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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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A randomized diversification strategy for solving satisfiability problem with long clauses

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Science China(Information Sciences) 2017年第9期60卷 121-131页

作者： Jian GAO ruizhi li Minghao YIN College of Computer Science Northeast Normal University College of Information Science and Technology Dalian Maritime University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University

Satisfiability problem(SAT) is a central problem in artificial intelligence due to its computational complexity and usefulness in industrial applications. Stochastic local search(SLS) algorithms are powerful to solve hard instances of satisfiability problems, among which CScore SAT is proposed for solving SAT instances with long clauses by using greedy mode and diversification mode. In this paper, we present a randomized variable selection strategy to improve efficiency of the diversification mode, and thus propose a new SLS *** perform a number of experiments to evaluate the new algorithm comparing with the recently proposed algorithms, and show that our algorithm is comparative with others for solving random instances near the phase transition threshold.

关键词： SAT local search randomized diversification strategy phase transition long clause

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Laboratory and numerical modelling of irrigation infiltration and nitrogen leaching in homogeneous soils

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Pedosphere 2024年第1期34卷 146-158页

作者： Lei WU ruizhi li Yan WANG Zongjun GUO Jiaheng li Hang YANG Xiaoyi MA Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYangling 712100China Blackland Research and Extension Center Texas A&M AgriLife ResearchTexas A&M UniversityTemple TX 76502USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

Nitrogen (N) plays a key role in crop growth and production;however,data are lacking especially regarding the interaction of biochar,grass cover,and irrigation on N leaching in saturated soil *** soil columns with 20-cm diameter and 60-cm height were designed to characterize the effects of different grass cover and biochar combinations,i.e.,bare soil+0%biochar (control,CK),perennial ryegrass+0%biochar (C1),Festuca arundinacea+0%biochar (C2),perennial ryegrass+1%biochar (C3),perennial ryegrass+2%biochar (C4),perennial ryegrass+3%biochar (C5),***+1%biochar (C6),***+2% biochar (C7),and ***+3%biochar (C8),on periodic irrigation infiltration and N leaching in homogeneous loess soils from July to December *** in CK were 10.2%–35.3%higher than those in C1 and *** perennial ryegrass and *** decreased the volumes of leachates and delayed the leaching process in the 1%,2%,and 3%biochar treatments,and the vertical leaching rate decreased with biochar *** N leaching losses were concentrated in the first few leaching tests,and both total N (TN) and nitrate (NO_(3)^(-))-N concentrations in CK and C1–C8 decreased with increasing leaching test *** addition (1%,2%,and 3%) could further reduce the leaching risk of NO_(3)^(-)-N and the NO_(3)^(-)-N loss decreased with biochar ***,compared to 1%biochar,2% biochar promoted the leaching of TN under both grass cover *** N leaching losses in CK,C1,C2,C3,C4,C6,and C7 were primarily in the form of NO_(3)^(-)-*** these treatments,CK,C1,and C2had the highest cumulative leaching fractions NO_(3)^(-)-N (>90%),followed by those in C3,C4,C6,and C7 (>80%).The cumulative leaching fraction of NO_(3)^(-)-N decreased with increasing leaching test times and biochar addition,and 3%biochar addition (i.e.,C5 and C8) reduced it to approximately 50%.The one-dimensional advective-dispersive-reactive transport equation can be used as an effective nume

关键词： leaching loss nitrate nitrogen biochar grass cover analytical modelling

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Direct growth of Fe3O4-MoO2 hybrid nanofilm anode with enhanced electrochemical performance in neutral aqueous electrolyte

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Progress in Natural Science:Materials International 2016年第3期26卷 258-263页

作者： ruizhi li Xin Ba Yimeng Wang Wenhua Zuo Chong Wang Yuanyuan li Jinping liu School of Chemistry Chemical Engineering and Life Science and State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of Technology Institute of Nanoscience and Nanotechnology Department of Physics Central China Normal University School of Optical and Electronic Information Huazhong University of Science and Technology

To enhance the electrochemical energy storage performance of supercapacitors（SCs）, the current researches are general directed towards the cathode materials. However, the anode materials are relatively less studied. In the present work, Fe3O4-MoO2（FO-MO） hybrid nano thin film directly grown on Ti substrate is investigated, which is used as high-performance anode material for SCs in li2SO4electrolyte with the comparison to pristine Fe3O4nanorod array. The areal capacitance of FO-MO hybrid electrode was initially found to be 65.0 m F cm-2at 2 m Vs-1and continuously increased to 260.0% after 50 cycles of activation. The capacitance values were considerably comparable or higher than many reported thinfilm iron oxide-based anodes in neutral electrolyte. With the protection of MoO2shell, the FO-MO electrode developed in this study also exhibited excellent cyclic stability（increased to 230.8% after 1000cycles）. This work presents a promising way to improve the electrochemical performance of iron oxidebased anodes for SCs.

关键词： Magnetite MoO2 Supercapacitor Binder-free anode Hybridization

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Research on Surface Defect Detection Method of E-TPU Midsole Based on Machine Vision

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Journal of Computer and Communications 2020年第11期8卷 145-160页

作者： ruizhi li Fang Tian Shiqiang Chen School of Mathematics and Statistics Hubei Minzu University Enshi China Key Laboratory of Green Manufacturing of Super-light Elastomer Materials of State Ethnic Affairs Commission (Hubei Minzu University) Enshi China School of Advanced Materials and Mechatronic Engineering Hubei Minzu University Enshi China

In the industrial production of expanded thermoplastic polyurethane (E-TPU) midsoles, the surface defects still rely on manual inspection at present, and the eligibility criteria are uneven. Therefore, this paper proposes an E-TPU midsole surface defect detection method based on machine vision to achieve automatic detection and defect classification. The proposed method is divided into three parts: image preprocessing, block defect detection, and linear defect detection. Image preprocessing uses RGB three channel self-inspection to identify scorch and color pollution. Block defect detection uses superpixel segmentation and background prior mining to determine holes, impurities, and dirt. linear defect detection uses Gabor filter and Hough transform to detect indentation and convex marks. After image preprocessing, block defect detection and linear defect detection are simultaneously performed by parallel computing. The false positive rate (FPR) of the proposed method in this paper is 8.3%, the false negatives rate (FNR) of the hole is 4.7%, the FNR of indentation is 2.1%, and the running time does not exceed 1.6 s. The test results show that this method can quickly and accurately detect various defects in the E-TPU midsole.

关键词： Midsole Surface Defect Detection Image Processing linear Defect Detection Block Defect Detection

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基于纵向测温的冻结井筒地层变化分析

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煤炭科学技术 2018年第S2期46卷 66-70页

作者：李锐志中煤邯郸特殊凿井有限公司河北邯郸056003

冻结温度场分析,是根据不同地层导热系数不同,冻结壁平均温度不同,反映到所测温度孔纵向温度数据不同,进行冻结温度场分析预测冻结壁发展状况。利用不同地层岩性导热系数差异,反映纵向温度差别,在母杜柴登副井冻结施工实例中应用,发现... 详细信息

冻结温度场分析,是根据不同地层导热系数不同,冻结壁平均温度不同,反映到所测温度孔纵向温度数据不同,进行冻结温度场分析预测冻结壁发展状况。利用不同地层岩性导热系数差异,反映纵向温度差别,在母杜柴登副井冻结施工实例中应用,发现地层所反映温度与所测地层不符,通过多次反复分析,判断出了地质报告可能存在的误差,并通过细致的纵向测温数据分析,得出数据偏差是煤系地层抬高,及时预报了副井煤系地层比原来地质报告数据提升8 m问题。

关键词：纵向测温地层误差煤系地层

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直接快剪试验的常见问题及解决方法

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结构工程师 2013年第2期29卷 168-171页

作者：李瑞芝山西省地质工程勘察院太原030024

土的抗剪强度是土的重要力学指标之一,它代表土体在外力作用下抵抗剪切滑动的极限强度。直接快剪试验以其操作简单、原理明确被认为是用来检测土的抗剪强度的一种有效方法。基于直接快剪试验的原理,研究了在直接快剪试验过程中影响试验... 详细信息

土的抗剪强度是土的重要力学指标之一,它代表土体在外力作用下抵抗剪切滑动的极限强度。直接快剪试验以其操作简单、原理明确被认为是用来检测土的抗剪强度的一种有效方法。基于直接快剪试验的原理,研究了在直接快剪试验过程中影响试验结果的各项因素,如土的均匀性、直剪速率、含水率与液性指数等。研究表明:土的均匀性、直剪速率、含水率与液性指数对直接快剪试验结果都有很大的影响。最后,针对这些问题,给出了相应的解决办法,完善了试验的具体操作过程,使试验数据更加合理可靠、接近样品的真实值。

关键词：土直接快剪试验抗剪强度剪切速率

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国际体育仲裁院对体育组织规则与决定的审查--以平昌冬奥会俄罗斯运动员参赛资格纠纷为例

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成都体育学院学报 2020年第2期46卷 49-56页

作者：李睿智郭树理苏州大学王健法学院江苏苏州215000

震惊体坛的俄罗斯运动员大规模使用兴奋剂事件引发了一系列后果,国际奥委会对俄罗斯奥委会实施禁赛,俄罗斯运动员必须经由国际奥委会特别设立的邀请程序方得参加平昌冬奥会。体育仲裁院平昌冬奥会特别仲裁处经审查认定该程序具有法律依... 详细信息

震惊体坛的俄罗斯运动员大规模使用兴奋剂事件引发了一系列后果,国际奥委会对俄罗斯奥委会实施禁赛,俄罗斯运动员必须经由国际奥委会特别设立的邀请程序方得参加平昌冬奥会。体育仲裁院平昌冬奥会特别仲裁处经审查认定该程序具有法律依据且实施得当。然而,该程序实际设立了一项特别参赛规则:存在兴奋剂违纪记录的俄罗斯运动员不得参加平昌冬奥会。该规则有违反"一事不再罚"原则之嫌,但特别仲裁处由于未能充分行使抽象审查的权力,未能为俄罗斯运动员的权利提供适当救济。体育组织应审慎行使规则和决定的自治权,充分考量规则和决定的合法性、合理性。另外,我国现有针对体育组织决定和规则的外部审查机制存在主体单一化、缺乏独立性的缺陷,不利于运动员权益的保障,应尽快建立具有可操作性的体育仲裁制度。

关键词：体育组织规则决定审查

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D-stability and D-stabilization of Descriptor Discrete Time-delay Systems with Poytopic Uncertainties

D-stability and D-stabilization of Descriptor Discrete Time-...

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第二十九届中国控制会议

作者： ZHANG ruizhi,ZHANG Xian,li Fanbiao School of Mathematical Science,Heilongjiang University,Harbin 150080,P.R.China

This paper is concerned with the problems of D-stability and D-stabilization for descriptor discrete time-delay systems with poytopic *** terms of LMIs,sufficient conditions based on parameter-dependent Lyapunov functions are *** conditions guarantee all the poles of a corresponding system in a specified circular region.A numerical example illustrates the validity of our approach.

关键词： Descriptor Discrete Time-delay System D-stability D-stabilization Poytopic Uncertainties linear Matrix In-equality(LMI)

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基于太赫兹量子级联激光器的生物医学成像研究进展

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中国激光 2020年第2期47卷 177-186页

作者：符张龙李锐志李弘义邵棣祥曹俊诚中国科学院上海微系统与信息技术研究所太赫兹固态技术重点实验室上海200050 中国科学院大学北京100049

太赫兹(THz)波对生物医学组织具有天然的非电离性、水含量敏感性和浅层穿透性等特点,这使得其非常适合应用于生物医学成像。由于太赫兹量子级联激光器(THz QCL)具有激射功率高、光束质量好、调制速率高、体积小的特点,基于THz QCL的生... 详细信息

太赫兹(THz)波对生物医学组织具有天然的非电离性、水含量敏感性和浅层穿透性等特点,这使得其非常适合应用于生物医学成像。由于太赫兹量子级联激光器(THz QCL)具有激射功率高、光束质量好、调制速率高、体积小的特点,基于THz QCL的生物医学成像系统相较于其他主动式生物医学成像系统成像信噪比高、成像分辨率高、成像速度快、结构更紧凑。基于此,对基于THz QCL的生物医学成像研究进展进行综述,并对THz生物成像优势、THz QCL生物医学成像优势、生物医学成像系统、生物医学成像目标进行了总结,对其未来发展方向进行了展望。

关键词：医用光学太赫兹成像量子级联激光器生物医学

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