检索结果-南通市图书馆

Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-Yue Tang Xue Shen run-sheng yuan Hui-yuan Li Xin-Wei Li Yi-Ming Jing Yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-Chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

引用

Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing Xu Zijian yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new radar stealth design excited by ^(210)Po and ^(242)Cm

引用

Nuclear Science and Techniques 2022年第6期33卷 45-53页

作者： Jin-Jian yuan Gui-Ping Meng Min Gu run-sheng Huang School of Physics Nanjing UniversityNanjing 210093China

Open plasma stealth technology excited by radionuclides is known to have several problems:(1)owing to disturbance from airflow,the plasma distribution is unstable.(2)The plasma is highly dependent on the atmosphere;therefore,it is difficult to modulate in target stealth.(3)Concerns regarding radiation harassment prevent the application of this *** avoid these problems,an enclosed plasma stealth method is *** simulation on an infinite conducting plate,this method was found to effectively solve the above concerns,which may offer a new approach for the practical application of plasma stealth technology excited by radionuclides,especially for small-satellite stealth because of its lightweight and selfprovided plasma.

关键词： Radiation ionization αDecay particles Plasma film Radar stealth technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of the characteristics of fault gouge on the stability of a borehole wall

引用

Journal of Mountain Science 2016年第5期13卷 930-938页

作者： WANG sheng CHEN Li-yi HUANG run-qiu LI Zhi-jun WU Jin-sheng yuan Chao-peng State Key Laboratory of Geohazard Prevention&Geoenvironment Protection Chengdu University of TechnologyChengdu Siehuan 610059China The Institute of Exploration Technology of CAGS Chengdu 611734China

How to find more effective way to stabilize the borehole wall in the fault gouge section is the key technical challenge to control the stability of the borehole wall in the Wenchuan fault gouge section during the process of core drilling. Here we try to describe the characters of deep fault gouge in fracture zones from the undisturbed fault gouge samples which are obtained during the core drilling. The X- Ray Diffraction （XRD）, X-Ray Fluorescence （XRF） and Scanning Electron Microscope （SEM） provided the detailed information of the fault gouge＇s microscopic characteristics on the density, moisture content, expansibility, dispersity, permeability, tensile strength and other main physical-mechanical properties. Based on these systematic experimental studies above and analysis of the fault gouge instability mechanism, a new technical procedure to stabilize the borehole wall is proposed -- a low water and a low loss low permeability drilling fluid system that consists of 4% day ＋ 0.5% CMC-HV ＋ 2% S-1 ＋ 3%sulfonated asphalt ＋ 1% SMC ＋ 0.5% X-1 ＋ 0-5% T type lubricant ＋ barite for core drilling in fault gouge sections.

关键词： Fault gouge Microscopic characteristics Borehole wall stability Drilling fluid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vacuum therapy prevents corporeal veno-occlusive dysfunction and penile shrinkage in a cavernosal nerve injured rat model

引用

Asian Journal of Andrology 2020年第3期22卷 274-279页

作者： sheng-Qiang Qian Feng Qin Shuang Zhang Yang Yang Qiang Wei run Wang Jiu-Hong yuan Andrology Laboratory West China HospitalSichuan UniversityChengdu 610041China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Department of Urology Chongqing Traditional Chinese Medicine HospitalChongqing 402760China Division of Urology University of Texas Medical School at HoustonHoustonTX 77030USA

Erectile dysf un ction and penile shri nkage are the comm on complications after radical *** rehabilitati on is widely applied after the *** therapy is one of the three penile rehabilitation methods used in the clinical setting,but its mechanism is not well *** study was designed to investigate whether vacuum erectile device(VED)can prevent corporeal veno-occlusive dysfunction and penile shrinkage in the bilateral cavernous nerve crush(BCNC)rat *** male Sprague-Dawley rats were randomly assigned into three groups:sham group,BCNC group,and BCNC+VED *** 4 weeks,penile length and intracavernosal pressure(ICP)were measured,and then the middle part of the penis was harvested after dynamic inf usion caver no sometry to complete the followi ng items:smooth muscle/collage n ratios and collagenⅠ/Ⅲratios;ultramicrostructure of the tunica albuginea,endothelial cell,and smooth muscle cell;and the expression of calponin・l and *** penile shortening,peak ICP and ICP drop rate after alprostadil injection were significantly improved with vacuum therapy after 4-week treatme *** with BCNC group,VED sign ifica ntly in creased smooth muscle/collagen ratios,decreased collagenⅠ/Ⅲratios,and preserved the ultramicrostructure of the tunica albuginea,endothelial cell,and smooth muscle *** data also showed that an imals exposed to VED could partially reverse the expression of calp onin・l and osteop ontin induced by *** conclusion,vacuum therapy is effective to prevent penile shrinkage and veno-occlusive dysfunction in penile rehabilitation,which may be associated with well-preserved structure and function of the tunica albuginea,endothelial cell,and smooth muscle cell.

关键词： corporeal veno-occlusive dysfunction erectile dysfunction penile rehabilitation penile shrinkage vacuum therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The steroid-induced microRNA let-7 regulates developmental growth by targeting cdc7 in the Drosophila body

引用

Insect Science 2021年第6期28卷 1621-1632页

作者： Dan-Yan Huang Xiao-Ling Xia run Huang sheng Li Dong-Wei yuan Su-Ning Liu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhou510631China

In insects,20-hydroxyecdysone(20E)limits systemic growth by triggering developmental *** studies have shown that 20E-induced let-7 exhibits crosstalk with the cell ***,we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body,an organ for energy storage and nutrient mobilization which plays a critical role in the larval ***,the overexpression of let-7 decreased the body size and led to the reduction of both nucleolus and cell sizes in the larval fat *** contrast,the overexpression of let-7-Sponge increased the nucleolus and cell ***,we found that cdc7,encoding a conserved protein kinase that controls the endocycle,is a target of ***,the mutation of cdc7 in the fat body resulted in growth ***,our findings revealed a novel role of let-7 in the control of endoreduplication-related growth during larval-prepupal transition in Drosophila.

关键词： cdc7 Drosophila fat body growth let-7

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of inebilizumab or rituximab in addition to glucocorticoid therapy for neuromyelitis optica spectrum disorders

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1073-1078页

作者： Chu-yuan Lou Yong Wang Jia-yuan Xing Teng Ma Lei Tao Xiao-Tang Wang run-sheng Wang Neuroophthalmic Center Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004Shaanxi ProvinceChina

AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were *** groups underwent hormone shock therapy during the acute ***,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after ***,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment ***:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab ***:The combination of inebilizumab and high-dose glucocorticoids proves to be *** comparison to rituximab injections,inebilizumab displays better tolerance and ***,it demonstrates a partial effect in preventing optic nerve ***,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.

关键词： neuromyelitis optica spectrum disorders inebilizumab rituximab glucocorticoids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Ink Molecular Weights and Annealing Conditions on Molecular Transfer Printing

引用

Chinese Journal of Polymer Science 2018年第6期36卷 697-702页

作者： yuan-yuan Pang sheng-Xiang Ji Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100049China

The molecular transfer printing（MTP） technique has been invented to fabricate chemical patterns with high fidelity using homopolymer inks. In this work, we systematically studied the effects of the molecular weights of homopolymer inks and transfer conditions on the MTP process. We explored a large range of molecular weights（~3.5-56 kg·mol^（-1）） of hydroxyl-terminated polystyrene（PS-OH） and hydroxyl-terminated poly（methyl methacrylate）（PMMA-OH） in the MTP process, and found that the resulting chemical patterns on replicas from all five blends were functional and able to direct the assembly of films of the same blends. The transfer temperature and the film annealing sequences had an impact on the MTP process. MTP was sensitive to the transfer temperature and could only be performed within a certain temperature range, i.e. higher than the glass transition temperature（T_g） of copolymers and lower than the rearrangement temperature of the assembled domains. Pre-organization of the blend films was also necessary for MTP since the preferential wetting of PMMA domains at the replica surface might result in the formation of a PMMA wetting layer to prevent the presentation of underlying chemical patterns to the replica surface.

关键词： Block copolymer Molecular transfer printing Thermal annealing Chemical pattern Directed self-assembly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Positive Solutions to m-point Boundary Value Problem of Fractional Differential Equation

引用

Acta Mathematicae Applicatae Sinica 2013年第3期29卷 661-672页

作者： yuan-sheng TIAN Department of Mathematics Xiangnan University

In this paper, we study the multiplicity of positive solutions to the following m-point boundary value problem of nonlinear fractional differential equations： Dqu（t）＋ f（t, u（t）） = 0, 0 t 1, u（0） = 0, u（1） =sum （μiDpu（t）｜t = ξi ） from i =1 to ∞ m-2, where q ∈R , 1 q ≤2 , 0 ξ1 ξ2 ··· ξm-2 ≤ 1/2 , μi ∈[0 , ＋∞） and p = q-1/2 , Γ（q） sum （μiξi（q-1）/2 Γ（（ q＋1）/2） from i =1 to ∞ m-2,Dq is the standard Riemann-Liouville differentiation, and f ∈C （[0 , 1]×[0 , ＋∞） , [0 , ＋∞））. By using the Leggett-Williams fixed point theorem on a convex cone, some multiplicity results of positive solutions are obtained.

关键词： fractional differential equation m-point boundary value problem fixed-point theorem positive solutions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prescribing Curvature Problems on the Bakry-Emery Ricci Tensor of a Compact Manifold with Boundary

引用

Chinese Annals of Mathematics,Series B 2014年第1期35卷 139-160页

作者： Weimin sheng Lixia yuan Department of Mathematics Zhejiang University Department of Mathematics Xinjiang Normal University

t The authors consider the problem of conformally deforming a metric such that the k-curvature defined by an elementary symmetric function of the eigenvalues of the Bakry-Emery Ricci tensor on a compact manifold with boundary to a prescribed function. A consequence of our main result is that there exists a complete metric such that the Monge-Amp^re type equation with respect to its Bakry-Emery Ricci tensor is solvable, provided that the initial Bakry-Emery Ricci tensor belongs to a negative convex cone.

关键词： k-Curvature Bakry-Emery Ricci tensor Complete metric Dirichletproblem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：