ye Qi ze-Mao Zheng Min Sha Xiang Zhao Yu-Rao Chen Zheng-Hai Chen Rong-Yu Qian Juan Yao Zheng-Dong Yang Department of Radiation Oncology Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina Department of Nursing Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina Institute of Clinical Medicine Taizhou People's Hospital Affiliated of Nantong University of MedicineTaizhou 225300Zhejiang ProvinceChina Department of Thoracic Surgery Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina

BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain *** the present study,the complementary sites between lncRNA SRA1,miRNA-363-5p,and phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC *** To investigate the molecular events of SRA1 in the malignant behavior in *** Thirty-eight ESCC tissues and paired adjacent normal tissues were ***1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain *** counting Kit-8 assay,transwell invasion assay,glycolysis assay,and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of *** t-test and theχ2 test were used for comparison between *** curve analysis was performed using the Kaplan-Meier *** SRA1 downregulation was identified in *** patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 *** introduction of SRA1 inhibited cell proliferation,glucose uptake,and lactate production in *** vivo,the growth of ESCC was hindered by SRA1 ***,SRA1 overexpresses the LHPP by inhibiting ***,the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by *** SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP *** SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.

关键词： Steroid receptor RNA activator 1 Esophageal squamous cell carcinoma Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Cancer therapy MicroRNA Long non-coding RNA

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Structure and Growth of Two-dimensional Ices at the Surfaces Probed by Scanning Probe Microscopy

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Chinese Journal of Structural Chemistry 2020年第3期39卷 381-387,375页

作者： TIAN ye MA run-ze JIANG Ying International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China

Scanning probe microscopy(SPM) stands out as one of the most powerful tools for characterizing the solid surface and the adsorbed molecules with ?ngstr?m resolution in real space. In particular, this unique technique provides an unprecedented opportunity for directly probing the low-dimensional ices at surfaces. In this perspective, we first review the recent advances of scanning tunneling microscopy(STM) imaging of various two-dimensional(2 D) ice structures on metal[1-7], insulator[8-12], graphite[13-15] surfaces and under strong confinement[10, 16-19]. We then introduce that noncontact atomic-force microscopy(AFM) with a CO-terminated tip enables atomic imaging of a genuine 2 D ice grown on a hydrophobic Au(111) surface with minimal perturbation[20], paying particular attention to the growth processes at the edges of 2 D ice. In the end, we present an outlook on the future applications of 2 D ice as well as the relation between the 2 D and 3 D ice growth.

关键词： scanning tunneling microscopy noncontact atomic-force microscopy two-dimensional ice growth processes

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新生代消费升级与共情驱动的创新

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中国工业经济 2024年第4期 152-169页

作者：叶泽樱郑馨陶琳中山大学管理学院中山大学岭南学院

推动需求侧管理与供给侧结构性改革的有效协同,是理论界和实践界关注的重要议题。本文在人口结构变化和消费观念变迁的背景下,挖掘新生代消费升级的复杂特征,识别企业开展“共情驱动的创新”的表现形式,探究新生代消费升级如何影响企业... 详细信息

推动需求侧管理与供给侧结构性改革的有效协同,是理论界和实践界关注的重要议题。本文在人口结构变化和消费观念变迁的背景下,挖掘新生代消费升级的复杂特征,识别企业开展“共情驱动的创新”的表现形式,探究新生代消费升级如何影响企业共情驱动的创新。通过深度访谈和探索性多案例研究发现,新生代消费升级体现为消费能力升级、消费内容升级和消费方式升级,呈现出价格敏感性下降、消费频次增加、注重消费内容的精神属性和非基础属性,以及高技术嵌入和消费圈层化等特征。企业共情驱动的创新包括:基于认知共情和情感共情,对需求进行理解和挖掘;基于观点采择和用户体验,设计原型产品并进行分层测试;基于情绪感染和情感依恋,进行“种草”推广和用户留存。新生代消费升级对共情驱动的创新具有激励作用,具体通过“潜在收益激发效应”“问题激发效应”和“适应性匹配效应”促进企业共情驱动的创新。本文在引入消费的代际差异、提出新的创新方式、厘清“需求-创新”的影响关系三方面拓展和丰富了需求引致创新理论,同时对企业洞察消费升级特征、把握消费升级新机遇、加强供给侧创新引领具有启示意义。

关键词：乙世代消费升级共情驱动的创新

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Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： zeng-Mei Sun Yuan-ze Du Su-Yuan Wang Shu-Yao Sun Yan ye Xue-Ping Sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled tozed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

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摩罗丹辅助瑞巴派特在慢性萎缩性胃炎患者治疗中的疗效观察

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四川生理科学杂志 2024年第7期46卷 1522-1524页

作者：叶润泽孙剑峰叶利君婺源县地方病防治院江西上饶333200

目的:分析摩罗丹辅助瑞巴派特在慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)患者治疗中的疗效。方法:随机将本院自2020年1月至2023年12月收治的62例CAG患者分为观察组和对照组,各31例。对照组接受瑞巴派特治疗,观察组摩罗丹辅助治... 详细信息

目的:分析摩罗丹辅助瑞巴派特在慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)患者治疗中的疗效。方法:随机将本院自2020年1月至2023年12月收治的62例CAG患者分为观察组和对照组,各31例。对照组接受瑞巴派特治疗,观察组摩罗丹辅助治疗,两组均治疗14 d;比较治疗后临床疗效,对治疗前后的中医症候积分、血清胃肠激素水平及炎症因子进行比较。结果:治疗后,观察组总有效率显著较高(93.55%vs 70.97%,P<0.05),观察组中医证候主症、次症、总分显著较高(P=0.003、0.001、0.000),胃动素、胃泌素水平均显著较高(P<0.05),生长抑素水平显著较低(P<0.05),观察组C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平均显著较低(P<0.05)。结论:摩罗丹辅助瑞巴派特治疗CAG患者疗效显著,能有效改善中医症候、肠胃功能、以及炎症反应,提高MTL、GAS水平,降低SS水平。

关键词：慢性萎缩性胃炎摩罗丹瑞巴派特

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Formation mechanism of nanopores in dense films of anodic alumina

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2918-2927页

作者： Peng-ze LI Yu ZHANG Jia-zheng ZHANG Lin LIU Shi-yi WANG Rui LIU ye SONG Xu-fei ZHU Key Laboratory of Soft Chemistry and Functional Materials of Education Ministry Nanjing University of Science and TechnologyNanjing 210094China School of Environmental and Chemical Engineering Jiangsu Ocean UniversityLianyungang 222005China

Constant-current anodization of pure aluminum was carried out in non-corrosive capacitor working electrolytes to study the formation mechanism of nanopores in the anodic oxide *** comparative experiments,nanopores are found in the anodic films formed in the electrolytes after high-temperature storage(HTS)at 130°C for 240 h.A comparison of the voltage-time curves suggests that the formation of nanopores results from the decrease in formation efficiency of anodic oxide films rather than the corrosion of the ***-IR and UV spectra analysis shows that carboxylate and ethylene glycol in electrolytes can easily react by esterification at high *** the electronic current theory and oxygen bubble mold effect,the change in electrolyte composition could increase the electronic current in the anodizing *** electronic current decreases the formation efficiency of anodic oxide films,and oxygen bubbles accompanying electronic current lead to the formation of nanopores in the dense *** continuous electronic current and oxygen bubbles are the prerequisites for the formation of porous anodic oxides rather than the traditional field-assisted dissolution model.

关键词： anodic alumina formation mechanism nanopores formation efficiency electronic current oxygen bubble

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不同荷载作用下二维硼烯的力学性能及变形破坏机理

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物理学报 2024年第11期73卷 251-262页

作者：韩同伟李选政赵泽若顾叶彤马川张小燕江苏大学土木工程与力学学院镇江212013 江苏大学化学化工学院镇江212013

二维硼烯具有丰富的物理和化学性质,在凝聚态物理和材料科学等领域引起了广泛的研究兴趣,但硼烯在不同荷载作用下的力学性能和变形破坏机理仍需进一步研究.本文采用分子动力学方法模拟了硼烯的拉伸、剪切和纳米压痕破坏过程,获得了硼烯... 详细信息

二维硼烯具有丰富的物理和化学性质,在凝聚态物理和材料科学等领域引起了广泛的研究兴趣,但硼烯在不同荷载作用下的力学性能和变形破坏机理仍需进一步研究.本文采用分子动力学方法模拟了硼烯的拉伸、剪切和纳米压痕破坏过程,获得了硼烯的关键力学性能参数,并从两种不同类型的B—B键长随应变/压入深度的变化规律分析了硼烯在不同载荷作用下的力学性能和变形破坏机理.研究发现,硼烯的拉伸力学性能表现出显著的各向异性特性,沿扶手椅方向的杨氏模量和强度远高于沿锯齿方向,而硼烯的剪切力学性能的各向异性特性不明显,产生以上现象的原因可归因于强σ键B—B键和弱多中心键的不同贡献.研究还发现,硼烯在球形和圆柱形压头载荷作用下表现出不同的力学响应规律.在球形压头载荷作用下,硼烯能承受的最大压入载荷远低于圆柱形压头的情况,而且无法测得与拉伸一致的本征力学性能参数,而采用圆柱形压头沿不同的方向压入硼烯薄膜时,硼烯也表现出与拉伸时类似的各向异性特性,并且可以测得与拉伸时一致的杨氏模量等力学性能参数.本文还研究了压痕模型尺寸与压头半径的比值、压头加载速率和加载温度等因素对硼烯力学性能参数的影响规律.以上研究结果可为基于硼烯的微/纳米机电系统的实际应用提供重要指导.

关键词：硼烯力学性能变形机理分子动力学

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基于数据湖实现气象资料存储优化

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黑龙江气象 2024年第2期41卷 36-37,41页

作者：白玉凌霄宋邦钰叶润泽黑龙江省气象数据中心黑龙江哈尔滨150030

本文借助数据湖(Datalake)技术,构建了一个高效的数据存储、共享和服务体系,以解决不断增长的数据需求。通过对NAS存储和虚拟目录进行一一映射,为用户授权不同的虚拟目录即可访问不同类型的气象数据,达到了分级管理数据的目的,提升了安... 详细信息

本文借助数据湖(Datalake)技术,构建了一个高效的数据存储、共享和服务体系,以解决不断增长的数据需求。通过对NAS存储和虚拟目录进行一一映射,为用户授权不同的虚拟目录即可访问不同类型的气象数据,达到了分级管理数据的目的,提升了安全管控气象数据的能力,打破了数据孤岛,实现了数据的统一管理,为用户提供更快速高效的数据服务。

关键词：气象数据数据湖虚拟目录

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