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Use of Spatial analysis to Assess Geographic Accessibility of Community Pharmacies in São Mateus

Pharmacology & Pharmacy 2013年第5期4卷 438-442页

作者： Brígida Dias fernandes Aracelli Ferreira Lírio Rodrigo Randow de Freitas ana carolina Melchiors Pharmacy Pratice Research Group Departamento de Ciências da Saúde-DCS Sao Mateus Brasil. Universidade Federal do Espírito Santo-UFES Centro Universitário Norte do Espírito Santo-CEUNES Departamento de Ciências da Saúde-DCS Sao Mateus Brasil Universidade Federal do Espírito Santo-UFES Centro Universitário Norte do Espírito Santo-CEUNES Departamento de Engenharias e Computacao-DETEC Núcleo de Pesquisa em Gestao de Sistemas de Producao (NPGSP) Laboratório de Gestao Costeira-Aquicultura e Pesca (LGCap) Sao Mateus Brasil Pharmacy Pratice Research Group Departamento de Ciências da Saúde-DCS Sao Mateus Brasil.

Pharmaceutical services contribute to the rational use of medicines by ensuring the provision of appropriate, safe and effective pharmacotherapies. Thus, it is important to investigate whether the geographical distribution of pharmacies causes inequalities in access in countries like Brazil, where there is no federal law regulating the opening of new establishments (in contrast to many European countries). This study analyzed the accessibility of community pharmacies in the city of Sao Mateus, Espírito Santo, Brazil. The authors obtained the geographical coordinates of pharmacies and healthfacilities, which scanned and georeferenced the study area. The 40 pharmacies included in the spatial analysis presented a heterogeneous distribution, with the existence of neighborhoods with an accumulation of pharmacies and others with no pharmacies. The authors found that only 43.7% of the study area received pharmaceutical service coverage, when buffer zones of 350 meters are incorporated, and that most of the districts have a minimum distance of 100 meters between health facilities and pharmacies. It was concluded that the use of GIS proved to be very suitable for analysis of pharmaceutical services, enabling knowledge of the local situation and serving as a stimulus for future studies.

关键词： Geographical Accessibility Quality Pharmaceutical Service Spatial analysis Distribution of Pharmacies Quality Assessment

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Assessing Cleaner Energy Alternatives for Bus Transit in Rio de Janeiro:A Life Cycle Inventory analysis

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Journal of Environmental Protection 2015年第11期6卷 1197-1218页

作者： Marcio de Almeida D’Agosto Cintia Machado de Oliveira Fabiana do Couto Assumpcao ana carolina Peixoto Deveza Programa de Engenharia de Transportes Instituto Alberto Luiz Coimbra de Pos-Graduacao e Pesquisa em Engenharia(COPPE)Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Centro Federal de Educacao Tecnologica Celso Suckow da Fonseca Engenharia Industrial MecanicaUnedItaguaiBrazil

From 2003 to 2009 in Brazilian municipalities of over 60,000 inhabitants, buses accounted for more than 25% of urban trips. This trend is not expected to change in the medium term. Worldwide, buses rely on petroleum diesel as fuel. In Brazil, alternative fuels such as biodiesel, natural gas and ethanol are available and the choice among them should depend on the assessment of the entire life cycle of such fuels. This paper uses a Life Cycle Inventory, which is essential to the implementation of a Life Cycle Assessment, to assess six energy alternatives: petroleum diesel, biodiesel, petroleum diesel with 5% of biodiesel, compressed natural gas, additivated hydrous ethanol and dual-fuel system composed by petroleum diesel with 5% of biodiesel and compressed natural gas. In saving total energy consumption, pure petroleum diesel or mixed with 5% biodiesel and dual-fuel systems stand out, in that order. If renewable energy use and net carbon dioxide emissions reduction are the goals, ethanol and biodiesel should be given preference. The addition of 5% of biodiesel in petroleum diesel increases the share of renewable energy in the supply chain of petroleum diesel by 47.5% with an increase of 0.58% in total energy consumption and a reduction of 3.8% in net CO2 emissions during the life cycle. In the case of biodiesel, the addition of 5% of biodiesel in petroleum diesel increases the share of renewable energy in the supply chain by 51.15% with an increase of 0.03% in the total energy consumption and a decrease of 7% in net CO2 emissions in the life cycle. The use of 5% of biodiesel in petroleum diesel does not significantly affect the use of renewable energy (+0.69%) or total energy consumption (+0.04%) in ethanol supply chain, which already shows a great use of renewable energy input. However, a decrease of 9.29% in the net CO2 emissions in the supply chain occurs, which reaches 5.28% in the life cycle.

关键词： Renewable Energy Total Energy Public Transportation Biofuels Life Cycle

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Preclinical stem cell therapy in Chagas Disease: Perspectives for future research

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World Journal of Transplantation 2013年第4期3卷 119-126页

作者： Katherine Athayde Teixeira de Carvalho Eltyeb Abdelwahid Reginaldo Justino Ferreira ana carolina Irioda Luiz Cesar Guarita-Souza Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pequeno Príncipe FacultyPelé Pequeno Príncipe InstituteCuritiba 80250-200ParanáBrazil Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritiba 81531-970ParanáBrazil CBRC Massachusetts General Hospital/Harvard Medical SchoolCharlestownMa 02129United States Federal University of Technology Curitiba 80230-901ParanáBrazil Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Parana Curitiba 80215-901ParanáBrazil

Chagas cardiomyopathy still remains a challenging problem that is responsible for high morbidity and mortality in Central and Latin America. Chagas disease disrupts blood microcirculation via various autoimmune mechanisms, causing loss of cardiomyocytes and severe impairment of heart function. Different cell types and delivery approaches in Chagas Disease have been studied in both preclinical models and clinical trials. The main objective of this article is to clarify the reasons why the benefits that have been seen with cell therapy in preclinical models fail to translate to the clinical setting. This can be explained by crucial differences between the cellular types and pathophysiological mechanisms of the disease, as well as the differences between human patients and animal models. We discuss examples that demonstrate how the results from preclinical trials might have overestimated the efficacy of myocardial regeneration therapies. Future research should focus, not only on studying the best cell type to use but, very importantly, understanding the levels of safety and cellular interaction that can elicit efficient therapeutic effects in human tissue. Addressing the challenges associated with future research may ensure the success of stem cell therapy in improving preclinical models and the treatment of Chagas disease.

关键词： Chagas Disease preclinical stem cell therapy co-cultured translation pathophysiologie myoblasts

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Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs

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World Journal of Virology 2015年第2期4卷 56-77页

作者： Joel da Cunha Luciana Morganti Ferreira Maselli ana carolina Bassi Stern Celso Spada Sérgio Paulo Bydlowski Laboratory of Genetics and Molecular Hematology(LIM31) University of Sao Paulo Medical School(FMUSP)Sao Paulo SP 05403-000Brazil Clinical analysis Department Health Sciences CenterFederal University of Santa Catarina(CCS/UFSC)Florianopolis SC 88040-900BraZIL Molecular Genetics and Biotechnology Department Research DivisionPró-Sangue Foundation/Blood Center of Sao PauloSao Paulo SP 05403-000Brazil

For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results.

关键词： Human immunodeficiency virus-1 infection Highly active antiretroviral therapy Protease inhibitors Dyslipidemia Atherosclerosis Lipodystrophy Statins Fibrates Diet Lifestyle

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Growth and Production of Crambe Submitted to Doses of Nitrogen and Potassium

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American Journal of Plant Sciences 2016年第1期7卷 8-16页

作者： Ramara Sena de Souza Lúcia Helena Garófalo Chaves Josely Dantas fernandes ana carolina Feitosa de Vasconcelos Federal University of Campina Grande Campina Grande Brazil State University of Paraiba Campus II Lagoa Seca Brazil

The dependence on non-renewable fuels of countries around the world increased the interest for the gradual replacement of fossil fuels with renewable ones. Thus, several development programs for the use of renewable sources for power generation have been created and, in this perspective, biofuels have been highlighted. Crambe is an alternative crop for the production of biodiesel due to its rusticity, precocity, high oil content and adaptability to different climates. Optimum management practices of fertilizer use in crambe cultivation are little known and there are no specific recommendations for its fertilization. Therefore, the objective of this research was to study the effects of mineral fertilizers concerning the nitrogen and potassium elements in the growth and production of crambe. The experiment was installed in a greenhouse, with a completely randomized design. Nitrogen doses used were 30, 60, 90 and 120 kg·ha-1and 50, 75, 100 to 125 kg·ha-1 for potassium. The increase in production was directly proportional to the increase in nitrogen levels. The potassium doses did not cause significant effect on the growth of crambe.

关键词： Biofuels Fertilization Crambe abyssinica N K

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SARS-CoV-2 Pandemic Impact Assessment for Hearing Impaired Patients

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Advances in Infectious Diseases 2021年第3期11卷 261-268页

作者： Natalia Chilinque Zambã o da Silva Manoela Moreira de Oliveira Vitória Francisco Pereira ana carolina Antônio Correia Universidade Estácio de Sá Presidente Vargas Rio de Janeiro Brazil Universidade Estácio de Sá Campus Presidente Vargas Rio de Janeiro Brazil

COVID-19 is a systemic infectious disease caused by the new SARS-CoV-2 coronavirus. The COVID-19 pandemic has caused social, economic, political, and cultural repercussions for humanity. Although Brazilian Sign Language (Libras) has been recognized since 2002 as a legal means of communication and expression, most individuals with hearing impairment in Brazil do not have access to accurate information about SARS-CoV-2 available to them in Libras. Between July 2020 and November 2020, the impact of COVID-19 on deaf and hearing impaired individuals was assessed through a closed questionnaire, using Libras, via a digital platform. Deaf and hearing impaired individuals over 18 years of age and living in the Metropolitan Region II of Rio de Janeiro were eligible to participate. Frequencies were calculated for categorical variables. From the total questionnaires submitted, 55.5% of respondents claim to have “a lot” of knowledge regarding COVID-19, and 44.4% of those individuals indicated they gained this knowledge through social media. Additionally, the main difficulties encountered by the deaf and hearing impaired population during the pandemic were: communicating with others wearing masks, and poor access to medical care. Thus, for full physical, mental, and social well-being, the state must invest in the inclusion of this population through public health measures.

关键词： COVID-19 Deafness Pandemic

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Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

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World Journal of Hepatology 2016年第29期8卷 1234-1243页

作者： Nathália Perpetua Peres ana Lívia Silva Galbiatti-Dias Marcia Maria Urbanin Castanhole-Nunes Renato Ferreira da Silva Erika Cristina Pavarino Eny Maria Goloni-Bertollo Mariangela Torreglosa ruiz-Cintra Genetics and Molecular Biology Research Unit UPGEM Sao Jose do Rio Preto Medical School FAMERP and Medical School Fundation FUNFARME Study Group of Liver Tumors GETF Hospital de Base Federal University of the Triangulo Mineiro UFTM

AIM To evaluated the association of the risk factors and polymorphisms in MTHFR C677 T, MTHFR A1298 C, MTR A2756 G and MTRR A66 G *** Patients with cirrhosis(n = 116), hepatocellular carcinoma(HCC)(n = 71) and controls(n = 356) were included. Polymerase chain reaction followed by enzymatic digestion and allelic discrimination technique real-time PCR techniques were used for analysis. MINITAB-14.0and SNPstats were utilized for statistical analysis. RESULTS Showed that age ≥ 46 years(OR = 10.31; 95%CI: 5.66-18.76; P < 0.001) and smoking(OR = 0.47; 95%CI: 0.28-0.78; P = 0.003) were associated with cirrhosis. Age ≥ 46 years(OR = 16.36; 95%CI: 6.68-40.05; P < 0.001) and alcohol habit(OR = 2.01; 95%CI: 1.03-3.89; P = 0.039) were associated with HCC. MTHFR A1298 C in codominant model(OR = 3.37; 95%CI: 1.52-7.50; P = 0.014), recessive model(OR = 3.04; 95%CI: 1.43-6.47; P = 0.0051) and additive model(OR = 1.71; 95%CI: 1.16-2.52; P = 0.0072) was associated with HCC, as well as MTR A2756 G in the additive model(OR = 1.68; 95%CI: 1.01-2.77; P = 0.047), and MTRR A66 G in the codominant model(OR = 3.26; 95%CI: 1.54-6.87; P < 0.001), dominant model(OR = 2.55; 95%CI: 1.24-5.25; P = 0.007) and overdominant model(OR = 3.05; 95%CI: 1.66-5.62; P < 0.001). MTR A2756 G in the additive model(OR = 1.54; 95%CI: 1.02-2.33; P = 0.042) and smokers who presented at least one polymorphic allele for MTRR A66G(OR = 1.71; 95%CI: 0.77-3.82; P = 0.0051) showed increased risk for cirrhosis. There was no association between clinical parameters and polymorphisms. CONCLUSION Age ≥ 46 years, alcohol habit and MTR A2756 G, MTHFR A1298 C and MTRR A66 G polymorphisms are associated with an increased risk of HCC development; age ≥ 46 years, tobacco habit and the MTR A2756 G polymorphism are associated with cirrhosis.

关键词： Polymorphism Folate metabolism Liver cirrhosis Hepatocellular carcinoma

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Crambe (<i>Crambe abyssinica</i>) Cultivation under Different Levels of Fertilization with Nitrogen, Phosphorus and Potassium

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American Journal of Plant Sciences 2017年第9期8卷 2031-2039页

作者： ana carolina F. de Vasconcelos Lúcia Helena G. Chaves Josely Dantas fernandes Gilvanise Alves Tito Department of Agricultural Engineering Federal University of Campina Grande Paraiba State Brazil Department of Agroecology and Agropecuaria State University of Paraiba Paraiba State Brazil

The effects of fertilization on crambe are poorly understood;in this sense, this study aimed to evaluate the crambe growth under different levels of nitrogen (0, 40, 80, 120 kg·ha-1), phosphorus (0, 50, 100, 150 kg·ha-1), and potassium (0, 30, 60, 90 kg·ha-1) in a greenhouse. The height of the plants, the production of dried biomass and that of 1000 grains of crambe were evaluated. The height of the plants was impaired as a function of increasing doses of nitrogen. The interaction of nitrogen and phosphorus in the crambe crop increased the number of grains and dry shoot biomass. The growth and yield of the crop were not influenced by the use of potassium in mineral fertilization.

关键词： Biodiesel Semiarid Region Mineral Fertilization Crambe Growth

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Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

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Journal of Life Sciences 2013年第3期7卷 276-281页

作者： ana carolina Pessoa Moreira Egberto Santos Carmo Paulo Alves Wanderley Evandro Leite de Souza Edeltrudes de Oliveira Lima Department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil Department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

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Morphological Patterns of a Hymenopteran Gall on the Leaflets of Caryocar brasiliense Camb.(Caryocaraceae)

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American Journal of Plant Sciences 2012年第7期3卷 921-929页

作者： ana carolina Ribeiro de Castro Germano Leao Demolin Leite Denis Coelho de Oliveira Rosy Mary dos Santos Isaias Departamento de Botanica Universidade Federal de Minas Gerais(UFMG)Belo HorizonteBrasil Instituto de Ciências Agrárias Universidade Federal de Minas Gerais(UFMG)Montes ClarosBrasil Instituto de Biologia Universidade Federal de Uberlandia(UFU)UberlandiaBrasil

anatomical studies in the leaflet globoid galls of Caryocar brasiliense, the “pequi”, aimed to answer how oviposition and the feeding behavior of the galling herbivores altered the morphogenical patterns of the host plant. C. brasiliense globoid gall was 1.28 ± 0.20 mm × 0.90 ± 0.25 mm, with hairy surface;it is sessile and projected to the abaxial surface. Young galls were red while the mature ones were green. Preferentially, they were formed next to leaf margin and possessed one larval chamber containing a single galling specimen. Gall epidermis was uniseriate, with thicker cuticle and more hairy. In some spots, epidermis was substituted by periderm, which indicated the expression of a character usually absent in the leaf laminas. Morphological and anatomical features of these gall morphotype, such as its position in leaf lamina, the fact of being truly closed galls, with typical nutritive tissue involved by sclerenchyma, made them next to the pattern proposed for galls induced by some Hymenoptera.

关键词： Gall anatomy Hymenoptera Morphogenesis Pequi

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