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Coupling Co-Ni phosphides for energy-saving alkaline seawater splitting

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Nano Research 2024年第6期17卷 4797-4806页

作者： Weijia Liu Wenxian Liu Tong Hou Junyang Ding Zhigui Wang ruilian Yin Xingyuan San Ligang Feng Jun Luo Xijun Liu State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured MaterialsMOE Key Laboratory of New Processing Technology for Nonferrous Metals and MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China hebei Key Laboratory of Optic-electronic Information and Materials the College of Physics Science and TechnologyHebei UniversityBaoding 071002China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaShenzhen 518110China

The coupling of energy-saving small molecule conversion reactions and hydrogen evolution reaction(heR)in seawater electrolytes can reduce the energy consumption of seawater electrolysis and mitigate chlorine corrosion ***,the fabrication of efficient multifunctional catalysts for this promising technology is of great ***,a heterostructured catalyst comprising CoP and Ni_(2)P on nickel foam(CoP/Ni_(2)P@NF)is reported for hydrazine oxidation(HzOR)-assisted alkaline seawater *** coupling of CoP and Ni_(2)P optimizes the electronic structure of the active sites and endows excellent electrocatalytic performance for HzOR and ***,the two-electrode HzOR-assisted alkaline seawater splitting(OHzS)cell based on the CoP/Ni_(2)P@NF required only 0.108 V to deliver 100 mA·cm^(−2),much lower than 1.695 V for alkaline seawater electrolysis ***,the OHzS cell exhibits satisfactory stability over 48 h at a high current density of 500 mA·cm^(−2).Furthermore,the CoP/Ni_(2)P@NF heterostructured catalyst also efficiently catalyzed glucose oxidation,methanol oxidation,and urea oxidation in alkaline seawater *** work paves a path for high-performance heterostructured catalyst preparation for energy-saving seawater electrolysis for H_(2) production.

关键词： seawater splitting heterostructure electrocatalysis hydrazine oxidation reaction hydrogen evolution reaction

Plasma proteome profiling reveals biomarkers of chemotherapy resistance in patients with advanced colorectal cancer

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Quantitative Biology 2024年第2期12卷 215-224页

作者： Jingxin Yang Jin Chen Luobin Zhang Fangming Zhou Xiaozhen Cui Ruijun Tian ruilian Xu Medical Genetic Center Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical UniversityShenzhenChina Clinical Center for Molecular Diagnosis and Therapy The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouChina Department of Chemistry and Research Center for Chemical Biology and Omics Analysis School of ScienceSouthern University of Science and TechnologyShenzhenChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenChina

Colorectal cancer(CRC)is one of the most common *** with advanced CRC can only rely on chemotherapy to improve ***,primary drug resistance frequently occurs and is difficult to *** in plasma protein composition have shown potential in clinical ***,it is urgent to identify potential protein biomarkers for primary resistance to chemotherapy for patients with *** sample preparation and high-throughput analysis were used to explore potential plasma protein *** susceptibility testing of circulating tumor cells(CTCs)has been investigated,and the relationship between their values and protein expressions has been *** addition,the differential proteins in different chemotherapy outcomes have been ***,the potential biomarkers have been detected via enzyme-linked immunosorbent assay(ELISA).Plasma proteome of 60 CRC patients were *** correlation between plasma protein levels and the results of drug susceptibility testing of CTCs was performed,and 85 proteins showed a significant positive or negative correlation with chemotherapy ***-four CRC patients were then divided into three groups according to their chemotherapy outcomes(objective response,stable disease,and progressive disease),and 37 differential proteins were found to be related to chemotherapy *** overlapping proteins were further investigated in an additional group of 79 patients using *** levels of F5 and PROZ significantly increased in the progressive disease group compared to other outcome *** study indicated that F5 and PROZ proteins could represent potential biomarkers of resistance to chemotherapy in advanced CRC patients.

关键词： biomarker chemotherapy resistance colorectal cancer plasma proteome

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西药房门诊处方点评和不合理处方分析

临床合理用药杂志 2021年第31期14卷 4-7页

作者：何瑞连余文飞广东省云浮市慢性病防治中心药剂科 527300

目的分析西药房门诊处方不合理情况,找出相应的改进措施,提高用药合理性。方法随机抽取云浮市慢性病防治中心西药房2020年1-6月门诊处方1200张,对处方进行点评,分析不合理处方情况。结果1200张处方中,合理处方1125张,合理率为93.75%;不... 详细信息

目的分析西药房门诊处方不合理情况,找出相应的改进措施,提高用药合理性。方法随机抽取云浮市慢性病防治中心西药房2020年1-6月门诊处方1200张,对处方进行点评,分析不合理处方情况。结果1200张处方中,合理处方1125张,合理率为93.75%;不合理处方75张,不合理率为6.25%。不合理处方包括不规范处方、不适宜处方和超常处方,同时存在2种不合理处方类型的处方19张占25.33%,只存在1种不合理处方类型的处方56张占74.67%。结论西药房门诊处方存在一定不合理性,应加强HIS系统学习和设置,加强审方系统建设,为合理用药提供设备基础,同时,健全相关规章制度,促进医师和药师的学习,更新知识,提高审核水平,减少不合理处方,促进合理用药和安全用药。

关键词：西药房门诊处方处方审核合理用药改进措施

慢性阻塞性肺疾病急性加重期抗凝治疗的疗效观察

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中国煤炭工业医学杂志 2014年第9期17卷 1435-1437页

作者：和瑞莲张国际焦作煤业(集团)有限责任公司中央医院呼吸科河南省焦作市454000

目的探讨在慢性阻塞性肺疾病急性加重期(AECOPD)应用低分子肝素钙抗凝治疗对患者肺功能、动脉血气分析和凝血功能的影响。方法 80例患者按随机原则分为对照组42例和抗凝组38例。对照组患者给予吸氧、抗感染、解痉平喘、止咳化痰治疗,抗... 详细信息

目的探讨在慢性阻塞性肺疾病急性加重期(AECOPD)应用低分子肝素钙抗凝治疗对患者肺功能、动脉血气分析和凝血功能的影响。方法 80例患者按随机原则分为对照组42例和抗凝组38例。对照组患者给予吸氧、抗感染、解痉平喘、止咳化痰治疗,抗凝组在对照组常规治疗的基础上加用低分子肝素钙4 100IU/次,腹壁皮下注射,每12h 1次。二组均7d为1个疗程。二组均于治疗前后检测肺功能、动脉血气分析和凝血功能。结果二组肺功能、血气分析在治疗7d后较治疗前均有改善(P均0.05)。抗凝组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论应用低分子肝素钙抗凝治疗AECOPD,在改善患者凝血功能的同时能更好的改善患者的肺功能、提高有效率。

关键词：慢性阻塞性肺疾病急性加重期抗凝治疗肺功能凝血功能

TabHLH27 orchestrates root growth and drought tolerance to enhance water use efficiency in wheat

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Journal of Integrative Plant Biology 2024年第7期66卷 1295-1312页

作者： Dongzhi Wang Xiuxiu Zhang Yuan Cao Aamana Batool Yongxin Xu Yunzhou Qiao Yongpeng Li Hao Wang Xuelei Lin Xiaomin Bie Xiansheng Zhang ruilian Jing Baodi Dong Yiping Tong Wan Teng Xigang Liu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell Signaling and Environmental AdaptationHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC‐CASBeijing 100101China

Cultivating high-yield wheat under limited water resources is crucial for sustainable agriculture in semiarid *** water scarcity,plants activate drought response signaling,yet the delicate balance between drought tolerance and development remains *** genome-wide association studies and transcriptome profiling,we identified a wheat atypical basic helix-loop-helix(b HLH)transcription factor(TF),Tab HLH27-A1,as a promising quantitative trait locus candidate for both relative root dry weight and spikelet number per spike in *** HLH27-A1/B1/D1 knockout reduced wheat drought tolerance,yield,and water use efficiency(WUE).Tab HLH27-A1 exhibited rapid induction with polyethylene glycol(PEG)treatment,gradually declining over *** activated stress response genes such as Ta CBL8-B1 and Ta CPI2-A1 while inhibiting root growth genes like Ta SH15-B1 and Ta WRKY70-B1 under short-term PEG *** distinct transcriptional regulation of Tab HLH27-A1 involved diverse interacting factors such as Ta ABI3-D1 and Tab *** variations of Tab HLH27-A1influence its transcriptional responses to drought stress,with Tab HLH27-A1^(Hap-II)associated with stronger drought tolerance,larger root system,more spikelets,and higher WUE in ***,the excellent Tab HLH27-A1^(Hap-II)was selected during the breeding process in China,and introgression of Tab HLH27-A1^(Hap-II)allele improved drought tolerance and grain yield,especially under water-limited *** study highlights Tab HLH27-A1's role in balancing root growth and drought tolerance,providing a genetic manipulation locus for enhancing WUE in wheat.

关键词： drought tolerance GWAS root growth wheat WUE

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呼吸机相关性肺炎的危险因素及病原学分析

中国社区医师 2014年第10期 26-26页

作者：和瑞莲张国际河南省焦作煤业(集团)有限责任公司中央医院呼吸科

目的:探讨呼吸机相关性肺炎(VAP)的危险因素及病原学特点,为今后的临床工作提供参考依据。方法:收治机械通气治疗时间>48小时的患者53例,分析VAP的危险因素、病原菌及耐药性。结果:53例患者中VAP患者23例(43.4%)。糖尿病、气管切开患者... 详细信息

目的:探讨呼吸机相关性肺炎(VAP)的危险因素及病原学特点,为今后的临床工作提供参考依据。方法:收治机械通气治疗时间>48小时的患者53例,分析VAP的危险因素、病原菌及耐药性。结果:53例患者中VAP患者23例(43.4%)。糖尿病、气管切开患者VAP的发病率增高(P<0.05);VAP组病死率明显高于无VAP组(P<0.05);VAP病原菌以革兰阴性菌为主(66.7%),其中以鲍曼不动杆菌为主要致病菌(21.4%),大多数病原菌出现严重耐药。结论:多种临床因素与VAP的发病有关,其主要危险因素为机械通气时间的长短;VAP病原菌以革兰阴性菌为主,耐药率高;VAP的发生严重影响患者的预后,应加强预防工作,降低VAP发生率及死亡率。

关键词：呼吸机相关性肺炎危险因素病原学

非小细胞肺癌放疗患者发生放射性肺炎的危险因素分析及血清sCD163对RP的诊断价值

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实用癌症杂志 2022年第1期37卷 32-35页

作者：和瑞莲张国际和文杰焦作煤业(集团)有限责任公司中央医院 454000

目的探讨非小细胞肺癌(NSCLC)放疗患者发生放射性肺炎(RP)的危险因素及血清可溶性清道夫受体分化抗原163(sCD163)对RP的早期诊断价值。方法选取接受放疗的NSCLC患者130例,根据患者有无发生RP将患者分为RP组(n=38)和非RP组(n=92),分析非... 详细信息

目的探讨非小细胞肺癌(NSCLC)放疗患者发生放射性肺炎(RP)的危险因素及血清可溶性清道夫受体分化抗原163(sCD163)对RP的早期诊断价值。方法选取接受放疗的NSCLC患者130例,根据患者有无发生RP将患者分为RP组(n=38)和非RP组(n=92),分析非小细胞肺癌(NSCLC)患者放疗后放射性肺炎(RP)的危险因素,比较2组血清sCD163水平,采用受试者工作特征曲线(ROC)评价血清sCD163对RP的诊断价值。结果单因素分析结果显示:肿瘤大体类型、肿瘤部位、GTV、全肺V5、AVS5、全肺V20、AVS20、MLD与NSCLC患者放疗后发生RP有关(P<0.05);多因素分析结果显示:肿瘤部位、V5、AVS5均是NSCLC患者放疗后发生RP的危险因素(P<0.05)。RP组血清sCD163水平明显高于非RP组(P<0.05)。ROC分析结果显示:血清sCD163诊断NSCLC患者放疗后发生RP的曲线下面积(AUC)为0.852(95%CI:0.763~0.940),灵敏度为80.49%,特异度为63.41%(P<0.001)。结论NSCLC患者放疗后RP发生率较高,导致RP发生的危险因素包括肿瘤部位、V5、AVS5。同时血清sCD163对NSCLC患者放疗后发生RP具有较高的诊断价值。

关键词：非小细胞肺癌放射性肺炎危险因素放疗可溶性清道夫受体分化抗原163 诊断价值

奥西替尼靶向治疗NSCLC的近远期疗效观察

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实用癌症杂志 2021年第3期36卷 486-489页

作者：和瑞莲张国际和文杰焦作煤业(集团)有限责任公司中央医院 454000

目的探讨奥西替尼靶向治疗NSCLC的近远期疗效。方法回顾性分析80例晚期NSCLC患者临床资料,依照治疗方案将给予吉西他滨联合卡铂的化疗的患者39例纳入B组,给予奥西替尼靶向治疗的患者41例纳入A组,比较2组患者治疗前后实体瘤疗效、血清肿... 详细信息

目的探讨奥西替尼靶向治疗NSCLC的近远期疗效。方法回顾性分析80例晚期NSCLC患者临床资料,依照治疗方案将给予吉西他滨联合卡铂的化疗的患者39例纳入B组,给予奥西替尼靶向治疗的患者41例纳入A组,比较2组患者治疗前后实体瘤疗效、血清肿瘤标志物[癌胚抗原(CEA)、细胞角蛋白19片断21-1(CYFRA21-1)、神经特异性烯醇酶(NSE)、癌胚抗原125(CA125)]水平、T淋巴细胞水平、不良反应发生率以及随访2年生存结果。结果A组临床治疗有效率(80.49%)高于B组(58.97%)(P0.05);A组2年生存率高于B组(P<0.05)。结论奥西替尼靶向治疗非小细胞肺癌近远期效果确切,可抑制血清肿瘤标志物表达,提高患者免疫力,延长生存期,且不良反应可耐受,安全性较高。

关键词：非小细胞肺癌靶向治疗奥西替尼近远期疗效

没食子酸分子印迹聚合物的合成及识别性能研究

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广东石油化工学院学报 2018年第3期28卷 39-44页

作者：殷亮何瑞莲蒋达洪黄敏中国石油大学(华东)化学工程学院山东青岛266580 广东石油化工学院化学工程学院广东茂名525000

采用分子印迹技术合成了没食子酸分子印迹聚合物,通过实验研究了功能单体种类、模板分子与功能单体的物质的量之比、交联剂和溶剂种类不同的条件下制备的印迹聚合物的吸附性能,从而确定了没食子酸印迹聚合物制备的适宜条件;对合成的没... 详细信息

采用分子印迹技术合成了没食子酸分子印迹聚合物,通过实验研究了功能单体种类、模板分子与功能单体的物质的量之比、交联剂和溶剂种类不同的条件下制备的印迹聚合物的吸附性能,从而确定了没食子酸印迹聚合物制备的适宜条件;对合成的没食子酸分子印迹聚合物进行了等温吸附和Scatchard分析,研究了没食子酸分子印迹聚合物的识别特性,并通过红外光谱和扫描电镜表征了印迹聚合物的微观结构和微观形貌。

关键词：没食子酸分子印迹聚合物识别性能吸附量