检索结果-南通市图书馆

Allergen immunotherapy in patients with atopic dermatitis allergic to house dust mite:A systematic review and meta-analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第18期137卷 2245-2247页

作者： Siyi You ruixi zhou Junjie Ying Shiping Li Xiaojuan Su Dezhi Mu Department of Pediatrics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationNHC Key Laboratory of ChronobiologySichuan UniversityChengduSichuan 610041China

To the Editor:Atopic dermatitis(AD)is the most common chronic allergic skin disease *** dust mite(HDM)is the most prevalent aeroallergen and pathogenic cause,which triggers skin barrier disruption and *** immunotherapy(AIT)may be the only etiologic treatment to improve the natural history of AD by applying a dose of specific allergens to stimulate adaptive immunity in the body.[1,2]However,the effects of HDM AIT showed controversial results *** study aimed to investigate the effectiveness and safety of AIT for HDM.

关键词： dermatitis allergic immunotherapy

A new cell death program regulated by toll-like receptor 9 through p38 mitogen-activated protein kinase signaling pathway in a neonatal rat model with sepsis associated encephalopathy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第12期135卷 1474-1485页

作者： ruixi zhou Junjie Ying Xia Qiu Luting Yu Yan Yue Qian Liu Jing Shi Xihong Li Yi Qu Dezhi Mu Department of Pediatrics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengduSichuan 610041China

Background:Sepsis,a serious condition with high mortality,usually causes sepsis associated encephalopathy(SAE)that involves neuronal cell ***,the cell death programs involved and their underlying mechanisms are not *** study aimed to explore the regulatory mechanisms of different cell death programs in ***:A neonatal rat model of SAE was established by cecal ligation and *** rate and vital signs(mean arterial pressure and heart rate)were monitored,nerve reflexes were evaluated,and cortical pathological changes were observed by hematoxylin and eosin *** expression of pyroptosis,apoptosis,and necroptosis(PANoptosis)-related proteins,mitogen-activated protein kinase(MAPK),and its upstream regulator toll-like receptor 9(TLR9)were *** expression of TLR9 in neurons was observed by immunofluorescence *** ultrastructure of neurons was observed by transmission electron ***:First,PANoptosis was found in cortical nerve cells of the SAE ***,the subunits of MAPKs,p38 MAPK,Jun N-terminal kinase,and extracellular signal-regulated kinase(ERK)were *** pharmacologically inhibiting each of the subunits,only p38 MAPK was found to be associated with ***,blocking the p38 MAPK signaling pathway activated necroptosis but inhibited apoptosis and *** necroptosis was pharmacologically inhibited,apoptosis and pyroptosis were ***,we found that the expression of TLR9,a regulator of MAPKs,was significantly increased in this *** down-regulation of TLR9,p38 MAPK,and ERK signaling pathways were inhibited,which led to the inhibition of *** analysis found that down-regulation of TLR9 improved the survival rate and reduced the pathological changes in SAE ***:Our study showed that the programs comprising PANoptosis are activated simultaneously in SAE ***9 activated PANoptosis through the p38 MAPK signaling pathw

关键词： Sepsis associated encephalopathy TLR9 Apoptosis Pyroptosis Necroptosis p38 mitogen-activated protein kinase

Association between low ambient temperature during pregnancy and adverse birth outcomes: A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2023年第19期136卷 2307-2315页

作者： Ruan Tiechao Yue Yan Lu Wenting zhou ruixi Xiong Tao Jiang Yin Ying Junjie Tang Jun Shi Jing Wang Hua Xiao Guoguang Li Jinhui Qu Yi Mu Dezhi Department of Pediatrics West China Second University Hospital Sichuan University Chengdu Sichuan China Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education Sichuan University Chengdu Sichuan China Department of General Practice West China Hospital Sichuan University Chengdu Sichuan China

Background: Extreme temperature events, including extreme cold, are becoming more frequent worldwide, which might be harmful to pregnant women and cause adverse birth outcomes. We aimed to investigate the association between exposure to low ambient temperature in pregnant women and adverse birth outcomes, such as preterm birth, low birth weight, and stillbirth, and to summarize the evidence ***: Relevant studies were searched in PubMed, Cochrane, and Embase electronic databases until November 2021. Studies involving low ambient temperature, preterm birth, birth weight, and stillbirth were included. The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses were followed to conduct this study risk of bias and methods for data ***: A total of 34 studies were included. First, pregnant women exposed to low ambient temperature had an increased risk of preterm birth (risk ratio [RR] 1.08; 95% confidence interval [CI] 1.04–1.13). Subgroup analyses revealed that exposure during late pregnancy was more likely to induce preterm birth. In addition, only pregnant women exposed to <1st percentile of the mean temperature suffered increased risk of preterm birth. Moreover, pregnant women living in medium or hot areas were more prone to have preterm births than those in cold areas when exposed to low ambient temperatures. Asians and Blacks were more susceptible to low ambient temperatures than Caucasians. Second, pregnant women exposed to low ambient temperature had an increased risk of low birth weight (RR 1.07; 95% CI 1.03–1.12). Third, pregnant women had an increased risk of stillbirth while exposed to low ambient temperature during the entire pregnancy (RR 4.63; 95% CI 3.99–5.38).Conclusions: Exposure to low ambient temperature during pregnancy increases the risk of adverse birth outcomes. Pregnant women should avoid exposure to extremely low ambient temperature (<1st percentile of the mean temperature), especially in their

关键词： Ambient temperature Pregnancy Preterm birth Birth weight Stillbirth

家庭参与式护理模式下支气管肺发育不良早产儿2岁内再入院的影响因素分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华护理杂志 2022年第12期57卷 1481-1485页

作者：周瑞茜倪王平柯若陈晓春温州医科大学附属第二医院新生儿重症监护室温州市325000

目的探讨家庭参与式护理模式下支气管肺发育不良(bronchopulmonary dysplasia,BPD)早产儿2岁内再入院的影响因素。方法选择2017年1月—2018年12月温州市某三级甲等医院新生儿重症监护室收治的胎龄≤32周进行家庭参与式护理的BPD早产儿... 详细信息

目的探讨家庭参与式护理模式下支气管肺发育不良(bronchopulmonary dysplasia,BPD)早产儿2岁内再入院的影响因素。方法选择2017年1月—2018年12月温州市某三级甲等医院新生儿重症监护室收治的胎龄≤32周进行家庭参与式护理的BPD早产儿作为研究对象,根据首次出院后至2岁内是否再入院分成未再入院组和再入院组。回顾性收集住院时的临床及随访资料,分析其再入院的影响因素。结果共178例BPD早产儿完成随访,其中98例(55.06%)未再入院,80例(44.94%)再入院。Logistic回归分析结果显示,家庭式护理的宣教人数≥3名(OR=5.806)和重度BPD(OR=2.725)为BPD早产儿2岁内再入院的危险因素(P<0.05);接受家庭氧疗(OR=0.311)是再入院的保护性因素(P=0.001)。结论在院开展家庭参与式护理期间,宣教人数不宜过多,宣教内容需同质化,规范化;对中重度BPD早产儿家庭需要进行必要的家庭氧疗培训;进行出院随访时需关注早产儿家庭氧疗的开展情况。

关键词：家庭参与式护理支气管发育不良再入院儿科护理学

在线全文

学校读者我要写书评

暂无评论

多元文化视角下贵州民族传统体育的传承路径

安顺学院学报 2014年第5期16卷 93-95页

作者：周瑞祥安顺学院体育学院贵州安顺561000

贵州省少数民族聚集,地域性差异很大,各民族文化存在差异,形成贵州多元文化的特征,民族传统体育项目的类型丰富多彩,展开形式各异。多元文化视角下贵州民族传统体育传承路径主要有:扩大民族体育产业发展,形成区域产业集群发展的局面;向... 详细信息

贵州省少数民族聚集,地域性差异很大,各民族文化存在差异,形成贵州多元文化的特征,民族传统体育项目的类型丰富多彩,展开形式各异。多元文化视角下贵州民族传统体育传承路径主要有:扩大民族体育产业发展,形成区域产业集群发展的局面;向非物质文化遗产迈进,增加民族体育传承的文化认同;与社区健身相结合,增加民族体育项目的健身形式;走进影视屏幕,扩大宣传;与教育环境箱结合,发扬新的传承途径。

关键词：多元文化贵州民族传统体育传承

新时代大学生国家形象认同现状及其影响因素——基于对北京市10所高校大学生志愿活动参与的实证调查

在线全文

学校读者我要写书评

暂无评论

内蒙古师范大学学报（教育科学版） 2024年第2期37卷 46-53页

作者：简臻锐周瑞玺中央财经大学马克思主义学院北京102206

国家形象是国家软实力的重要体现。大学生是国家形象塑造和传播的重要主体。深入探析新时代大学生国家形象认同及其培育既是爱国主义教育的应有之义,又是坚定“四个自信”的重要体现。大学生国家形象认同可划分为对文明大国、东方大国... 详细信息

国家形象是国家软实力的重要体现。大学生是国家形象塑造和传播的重要主体。深入探析新时代大学生国家形象认同及其培育既是爱国主义教育的应有之义,又是坚定“四个自信”的重要体现。大学生国家形象认同可划分为对文明大国、东方大国、负责任大国和社会主义大国的四维度认同。对北京市10所高校大学生进行问卷调查发现,他们的国家形象整体认同度高,但在各维度上存在一定差异。大学生国家形象认同的影响机理复杂:国内媒体因素、社会支持因素是大学生国家形象认同的重要影响因素;志愿活动参与对大学生国家形象认同的影响有待进一步提升;志愿活动在其中发挥重要中介作用。鼓励志愿活动参与、强化志愿服务效用,营造良好的社会氛围、强化社会支持,加强改进宣传工作、增强舆论引导力,是增强当代大学生国家形象认同的有效举措。

关键词：国家形象认同志愿活动参与志愿活动效用思想政治教育

半微分循环伏安法对Fe^(3+)(w)/FeCP_2(nb)在水/硝基苯界面上电子传递行为的研究

在线全文

学校读者我要写书评

暂无评论

苏州大学学报（自然科学版） 1995年第3期11卷 86-89页

作者：吴莹范瑞溪周剑峰化学系

本文用四电极系统半微分循环伏安法对FeCl_3(w)/FeCP_2(nb)体系间的电子传递进行了研究,得到了FeCl_3(w)/FeCP_2(nb)在水/硝基苯界面电子传递良好的半微分极谱峰,且通过对本体系的半积分定量测定,证实半微分实验的结论。

关键词：水硝基苯界面电子传递生物膜循环伏安法铁

在线全文

学校读者我要写书评

暂无评论

pH敏感的荧光探针及在活细胞中的应用

激光生物学报 2016年第6期25卷 491-500页

作者：陈瑞希周宏福刘秀丽曾绍群华中科技大学-武汉光电国家实验室(筹) Britton Chance生物医学光子学研究中心湖北武汉430074 华中科技大学生物医学工程系生物医学光子学教育部重点实验室湖北武汉430074

细胞内的pH是细胞内多种酶活性和生理活动的重要调节因素,准确、动态的监测细胞内pH变化对研究细胞内的活动至关重要。一些荧光小分子可以感应pH的变化,同时具有较高的灵敏度和特异性,对细胞损伤较小且标记操作简单,已逐渐发展成为一种... 详细信息

细胞内的pH是细胞内多种酶活性和生理活动的重要调节因素,准确、动态的监测细胞内pH变化对研究细胞内的活动至关重要。一些荧光小分子可以感应pH的变化,同时具有较高的灵敏度和特异性,对细胞损伤较小且标记操作简单,已逐渐发展成为一种监测细胞内pH变化的有效方法。本文主要介绍目前常用pH敏感的荧光探针及其在活细胞研究中的进展。

关键词： pH敏感荧光探针小分子活细胞

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode