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Phosphoglucose isomerase gene expression as a prognostic biomarker of gastric cancer

Chinese Journal of Cancer Research 2019年第5期31卷 771-784页

作者： Han-chen Huang Xian-Zi Wen Hua Xue Run-Sheng Chen Jia-Fu Ji Lei Xu Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Guangdong Geneway Decoding Bio-Tech Co.Ltd Foshan 528316China Centre for Cognitive Machines and Computational Health(CMaCH) School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Computer Science and Engineering The Chinese University of Hong KongHong Kong 999077China

Objective: Tumor heterogeneity renders identification of suitable biomarkers of gastric cancer(GC)challenging. Here, we aimed to identify prognostic genes of GC using computational analysis.Methods: We first used microarray technology to profile gene expression of GC and paired nontumor tissues from 198 patients. Based on these profiles and patients’ clinical information, we next identified prognostic genes using novel computational approaches. Phosphoglucose isomerase, also known as glucose-6-phosphate isomerase(GPI), which ranked first among 27 candidate genes, was further investigated by a new analytical tool namely enviro-geno-pheno-state(E-GPS) analysis. Suitability of GPI as a prognostic marker, and its relationship with physiological processes such as metabolism, epithelial-mesenchymal transition(EMT), as well as drug sensitivity were evaluated using both our own and independent public datasets.Results: We found that higher expression of GPI in GC correlated with prolonged survival of patients.Particularly, a combination of CDH2 and GPI expression effectively stratified the outcomes of patients with TNM stage Ⅱ/Ⅲ. Down-regulation of GPI in tumor tissues correlated well with depressed glucose metabolism and fatty acid synthesis, as well as enhanced fatty acid oxidation and creatine metabolism, indicating that GPI represents a suitable marker for increased probability of EMT in GC cells.Conclusions: Our findings strongly suggest that GPI acts as a novel biomarker candidate for GC prognosis,allowing greatly enhanced clinical management of GC patients. The potential metabolic rewiring correlated with GPI also provides new insights into studying the relationship between cancer metabolism and patient survival.

关键词： Gastric cancer gene expression profile prognostic biomarker phosphoglucose isomerase tumor metabolism

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Genome-wide long non-coding RNA association study on Han Chinese women identifies lncHSAT164 as a novel susceptibility gene for breast cancer

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Chinese Medical Journal 2021年第10期134卷 1138-1145页

作者： Jing-Kai Xu Guo-Zheng Li Zhi Li Wen-Jing Li Run-Sheng Chen Bo Zhang Xue-Jun Zhang Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of DermatologyAnhui Medical UniversityMinistry of EducationHefeiAnhui 230032China Department of Genetics School of Life SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Oncology No.2 HospitalAnhui Medical UniversityHefeiAnhui 230032China Laboratory of Bioinformatics and Noncoding RNA Key Laboratory of RNA BiologyInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

Background:Single-nucleotide polymorphisms(SNPs)-associated genes and long non-coding RNAs(lncRNAs)can contribute to human disease.To comprehensively investigate the contribution of lncRNAs to breast cancer,we performed the first genome-wide lncRNA association study on Han Chinese women.Methods:We designed an lncRNA array containing>800,000 SNPs,which was incorporated into a 96-array plate by Affymetrix(CapitalBio Technology,China).Subsequently,we performed a two-stage genome-wide lncRNA association study on Han Chinese women covering 11,942 individuals(5634 breast cancer patients and 6308 healthy controls).Additionally,in vitro gain or loss of function strategies were performed to clarify the function of a novel SNP-associated gene.Results:We identified a novel breast cancer-associated susceptibility SNP,rs11066150(P_(meta)=2.34×10^(-8)),and a previously reported SNP,rs9397435(P_(meta)=4.32×10^(-38)),in Han Chinese women.rs11066150 is located in NONHSAT164009.1(lncHSAT164),which is highly expressed in breast cancer tissues and cell lines.lncHSAT164 overexpression promoted colony formation,whereas lncHSAT164 knockdown promoted cell apoptosis and reduced colony formation by regulating the cell cycle.Conclusions:Based on our lncRNA array,we identified a novel breast cancer-associated lncRNA and found that lncHSAT164 may contribute to breast cancer by regulating the cell cycle.These findings suggest a potential therapeutic target in breast cancer.

关键词： Breast cancer lncHSAT164 Single-nucleotide polymorphisms

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Restoration of Brain Acid Soluble Protein 1 Inhibits Proliferation and Migration of Thyroid Cancer Cells

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Chinese Medical Journal 2016年第12期129卷 1439-1446页

作者： run-sheng Guo Yue YU Jun chen Yue-Yu chen Na Shen Ming Qiu Department of General Surgery Changzheng Hospital Second Military Medical University Shanghai 201705 China Department of General Surgery Jiading Central Hospital Shanghai 201822 China Department of General Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China Department-of Pathology Jiading Central Hospital Shanghai 201822 China Department of Otorhinolaryngology Zhongshan Hospital Fudan University Shanghai 200032 China

Background： Brain acid soluble protein 1 （BASPI） is identified as a novel potential tumor suppressor in several cancers. However, its role in thyroid cancer has not been investigated yet. In the present study, the antitumor activities of BASP1 against the growth and migration of thyroid cancer cells were evaluated. Methods： BASP1 expression in thyroid cancer tissues and normal tissues were examined by immunohistochemical staining and the association between its expression and prognosis was analyzed, pcDNA-BASP 1 carrying full length of BASP1 cDNA was constructed to restore the expression of BASP1 in thyroid cancer cell lines （BHT- I 01 and KMH-2）. The cell proliferation in vitro and in vivo was evaluated by WST-1 assay and xenografl tumor models, respectively. Cell cycle distribution after transfection was analyzed using flow cytometry. Cell apoptosis after transfection was examined by annexin V/propidium iodide assay. The migration was examined using transwell assay. Results： BASP1 expression was abundant in normal tissues while it is significantly decreased in cancer tissues （P = 0.000）. pcDNA-BASP1 restored the expression of BASPI and significantly inhibited the growth of BHT-101 and KMH-2 cells as well as xenograft tumors in nude mice （P = 0.000）. pcDNA-BASPI induced G1 arrest and apoptosis in BHT-101 and KMH-2 cells. In addition, pcDNA-BASP1 significantly inhibited the cell migration. Conclusions： Downregulation of BASP1 expression may play a role in the tumorigenesis of thyroid cancer. Restoration of BASPI expression exerted extensive antitumor activities against growth and migration of thyroid cancer cells, which suggested that BASPI gene might act as a potential therapeutic agent for the treatment of thyroid cancer.

关键词： Brain Acid Soluble Protein 1 Gene Transfection Proliferation Thyroid Cancer

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Synergistic reaction behavior of pyrolysis and reduction of briquette prepared by weakly caking coal and metallurgical dust

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Journal of Iron and Steel Research(International) 2023年第7期30卷 1367-1380页

作者： Zheng-jian Liu Ming-hui Cao Jian-liang Zhang run-sheng Xu Yao-zu Wang Ji-yong Yu Yu-chen Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Co-carbonization of weakly caking coal and zinc-containing dust to prepare highly reactive ferro-coke and collaboratively recover zinc powder is one of the feasible ways for steel enterprises to recycle zinc-containing dust.The pyrolysis mass loss behavior of adding blast furnace dust with different zinc contents to different ferro-coke materials was systematically studied by thermogravimetry and differential thermogravimetry analysis,and the kinetic mechanism of pyrolysis-reduction reaction of hybrid briquette was explored.The results of thermogravimetric curve analysis show that the addition of zinc oxide to the sample has no significant effect on the mass loss rate of the sample below 580℃,and the pyrolysis mass loss of zinc oxide mainly occurs between 800 and 1000℃.Kinetic analysis results show that the pyrolysis of zinc-containing samples is controlled by chemical reactions below 580℃.The reaction at 580–700℃ is controlled by the nucleation and growth model,and that above 700℃ is mainly controlled by diffusion.The results of X-ray diffraction analysis show that the pyrolysis process can effectively remove zinc oxide from ferro-coke.

关键词： Zinc-containing dust Weakly caking coal Ferro-coke Pyrolysis Reduction Thermal reaction analysis Kinetic analysis

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Fault geometrical model of Dujiangyan section in Longmenshan fault zone

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Earthquake Science 2018年第3期31卷 126-136页

作者： Hu-Rong Duan sheng-Lei chen run Li Quan-Chao Yan College of Geomatics Xi'an University of Science and Technology

The focal mechanism solution on the seismic fault plane can reflect the geometric and kinematic characteristics of faults, and it is an important way to further study the fine structure of fault plane. From the focal mechanism solution of the earthquakes around the Dujiangyan fault in Longmenshan fault zone, we derived the average dip angle of Dujiangyan fault is 45.1° based on the seismic moment tensor theory. In order to refine the fault geometry structure, this paper decomposed it into multiple sub-fault planes along the length and width of the fault plane and forms a number of models A13, B13, A23 a, A23 b, A23 c, B23 a,B23 b and B23 c, then calculated the sub-fault’s dip of each model. In order to clarify exactly which one of the fault models is closest to the real fault model, the fault slip was carried out for each model in turn, then compared the surface displacement of each model with GPS observations. The results show that B23 c model with high dip in shallow and small dip in deep is the best model, the lengths of each subfault of Dujiangyan fault from south to north are 33 km, 21 km and 46 km, respectively. When the depth of the fault bottom is about 11 km, the dip angles are 70.56°, 67.41° and 45.55°.When the depth of the fault bottom is about 30 km, The fault dip angles are 44.55°, 29.18° and 44.25°.

关键词： focal mechanism solution seismic moment tensor fault dip fault fine structure Dujiangyan fault

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Research progress on multiscale structural characteristics and characterization methods of iron ore sinter

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Journal of Iron and Steel Research(International) 2020年第4期27卷 367-379页

作者： Wei Wang Xu-heng chen run-sheng Xu Jun Li Wen-jun Shen Su-ping Wang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Branch of Baosteel Central Research Institute Wuhan 430083HubeiChina

At present,blast furnace ironmaking is still the main process for producing molten iron,and sinters are the main raw material for blast furnace ironmaking.A sinter with good metallurgical performance can not only ensure smooth operation of the blast furnace but also reduce the blast furnace fuel ratio and increase the molten iron production.Structure is the most important factor affecting the metallurgical properties of the sinter.Thus,the research progress of sinter pore and mineral phase structures was reviewed and the mechanism by which they influence sinter properties was expounded.Multiscale characterization methods for the sinter and their advantages and disadvantages were introduced,and the future research direction of sinter was discussed.

关键词： Iron ore sinter Pore structure Mineral phase structure Characterization method Multiscale characterization

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Nonchaoticity of Ordinary Differential Equations Describing Autonomous Transcriptional Regulatory Circuits

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Communications in Theoretical Physics 2008年第6期49卷 1639-1642页

作者： LI Peng-Fei HU Gang chen run-sheng Department of Physics Beijing Normal University Beijing 100875 China Beijing-Hong Kong-Singapore Joint Center of Nonlinear and Complex Systems Beijing Normal University Branch Beijing 100875 China Bioinformatics Laboratory Institute of Biophysics the Chinese Academy of Sciences Beijing 100101 China

基因 transcriptional 规定(TR ) 过程经常被描述由联合了非线性的平常的微分方程(颂诗) 。当 TR 电路的尺寸高时(例如 n ≥3 ) 相应颂诗的运动可以，很可能，显示出自我支撑的摆动和混乱。在另一方面， chaoticity 可能为 TR 进程的正... 详细信息

基因 transcriptional 规定(TR ) 过程经常被描述由联合了非线性的平常的微分方程(颂诗) 。当 TR 电路的尺寸高时(例如 n ≥3 ) 相应颂诗的运动可以，很可能，显示出自我支撑的摆动和混乱。在另一方面， chaoticity 可能为 TR 进程的正常生物函数是有害的。在这封信，我们数字地详细地学习 3 基因 TR 颂诗的动力学，并且由随机在通常接受的范围选择图和参数调查许多 4- ， 5- ，和 10 基因 TR 系统。并且我们发现摆动是很很少并且不混乱的运动被观察，就算系统的尺寸足够地高(n ≥3 ) 。这些颂诗的 nonchaoticity 的观察同意实际 TR 进程的正常函数，这被说服。

关键词：纳米混沌状态调整电路定期振荡热学

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Intermittent melena and refractory anemia due to jejunal cavernous lymphangioma:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1208-1214页

作者： Kai-Rui Liu sheng Zhang Wei-run chen You-Xing Huang Xu-Guang Li Department of Abdominal Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Lymphangiomas in the gastrointestinal tract are extremely rare in adults.As a benign lesion,small intestine lymphangiomas often remain asymptomatic and pose challenges for definitive diagnosis.However,lymphangiomas can give rise to complications such as abdominal pain,bleeding,volvulus,and intussusception.Here,we report a case of jejunal cavernous lymphangioma that presented with intermittent melena and refractory anemia in a male adult.CASE SUMMARY A 66-year-old man presented with intermittent melena,fatigue and refractory anemia nine months prior.Esophagogastroduodenoscopy and colonoscopy were performed many times and revealed no apparent bleeding.Conservative management,including transfusion,hemostasis,gastric acid secretion inhibition and symptomatic treatment,was performed,but the lesions tended to recur shortly after surgery.Ultimately,the patient underwent capsule endoscopy,which revealed a more than 10 cm lesion accompanied by active bleeding.After singleballoon enteroscopy and biopsy,a diagnosis of jejunal cavernous lymphangioma was confirmed,and the patient underwent surgical resection.No complications or recurrences were observed postoperatively.CONCLUSION Jejunal cavernous lymphangioma should be considered a cause of obscure gastrointestinal bleeding.Capsule endoscopy and single-balloon enteroscopy can facilitate diagnosis.Surgical resection is an effective management method.

关键词： Intermittent melena Refractory anemia Capsule endoscopy Single-balloon enteroscopy Jejunal cavernous lymphangioma Enterectomy Case report

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Microstructure and mechanical properties of Ni3Al intermetallics prepared by directional solidification electromagnetic cold crucible technique

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China Foundry 2017年第3期14卷 169-175页

作者： Hong-sheng Ding Guo-tian Wang Rui-run chen Jing-jie Guo Heng-zhi FuNational Key Laboratory for Precision Hot Processing of Metals School of Materials Science and Engineering Harbin Institute of Technology

The present work focused on the Ni_3Al-based alloy with a high melting point. The aim of the research is to study the effect of withdrawal rate on the microstructures and mechanical properties of directionally solidified Ni-25 Al alloy. Ni_3 Al intermetallics were prepared at different withdrawal rates by directional solidification(DS) in an electromagnetic cold crucible directional solidification furnace. The DS samples contain Ni_3 Al and Ni Al phases. The primary dendritic spacing(λ) decreases with the increasing of withdrawal rate(V), and the volume fraction of Ni Al phase increases as the withdrawal rate increases. Results of tensile tests show that ductility of DS samples is enhanced with a decrease in the withdrawal rate.

关键词：金属间化合方向性的团结微观结构机械性质骨折 TG146.23 A

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Elevated-temperature tribological behavior of Ti–B–C–N coatings deposited by reactive magnetron sputtering

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Rare Metals 2015年第12期34卷 838-843页

作者： Xiang-Yang chen Shao-Fu Huang sheng-Li Ma run Huang Jin Zhang Hai-Xia Hu School of Mechanical Engineering Anhui University of Science and Technology State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong University School of Materials Science and Engineering Anhui University of Science and Technology

Quaternary Ti–B–C–N coatings with various carbon contents were deposited on high-speed steel (HSS) substrates by reactive magnetron sputtering (RMS) system. The elevated-temperature tribological behavior of Ti–B–C–N coatings was explored using pin-on-disk tribometer, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The present results show that the steady-state friction coefficient value and the instantaneous friction coefficient fluctuation range of Ti–B–C–N coatings decrease as carbon content increases at 100 and 300°C, while the steady-state friction coefficient value of all Ti–B–C–N coatings becomes higher than 0.4 at 500°C. As ambient temperature increases, the running-in periods of all Ti–B–C–N coatings become shorter. Wear damage to Ti–B–C–N coatings during sliding at elevated temperature is mainly caused by adhesive wear, and adhesive-wear damage to Ti–B–C–N coatings increases as ambient temperature increases; however, higher carbon content is beneficial for decreasing the adhesive-wear damage to Ti–B–C–N coatings during sliding at elevated temperature.

关键词： Tribological behavior Ti–B–C–N coatings Reactive magnetron sputtering Elevated temperature

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