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Clinical effectiveness of adding probiotics to a low FODMAP diet:Randomized double-blind placebo-controlled study

World Journal of Clinical Cases 2021年第25期9卷 7417-7432页

作者： Beril Turan Göksel Bengi ruksan cehrel. Hale Akpınar Müjde Soytürk Department of Internal Medicine Dokuz Eylül UniversityIzmir 35000Turkey Department of Gastroenterology Dokuz Eylul University IzmirIzmir 35000Turkey Department of Preventive Oncology Dokuz Eylül UniversityInstitute of Oncologyİzmir 35000Turkey

BACKGROUND There are various studies showing the relationship between irritable bowel syndrome(IBS)and diet,and some dietary adjustments are recommended to reduce *** recent years,there is a growing number of studies that show a 4-8 wk low fermentable oligo,di-and mono-saccharides and polyols(FODMAP)diet has a 50%-80%significant effect on symptoms in IBS *** is strong evidence suggesting that changes in fecal microbiota have an impact on IBS *** on this argument,probiotics have been used in IBS treatment for a long *** is seen,the FODMAP diet and probiotics are used separately in IBS *** To evaluate the effectiveness of adding probiotics to a low FODMAP diet to control the symptoms in patients with *** The patients who were admitted to the Gastroenterology Clinic of Dokuz Eylul University Hospital and diagnosed with IBS according to Rome IV criteria were enrolled into the *** were randomized into 2 groups each of which consisted of 50 *** patients were referred to a dietitian to receive dietary recommendations for the low FODMAP diet with a daily intake of 9 *** patients were asked to keep a diary of foods and beverages they *** patients in Group 1 were given supplementary food containing probiotics(2 g)once a day in addition to their low FODMAP diet,while the patients in Group 2 were given a placebo once a day in addition to their low FODMAP *** analogue scale(VAS),the Bristol Stool Scale and IBS Symptom Severity Scale(IBSSSS)scores were evaluated before and after the 21 d *** The rate of adherence of 85 patients,who completed the study,to the FODMAP restricted diet was 92%,being 90%in Group 1 and 94%in Group *** mean scores of VAS and IBS-SSS of the patients in Group 1 before treatment were 4.6±2.7 and 310.0±78.4,respectively,and these scores decreased to 2.0±1.9 and 172.0±93.0 after treatment(both P<0.001).The mean VAS and IBS-SSS scores of the patients in G

关键词： Irritable bowel syndrome Probiotics Low Fermentable Oligo,Di-and Mono-Saccharides and Polyols diet Visual Analogue Scale the Bristol Stool Scale Irritable Bowel Syndrome Symptom Severity Scale

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Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy

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World Journal of Gastroenterology 2005年第18期11卷 2764-2767页

作者： Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu Departments of Gastroenterology Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey Departments of Pathology Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey Central Laboratory Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey

AIM: To determine whether Helicobacter pylori (H pylori) infection caused hyperhomocysteinemia by altering serum vitamin B_(12), serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level. METHODS: The study involved 73 dyspeptic H pylork positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of H pylori 4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B_(12) folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after H pylori eradication therapy were compared. RESULTS: The group with a successful eradication of H pylori had significantly higher serum vitamin B_(12) and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs 237±94 pg/mL,P＜0.001 and 442±212 ng/mL vs 539±304 ng/mL, P=0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0+2.4 ng/mL, P=0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P=0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P=0.01) and negatively with serum folate level before therapy (P=0.003). CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B_(12), serum folate and erythrocyte folate levels.

关键词： H pylorr Gastritis Vitamin B_(12) Folate Erythrocyte folate Homocysteine

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