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Efficient Computational Method for the Non-Probabilistic Reliability of Linear Structural Systems

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Acta Mechanica Solida Sinica 2016年第3期29卷 284-299页

作者： ruixing wang Xiao jun wang Lei wang Xianjia Chen Institute of Solid Mechanics Beihang University

The non-probabilistic reliability in higher dimensional situations cannot be calcu- lated efficiently using traditional methods, which either require a large amount of calculation or cause significant error. In this study, an efficient computational method is proposed for the cal- culation of non-probabilistic reliability based on the volume ratio theory, specificMly for linear structural systems. The common expression for non-probabilistic reliability is obtained through formula derivation with the amount of computation considerably reduced. The compatibility be- tween non-probabilistic and probabilistic safety measures is demonstrated through the Monte Carlo simulation. The high efficiency of the presented method is verified by several numerical examples.

关键词： non-probabilistic reliability linear structural system formula derivation compatibility high efficiency

A novel method of Newton iteration-based interval analysis for multidisciplinary systems

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Science China(Physics,Mechanics & Astronomy) 2017年第9期60卷 47-62页

作者： Lei wang Chuang Xiong ruixing wang XiaoJun wang Di Wu Institute of Solid Mechanics Beihang University China Academy of Launch Vehicle Technology R&D Center

A Newton iteration-based interval uncertainty analysis method(NI-IUAM) is proposed to analyze the propagating effect of interval uncertainty in multidisciplinary systems. NI-IUAM decomposes one multidisciplinary system into single disciplines and utilizes a Newton iteration equation to obtain the upper and lower bounds of coupled state variables at each iterative ***-IUAM only needs to determine the bounds of uncertain parameters and does not require specific distribution formats. In this way, NI-IUAM may greatly reduce the necessity for raw data. In addition, NI-IUAM can accelerate the convergence process as a result of the super-linear convergence of Newton iteration. The applicability of the proposed method is discussed, in particular that solutions obtained in each discipline must be compatible in multidisciplinary systems. The validity and efficiency of NI-IUAM is demonstrated by both numerical and engineering examples.

关键词： multidisciplinary systems uncertainty propagation insufficient sample data interval uncertainty analysis method Newton iteration

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Γ函数在教学中的设计策略及其应用分析

辽宁师专学报（自然科学版） 2024年第1期26卷 5-9,21页

作者：王瑞星吴克坚空军军医大学基础医学院陕西西安710032

Γ函数作为反常积分中的一个特殊函数,它将阶乘运算推广到实数域和复数域上,是数学教学中不可避开的一个知识点.在教学过程中,对于Γ函数的讲解仅在反常积分中涉及,鲜有学时来分析其具体性质及其应用,学生在学习过程中也容易忽略Γ函数... 详细信息

Γ函数作为反常积分中的一个特殊函数,它将阶乘运算推广到实数域和复数域上,是数学教学中不可避开的一个知识点.在教学过程中,对于Γ函数的讲解仅在反常积分中涉及,鲜有学时来分析其具体性质及其应用,学生在学习过程中也容易忽略Γ函数的应用.针对此问题,在介绍Γ函数的相关概念及其性质基础上,重点讨论和分析了Γ函数在微积分、概率论与数理统计、物理学、工程学和经济学等领域中的具体应用,并结合Γ函数的特点与应用给出了在教学中的设计策略,最后简要分析了Γ函数的优势和局限性以及在其他领域的潜在应用.

关键词： Γ函数 Γ分布应用设计策略潜在应用

A cementation method of loose particles based on microbe-based cement

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Science China(Technological Sciences) 2011年第7期54卷 1722-1729页

作者： RONG Hui QIAN ChunXiang wang ruixing School of Materials Science and Engineering Southeast UniversityNanjing 211189China Jiangsu Key Laboratory of Construction Material Nanjing 211189China

Microbe-based cement has been widely reported in recent literatures. It is a new method of consolidating loose fine particles, which relies on the bacterially induced formation of a compatible carbonate precipitation around individual particles and at particle-particle contacts. Materials and cementation procedure are two major factors that influence the cementation performance of microbe-based cement. Besides, there are some other factors related to the performance, such as pH, temperature, metabolism activity, the flushed times of bacterial solution, concentration of substrate and calcium ion, etc., which affect consolidation function. The assessment methods for cementation process are carried out by various techniques. The performance of consolidation loose grains based on microbe-based cement is tested with the help of experiment. In this paper a review is presented on the cementation mechanism of microbe-based cement, techniques utilized to monitor cementation process, the consolidated performance by microbe-based cement and bond factors.

关键词： microbe-based cement bacteria loose particles consolidation carbonate precipitation compressive strength permeability porosity

Six sigma robust design optimization for thermal protection system of hypersonic vehicles based on successive response surface method

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Chinese Journal of Aeronautics 2019年第9期32卷 2095-2108页

作者： Jingjing ZHU Xiaojun wang Haiguo ZHANG Yuwen LI ruixing wang Zhiping QIU Institute of Solid Mechanics School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100083China The 704 Research Institute of CSIC Shanghai 200031China Institute of Mechanics Chinese Academy of ScienceBeijing 100190China

Lightweight design is important for the Thermal Protection System(TPS) of hypersonic vehicles in that it protects the inner structure from severe heating environment. However, due to the existence of uncertainties in material properties and geometry, it is imperative to incorporate uncertainty analysis into the design optimization to obtain reliable results. In this paper, a six sigma robust design optimization based on Successive Response Surface Method(SRSM) is established for the TPS to improve the reliability and robustness with considering the uncertainties. The uncertain parameters related to material properties and thicknesses of insulation layers are considered and characterized by random variables following normal distributions. By employing SRSM, the values of objective function and constraints are approximated by the response surfaces to reduce computational cost. The optimization is an iterative process with response surfaces updating to find the true optimal solution. The optimization of the nose cone of hypersonic vehicle cabin is provided as an example to illustrate the feasibility and effectiveness of the proposed method.

关键词： Hypersonic vehicle Six sigma robust optimization Successive response surface Thermal protection system Uncertainty

Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility

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Research 2022年第4期2022卷 381-396页

作者： Lan Suno Yangmei Li Yun Yu Peiliang wang Shengquan Zhu KaijieWu Yan Liu ruixing wang Li Min Chao Chan Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China Aerospace Information Research Institute School of ElectronicElectrical and Communication EngineeringUniversity of the Chinese Academy of SciencesBeijing 100049China Key Laboratory of Electromagnetic Illumination and Sensing Technology Chinese Academy of SciencesBeijing 100190China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory for Precancerous Lesion of Digestive Disease National Clinical Research Center for Digestive DiseaseBeijing100171China School of Physics Peking UniversityBeijing 100871China

Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 μm (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 μm THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 μm suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 μm on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM in vivo. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments.

关键词： drugs Together migration

Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow

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Theoretical & Applied Mechanics Letters 2018年第4期8卷 272-276,300页

作者： Xiaodong Xing Te Ma ruixing wang Chenyu Cao Hongwei Song Chenguang Huang Harbin Engineering University Harbin 150000China Key Laboratory for Mechanics in Fluid-Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow,which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory,a coupled numerical model considering the interaction and evolution of metal elastoplastic deformation and aerodynamic pressure profile is *** the thermal elastoplastic constitutive relationship and failure criterion,the simulated failure modes and dynamic rupture process are basically consistent with the experimental results,indicating plastic flow and multiple fracturing is the main failure *** with the case of non-airflow,subsonic airflow not only accelerates deformation,but also turns the bugle deformation,plastic strain and rupture mode into asymmetric.

关键词： Thermal-fluid-structure coupling Thermal elastoplastic Aerodynamic pressure Laser damage Dynamic rupture

Investigating the Genetic Bases of Growth Regulation by E2F3 in Dwarf Surf Clams Mulinia lateralis

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Journal of Ocean University of China 2024年第5期23卷 1347-1358页

作者： YAO ruixing wang Chen KONG Lingling wang Yujue BAO Zhenmin HU Xiaoli MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life Sciences Ocean University of China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and TechnologyCenter Key Laboratory of Tropical Aquatic Germplasm of Hainan Province Sanya Oceanographic Institution Ocean University of China

Bivalve aquaculture plays a crucial role in the aquaculture industry due to the economic value of many bivalve species. Understanding the underlying genetic basis of bivalve growth regulation is essential for enhancing germplasm innovation and ensuring sustainable development of the industry. Though numerous candidate genes have been identified, their functional validation remains challenging. Fortunately, the dwarf surf clam(Mulinia lateralis) serves as a promising model organism for investigating genetic mechanisms underlying growth regulation in bivalves. The GWAS study in the Yesso scallop(Patinopecten yessoensis) has pinpointed the E2F3 gene as a key regulator of growth-related traits. However, the specific role of E2F3 in bivalve growth remains unclear. This study aimed to further confirm the regulatory function of the E2F3 gene in the dwarf surf clam through RNA interference experiments. Our results revealed several genes are associated with individual growth and development, including CTS7, HSP70B2, and PGLYRP3, as well as genes involved in lipid metabolism such as FABP2 and FASN. Functional enrichment analysis indicated that E2F3 primarily modulates critical processes like amino acid and lipid metabolism. These findings suggest that E2F3 likely regulates growth in the dwarf surf clam by influencing amino acid and lipid metabolism. Overall, this study advances our understanding on the function of E2F3 gene in growth regulation in bivalves, providing valuable insights for future research in this field.

关键词： bivalve dwarf surf clam Mulinia lateralis E2F3 growth regulation RNA interference experiment transcriptomic analysis

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提高林业调查规划设计质量的对策探讨

广东蚕业 2024年第4期58卷 17-19页

作者：雷富生黄思远王锐行林春净朱其东广西壮族自治区国有博白林场广西玉林537600

林业调查规划设计对林业资源发展及环境管控工作有着直接影响,能够维持林业生产活动的有效性和可靠性,满足可持续发展要求。文章阐述了林业调查规划设计,提出了提高林业调查规划设计质量的对策建议,以供参考。

关键词：林业调查规划设计设计质量对策

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