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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen ruixin yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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限时进食在小鼠和细胞模型中通过溶酶体生物发生缓解非酒精性脂肪性肝炎

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中国病理生理杂志 2023年第9期39卷 1611-1619页

作者：蒋秋艳吕岳要睿昕许凯星宋维芳山西医科大学汾阳学院山西汾阳032200

目的:探讨AMP活化蛋白激酶(AMPK)/转录因子EB(TFEB)介导的溶酶体生物发生在限时进食(TRF)对非酒精性脂肪性肝炎(NASH)小鼠肝脏及油酸(OA)诱导的人肝母细胞瘤HepG2细胞损伤的缓解作用及其分子机制。方法:(1)用高脂高胆固醇饮食构建小鼠N... 详细信息

目的:探讨AMP活化蛋白激酶(AMPK)/转录因子EB(TFEB)介导的溶酶体生物发生在限时进食(TRF)对非酒精性脂肪性肝炎(NASH)小鼠肝脏及油酸(OA)诱导的人肝母细胞瘤HepG2细胞损伤的缓解作用及其分子机制。方法:(1)用高脂高胆固醇饮食构建小鼠NASH模型,将18只C57BL/6J小鼠分为正常对照(NC)组、模型(model)组和TRF组,每组6只。饲养10周后麻醉小鼠,摘眼球取血,分离血清,检测小鼠血清中的总胆固醇(TC)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)的水平;收集小鼠肝脏,计算肝脏系数,检测肝脏TC和TG的水平。苏木精-伊红(HE)和Masson马松染色观察肝脏形态学变化;Western blot法检测肝脏溶酶体关联膜蛋白1(LAMP1)、AMPK、p-AMPK和核TFEB、肿瘤坏死因子α(TNF-α)和白细胞介素1β(IL-1β)蛋白表达水平。(2)用OA干预HepG2细胞建立肝损伤模型,用血清剥夺模拟禁食条件。将HepG2细胞分为对照(control)组、血清剥夺(FBS-)组、OA组和OA+FBS-组;用siRNA敲低TFEB探讨TFEB介导的溶酶体生物发生与肝细胞脂质积累和肝损伤的关系;用AMPK抑制剂化合物C(CC)抑制AMPK活性研究AMPK与TFEB介导的溶酶体生物发生的关系。油红O染色检测肝细胞脂质积累;试剂盒检测肝细胞TG、TC、ALT和AST水平;Western blot法检测肝细胞LAMP1、AMPK、p-AMPK和核TFEB蛋白表达水平。结果:(1)TRF干预显著降低了NASH小鼠的血清TC、TG、ALT和AST水平及肝脏中IL-1β、TNF-α、TG和TC的表达,缓解了肝组织中的脂肪变性和炎症浸润(P<0.05);(2)血清剥夺干预减少了OA诱导的HepG2细胞中的脂滴数量以及TG、ALT和AST水平(P<0.01);(3)Western blot结果显示,TRF干预后NASH小鼠肝脏中TFEB核易位水平、LAMP1蛋白水平和AMPK磷酸化水平显著升高(P<0.01);血清剥夺干预后,OA诱导的HepG2细胞中TFEB核易位水平、LAMP1蛋白水平和AMPK磷酸化水平显著增加(P<0.01);(4)siRNA干预后,TFEB和LAMP1蛋白水平降低,血清剥夺对OA组脂肪积累和肝损伤的改善作用被显著削弱(P<0.05);(5)CC干预后,AMPK磷酸化水平、LAMP1蛋白水平和TFEB核易位水平显著降低(P<0.01)。结论:(1)TRF能够减轻NASH小鼠肝脏的脂质积累和炎症;(2)TRF对NASH小鼠肝脏的有益作用可能与其促进AMPK/TFEB介导的溶酶体生物发生有关。

关键词：非酒精性脂肪性肝炎限时进食溶酶体生物发生 AMP活化蛋白激酶转录因子EB

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融合改进粒子群算法的模糊控制策略在汽包锅炉的应用

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电工技术 2022年第6期 12-15页

作者：姚瑞鑫田彬陆会明华北电力大学控制与计算机工程学院北京102206 国能智深控制技术有限公司北京102211

针对机炉协调控制中锅炉具有非线性、大延迟、大惯性等特点,设计了一种融合改进粒子群(PSO)算法的模糊优化控制器。引入惯性权重递减策略和模拟退火算法(SA),改善粒子群易陷入局部最优等缺点,对模糊控制器输入输出的量化因子寻优。将该... 详细信息

针对机炉协调控制中锅炉具有非线性、大延迟、大惯性等特点,设计了一种融合改进粒子群(PSO)算法的模糊优化控制器。引入惯性权重递减策略和模拟退火算法(SA),改善粒子群易陷入局部最优等缺点,对模糊控制器输入输出的量化因子寻优。将该控制策略应用到某电厂300 MW汽包炉协调控制过程,控制燃料量输出,消除外界负荷需求变化造成的汽压偏差。MATLAB仿真结果表明,改进后的模糊控制器性能更好,锅炉内部汽压达到稳定的时间更短,静态偏差更小。

关键词：协调控制系统模糊控制粒子群优化算法模拟退火算法

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磁共振成像对创伤性臂丛神经损伤的诊断价值

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现代医用影像学 2022年第3期31卷 408-412页

作者：姚瑞鑫郭会利张斌青叶艳君河南中医药大学河南郑州450046 河南省洛阳正骨医院(河南省骨科医院)影像中心河南洛阳471000

目的:探究磁共振成像在创伤性臂丛神经损伤中的诊断价值。方法:回顾性分析41例创伤性臂丛神经损伤的磁共振表现,并与手术探查结果作对比。结果:MRI诊断与手术探查在诊断神经周围水肿、瘢痕、神经瘤、根性撕脱伤、节后神经断裂以及创伤... 详细信息

目的:探究磁共振成像在创伤性臂丛神经损伤中的诊断价值。方法:回顾性分析41例创伤性臂丛神经损伤的磁共振表现,并与手术探查结果作对比。结果:MRI诊断与手术探查在诊断神经周围水肿、瘢痕、神经瘤、根性撕脱伤、节后神经断裂以及创伤性脊膜囊肿方面差异均不具有统计学意义(P>0.05)。MRI诊断神经周围水肿、瘢痕、神经瘤、根性撕脱伤、节后神经断裂以及创伤性脊膜囊肿的敏感性分别为86.8%、65.4%、57.1%、78.6%、66.7%、78.2%;特异性分别为66.7%、86.7%、100.0%、92.3%、82.3%、94.4%;准确度分别为82.9%、73.2%、92.7%、80.5%、73.2%、85.4%;阳性预测值分别为97.1%、89.5、100.0%、91.7%、84.2%、94.7%;阴性预测值分别为28.6%、59.1%、91.9%、64.7%、63.6%、77.3%。若将创伤性脊膜囊肿作为诊断根性撕脱伤的依据,其敏感性、特异性及准确度均较低,分别为57.1%、45.5%、63.4%。结论:MRI在臂丛神经诊断时存在对神经周围水肿、瘢痕、神经瘤及部分节后神经断裂等误诊或过度诊断的情况,但仍可作为首选的诊断方式;创伤性脊膜囊肿对诊断根性撕脱伤有提示意义,但不能作为诊断臂丛神经根性撕脱伤的标准。

关键词：磁共振成像臂丛神经损伤手术探查 3D SPACE-STIR序列

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An easy CTAB-assisted path towards bayberry-like Ni–Co–Mn ternary hydroxide with enhancing supercapacitor performance

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Progress in Natural Science:Materials International 2023年第4期33卷 433-441页

作者： Huiling Zhu Kai Wang yao Qi ruixin Li Jianxu Ding Rui Liu School of Materials Science and Engineering Shandong University of Science and Technology College of Energy and Mining Engineering Shandong University of Science and Technology

In this study, we synthesized a bayberry-like Ni–Co–Mn ternary hydroxide with a secondary nanoneedle structure using a modified and cost-effective hydrothermal process assisted by the surfactant cetyltrimethylammonium bromide(CTAB). The incorporation of CTAB and graphene in the preparation process significantly enhances the electrochemical performance of NiCoMn–OH. The achieved results are truly impressive, with a high specific capacity of 1450 F g-1and an outstanding capacity retention of 52.57% over 5000 cycles. The superior performance could be attributed to the specific bayberry-like microstructure with high effective specific surface area,which allowed for facile and rapid transport of ions and electrons. Moreover, the synergistic effect of CTAB and graphene proved to be crucial in stabilizing the Co2+and Mn2+ions within the ternary hydroxide structure. We developed a hybrid capacitor using a NiCoMn–OH-CTAB/Graphene composite electrode and an active electrode,which delivered a superior energy density of 50.79 Wh kg-1at a power density of 400 W kg-1and a cycling stability of 60.37% after 10000 cycles. These results indicate that the NiCoMn–OH-CTAB/Graphene composite electrode has great potential as an electrode material for energy storage devices.

关键词： Bayberry-like microstructure CTAB Graphene Ni-Co-Mn ternary hydroxide Supercapacitors

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梅花鹿源大肠杆菌ESBLs基因型检测与分析

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现代畜牧科技 2024年第2期 19-21页

作者：姚茵茵聂瑞欣周航薛原东北林业大学野生动物与自然保护地学院黑龙江哈尔滨150040

为分析黑龙江省梅花鹿源产超广谱β-内酰胺类酶(ESBLs)大肠杆菌耐药基因的分布情况,为临床抗微生物药的合理使用提出指导意见。从黑龙江省4个养殖场中分离出130株梅花源大肠杆菌,采用K-B纸片法,结果显示对诺氟沙星、环丙沙星、氧氟沙星... 详细信息

为分析黑龙江省梅花鹿源产超广谱β-内酰胺类酶(ESBLs)大肠杆菌耐药基因的分布情况,为临床抗微生物药的合理使用提出指导意见。从黑龙江省4个养殖场中分离出130株梅花源大肠杆菌,采用K-B纸片法,结果显示对诺氟沙星、环丙沙星、氧氟沙星的耐药率达到10%以上。采用PCR技术对ESBLs基因进行检测。结果显示,耐药基因OXA、TEM的检出率分别为13.85%(18/130)、76.15%(99/130),CTX-M和SHV均未检出。4个养殖场的ESBLs基因以TEM为主。

关键词：梅花鹿 ESBLs 大肠杆菌耐药表型

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Electrospun Bi-decorated Bi_(x)Ti_(y)O_(z)/TiO_(2) flexible carbon nanofibers and their applications on degradating of organic pollutants under solar radiation

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Journal of Materials Science & Technology 2023年第19期150卷 114-123页

作者： Liangtao yao Changpo Sun Hui Lin Guisheng Li Zichao Lian ruixin Song Songlin Zhuang Dawei Zhang Engineering Research Center of Optical Instrument and System Ministry of Education and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China Standards and Quality Center of National Food and Strategic Reserves Administration Beijing 100834China Department of Chemistry College of ScienceUniversity of Shanghai for Science and TechnologyShanghai 200093China

Presently,photocatalytic degradation has emerged as an attractive and efficient technology for wastewater treatment.In order to avoid hurdles,such as difficulty in the suspended photocatalyst segregation from the aqueous system and low reutilization rate,the strategy of immobilizing photocatalysts with electro-spun fibers has been widely studied.However,those methods usually require multi-step preparation and complex operations.Considering this,a novel metallic Bi-decorated flexible multiphase Bi_(x)Ti_(y)O_(z)/TiO_(2) electrospun carbon nanofibers(Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs)with high photocatalytic efficiency,good mechanical property,good stability,easy separation,and recovery were synthesized via a one-step approach of pre-oxidation and carbonization treatment.The as-prepared Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs with multiphase Bi_(x)Ti_(y)O_(z),anatase TiO_(2),and metallic Bi particles embedded not only enhance the harvest of light but also pro-vide more separation paths for photogenerated carriers,which improve photocatalytic efficiency greatly.The Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs(S3)exhibited excellent photocatalytic performance and the degradation rate of 10 mg L^(-1) Rhodamine B(RhB)was up to 97%in only 30 min under simulated sunlight irradiation.Also,S3 exhibited stable activity during 5 cycles of experiments since the degradation rates remained at about 97%in 30 min.The mechanism of degradation of RhB by Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs in the photocat-alytic process was also proposed based on active species trapping experiments.The work in this paper shows that Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs are easy to prepare and have high photocatalytic ability and stability,thereby offering a new strategy in catalyst immobilization and wastewater treatment.

关键词： Electrospun nanofibers Photocatalyst Flexible

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A novel numerical simulation method for predicting compressive properties of 3D multiaxial braided composites considering various defects

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中国航空学报:英文版 2023年第9期36卷 369-379页

作者： ruixin LEI Hao DOU Yan SUN Tao LIU Wei FAN Chenyang SONG Shujuan WANG yao LU Xue YANG Diansen LI School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710048China Key Laboratory of Functional Textile Material and Product(Xi’an Polytechnic University) Ministry of EducationXi’an 710048China School of Chemistry Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology Ministry of EducationSchool of ChemistryBeihang UniversityBeijing 100191China

This paper reports a novel manufacturing process of preparing the Three-Dimensional Multiaxial Braided Composites(3DMBCs) and the effects of various defects generated in the manufacturing process on the compressive mechanical properties of 3DMBCs through the experimental and numerical methods. The five-step fabrication process of the 3D multiaxial braided preform was firstly introduced in detail. Then, the influences of various defects such as voids, waviness, and fiber breakage defects on the compressive properties of 3DMBCs were discussed. It is found that the fiber breakage defect and waviness defects were the two primary factors on the decrease of compressive properties of 3DMBCs. However, void defects in the resin and interface had little effect on the composites. When the fiber breakage defect content was 25% and the waviness was 7°, the composite compressive modulus decreased by 51%. The progressive damage process and failure mechanism of the composite under 90° compressive loading confirmed the validity of the numerical model by comparing with the experiments.

关键词： Defects 3-Dimensional reinforcement Mechanical properties Numerical model Stress concentrations

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中成药安慰剂辅料、制备与评价的研究进展

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药物评价研究 2024年第3期47卷 632-641页

作者：李啸鹏姚静施钧瀚桂新景王盼盼李涵任延娜董峰宇杨霄刘瑞新河南中医药大学河南郑州450046 河南中医药大学第一附属医院河南郑州450000 河南省中药临床应用、评价与转化工程研究中心河南郑州450000 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046 河南省中药临床药学中医药重点实验室河南郑州450000 中药制药与新药开发教育部工程研究中心北京100029

安慰剂对照试验是新药研发最常用的临床随机对照试验方法之一,但目前中成药安慰剂的制备存在诸多困难,其难点在于中药复方成分复杂且中药“气味、味道、颜色”较化学药、药用辅料及食品更为突出独特,而用于模拟味道和气味的辅料种类较少... 详细信息

安慰剂对照试验是新药研发最常用的临床随机对照试验方法之一,但目前中成药安慰剂的制备存在诸多困难,其难点在于中药复方成分复杂且中药“气味、味道、颜色”较化学药、药用辅料及食品更为突出独特,而用于模拟味道和气味的辅料种类较少,且尚无完善的“气味、味道、颜色”模拟辅料的统计与归纳,因此模拟难度较大。针对中成药安慰剂制备难点,整理归纳出可用于模拟“气味、味道、颜色”的食品添加剂、食品或药食两用物质及香料等辅料,并对现有的制备和评价方法进行总结,以期为中成药安慰剂的辅料、制备、评价方法等研究提供参考。

关键词：中成药安慰剂药用辅料新药研发制剂添加剂

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Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents

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Chinese Journal of Cancer Research 2023年第6期35卷 636-644页

作者： ruixin Yang Zhen Xiang Ranlin Yan Wingyan Kwan Lu Zang Zhenggang Zhu yao Qi Yanping Xu Xiaoyan Zhang Hengjun Gao Yingyan Yu Department of General Surgery of Ruijin Hospital Shanghai Institute of Digestive Surgeryand Shanghai Key Laboratory for Gastric NeoplasmsShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Engineering Center for Molecular Medicine Shanghai 200120China

Gastrointestinal cancers are a public health problem that threatens the lives of human being. A good experimental model is a powerful tool to promote the uncovering pathogenesis and establish novel treatment methods. High-quality biomedical research requires experimental models to recapitulate the physiological and pathological states of their parental tissues as much as possible. Organoids are such experimental models. Organoids refer to small organlike cellular clusters formed by the expansion and passaging of living tissues in 3D culture medium in vitro.Organoids are highly similar to the original tissues in terms of cellular composition, cell functions, and genomic profiling. Organoids have many advantages, such as short preparation cycles, long-term storage based on cryopreservation, and reusability. In recent years, researchers carried out the establishment of organoids from gastrointestinal mucosa and cancer tissues, and accumulated valuable experiences. In order to promote effective usage and further development of organoid-related technologies in the research of gastrointestinal diseases, this study proposes a benchmark based on utilization of available experimental consumables and reagents, which are involved in the key steps such as collection and pretreatment of biospecimen, organoid construction, organoid cryopreservation and recovery, growth status evaluation, and organoid quality control. We believe that the standard for the construction and preservation of organoids derived from human gastrointestinal epithelium and cancer tissues can provide an important reference for the majority of scientific researchers.

关键词： Organoid construction gastrointestinal epithelium gastrointestinal carcinoma methods

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