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Green Synthesized Liquid-like Dynamic Polymer Chains with Decreased Nonspecific Adhesivity for High-Purity Capture of Circulating Tumor Cells

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CCS Chemistry 2024年第2期6卷 507-517页

作者： Feng Wu Xiaofeng Chen Shuli Wang ruimin zhou Chunyan Wang Lejian Yu Jing Zheng Chaoyong Yang Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005 College of Physical Science and Technology Xiamen UniversityXiamenFujian 361005 College of Physics and New Energy Xuzhou University of TechnologyXuzhouJiangsu 221018 Fujian Engineering Research Center for Solid-State Lighting Department of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamenFujian 361005 Institute of Artificial Intelligence Xiamen UniversityXiamenFujian 361005 Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) XiamenFujian 361102 State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdaoShandong 266071

The capture of circulating tumor cells(CTCs)is of great significance in reducing cancer mortality and complications.However,the nonspecific binding of proteins and white blood cells(WBCs)weakens the targeting capabilities of the capture surfaces,which critically hampers the efficiency and purity of the captured CTCs.Herein,we propose a liquid-like interface design strategy that consists of liquid-like polymer chains and anti-EpCAM modification processes for high-purity and high-efficiency capture of CTCs.The dynamic flexible feature of the liquid-like chains endows the modified surfaces with excellent antiadhesion property for proteins and blood cells.The liquid-like surfaces can capture the target CTCs and show high cell viability due to the environmentfriendly surface modification processes.When liquid-like surface designs were introduced in the deterministic lateral displacement(DLD)-patterned microfluidic chip,the nonspecific adhesion rate of WBCs was reduced by more than fivefold compared to that in the DLD chip without liquid-like interface design,while maintaining comparable capture efficiency.Overall,this strategy provides a novel perspective on surface design for achieving high purity and efficient capture of CTCs.

关键词： green synthesis dynamic polymer chains liquid-like interface nonspecific adsorption capture of circulating tumor cells microfluidics

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Photochemical effect driven fluid behavior control in microscale pores and channels

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Chinese Chemical Letters 2022年第8期33卷 3650-3656页

作者： Shuli Wang ruimin zhou Yaqi Hou Miao Wang Xu Hou Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Materials Xiamen UniversityXiamen 361005China Tan Kah Kee Innovation Laboratory Xiamen 361102China

Manipulating the fluid transport in the microscale pores and channels is playing a paramount role in the realization of the versatile functions of microfluidics.In recent years,using light to control the fluid behavior in the microchannels/pores has attracted many researchers'attention due to the advantages of light such as non-contact stimulation,tunable excitation,high spatial and temporal resolution.With efforts,great achievements and progresses have been achieved for photochemical effect driven microscale flow control,including fluid pumping,flow rate control,and fluid mixing,etc.In this review,we discuss the responsive mechanisms of photochemical effect driven fluid behavior control at the microscale.We also give a comprehensive review on the latest research progresses in photochemical effect controlled microfluid behaviors.Besides,prospective opportunities for the future development of light control of microscale flow are provided to attract scientific interest for the fast development and applications of various microchannel/pore systems.

关键词： Photochemical effect Fluid behavior Microscale pore Microchannel Microfluidics

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Conversion of D-glucose to L-lactate via pyruvate by an optimized cell-free enzymatic biosystem containing minimized reactions

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Synthetic and Systems Biotechnology 2018年第3期3卷 204-210页

作者： Leipeng Xie Xinlei Wei Xigui zhou Dongdong Meng ruimin zhou Yi-Heng P.Job Zhang Shuxia Xu Chun You College of Life Sciences Henan Agricultural University95 Wenhua RoadZhengzhou450002China Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences32 West 7th AvenueTianjin Airport Economic AreaTianjin300308China

Cell-free synthetic enzymatic biosystem is emerging to expand the traditional biotechnological mode by utilizing a number of purified/partially purified enzymes and coenzymes in a single reaction vessel for the production of desired products from low-cost substrates.Here,a cell-free synthetic biosystem containing minimized number of reactions was designed for the conversion of D-glucose to L-lactate via pyruvate.This NADH-balanced biosystem was comprised of only 5 thermophilic enzymes without ATP supplementation.After optimization of enzyme loading amounts,buffer concentration and cofactor concentration,D-glucose was converted to L-lactate with a product yield of∼90%.Our study has provided an emerging platform with potentials in producing pyruvatederived chemicals,and may promote the development of cell-free synthetic enzymatic biosystems for biomanufacturing.

关键词： Cell-free synthetic enzymatic biosystem Minimized reactions Thermophilic enzymes L-lactate Pyruvate Biomanufacturing

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Ternary Organic Solar Cells Based on Two Non-fullerene Acceptors with Complimentary Absorption and Balanced Crystallinity

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Chinese Journal of Chemistry 2020年第9期38卷 935-940页

作者： Lan Xie Chen Yang ruimin zhou Zhen Wang Jianqi Zhang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hiearchical Fabrication CAS Center for Exelence in NonoscienceNational Center for Nonoscience ond Technology Beijing 100190China University of Chinese Academy of Sciences Bejing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China

Summary of main observation and conclusion The ternary blend structure has been demonstrated as an effective approach to increase the power conversion efficiency of organic solar cells.An effective approach to enhance the power conversion efficiency of ternary solar cells is based on two non-fullerene acceptors with complimentary absorption range and balanced crystallinity.In this work,we have introduced a high crystallinity small-molecule acceptor,named C8IDTT-4CI with appropriate alkyl side chains into a low crystalline blend of conjugated polymer donor PBDT-TPD and fused-ring electron acceptor ITIC-4F.A ternary device based on the blend PBDT-TPD:1TIC-4F:C81DTT-4CI exhibits a best power conversion efficiency of 9.51%with a simultaneous improvement of the short-circuit current density to 18.76 mA-cm^-2 and the fill factor up to 67.53%.The absorption onset for C8IDTT-4CI is located at 900 nm,so that the well complementary light absorption is beneficial to the photocurrent.In addition,the existence of high crystallinity C8IDTT-4CI in the ternary device is found helpful to modulate crystallinity,improve heterojunction morphologies and stacking structure,therefore to realize higher charge mobility and better performance.

关键词： ternary absorption acceptor

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The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018

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China CDC weekly 2020年第17期2卷 289-292页

作者： Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian ruimin zhou Suhua Li zhou Guan Deling Lu Hongwei Zhang Wanshen Guo Henan Center for Disease Prevention and Control ZhengzhouChina College of Public Health Zhengzhou UniversityZhengzhouChina.

What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too.

关键词： Henan specified eliminating

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Fluorination-substitution effect on all-small-molecule organic solar cells

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Science China Chemistry 2019年第7期62卷 837-844页

作者： Qiong Wu Dan Deng Jianqi Zhang Wenjun Zou Yang Yang Zhen Wang Huan Li ruimin zhou Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Sino-Danish College University of Chinese Academy of Sciences Beijing 100190 China

Due to the strong crystallinity and anisotropy of small molecules, matched molecular photoelectric properties and morphologies between small molecules and non-fullerene acceptors are especially important in all-small-molecule organic solar cells(OSCs).Introducing fluorine atoms has been proved as an effective strategy to achieve a high device performance through tuning molecular energy levels, absorption and assembly properties. Herein, we designed a novel benzodithiophene-based small molecule donor BDTF-CA with deep highest occupied molecular orbital(HOMO) energy level. All-small-molecule OSCs were fabricated by combing non-fullerene acceptor IDIC with different fluorine-atom numbers. Two or four fluorine atoms were introduced to the end-capped acceptor of IDIC, which are named as IDIC-2 F and IDIC-4 F, respectively. With the increase of fluorination from IDIC to IDIC-4 F, the open circuit voltage(Voc) of the devices decreased, while hole and electron mobilities of the active layers increased by one order of magnitude. Contributed to the most balanced Voc, short-circuit current(Jsc) and fill factor(FF), the device based on BDTF-CA/IDIC-2 F achieved the highest power conversion efficiency of 9.11%.

关键词： organic solar cells all-small-molecule fluorination blend morphology energy levels

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Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells

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Journal of Energy Chemistry 2021年第1期30卷 228-233,I0008页

作者： ruimin zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li Min Lv Ziyun Huang Menglan Lv Jianqi Zhang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish Center for Education and Research Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100190China Nano-Science Center&Department of Chemistry University of CopenhagenCopenhagen DK-2100Denmark School of Chemical Engineering Guizhou Institute of TechnologyGuiyang 550003GuizhouChina

Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end group.Energy levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration strategies.Especially,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor.

关键词： All-small-molecule Chlorination and sulfuration Fibrous morphology Crystallinity

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Single-bond-linked oligomeric donors for high performance organic solar cells

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Chinese Chemical Letters 2023年第2期34卷 604-609页

作者： Min Lv Yi Tang Dingding Qiu Wenjun Zou ruimin zhou Lixuan Liu Ziyun Huang Jianqi Zhang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The effective design and synthesis of novel small-molecule donors(SMDs) is extremely essential for the in-depth study of the scientific problems of bulk heterojunction morphology and the improvement of photovoltaic performance in organic solar cells(OSCs). Importantly, developing a series of donors with different conjugated central donor(D) units is a remarkable strategy to obtain high-performance donors. Herein, two acceptor-donor-donor-acceptor(A-D-D-A) type oligomeric donors 2DTBDT and2DTBDT-2T with two dithieno[2,3-d:2,3-d’]benzo[1,2-b:4,5-b’]dithiophene(DTBDT) as D units, without and with bithiophene as the π bridge respectively are designed and synthesized successfully. The central linked-DTBDT unit can provide a larger conjugated plane and promote π electron delocalization, which can effectively improve π-π interactions between donors and regulate the crystallinity. And we found that the π bridge provided 2DTBDT-2T with 12.31% efficiency that is already a high efficiency in OSCs,whereas 2DTBDT with merely 3.63% efficiency, both with 2,2-((2Z,2 Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2,"3 ’:4,5 ]thieno[2,3 :4,5]pyrrolo[3,2-g]thieno-[2,3 :4,5]thieno[3,2-b]indole,10-diyl)bis(methanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene)) dimalononitrile(Y6) as the acceptor. We conjecture that the main reason for the different device performance may be ascribed to the different molecular stacking orientation of the oligomeric donors and morphology features of the donors:Y6 blend films. Compared to the predominant face-on orientation of the 2DTBDT neat film, the 2DTBDT-2T neat film performed a preferential edge-on orientation, which obtained a smoother surface, stronger crystallinity and more uniform phase separation in the 2DTBDT-2T:Y6 blend films with nanofiber structure, which delivered higher and more balanced carrier mobilities, the more efficient exciton dissociation and reduced biomolecule recombination, therefore obtaining better power conve

关键词： Linked donor Oligomeric donors Molecular stacking orientation Organic solar cells

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A-π-D-π-A small-molecule donors with different end alkyl chains obtain different morphologies in organic solar cells

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Chinese Chemical Letters 2019年第4期30卷 906-910页

作者： Yanan Shi Chen Yang Huan Li Lixuan Liu ruimin zhou Wenjun Zou Zhen Wang Qiong Wu Dan Deng Jianqi Zhang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences Sino-Danish College University of Chinese Academy of Sciences

For bulk-heterojunction organic solar cells, the morphology of the blend films highly influence the exciton dissociation and charge transport process. In this work, two novel A-π-D-π-A(A represents the acceptor unit and D represents the donor unit) backbone structure small molecular electron donors based on two dimensional conjugated naphtho[1,2-b:5,6-b']dithiophene(NDT) with different end alkyl chains, named as NDT-3T-EH and NDT-3T-O, have been designed and synthesized. The photovoltaic property of NDT-3T-O-based device is better than that of the NDT-3T-EH and the best efficiency reaches 7.06%, and the photovoltaic property of NDT-3T-EH reaches 6.11%. The difference in the performance should be attributed to the different morphology and phase separation resulted from the different crystallinity and aggregation ability of two donors. The results demonstrate that the optimized end alkyl chains can be used to design A-π-D-π-A backbone structure small molecular electron donors for smallmolecule organic solar cells.

关键词： Organic solar cells All-small-molecule A-π-D-π-A small molecular donor End alkyl chain Morphology of active layer

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金融服务新时代“千万工程”研究

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农银学刊 2024年第1期 30-34页

作者：龚志坚李万文张微雅周睿旻中国农业银行浙江省分行

“千村示范、万村整治”工程是习近平总书记在浙江工作时亲自谋划、亲自部署、亲自推动的一项重大决策。2024年中央农村工作会议讨论了《中共中央、国务院关于学习运用“千村示范、万村整治”工程经验有力有效推进乡村全面振兴的意见(... 详细信息

“千村示范、万村整治”工程是习近平总书记在浙江工作时亲自谋划、亲自部署、亲自推动的一项重大决策。2024年中央农村工作会议讨论了《中共中央、国务院关于学习运用“千村示范、万村整治”工程经验有力有效推进乡村全面振兴的意见(讨论稿)》。本文从“千万工程”浙江经验入手,介绍中国农业银行浙江省分行近年来在服务“千万工程”中的具体做法,分析新形势下金融服务“千万工程”面临的机遇与挑战,探讨新时代金融服务“千万工程”的新思路新方法。

关键词：千万工程浙江经验金融服务

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