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江汉石油职工大学学报 2024年第2期37卷 33-34,41页

作者：黄睿雪中石化江汉石油工程有限公司井下测试公司湖北武汉430075

江汉油区Φ86mm小井眼井由于套管内径小,入井工具尺寸受限,对修井管柱、工具的要求与常规井修井存在差异。通过现场实例,就小井眼井打捞工具储备进行相应论述,对指导生产有一定参考价值。

关键词：小井眼井打捞受限工具储备

法治公安建设助推社会治理法治化的实践与思考

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公安研究 2024年第3期 5-11页

作者：黄瑞雪甘肃省政府甘肃省公安厅

法治是治国理政的基本方式,是强国建设、民族复兴的重要保障。党的十八大以来,习近平法治思想引领推动社会主义法治国家建设取得历史性成就。公安机关作为国家重要的治安行政和刑事司法力量,是法治国家、法治政府、法治社会建设的重要... 详细信息

法治是治国理政的基本方式,是强国建设、民族复兴的重要保障。党的十八大以来,习近平法治思想引领推动社会主义法治国家建设取得历史性成就。公安机关作为国家重要的治安行政和刑事司法力量,是法治国家、法治政府、法治社会建设的重要参与者、推动者、捍卫者。立足公安机关敏锐感知社会治理问题的优势,结合甘肃省公安工作,就深入贯彻习近平法治思想,从环境之“变”、实践之“问”、改进之“策”三个方面,对法治公安建设助推社会治理法治化进行了研究思考。

关键词：习近平法治思想依法治国法治公安

百里杜鹃国家森林公园植物群落物种多样性及优势种生态位宽度对人为干扰的响应

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生态学杂志 2024年第5期43卷 1217-1226页

作者：黄睿雪欧静王洪飞周玉梅贵州大学林学院贵阳550025

为探究百里杜鹃国家森林公园植物群落物种多样性及优势种生态位宽度与人为干扰的耦合关系,为公园内植物景观资源可持续利用及植物多样性保护提供理论依据,分析了不同人为干扰下植物群落物种组成及优势种群间功能关系。结果表明:(1)调查1... 详细信息

为探究百里杜鹃国家森林公园植物群落物种多样性及优势种生态位宽度与人为干扰的耦合关系,为公园内植物景观资源可持续利用及植物多样性保护提供理论依据,分析了不同人为干扰下植物群落物种组成及优势种群间功能关系。结果表明:(1)调查15个样地共记录49科80属109种。(2)群落各结构层物种多样性对人为干扰响应具有显著性差异,乔木层与灌木层物种多样性指数在中度干扰下最高;灌木层与草本层Margalef指数与人为干扰强度呈极显著负相关(P<0.01)。(3)乔木层与灌木层杜鹃花科植物生态位宽度在各干扰水平下均为最高;灌木层迷人杜鹃的生态位宽度与干扰强度呈显著正相关(P<0.05),白栎的生态位宽度与干扰强度呈极显著负相关(P<0.01);草本层常春藤的生态位宽度与人为干扰呈极显著正相关(P<0.01),牛尾菜的生态位宽度与人为干扰呈极显著负相关(P<0.01)。综合分析表明,植物群落各结构层物种多样性对人为干扰的响应关系具有显著性差异,同时人为干扰会改变群落物种组成,直接或间接影响植物种群的结构和功能,进而破坏群落生境,不利于群落发展。

关键词：人为干扰杜鹃群落物种多样性生态位宽度

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类器官在放射治疗中应用的研究进展

中华放射医学与防护杂志 2024年第1期44卷 72-77页

作者：郭佩玉莫一青黄瑞雪中南大学湘雅公共卫生学院劳动与环境卫生系长沙410078 杭州市拱墅区长庆潮鸣街道社区卫生服务中心杭州310003

随着核能在军事、科研和医学各个领域的广泛应用,放射医学已成为一门重要的学科。迄今为止,放射医学的研究大多使用细胞模型和动物模型,然而这两种模型都有其局限性,类器官模型的出现填补了这些传统模型留下的空白。类器官是源自组织干... 详细信息

随着核能在军事、科研和医学各个领域的广泛应用,放射医学已成为一门重要的学科。迄今为止,放射医学的研究大多使用细胞模型和动物模型,然而这两种模型都有其局限性,类器官模型的出现填补了这些传统模型留下的空白。类器官是源自组织干细胞的3D体外培养系统,类器官因其具有与原始组织相似的结构、功能和遗传特征而被广泛应用于放射医学、疾病研究、药物开发和癌症建模等领域。本综述按放射治疗部位介绍了各种类器官模型在放射治疗中的研究应用,并对类器官模型目前的局限性及未来前景进行相关论述。

关键词：器官类器官模型放射治疗放射医学

Risk and mechanism of metabolic syndrome associated with radiation exposure

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Radiation Medicine and Protection 2023年第2期4卷 65-69页

作者： ruixue huang Justyna Miszczyk Ping-Kun Zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South UniversityHunan 410078China Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijing 100850China Department of Experimental Physics of Complex Systems Institute of Nuclear Physics Polish Academy of SciencesKraków PL-31342Poland

Obesity, hyperglycemia, hypertension, hypertriglyceridemia and low high-density lipoprotein cholesterol are the typical features of Metabolic syndrome (MetS). Exploring the risk factors would benefit for prevention control. Several studies have revealed an association between ionizing radiation (IR) exposure and MetS, likely attributable to production of reactive oxygen species (ROS), oxidative stress, DNA damage. Understanding the health effects of IR exposure, which have long been overlooked, would improve knowledge on MetS and help identify effective strategies for targeted prevention of MetS. In this review, we first highlight the importance of IR and MetS, providing information on the wide use of IR in the field, IR-induced damage, and the prevalence and burden of MetS. Then, we summarize the findings association between IR and various components of MetS addressing the dual effects of IR on MetS in a dose-response manner. Although there remain unresolved challenges, study on the association of radiation and MetS could open new perspectives in the future.

关键词： Radiation Risk Metabolic syndrome

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番茄红素对小鼠原始卵泡发育的影响及机制

中国兽医学报 2024年第2期44卷 363-370页

作者：杨雪唐紫雯刘冬菊彭毛卓玛莫罗钰马骏黄瑞雪殷实西南民族大学畜牧兽医学院四川成都610041 西南民族大学现代生物技术国家民委重点实验室四川成都610041

旨在探究体外培养条件下番茄红素对小鼠原始卵泡激活的作用及机制。分离出生后3 d的ICR小鼠卵巢并对其在体外连续培养4 d,在培养过程中添加不同浓度番茄红素0(对照组)、5、50和500μmol/L,通过HE染色分析不同浓度番茄红素对小鼠原始卵... 详细信息

旨在探究体外培养条件下番茄红素对小鼠原始卵泡激活的作用及机制。分离出生后3 d的ICR小鼠卵巢并对其在体外连续培养4 d,在培养过程中添加不同浓度番茄红素0(对照组)、5、50和500μmol/L,通过HE染色分析不同浓度番茄红素对小鼠原始卵泡发育的影响,通过过碘酸-希夫(periodic acid Schiff,PAS)染色及TUNEL染色检测卵泡闭锁及细胞凋亡情况,通过增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)染色检测颗粒细胞增殖情况,应用ELISA检测卵巢中活性氧(reactive oxygen species,ROS)水平,通过Real-time PCR检测部分凋亡及抗氧化基因表达,并通过Western blot检测卵泡激活关键信号通路PI3K-AKT中部分成员蛋白的表达。结果显示,与对照组相比,500μmol/L番茄红素浓度培养条件下原始、过渡态、初级及次级卵泡数量均显著升高(P<0.05),而退化卵泡及凋亡细胞数量显著减少(P<0.05),处于增殖状态的颗粒细胞数量显著增多(P<0.05);与对照组相比,500μmol/L处理组中ROS水平明显降低(P<0.05),部分抗凋亡基因及抗氧化基因,包括Bcl-2、Xiap、Apaf-1、Cat、Prdx1、Gpx1的表达显著升高(P<0.05),而促凋亡基因Bax、Caspase-3、Caspase-8的表达显著下调(P<0.05);500μmol/L处理组中PTEN、AKT和FOXO3A蛋白的表达水平与对照相比明显下调(P<0.05),而磷酸化AKT及磷酸化FOXO3A蛋白的表达水平显著上调(P<0.05)。综上所述,500μmol/L番茄红素可能通过增强细胞的抗氧化性和调控PI3K-AKT通路部分蛋白的表达促进原始卵泡的存活和激活。本试验为深入探讨番茄红素调控原始卵泡发育的分子机制提供了一定的试验数据,并为原始卵泡发育障碍引发的相关不孕症的治疗提供了新的思路。

关键词：番茄红素原始卵泡卵泡激活抗氧化 PI3K-AKT信号通路

DNA damage repair:historical perspectives,mechanistic pathways and clinical translation for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2391-2425页

作者： ruixue huang Ping-Kun Zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South UniversityChangshaHunanChina Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijingChina

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA *** application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of ***,the adverse effects including normal tissues injury are also accompanied by the radiotherapy and *** cancer therapy has the potential to suppress cancer cells'DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response ***,understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy,in particular,raising novel hypothesis or theory in this field on the basis of previous scientists'findings would be important for future promising druggable emerging *** this review,we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed,then we summarize the mechanisms regarding DNA damage repair associated with targeted cancer therapy,highlighting the specific proteins behind targeting DNA damage repair that initiate functioning abnormally duo to extrinsic harm by environmental DNA damage factors,also,the DNA damage baseline drift leads to the harmful intrinsic targeted cancer *** addition,clinical therapeutic drugs for DNA damage and repair including therapeutic effects,as well as the strategy and scheme of relative clinical trials were intensive *** on this background,we suggest two hypotheses,namely"environmental gear selection”to describe DNA damage repair pathway evolution,and"DNA damage baseline drift”,which may play a magnified role in mediating repair during cancer *** two new hypothesis would shed new light on targeted cancer therapy,provide a much better or more comprehensive holistic view and also promote the development of new research direction and new overcoming strategies for

关键词： damage clinical targeted

HIF-1 signaling: A key orchestrator of cancer radioresistance

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Radiation Medicine and Protection 2020年第1期1卷 7-14页

作者： ruixue huang Ping-Kun Zhou Department of Occupational and Environmental Health Xiangya School of Public HeathCentral South UniversityChangshaHunan Province410078China Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijing100850China

Hypoxia is a big roadblock for cancer radiotherapy,in which the hypoxia-inducible factor(HIF-1)creates a microenvironment and cancer cells’intrinsic signaling networks conferring radioresistance to ***-1 is a heterodimeric transcription factor HIF-1α/HIF-1β,that regulates the transcription of a broad range of downstream genes possessing an E-box-like hypoxia response element(HRE).The expression of HIF-1αis oxygensensitive while HIF-1βis constitutively *** addition to hypoxia,ionizing radiation can also induce the expression of HIF-1α.The HIF-1 modulates a set of signaling pathways to cause profound effects on the response of cancer to radiotherapy,including radiation-induced DNA damage response(DDR),vasculogenesis and glucose metabolism reprograming,epithelial mesenchymal transition(EMT),*** this review,our aim is to summarize the current knowledge about the role and the related signal pathways of HIF-1 in association with the resistance of cancers to *** HIF-1 and its signal pathways is a promising strategy for sensitization of cancers to radiotherapy.

关键词： HIF-1 Radiotherapy Radioresistance DNA damage response Hypoxia

Harpoon-shaped topological photonic crystal for on-chip beam splitter

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 95-102页

作者： Zhiwei Guan ruixue Dou Chuangxin Xie Tianyimei Zuo Liyu huang Keyin Wen Chaofeng Wang Huapeng Ye Junmin Liu Ze Dong Dianyuan Fan Shuqing Chen Institute of Microscale Optoelectronics Shenzhen University College of Physics and Engineering Technology Minzu Normal University of Xingyi Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal University College of New Materials and New Energies Shenzhen Technology University School of Information and Electronics Beijing Institute of Technology

The advancement of integrated optical communication networks necessitates the deployment of on-chip beam splitters for efficient signal interconnections at network nodes. However, the pursuit of micron-scale beam splitting with large corners and reducing the device footprint to boost connection flexibility often results in phase mismatches. These mismatches, which stem from radiation modes and backward scattering, pose significant obstacles in creating highly integrated and interference-resistant connections. To address this, we introduce a solution based on the topological valley-contrasting state generated by photonic crystals with opposing valley Chern numbers, manifested in a harpoon-shaped structure designed to steer the splitting *** approach enables adiabatic mode field evolution over large corners, capitalizing on the robust phase modulation capabilities and topological protection provided by the subwavelength-scale valley-contrasting state. Our demonstration reveals that beam splitters with large corners of 60°, 90°, and 120° exhibit insertion loss fluctuations below 2.7 dB while maintaining a minimal footprint of 8.8 μm × 8.8 μm. As a practical demonstration, these devices facilitate three-channel signal connections, successfully transmitting quadrature phase shift keying signals at 3.66 Tbit/s with bit error rates below the forward error correction threshold, demonstrating performance comparable to that in defects scenarios. By harnessing the unidirectional excitation feature, we anticipate significant enhancements in the capabilities of signal distribution and connection networks through a daisy chain configuration.

关键词： channel interconnection on-chip beam splitter topological valley-contrasting state

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网络舆情法治化治理的研究思考

公安研究 2023年第8期 5-9页

作者：黄瑞雪甘肃省公安厅党委

网络空间治理是国家和社会治理的重要组成部分。本文深入贯彻习近平法治思想和习近平总书记关于网络强国的重要思想,全面贯彻落实党的二十大精神,围绕加强新时代网络法治建设这一时代课题,聚焦当前比较突出的网络舆情问题,以典型案例为... 详细信息

网络空间治理是国家和社会治理的重要组成部分。本文深入贯彻习近平法治思想和习近平总书记关于网络强国的重要思想,全面贯彻落实党的二十大精神,围绕加强新时代网络法治建设这一时代课题,聚焦当前比较突出的网络舆情问题,以典型案例为样本,研究分析舆情生发演变的规律特点,深入剖析舆情背后的治理之痛,并从高举法治大旗、依法应对处置的角度提出对策建议。

关键词：网络强国网络法治建设网络舆情依法管网治舆