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A novel Tb^(3+) and Eu^(3+) co-doped dual-emitting phosphate K_(3)SrBi(P_(2)O_(7))_(2) phosphor for application in FIR thermometers

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Journal of Rare Earths 2024年第3期42卷 455-463,I0001页

作者： Baochen wang Shifeng Sun Zeqi Li Zongwang Li Weiwei Lin Chao Zeng Yan-gai Liu ruiyu Mi School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu241000China State-Province Joint Engineering Laboratory of Zeolite Membrane Materials Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationInstitute of Advanced MaterialsCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing100083China

Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate phosphors were reported. The crystal structure of the title phosphor was determined using Rietveld refinement and proved to have a three-dimensional structure. The time-resolved spectroscopy reveals that there is almost no energy transfer between Tb^(3+)and Eu^(3+). More importantly, Tb^(3+)and Eu^(3+)emissions show different thermal quenching behaviors, which claims the potential of this material for application in optical thermometer. The FIR of the typical KSBP:0.02Tb^(3+),0.04Eu^(3+)sample demonstrates a polynomial relationship as a function of temperature and the absolute and relative sensitivity are0.025 K^(-1) and 0.59%/K, respectively. In general, our study reports a novel and potential KSBP:Tb^(3+),Eu^(3+)phosphate phosphor that is promising for use in high-sensitive FIR thermometers.

关键词： Phosphor Thermometer Fluorescence intensity ratio Thermal stability Rare earths

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Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

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Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong wang Zhixing MA Zhi JIA Kexin LI Fanghong ZHANG Yinhao WU ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver fibrosis.Our previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed fibrogenesis.However,the mechanisms by which SWT influences H19 remain unclear.Thus,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the liver.Our results showed that SWT markedly improved ECM deposition and bile duct reactions in the liver.Notably,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular injury.This modulation collectively led to reduced ECM deposition.Through extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory pathways.Meanwhile,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver fibrosis.However,these protective effects of SWT were diminished with the overexpression of H19 in vivo.In conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

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Progress in Mechanical Modeling of Implantable Flexible Neural Probes

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1205-1231页

作者： Xiaoli You ruiyu Bai Kai Xue Zimo Zhang Minghao wang Xuanqi wang Jiahao wang Jinku Guo Qiang Shen Honglong Chang Xu Long Bowen Ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Unmanned Aerial Vehicle Technology Northwestern Polytechnical UniversityXi’an710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Automobile Chang’an UniversityXi’an710018China MOE Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhou310018China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue,thus as important tools for brain science research,as well as diagnosis and treatment of brain diseases.However,the rigid neural probes,such as Utah arrays,Michigan probes,and metal microfilament electrodes,are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation,which leads to a significant degradation in the signal quality with the implantation time.In recent years,flexible neural electrodes are rapidly developed with less damage to biological tissues,excellent biocompatibility,and mechanical compliance to alleviate scarring.Among them,the mechanical modeling is important for the optimization of the structure and the implantation process.In this review,the theoretical calculation of the flexible neural probes is firstly summarized with the processes of buckling,insertion,and relative interaction with soft brain tissue for flexible probes from outside to inside.Then,the corresponding mechanical simulation methods are organized considering multiple impact factors to realize minimally invasive implantation.Finally,the technical difficulties and future trends of mechanical modeling are discussed for the next-generation flexible neural probes,which is critical to realize low-invasiveness and long-term coexistence in vivo.

关键词： Mechanical modeling flexible neural probes invasive theoretical calculation simulation

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The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

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Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng Jin ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei wang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China Department of Food Science Rutgers University New BrunswickNJ 08901USA Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic activity.Hence,in this study,the quality standard and the hypoglycemic effect of CCAE were investigated.Cinnamaldehyde and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)method.The results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,respectively.The investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)levels.The results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： Cinnamomi Cortex Cinnamaldehyde Coumarin Hypoglycemic effect

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Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension

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Genes & Diseases 2022年第3期9卷 753-765页

作者： ruiyu wang Yongzheng Guo Lingjiao Li Minghao Luo Linqian Peng Dingyi Lv Zhe Cheng Qian Xue Liang wang Jing Huang Department of Cardiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010PR China Department of Cardiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Institute of Life Science Chongqing Medical UniversityChongqing 400016PR China

Excessive oxidative stress is a major causative factor of endothelial dysfunction in hypertension.As an endogenous pro-oxidant,thioredoxin-interacting protein(TXNIP)contributes to oxidative damage in various tissues.The present study aimed to investigate the role of TXNIP in mediating endothelial dysfunction in hypertension.In vivo,an experimental model of acquired hypertension was established with two-kidney,one-clip(2K1C)surgery.The expression of TXNIP in the vascular endothelial cells of multiple vessels was significantly increased in hypertensive rats compared with sham-operated rats.Resveratrol,a TXNIP inhibitor,suppressed vascular oxidative damage and increased the expression and activity of eNOS in the aorta of hypertensive rats.Notably,impaired endothelium-dependent vasodilation was effectively improved by TXNIP inhibition in hypertensive rats.In vitro,we observed that Ang II increased the expression of TXNIP in primary human aortic endothelial cells(HAECs)and that TXNIP knockdown by RNA interference alleviated cellular oxidative stress damage and mitigated the impaired eNOS activation and intracellular nitric oxide(NO)production observed in Ang Il-treated HAECs.However,inhibiting thioredoxin(TRX)with PX-12 completely blunted the protective effect of silencing TXNIP.In addition,TXNIP knockdown facilitated TRX expression and promoted TRX nuclear translocation to further activate AP1 and REF1.TRX overexpressi on exhibited favorable effects on eNOS/NO homeostasis in Ang 11-treated HAECs.Thus,TXNIP contributes to oxidative stress and endothelial dysfunction in hypertension,and these effects are dependent on the antioxidant capacity of TRX,suggesting that targeting TXNIP may be a novel strategy for antihypertensive therapy.

关键词： Endothelial dysfunction eNOS Hypertension Oxidative stress Thioredoxininteracting protein

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我国人工智能发展的产业结构高级化效应

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西北民族大学学报（哲学社会科学版） 2024年第2期 162-174页

作者：王瑞瑜山西师范大学经济与管理学院山西太原030031

人工智能迅速崛起对我国实现产业结构高级化具有重要作用。研究在CES生产函数和柯布道格拉斯生产函数的基础上构建数理模型,揭示了人工智能促进产业结构高级化的内在理论机制,并选取2006—2021年我国31个省份面板数据,实证检验人工智能... 详细信息

人工智能迅速崛起对我国实现产业结构高级化具有重要作用。研究在CES生产函数和柯布道格拉斯生产函数的基础上构建数理模型,揭示了人工智能促进产业结构高级化的内在理论机制,并选取2006—2021年我国31个省份面板数据,实证检验人工智能对产业结构高级化的影响效应。研究表明:人工智能生产能够减弱现阶段实现产业结构高级化所面临的不利因素,促进产业结构高级化;异质性检验结果显示,人工智能对东部地区产业结构高级化的促进作用最强。因此,提出加大人工智能研发力度、提高人力资本积累水平、制定差异化产业发展战略的对策建议,以期为人工智能赋能产业结构高级化提供思路借鉴。

关键词：人工智能产业结构高级化 CES生产函数柯布道格拉斯生产函数

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Light at night and lung cancer risk:A worldwide interdisciplinary and time-series study

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 56-62页

作者： Runchen wang Qixia wang Jianfu Li Jianrong Zhang Shixuan Lyu Wenhao Chi Zhiming Ye Xuanzhuang Lu Ying Shi Yubin wang Xinjian Wu ruiyu Hu Mónica Pérez-Ríos Jianxing He Wenhua Liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510120China Department of Respiratory Disease China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Centre for Cancer Research&Department of General Practice Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneVictorian Comprehensive Cancer CentreMelbourneVictoria 3010Australia Department of Civil Engineering University of BristolBristolBS81TRUK Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Nanshan School Guangzhou Medical UniversityGuangzhouGuangdong 511436China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan UniversityWuhanHubei 430079China GNSS Research Center Wuhan UniversityWuhanHubei 430079China First Clinical School Guangzhou Medical UniversityGuangzhouGuangdong 511436China Preventive Medicine and Public Health Department University of Santiago de CompostelaCIBER de Epidemiología y Salud Pública(CIBERESP)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaGalicia 15782Spain Southern Medical University GuangzhouGuangdong 510515China

Background:Light at night(LAN)has become a concern in interdisciplinary research in recent years.This global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung cancer incidence.Methods:LAN data were obtained from the Defense Meteorological Satellite Program’s Operational Linescan System.Data of lung cancer incidence,socio-demographic index,and smoking prevalence of populations in 201 countries/territories from 1992 to 2018 were collected from the Global Burden of Disease Study.Spearman correlation tests and population-weighted linear regression analysis were used to evaluate the correlation between LAN exposure and lung cancer incidence.A distributed lag nonlinear model(DLNM)was used to assess the exposure-lag effects of LAN exposure on lung cancer incidence.Results:The Spearman correlation coefficients were 0.286-0.355 and the population-weighted linear regression correlation coefficients were 0.361-0.527.After adjustment for socio-demographic index and smoking preva-lence,the Spearman correlation coefficients were 0.264-0.357 and the population-weighted linear regression correlation coefficients were 0.346-0.497.In the DLNM,the maximum relative risk was 1.04(1.02-1.06)at LAN exposure of 8.6 with a 2.6-year lag time.After adjustment for socio-demographic index and smoking prevalence,the maximum relative risk was 1.05(1.02-1.07)at LAN exposure of 8.6 with a 2.4-year lag time.Conclusion:High LAN exposure was associated with increased lung cancer incidence,and this effect had a specific lag period.Compared with traditional individual-level studies,this group-level study provides a novel paradigm of effective,efficient,and scalable screening for risk factors.

关键词： Light at night Satellite imagery Lung cancer Distributed lag nonlinear model(DLNM) Melatonin

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An optical brain-to-brain interface supports rapid information transmission for precise locomotion control

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Science China(Life Sciences) 2020年第6期63卷 875-885页

作者： Lihui Lu ruiyu wang Minmin Luo School of Life Sciences Tsinghua UniversityBeijing 10084China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBejing 100084China National Institute of Biological Sciences(NIBS) Beijing 102206China School of Life Sciences Peking UniversityBejing 100871China Peking University-Tsinghua University-NIBS Joint Graduate Program Bejing 102206China Chinese Institute for Brain Research Beiing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research(TIMBR) Beijing 102206China

Brain-to-brain interfaces(BtBIs) hold exciting potentials for direct communication between individual brains. However,technical challenges often limit their performance in rapid information transfer. Here, we demonstrate an optical brain-to-brain interface that transmits information regarding locomotor speed from one mouse to another and allows precise, real-time control of locomotion across animals with high information transfer rate. We found that the activity of the genetically identified neuromedin B(NMB) neurons within the nucleus incertus(NI) precisely predicts and critically controls locomotor speed. By optically recording Ca2+ signals from the NI of a "Master" mouse and converting them to patterned optogenetic stimulations of the NI of an "Avatar" mouse, the Bt BI directed the Avatar mice to closely mimic the locomotion of their Masters with information transfer rate about two orders of magnitude higher than previous Bt BIs. These results thus provide proof-of-concept that optical Bt BIs can rapidly transmit neural information and control dynamic behaviors across individuals.

关键词： brain-to-brain interface locomotion nucleus incertus fiber photometry optogenetics support vector machine(SVM)classifier

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基于实测扭转度误差对叶片气动合格性探讨

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工程热物理学报 2024年第3期45卷 707-714页

作者：但玥王浩浩高丽敏李瑞宇西北工业大学动力与能源学院西安710072 西北工业大学翼型、叶栅空气动力学国家级重点实验室西安710072

在叶片实际加工过程中,不可避免会产生扭转度超差叶片,为探究其气动合格性,以跨声速叶片Rotor37为研究对象,首先将加工公差[-0.5°,+0.5°]添加至设计叶片,采用数值模拟的方法确定气动性能合格范围,分析性能变化规律;而后基于实测扭转... 详细信息

在叶片实际加工过程中,不可避免会产生扭转度超差叶片,为探究其气动合格性,以跨声速叶片Rotor37为研究对象,首先将加工公差[-0.5°,+0.5°]添加至设计叶片,采用数值模拟的方法确定气动性能合格范围,分析性能变化规律;而后基于实测扭转度误差均值及标准差,创建加工合格以及超差叶片,总结其气动合格性。研究结果表明:受扭转度误差影响,叶片特性曲线整体偏移,因此在选择近失速及峰值效率工况参数衡量稳定裕度的前提下,“欠偏转”叶片稳定裕度减小,而“过偏转”叶片的增大;以加工公差为参考,叶片超差区域与未超差区域的通流面积和攻角变化趋势相反,即两区域对叶片性能的影响存在抵消作用,使得存在超差叶片气动合格的情况。

关键词：跨声速压气机叶片加工误差扭转度气动性能

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地形跟随中航迹跟踪模型预测控制方案设计

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系统工程与电子技术 2024年第4期46卷 1383-1392页

作者：卜瑞宇王彪李宏成唐超颖朱日楠南京航空航天大学自动化学院江苏南京211100

针对地形跟随飞行中的航迹跟踪问题,设计了航迹跟踪模型预测控制器,并讨论了模型预测控制中时域参数切换的自适应方案设计。首先,结合被控对象的特点,设计了用于实现全局稳定跟踪参考航迹的模型预测航迹控制器,并对控制器展开了稳定性... 详细信息

针对地形跟随飞行中的航迹跟踪问题,设计了航迹跟踪模型预测控制器,并讨论了模型预测控制中时域参数切换的自适应方案设计。首先,结合被控对象的特点,设计了用于实现全局稳定跟踪参考航迹的模型预测航迹控制器,并对控制器展开了稳定性分析。然后,充分发挥模型预测控制的预测能力,进行了航迹跟踪方法和综合误差评价策略设计。同时,通过分析不同航迹段的跟踪需求,设计了自适应调整模型预测控制中时域参数的优化方案。仿真验证结果表明,自适应方案相比固定时域方案航迹跟踪精度更高、飞行颠簸小、稳定性好,预设的评价指标函数能有效评估跟踪性能。

关键词：地形跟随模型预测控制稳定性分析自适应时域误差评价

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