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原发纵隔大B细胞淋巴瘤60例临床病理特征及预后

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中华病理学杂志 2021年第10期50卷 1139-1144页

作者：刘宏艳钟睿琦张开鹏朱铁男钟定荣中日友好医院病理科北京100029 北京大学生命科学学院 100871 中国医学科学院北京协和医学院北京协和医院血液科100730

目的探讨原发纵隔大B细胞淋巴瘤(PMBL)的临床病理特征及影响预后的相关因素。方法回顾性分析中日友好医院(14例)和北京协和医院(46例)2000年9月至2019年11月外检(44例)及会诊(16例)共60例PMBL的临床资料、病理形态学特征、免疫表型、免... 详细信息

目的探讨原发纵隔大B细胞淋巴瘤(PMBL)的临床病理特征及影响预后的相关因素。方法回顾性分析中日友好医院(14例)和北京协和医院(46例)2000年9月至2019年11月外检(44例)及会诊(16例)共60例PMBL的临床资料、病理形态学特征、免疫表型、免疫球蛋白基因重排及microRNA表达谱。结果60例患者中,男性23例,女性37例,年龄15~64岁(中位年龄28岁)。免疫组织化学染色表达全B细胞抗原,77.4%(24/31)的病例表达CD30,73.1%(19/26)表达CD23,45.8%(11/24)MUM1阳性,Ki-67阳性指数≥70%占90.6%(29/32);21例PMBL进行EB病毒编码的mRNA(EBER)检测,仅1例(4.8%)瘤细胞散在阳性;20例PMBL中的7例免疫球蛋白基因重排检测结果阳性(阳性率35.0%)。选取7例PMBL与9例弥漫大B细胞淋巴瘤作对照研究microRNA基因表达谱的差异,结果发现其表达差异有统计学意义的microRNA共计33个。单因素分析结果显示,血清乳酸脱氢酶(LDH)升高、临床分期Ⅲ~Ⅳ期、国际预后指数(IPI)评分≥3、未联合利妥昔单抗的化疗方案及免疫组织化学染色MUM1阳性的PMBL患者的生存率低,预后差(P<0.05);多因素分析结果显示其中联合利妥昔单抗的治疗方案是影响患者生存时间的独立预后因素(P<0.05)。结论PMBL从临床病理特征到免疫分子表型均不同于弥漫大B细胞淋巴瘤,本研究所揭示的预后因素、分子遗传学、免疫学特征丰富了对PMBL生物学的认识和理解,从而为治疗提供依据和策略。

关键词：淋巴瘤,大B-细胞,弥漫性病理学,临床预后

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论企业社会责任的性质与边界

四川大学学报（哲学社会科学版） 2014年第2期 78-84页

作者：余澳朱方明钟芮琦四川大学经济学院四川成都610064

企业社会责任是企业在追逐自身价值最大化的过程中不仅不对相关利益者造成侵害,同时还尽可能致力于提高总体社会福利的责任。其核心思想体现为:界定企业社会责任要承认企业的逐利性;企业社会责任具有层次性,以不侵害利益相关者利益为底... 详细信息

企业社会责任是企业在追逐自身价值最大化的过程中不仅不对相关利益者造成侵害,同时还尽可能致力于提高总体社会福利的责任。其核心思想体现为:界定企业社会责任要承认企业的逐利性;企业社会责任具有层次性,以不侵害利益相关者利益为底线要求,以提高社会整体福利为最高表现;企业社会责任的核心是以人为本,其责任范畴包括人本责任、经济责任、法律责任、伦理责任和环境责任,其中经济责任的内涵不同于以往的认识;企业社会责任具有边界,其边界是企业自身利益与社会利益的均衡点。

关键词：企业社会责任相关利益者性质边界

肺移植治疗终末期肺疾病合并神经内分泌癌的临床病理分析

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中华器官移植杂志 2022年第8期43卷 466-471页

作者：刘宏艳钟睿琦赵玲罗杰王蓓钟定荣中日友好医院病理科北京100029 北京协和医学院临床医学系培养模式改革试点班北京100006

目的探讨肺移植治疗终末期肺疾病合并神经内分泌癌的临床病理特征。方法中日友好医院2017年4月至2021年12月间确诊终末期肺疾病行肺移植手术且经HE染色及免疫组织化学染色确诊神经内分泌癌5例,对其临床及随访资料、组织学特征和免疫表... 详细信息

目的探讨肺移植治疗终末期肺疾病合并神经内分泌癌的临床病理特征。方法中日友好医院2017年4月至2021年12月间确诊终末期肺疾病行肺移植手术且经HE染色及免疫组织化学染色确诊神经内分泌癌5例,对其临床及随访资料、组织学特征和免疫表型进行回顾性分析。结果5例受者男女比例为4∶1;平均年龄64岁,范围在56~73岁。其中,3例为特发性肺纤维化合并小细胞癌(包括1例复合型小细胞癌),1例为支气管扩张合并类癌,1例为结缔组织病相关性肺纤维化合并类癌。HE染色结果显示,合并类癌的支气管扩张受者移植病肺中可观察到从神经内分泌细胞增生到类癌的形态学谱系变化。免疫组织化学染色结果显示,小细胞癌及类癌神经内分泌标记物CgA、Syn、CD56和上皮标记物AE1/AE3和TTF-1均呈阳性表达。2例小细胞癌和1例复合型小细胞癌Ki-67指数为80%,2例类癌Ki-67指数≤1%。截至完稿,5例中,3例存活,余2例分别于移植术后33 d和196 d死于全耐药肺炎克雷伯菌、纹带棒杆菌及鲍曼不动杆菌感染并发重症肺炎和气道狭窄。结论移植肺合并神经内分泌癌多见于老年男性,临床终末期肺疾病以特发性肺纤维化居多;神经内分泌癌类型以小细胞癌为主,均表达特异性神经内分泌标记物和TTF-1,有助于神经内分泌癌的诊断;术后感染是影响预后的重要因素。

关键词：肺移植小细胞癌类癌特发性肺纤维化

通过键共价性增加策略获得高性能Cu_(3)SbSe_(4)基热电材料

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Science China Materials 2023年第9期66卷 3644-3650页

作者：张旦钟瑞奇高仕康杨磊徐芳何平柳冠楠伞星源杨君友罗裕波王淑芳 Key Laboratory of High-precision Computation and Application of Quantum Field Theory of Hebei Province College of Physics Science and TechnologyHebei UniversityBaoding 071002China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

通过Cu_(3)SbSe_(4)-MTe (M=Ge/Sn)固溶体系的对比研究,本文报道了一种增加键共价性来弱化电声耦合进而获得高迁移率的策略,也证实了该策略能提升Cu_(3)SbSe_(4)化合物的热电性能.研究发现,相比于SnTe固溶,GeTe固溶赋予Cu_(3)SbSe_(4)... 详细信息

通过Cu_(3)SbSe_(4)-MTe (M=Ge/Sn)固溶体系的对比研究,本文报道了一种增加键共价性来弱化电声耦合进而获得高迁移率的策略,也证实了该策略能提升Cu_(3)SbSe_(4)化合物的热电性能.研究发现,相比于SnTe固溶,GeTe固溶赋予Cu_(3)SbSe_(4)化合物在相似载流子浓度情况下更高的迁移率,进而获得更优越的电输运性能.密度泛函理论计算表明,与SnTe固溶相比,GeTe固溶能增加Cu_(3)SbSe_(4)化学键共价性因而具有优越的电输运性能.最终,在Cu_(3)SbSe_(4)-1%GeTe样品中取得了0.8的最大热电优值(@648 K)和0.41的平均热电优值(300–648 K).此研究表明,通过增加键共价性来弱化电声耦合进而获得高迁移率是提升热电性能的有效途径.

关键词：密度泛函理论计算共价性热电性能热电优值高迁移率热电材料载流子浓度

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基于MSP430单片机的应答器设计与应用

石油管材与仪器 2015年第4期1卷 25-27,32页

作者：王钗钟睿祺任文静樊俊明唐兴虎东方地球物理公司西安物探装备分公司陕西西安710077 北京航空航天大学电子信息工程学院北京100191

针对声学定位系统的需要,设计了一种基于MSP430单片机的应答器。文章阐述了应答器的工作原理,并对基于MSP430单片机应答器的硬件和软件系统进行了详细的论述,同时给出了该应答器的应用情况。

关键词： MPS430 应答器声学定位

Plasma-enabled synthesis of ordered PtFe alloy nanoparticles encapsulated with ultrathin N-doped carbon shells for efficient methanol electrooxidation

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Nano Research 2023年第2期16卷 2065-2075页

作者： Xuxu Sun Zhijian Mao ruiqi Wang Xiaohu Pi Changle Chen Junbo zhong Qi Wang Kostya(Ken)Ostrikov Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Rutgers Preparatory School New Jersey1345 Easton AveSomersetNJ 08873USA Institute of Intelligent Machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China College of Chemical Engineering Sichuan University of Science and EngineeringZigong 643000China School of Chemistry and Physics and QUT Centre for Materials Science Queensland University of Technology(QUT)BrisbaneQLD 4000Australia

Methanol oxidation reaction(MOR),the key reaction for clean energy generation in fuel cells,is kinetically sluggish and short-lasting because of insufficient catalytic activity and stability of the common Pt-based *** Pt alloy structures which promise to surmount these issues,are challenging and impractical to fabricate using common high-temperature *** address the urgent need for simple and rapid synthesis methods for such alloys,here we report the versatile plasma-assisted thermal annealing synthesis of a robust electrocatalyst with PtFe alloys supported on N-doped carbon nanotubes(denoted as PtFe@NCNT-P).Benefiting from the reactive plasma-specific effects,the PtFe@NCNT-P electrocatalyst features ultrafine PtFe alloy nanoparticles(mean size~2.88 nm,ordered degree~87.07%)and ultrathin N-doped carbon(NC)shells(0.3–0.7 nm),leading to the excellent catalytic activity and stability toward *** catalyst shows the specific and mass activities of 3.99 mA/cm^(2)and 2,148.5 mA/mg,which are 7.82 and 7.41 times higher than those for commercial Pt/C(0.51 mA/cm^(2),290 mA/mg),and 2.18 and 2.59 times higher compared to the plasma-untreated PtFe@NCNT(1.83 mA/cm2,829.5 mA/mg),*** PtFe@NCNT-P further exhibits extraordinary stability during the long-term chronoamperometry test and 1,000-cycle cyclic voltammetry scanning,much better compared to PtFe@NCNT samples even after the longer thermal *** findings show great potential of the plasma-enabled synthesis of high-performance carbon-supported metallic electrocatalysts for the emerging clean energy technologies.

关键词： methanol oxidation reaction highly ordered PtFe alloy nanoparticles ultrathin N-doped carbon shell N-doped carbon support plasma nanotechnology

An odyssey of lithium metal anode in liquid lithium-sulfur batteries

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Chinese Chemical Letters 2022年第10期33卷 4421-4427页

作者： Xiao-zhong Fan Meng Liu ruiqi Zhang Yuezhou Zhang Songcan Wang Haoxiong Nan Yunhu Han Long Kong Frontiers Science Center for Flexible Electronics and Xi'an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi'an 710129China Ningbo Institute of Northwestern Polytechnical University Ningbo 315103China School of Science Hainan UniversityHaikou 570228China

Lithium-sulfur(Li-S)batteries exhibit outstanding energy density and material *** effects have been devoted to the sulfur cathode to address redox kinetics and polysulfide intermediates *** attentions are gradually turning to the protection of the lithium metal anodes,since electrochemical performances of Li-S batteries are closely linked to the working efficiency of the anode side,especially in pouch cells that adopt stringent test *** Perspective article summarizes critical issues encountered in the lithium metal anode,and outlines possible solutions to achieve efficient working lithium anode in Li-S *** lithium metal anode in Li-S batteries shares the common failure mechanisms of volume fluctuation,nonuniform lithium flux,electrolyte corrosion and lithium pulverization occurring in lithium metal batteries with oxide cathodes,and also experiences unique polysulfide corrosion and massive lithium *** issues can be partially addressed by developing three-dimensional scaffold,exerting quasi-solid reaction,tailoring native solid electrolyte interphase(SEI)and designing artificial *** practical evaluation of Li-S batteries highlights the importance of pouch cell platform,which is distinguished from coin-type cells in terms of lean electrolyte-to-sulfur ratio,thin lithium foil,as well as sizable total capacity and current that are loaded on pouch *** Perspective underlines the development of practically efficient working lithium metal anode in Li-S batteries.

关键词： Lithium-sulfur batteries Lithium metal anode Electrolytes Solid electrolyte interphase Pouch cell

Interfacial Challenges and Strategies toward Practical Sulfide-Based Solid-State Lithium Batteries

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Energy Material Advances 2023年第1期4卷 144-174页

作者： ruiqi Guo Kun Zhang Wenbin Zhao Zhifan Hu Shuqiang Li Yuxi zhong Rong Yang Xinran Wang Jiantao Wang Chuan Wu Ying Bai Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081P.R.China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019P.R.China China Automotive Battery Research Institute Co.Ltd. Beijing 100088P.R.China General Research Institute for Nonferrous Metals Beijing 100088P.R.China

All-solid-state lithium batteries are considered as the priority candidates for next-generation energy storage devices due to their better safety and higher energy *** the key part of solid-state batteries,solid-state electrolytes have made certain research progress in recent *** the various types of solid-state electrolytes,sulfide electrolytes have received extensive attention because of their high roomtemperature ionic conductivity and good ***,sulfide-based solid-state batteries are still in the research *** situation is mainly due to the fact that the application of sulfide electrolytes still faces challenges in particular of interfacial issues,mainly including chemical and electrochemical instability,unstable interfacial reaction,and solid-solid physical contact between electrolyte and ***,this review provides a comprehensive summary of the existing interfacial issues in the fabrication of sulfide-based solid-state *** in-depth mechanism of the interfacial issues and the current research progress of the main coping strategies are discussed in ***,we also present an outlook on the future development of sulfide-based solid-state batteries to guide the rational design of nextgeneration high-energy solid-state batteries.

关键词： sulfide Solid electrolyte

EXPERIMENTAL　STUDY　OF　EFFECTS　ON　DELAMINATION　NEAR　CRACK　OF　ARALL　BY　RESIDUAL　STRESS　UNDER　FATIGUE　＆　STATIC　LOADS

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Chinese Journal of Aeronautics 1996年第3期9卷 211-216页

作者： zhong Weihong Chen Changqi Kou Changhe (Beijing University of Aeronautics and Astronautics, Beijing, China, 100083)Zheng ruiqi (Beijig Institute of Aeronautical Materials, Beijing, China, 100095) Beijng Univ. of Aero. and Astronaut. Beijing 100083 China Beijng Inst. of Aero. Materials Beijing 100095 China

The delamination near the centre crack of ARALL under fatigue and static loads is investigated, and the effects on delamination by different residual stresses are analyzed. The results show that the situations under the two kinds of loads are *** the fatigue load, the typical delamination with crack growth presents symmetrical hi-ellipse-shape, whereas under the condition of static tensile, the edge-effect becomes more evident. Applying a proper pre-stress to the laminate can increase the ability of anti-delamination damage.

关键词： composite materials. laminates fatigue delaminating residual stress