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Cycladophora davisiana(Radiolarian)in the Bering Sea during the late Quaternary:A stratigraphic tool and proxy of the glacial Subarctic Pacific Intermediate Water

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Science China Earth Sciences 2005年第10期48卷 1698-1707页

作者： WANG rujian1 & CHEN Ronghua2.1. State Key Laboratory of Marine Geology, Tongji University, Shanghai 2.0092. China 2. The Key Laboratory of Submarine Geoscience, State Oceanic Administration, Hangzhou 310012. China State Key Laboratory of Marine Geology Tongji University Shanghai China The Key Laboratory of Submarine Geoscience State Oceanic Administration Hangzhou China

Cycladophora davisiana (Radiolarian) contents are counted in two cores of the Ber-ing Sea and correlated well with the oxygen isotopic records of ice in the deep core obtained by the Greenland Ice Sheet Project II (GISP 2. and deep-sea sediments (SPECMAP) of the world oceans. Millennial scale climatic events, for example, Younge Dryas and B?lling/Aller?d events, Heinrich1 and Dansgaard-Oeschger1events, recorded by C. davisiana percents are distin-guished from Core B4-2. C. davisiana events b, c1, c2. d, e1 and e2. respectively, corresponding to oxygen isotopic 2.0, 3.1, 3.3, 4.0, 5.1 and 5.3, are identified from Core B2.9. High resolution re-cords of C. davisian are tuned to the oxygen isotopic records in GISP 2.and SPECMAP and the depth-age frameworks are established in the two cores, supplying a stratigraphic base for future paleoceanographic and paleoclimatic studies. High C. davisiana during the glacial periods in the two cores indicate that they can serve as a proxy of the glacial Subarctic Pacific Intermediate Water, which verifies the glacial Subarctic Pacific Intermediate Water brought from the Bering Sea.

关键词： Cycladophora davisiana, stratigraphic tool, YD and B/A events, Heinrich 1 and D/O1 events, proxy of glacial Subarctic Pacific Intermediate Water, late Quaternary, Bering Sea.

基于代谢组学和网络药理学的橄榄类黄酮组分评价

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食品科学 2024年第12期45卷 42-51页

作者：赖瑞联沈朝贵龙宇林炎娟韦晓霞吴如健福建省农业科学院果树研究所福建福州350013

目的:探究橄榄类黄酮组分的潜在功效及其在不同种质资源中的差异。方法:通过网络药理学和分子对接技术挖掘橄榄功效类黄酮组分,并结合代谢组学评价橄榄种质资源中类黄酮组分的积累水平。结果:从橄榄中鉴定获得44种类黄酮组分,基于TCMSP... 详细信息

目的:探究橄榄类黄酮组分的潜在功效及其在不同种质资源中的差异。方法:通过网络药理学和分子对接技术挖掘橄榄功效类黄酮组分,并结合代谢组学评价橄榄种质资源中类黄酮组分的积累水平。结果:从橄榄中鉴定获得44种类黄酮组分,基于TCMSP数据库、类药性和口服生物利用度筛选获得18种潜在的功效类黄酮组分及对应的180个作用靶点,其中木犀草素、槲皮素、儿茶素和表儿茶素是潜在影响橄榄药理活性的重要化学物质。基于类黄酮组分与靶点连通度筛选的35个关键作用靶点共富集到348条基因本体通路和136条京都基因与基因组百科全书信号通路,涉及抗癌、抗病毒、抗菌消炎、调节血糖和保护肝脏等药理活性。通过分子对接及可视化分析表明,所筛选的橄榄功效类黄酮组分能与关键作用靶点稳定结合。结论:代谢组学和网络药理学可为橄榄药用价值开发提供依据,橄榄类黄酮组分通过多成分-多靶点-多通路协同作用发挥多样化的药理作用。

关键词：橄榄种质资源代谢组学网络药理学类黄酮

甲状舌管癌的CT影像学表现:11例初步分析

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中国眼耳鼻喉科杂志 2024年第1期24卷 56-59页

作者：耿悦洪汝建沙炎复旦大学附属眼耳鼻喉科医院放射科上海200031

目的探讨甲状舌管癌(TDCa)的CT影像学表现,提高对该肿瘤的认识。方法回顾分析11例经手术病理证实的TDCa的CT平扫及增强图像,并复习相关文献,总结影像学特征。结果11例TDCa均表现为颈前中线区肿块,边界欠清,8例位于舌骨下方水平,3例位于... 详细信息

目的探讨甲状舌管癌(TDCa)的CT影像学表现,提高对该肿瘤的认识。方法回顾分析11例经手术病理证实的TDCa的CT平扫及增强图像,并复习相关文献,总结影像学特征。结果11例TDCa均表现为颈前中线区肿块,边界欠清,8例位于舌骨下方水平,3例位于舌骨水平。11例病灶内均见实质性软组织成分,9例伴微钙化灶。10例病灶呈囊实性肿块,增强扫描囊壁及附壁结节中等-明显强化。1例病灶呈实性肿块,侵袭破坏舌骨,增强扫描明显强化。1例伴双侧颈部肿大淋巴结,病理证实为淋巴结转移。结论CT发现颈前中线区肿块伴有如囊性病灶内出现实性附壁结节、囊壁或内部分隔增厚、微钙化灶、舌骨侵袭性破坏或颈部肿大淋巴结影像学特征,应考虑TDCa的诊断。

关键词：甲状舌管癌乳头状癌体层摄影术,X线计算机

植物类黄酮的分类、药理活性及其生物合成调控研究进展

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东南园艺 2024年第2期12卷 81-99页

作者：赖瑞联吴如健赖钟雄福建省农业科学院果树研究所福建福州350013 福建农林大学园艺植物生物工程研究所福建福州350002

类黄酮是植物中重要的次生代谢产物之一,包括黄酮、黄酮醇、异黄酮、黄烷酮、黄烷醇、查尔酮、花青素和原花青素等,在植物生长发育和逆境胁迫响应过程中发挥重要作用,同时具有抗氧化、抗衰老、抗菌消炎等药理活性。植物类黄酮的生物合... 详细信息

类黄酮是植物中重要的次生代谢产物之一,包括黄酮、黄酮醇、异黄酮、黄烷酮、黄烷醇、查尔酮、花青素和原花青素等,在植物生长发育和逆境胁迫响应过程中发挥重要作用,同时具有抗氧化、抗衰老、抗菌消炎等药理活性。植物类黄酮的生物合成主要受两类基因控制,一类是直接编码类黄酮合成相关生物酶的结构基因,另一类是调控这些结构基因表达的转录因子。本文对植物类黄酮的种类、药理活性及其生物合成调控研究进展进行了综述,并探讨了今后的研究趋势,以期为植物类黄酮的研究和开发应用提供科学依据。

关键词：植物类黄酮药理活性生物合成转录因子

沙库巴曲缬沙坦联合酒石酸美托洛尔片治疗老年慢性心力衰竭调节心功能、血清指标的分析

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系统医学 2024年第16期9卷 28-31页

作者：刘汝建张凯鱼台县第三人民医院内科山东济宁272300 鱼台县人民医院急诊医学科山东济宁272300

目的对沙库巴曲缬沙坦+酒石酸美托洛尔片治疗老年慢性慢性心力衰竭(chronic heart failure,CHF),调节其心功能、血清指标的效果进行分析。方法非随机选取2.2.年6月—2.2.年11月鱼台县第三人民医院进行医治的CHF老年患者90例,按照用药... 详细信息

目的对沙库巴曲缬沙坦+酒石酸美托洛尔片治疗老年慢性慢性心力衰竭(chronic heart failure,CHF),调节其心功能、血清指标的效果进行分析。方法非随机选取2.2.年6月—2.2.年11月鱼台县第三人民医院进行医治的CHF老年患者90例,按照用药方式不同分为观察组及对照组,各45例。对照组治疗用酒石酸美托洛尔片,观察组治疗用巴曲缬沙坦+酒石酸美托洛尔片,对比两组最终治疗结果(心功能情况、血清指标与治疗有效率)。结果观察组心功能情况比对照组优,差异有统计学意义(P均2.=8.459,P=0.004)。结论老年CHF患者采用巴曲缬沙坦+酒石酸美托洛尔片进行治疗可很好恢复血清指标,改善其心功能情况,进一步提升治疗的有效率,综合效果佳。

关键词：巴曲缬沙坦酒石酸美托洛尔片老年慢性心力衰竭心功能血清指标

Paleoenvironmental implications of Holocene long-chain n-alkanes on the northern Bering Sea Slope

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Acta Oceanologica Sinica 2017年第8期36卷 137-145页

作者： ZHANG Haifeng WANG rujian XIAO Wenshen Laboratory of Marine Ecosystem and Biogeochemistry State Oceanic Administration State Key Laboratory of Marine Geology Tongji University

The records of high-resolution terrestrial biological markers （biomarkers） from Core B2.9 from the northern Bering Sea Slope over the last 9.6 ka BP were presented in the study. Variations in input of terrestrial long-chain n-alkanes （referred to as n-alkanes） and vegetation structure in their source regions were investigated. The results show that the nCz7 is the main carbon peak and has the greatest contribution rate of the total n-alkane content; this might be related to the abundance of woody plants and their spatial distribution in the source region, nC2. is another n-alkane having a relatively high content; this was mainly derived from submerged plants widespread along the coastal areas in the northern hemisphere. Total n-alkane content dropped quickly at ca. 7.8 ka BP, ca. 6.7 ka BP and ca. 5.4 ka BP, and was followed by four relatively stable stages mostly controlled by sea-level rise, climate change and vegetation distribution in the source region. Variation in carbon preference index （CPI） indicates that the n-alkanes primarily originated from higher land plants, and the average chain length （ACL） and nCa1/nC2. ratio reveal the relatively stable presence of woody/herbaceous plants during the Holocene, and dominate woody plants in most of the time. Simultaneous variation in total n-alkane content, nC2. content and its contribution, CPI, ACL and nC31/nC2. ratio over several short periods suggest that the growth rate of the woody plant n-alkane contribution was lower than that of herbaceous plants and fossil n-alkanes under the particular climatic conditions of the source region.

关键词： Bering Sea terrestrial input long-chain n-alkanes vegetation structure Holocene

基于多项Logit模型的高速公路事故延误程度影响分析

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湖南交通科技 2024年第1期50卷 176-182,192页

作者：李汝鉴林坤胡涵潇孙煦焦朋朋北京中交华安科技有限公司北京100070 福州市规划设计研究院集团有限公司福建福州3501081 北京建筑大学通用航空技术北京实验室北京100044

为了减少高速公路交通事故导致的延误损失,有必要定量剖析不同因素对高速公路事故延误严重程度的差异性影响。首先,基于真实高速公路事故数据,采取多重共线性检验,避免不同影响因素间的同质性问题;引入随机参数,对多项Logit模型进行改进... 详细信息

为了减少高速公路交通事故导致的延误损失,有必要定量剖析不同因素对高速公路事故延误严重程度的差异性影响。首先,基于真实高速公路事故数据,采取多重共线性检验,避免不同影响因素间的同质性问题;引入随机参数,对多项Logit模型进行改进,结合显著变量边际效应探究各类潜在因素对事故延误严重程度的影响。对实际事故数据进行清洗,共获得3148条有效数据,利用GIS技术进行空间匹配,将事故数据与实际道路网进行连接,获得事故发生地点的道路属性,共获得2.个潜在因素。其次,将延误程度分为3级,对不同类型的因素进行时空特性分析,最终选取2.个潜在因素构建基于多项Logit模型的高速公路事故延误程度分析模型,并分析显著变量边际效应。结果表明:模型拟合效果较好,统计量的显著性均大于0.05,根据模型参数估计结果共获得11个显著变量,以轻度延误作为参照类,不同因素对于道路延误的影响程度不同,夜晚、交通信号灯及能见度等因素对于中度延误的影响较大,而夜晚、事故持续时间对于严重延误的影响最为明显,可为高速公路设施优化提供参考。

关键词：交通工程高速公路交通事故多项Logit模型 GIS技术边际效用

Forcing mechanism of the Pleistocene east Asian monsoon variations in a phase perspective

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Science China Earth Sciences 2005年第10期48卷 1708-1717页

作者： TIAN Jun1,2. WANG Pinxian1, CHENG Xinrong1, WANG rujian1 & SUN Xiangjun1,3 1. State Key Laboratory of Marine Geology, Tongji University, Shanghai 2.0092. China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 10002., China 3. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China State Key Laboratory of Marine Geology Tongji University Shanghai China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China Institute of Botany Chinese Academy of Sciences Beijing China

The deep sea records from the ODP Sites 1143 and 1144 in the northern and southern South China Sea (SCS), including foraminiferal δ 18O and δ 13C, Opal% and pollen percentage, reveal that the variations of the east Asian monsoon have been closely correlated with the variations of the Earth’s orbital parameters (eccentricity, obliquity and precession) and the global ice volume on orbital scale. All the monsoonal proxies show strong 100 ka, 41 ka and 2. ka cycles. Although G. ruber δ 13C of Site 1143 is coherent with the ETP (ETP= normalized (eccentricity + obliquity-precession) at eccentricity, obliquity and precession bands, most of the coherent relationship focuses on the precession band, and the other monsoonal proxies are coherent with the ETP only at the precession band, which indicate that precession dominates the Pleistocene tropical climate changes. The phase relationship of the monsoonal proxies with the foraminiferal δ 18O implies that the global ice volume changes have played a significant role in modulating the east Asian monsoon climate, at least dominating the winter monsoon. This forcing mechanism of the east Asian monsoon is apparently different from that of the Indian ocean mon-soon. The variations of the east Asian monsoon at the precession band, at least that of the winter monsoon, have been controlled not only by the sensible heating but also by the latent heating of the surface water in the South China Sea.

关键词： South China Sea, ODP, east Asian monsoon, orbital forcing, global ice volume.

Variations of opal accumulation rates and paleoproductivity over the past 12.Ma at ODP Site 1143, southern South China Sea

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Chinese Science Bulletin 2002年第7期47卷 596-598页

作者： Li Jianru Wang rujian Li Baohua Laboratory of Marine Geology MEOTongji University200092ShanghaiChina Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences210008NanjingChina

The biogenic silica analysis was performed on 463 samples from ODP 184 Site 1143, the southern South China Sea. The results show that the opal content and MAR evidently increased between 12.3 and 5.7 Ma, which was contemporary with the high carbonate and total MARs, reflecting the high biogenic productivity in the late Miocene. This demonstrates the occurrence of the late Miocene 'Biogenic Bloom Event' in the southern South China Sea, corresponding to the late Miocene-early Pliocene 'Biogenic Bloom Event' in the Indian-Pacific Ocean. The increases of opal content and MAR after the middle Pleistocene (about 0.7 Ma) is inferred to result from the enhanced upwelling and nutrient supply, which was induced by the intensified monsoon circulation after the 'Mid-Pleistocene Revolution'.

关键词： opal MAR biogenic productivity Biogenic Bloom Event late Miocene South China Sea.